SFEBES2026 Poster Presentations Metabolism, Obesity and Diabetes (68 abstracts)
Utilising urine as a non-invasive biofluid to assess type 2 diabetes and predict metabolic improvement with bariatric surgery
Alice Murphy 1 , Vaishali Asawala 1 , Graham Ball 2 , Ioannis Kyrou 3 , Jana Vrbikova 4 , Vojtech Hainer 4 , Petra Sramkova 5 , Martin Fried 5 , Gyanendra Tripathi 1 & Philip McTernan 6
1Nottingham Trent University, Nottingham, United Kingdom; 2Intelligent OMICS Limited, Nottingham, United Kingdom; 3University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; 4Institute of Endocrinology, Prague, Czech Republic; 5OB Clinic, Prague, Czech Republic; 6De Montfort University, Leicester, United Kingdom
Introduction: Diagnosing and monitoring type 2 diabetes (T2DM) requires blood testing, which, although being minimally invasive, requires trained medical professionals. Additionally, bariatric surgery may result in T2DM remission, but this varies between 40-80% of patients. Urine samples offer a non-invasive method which may be suitable to screen, monitor, and predict changes in hyperglycaemia/T2DM following bariatric surgery. We investigated pre- and post-surgery urine samples as a method to distinguish between disease states (obesity and T2DM), bariatric surgery type, and T2DM improvement following surgery.
Methods: Urine samples were collected from female white European participants (age=52.7±1.39 years; body mass index=41.6±1.09 kg/m2; n = 40) with T2DM undergoing bariatric surgery, at baseline (pre-surgery), 1-month and 6-months post-surgery. Samples were assessed via mass spectrometry (MS), identifying 2557 proteins in total; Amica software was used to determine differences in (1) obesity status; (2) diabetic status; (3) surgery type; and (4) T2DM improvement.
Results: MS identified differentially expressed proteins based on obesity status (class-1 vs class-2: n = 46; class-1 vs class-3: n = 134; class-2 vs class-3: n = 330) and T2DM status (no T2DM vs T2DM: n = 75; no T2DM vs prediabetes: n = 112; prediabetes vs T2DM: n = 385). One month post-surgery, gastric plication (GP) patients had a different protein profile to laparoscopic adjustable gastric banding (LAGB) and biliopancreatic diversion (BPD) patients; this was lost at 6-months post-surgery. 57 differential proteins were identified in pre-surgery urine based on T2DM improvement at 6-months post-surgery.
Discussion: This highlights urine as a useful, non-invasive biofluid that can distinguish between obesity and T2DM statuses. Moreover, urinary protein profiles differ based on bariatric surgery type, and pre-surgery urine samples may be used to predict T2DM improvement following bariatric surgery. This suggests that urine sampling could be utilised as an additional screening/monitoring tool, which could also aid to stratify patients for personalised support to improve success rates post-bariatric surgery.
Volume 117
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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