Endocrine Abstracts

Background: The NCYPDN plan describes a care model where children, young people (CYP) and families ‘co-design their care plan during appointments’ and ‘have a say in service planning.’ RCPCH ‘Voice Matters’ notes children want clinicians to ‘better understand how we are feeling, to ensure we’re involved in our treatment and have the support we need’. Our clinic experience found some CYP we...

This talk will cover the currently available evidence describing the endocrine and metabolic consequences of radiotherapy treatment to the hypothalamus and pituitary. A practical approach to surveillance, diagnosis and management of these consequences in childhood and adult cancer survivors will be provided....

Cranial Diabetes Insipidus (CDI) is associated with significant polyuria and is treated with desmopressin. Inappropriate or missed treatment can result in significant electrolyte imbalance and potential harm. A recent UK survey of Endocrinologists reported 55% had concerns about knowledge in their trust, 39% felt they had observed patients come to harm. Patients not receiving desmopressin have been associated with death, leading to an NHS England (NHSE) safety alert in 2016. W...

Background: Acute adrenal insufficiency is a life threatening condition. Signs and symptoms are often non-specific. The adrenal gland has the richest arterial supply of any tissue with limited venous drainage and this mismatch predisposes to haemorrhagic infarction. We present a case report of acute adrenal insufficiency due to bilateral adrenal haemorrhagic infarcts associated with an open ankle fracture.Case history: A 52-year man fell from a ladder su...

IntroductionCardiovascular complications are the main cause of increased mortality in Turner Syndrome (TS). We have previously described a high prevalence of occult aortic dysmorphology in women with TS. The aim of this study was to introduce a classification system for the variety of appearances seen by magnetic resonance imaging (MRI).Method98 women (median age 29.0, range 18.1-64.2 years) underwent MRI scanning of the aorta. MRI appearances were correlated with ...

Glucocorticoids are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, importan...

Cancer and treatments for cancer can have a significant impact on bone health in both children and adults. There are emerging data that bone mineral density is often reduced in survivors of childhood cancers and survivors of both solid tumours and haematological malignancies in adults. Fracture rates in childhood cancer survivors have not been shown to be increased. Older adult cancer survivors, particularly those treated with aromatase inhibitors and androgen deprivation ther...

Glucocorticoids are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, importan...

Cancer and treatments for cancer can have a significant impact on bone health in both children and adults. There are emerging data that bone mineral density is often reduced in survivors of childhood cancers and survivors of both solid tumours and haematological malignancies in adults. Fracture rates in childhood cancer survivors have not been shown to be increased. Older adult cancer survivors, particularly those treated with aromatase inhibitors and androgen deprivation ther...

Background: Hypothyroidism is characterised by insufficient secretion of the thyroid and its detection measured by elevated serum TSH levels.Although relatively common during pregnancy, untreated maternal hypothyroidism is associated with adverse obstetric and neonatal outcomes such as preeclampsia, placental abruption and miscarriage, or foetal neurodevelopment defects.Highlighting a nurse led specialised telephone clinic in the c...