Endocrine Abstracts

This talk will cover the currently available evidence describing the endocrine and metabolic consequences of radiotherapy treatment to the hypothalamus and pituitary. A practical approach to surveillance, diagnosis and management of these consequences in childhood and adult cancer survivors will be provided....

A 47-year-old man attending Endocrine services for the management of Cushing’s disease in remission, presented with resistant hypertension which warranted further investigation. He initially presented in 2013 with Cushing’s disease and underwent successful transsphenoidal surgery. Postoperatively he was diagnosed with ACTH deficiency, partial growth hormone deficiency, and diabetes insipidus for which he was prescribed hydrocortisone 10 mg daily and desmotab 0.2 mg n...

Primary aldosteronism (PA) is the most common cause of endocrine hypertension. Following biochemical confirmation of aldosterone excess, adrenal venous sampling (AVS) is the gold standard investigation to lateralise the source of aldosterone hypersecretion in patients deemed suitable for potential adrenalectomy. AVS has been performed for all suitable patients with a diagnosis of PA in Beaumont Hospital since implementation of a new protocol involving collaboration between End...

Introduction: SARS-CoV2 infection or vaccination against SARS-CoV2 has been linked to the onset or recurrence of Autoimmune and subacute thyroiditis resulting in thyroid dysfunction.Case: We describe a case of Thyroid eye disease temporally associated with SARS-CoV 2 infection in a 48 year old female with a one-year history of subclinical hypothyroidism without interval thyroid hormone replacement or SARS-CoV2 vaccination. Two months following PCR confir...

Glucocorticoids are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, importan...

Cancer and treatments for cancer can have a significant impact on bone health in both children and adults. There are emerging data that bone mineral density is often reduced in survivors of childhood cancers and survivors of both solid tumours and haematological malignancies in adults. Fracture rates in childhood cancer survivors have not been shown to be increased. Older adult cancer survivors, particularly those treated with aromatase inhibitors and androgen deprivation ther...

Glucocorticoids are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, importan...

Cancer and treatments for cancer can have a significant impact on bone health in both children and adults. There are emerging data that bone mineral density is often reduced in survivors of childhood cancers and survivors of both solid tumours and haematological malignancies in adults. Fracture rates in childhood cancer survivors have not been shown to be increased. Older adult cancer survivors, particularly those treated with aromatase inhibitors and androgen deprivation ther...

Background: Hypothyroidism is characterised by insufficient secretion of the thyroid and its detection measured by elevated serum TSH levels.Although relatively common during pregnancy, untreated maternal hypothyroidism is associated with adverse obstetric and neonatal outcomes such as preeclampsia, placental abruption and miscarriage, or foetal neurodevelopment defects.Highlighting a nurse led specialised telephone clinic in the c...

Case History: A 26 year old female patient was referred to her local endocrine clinic having presented to her GP complaining of ankle swelling. Routine biochemistry revealed a suppressed TSH (<0.05 U/l), and reduced serum levels of free T4 (2.0 pmol/l) and T3 (3.2 pmol/l). Random serum cortisol measurements were also elevated on 2 separate occasions (1266 nmol/l and 991 nmol/l). Clinical examination revealed her to be clinically euthyroid with no evidence of ...