SFEBES2026 Poster Presentations Metabolism, Obesity and Diabetes (68 abstracts)
Metabolic-bariatric surgery outcomes in people with pre-surgical mental health diagnoses
Luke Boyle 1,2 , Dana Madhi 1 , Zahra Al-Essah 1 , Ali Abdul Hussein 1 , Mina Abdul Hussein 1 , Aslesha Deshraju 1 , Elena Brachimi 1 , Prasidha Rai 1 , Elsie Ampomah 3 , Neha Hussain 3 , Faizan Kiani 3 , Mary Obigbesan 3 , Sanjay Purkayastha 1,4 , Christos Tsironis 1 , Sherif Hakky 1 , Ahmed Ahmed 1,3 , Tricia Tan 1,3 , Julia Kenkre 1 , Kleopatra Alexiadou 1,3 , Saira Hameed 1,3 , Harvinder Chahal 1 , Lucy Tweedle 1 , Samantha Scholtz 1 , Patricia Ortega 1 & Chioma Izzi-Engbeaya 1,3
1Imperial College Healthcare NHS Trust, London, United Kingdom; 2Barts Health NHS Trust, London, United Kingdom; 3Imperial College London, London, United Kingdom; 4Brunel University, London, United Kingdom
Background: Metabolic–bariatric surgery (MBS) is increasingly performed in patients with obesity and mental health (MH) conditions, yet the interplay between these conditions, weight loss and other outcomes remains unclear.
Objective: To evaluate relationships between preoperative MH conditions and postoperative psychological complications and metabolic outcomes two years after MBS.
Methods: We analysed a cohort of adults who underwent primary MBS at a tertiary bariatric centre from 2021-2024. Multivariable linear and modified Poisson regression models were used to assess weight, metabolic, and psychological outcomes adjusted for age, sex, BMI, type 2 diabetes, and type of bariatric surgery.
Results: After excluding patients who became pregnant or were diagnosed with cancer postoperatively, 482 were included and of these, 217 (45%) had ≥1 MH condition diagnosed preoperatively (81.5% women, mean±SD age 44.6±11.5 years, mean±SD BMI 45.2±8.2 kg/m2). Baseline characteristics were comparable between MH and non-MH groups, apart from a higher proportion of women among those with MH conditions (88% vs 76%; P < 0.001). Two years post-surgery, %TWL was similar between patients with and without MH conditions (P = 0.34). Likelihood of suboptimal weight loss (<20%TWL) or weight regain did not differ by MH status. Psychotropic medication use remained stable after surgery (Rr = 0.99, 95% CI 0.88–1.12; P = 0.87), while higher baseline BMI modestly increased likelihood of ongoing psychotropic medication use postoperatively (β 1.02 per kg/m2; P = 0.01). Patients with MH conditions had increased risks of postoperative suicidal ideation (RR 9.67, 95% CI 1.53–61.04; P = 0.016) and self-harm/attempted suicide (RR 7.00, 95% CI 1.08–45.46; P = 0.042).
Conclusions: People with preexisting MH conditions have comparable post-surgical weight loss outcomes to people without MH conditions. Significant associations exist between preoperative MH conditions and postoperative suicidal ideation and self-harm/attempted suicide. These findings suggest that postoperative care should integrate dedicated mental health follow-up to optimise long-term outcomes.
Volume 117
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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