SFEBES2026 Poster Presentations Neuroendocrinology and Pituitary (40 abstracts)
Histological and biochemical analysis of pituitary surgeries performed over a decade
Zenab Sher 1 , Jamie Rosen 1,2 , Miran Albatayneh 1,3 , Mehdi Maqsood 1 , Mekha Mathew 1 , Harpal Randeva 1 , Amjad Shad 1 & Pratibha Natesh 1,2
1University Hospitals Coventry and Warwickshire, Coventry, United Kingdom; 2Warwick Medical School, Warwick, United Kingdom; 3Mutah University, Karak, Jordan
Methods: A retrospective cross-sectional analysis of 152 patients who underwent endoscopic endonasal transsphenoidal surgery (EETS) in University Hospitals Coventry and Warwickshire over a 10-year period from 2013 to 2024.
Results: Histology, endocrine dysfunction and recurrence of pituitary adenoma were reviewed in 64 males (42.1%) and 88 female patients (57.9%). Presentations included visual field disturbance, incidentaloma, acromegaly, headaches and Cushing’s disease. Histology showed that 133 (87.5%) were macroadenomas and 14 (9.2%) microadenomas. Recurrence requiring re-do surgery occurred in 17 (11.2%) patients. Postoperative complications were similar to that reported in literature. Of note, we found that recurrent tumours had a low Ki-67 index of 0-3%.
| Number | Percentage | |
| Non-functioning Gonadotroph adenomas | 72 | 47.4 % |
| Somatotroph adenomas | 25 | 16.4 % |
| Non staining adenomas | 12 | 7.9 % |
| Corticotroph adenomas | 12 | 7.9 % |
| Plurihormonal adenomas | 11 | 7.2 % |
| Silent corticotroph adenomas | 4 | 2.6 % |
| Cyst | 4 | 2.6 % |
| Prolactinoma | 1 | 0.7 % |
| Thyrotroph adenoma | 1 | 0.7 % |
| Miscellaneous | 11 | 7.2 % |
Discussion: Pituitary adenomas account for about 15% of all intra-cranial tumours. Pituitary adenomas that do not cause a characteristic hormone hypersecretion syndrome (null cell and the majority of gonadotroph adenomas) are referred to as non-functioning pituitary neuroendocrine tumours (PitNETs). Gonadotroph adenomas are pituitary adenomas derived from steroidogenic factor 1 (SF-1) lineage, and remain the most common subtype of non-functioning pituitary neuroendocrine tumours (PitNETs). Surgical resection is the preferred first-line treatment for all functioning pituitary adenomas except prolactinomas.
Conclusion: Histology analysis in this patient cohort is consistent with existing literature on incidence of pituitary adenomas. Although medical therapy offers effective treatment for functional tumours in specific situations, transsphenoidal surgery continues to provide optimal outcomes for non-prolactin secreting adenomas with a low incidence of major morbidity.
Volume 117
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Endocrine Abstracts
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