IDSD2026 Poster Abstracts Poster Abstracts (93 abstracts)
Gender-related behaviour in children with different DSD diagnoses using the validated questionnaire KI-GRB
Carl Lundeberg 1 , Luise Landreh 1,2 , Dina Bolander 1 , Vant Westeinde 1 , Annika Reims 3 , Anna Strandqvist 1,4 , Svetlana Lajic 1,2 & Anna Nordenström 1,2
1Department Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; 2Department of Pediatric Endocrinology, Karolinska University Hospital, Stockholm Sweden; 3Department of Pediatric Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden; 4Department of Psychology, Karolinska University Hospital, Stockholm Sweden. Correspondence to: [email protected]
Background: Gender- related behaviour is described to be influenced by many different factors. Prenatal exposure to sex hormones has been previously shown to play a role in the development. Girls with congenital adrenal hyperplasia (CAH) show more masculine behavior patterns but the relationship between prenatal exposure and postnatal behavior in children with other disorders of sex development (DSD) is less studied.
Aim: To investigate the relationship between prenatal exposure to sex hormones and gender-related behaviour in children with different DSD diagnoses. To test the validated KI-GRB (KI-gender related behaviour) questionnaire as a tool for studying DSD patients.
Material and Methods: The study included 107 participants aged 3-17 years from both Stockholm and Gothenburg with various forms of DSD and healthy controls. Gender-related behaviour was evaluated using the validated KI-GRB questionnaire, with responses categorized as masculine, feminine, or neutral.
Results: CAH girls showed a more masculine behaviour pattern compared to matching controls (P <0,001) with an increasing effect according to disease severity. Boys with hypospadias showed higher feminine scores (P =0.001) and XY girls higher masculine scores (P =0.049) compared to controls. Neutral behavior increased with age in both sexes, significant in girls (P =0.007).
Conclusions: Our study confirms that prenatal androgen exposure influences gender-related behavior while revealing unexpected patterns in hypospadias. These findings highlight the complex interplay between hormonal, developmental, and social factors in behavioural development. The KI-GRB questionnaire proved to be a useful tool in the study of gender-related behavior of children with DSD, confirming previous results in the CAH group.
Volume 118
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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