Endocrine Abstracts

Emerging evidence indicates that the cellular machinery controlling the splicing process (spliceosome) is altered in several tumour types, leading to oncogenic splicing events associated with tumour progression and aggressiveness. However, whether this molecular phenomenon also occurs in thyroid cancer has not been yet explored. Therefore, our main aim was to explore the potential dysregulation of the expression of relevant spliceosome components and splicing factors in clinic...

Emerging evidence indicates that the cellular machineries controlling gene expression mechanisms and genomic stability are altered in several endocrine-related cancers (ERCs), leading to some oncogenic events associated with tumour progression/aggressiveness. However, whether this phenomenon also occurs in thyroid cancer has not been yet explored. Therefore, this study was focused on: 1) investigating the potential alteration in the levels of components of the molecular machin...

Diabetes Insipidus (DI) results from a relative or absolute deficiency in either the production or action of the posterior pituitary hormone Vasopressin (AVP), the principle endocrine regulator of renal water excretion. The challenges in DI encompass its diagnosis, its treatment and in managing the co-morbidities and complications of the condition. This presentation will cover all these elements, highlighting cases that illustrate some of the key principles in the clinical app...

Diabetes Insipidus (DI) results from a relative or absolute deficiency in either the production or action of the posterior pituitary hormone Vasopressin (AVP), the principle endocrine regulator of renal water excretion. The challenges in DI encompass its diagnosis, its treatment and in managing the co-morbidities and complications of the condition. This presentation will cover all these elements, highlighting cases that illustrate some of the key principles in the clinical app...

Craniopharyngiomas (CPs) are a relatively benign subtype of epithelial tumors that typically originate from the sellar and suprasellar regions of the brain. These endocrine tumors are classified as adamantinomatous (ACP) or papillary (PCP) based on their histological characteristics. Unfortunately, the diagnosis of CPs is frequently made at an advanced stage of tumor development, and therefore relevant associated comorbidities are often present. The first-line treatment is typ...

I present a case of a 32 year old woman who presented in September 2023 with abdominal pain and vomiting. Her blood tests showed; Hb 151 g/l, WCC 18.3, Na 130 mmol/l, K 1.8 mmol/l, Ur 4.7 mmol/l, Creatinine 91 umol/l, Corrected Calcium 2.93 mmol/l, Phosphate 0.54 mmol/l, Lipase 191 unilts/l. Venous Blood Gases showed pH 7.25, Bicarbonate 15.6, Lactate 1.9, pCO2 4.5, Glucose 7.0 mmol/l. She had a background of treated TB aged 25, recent diagnosis of H. Pylori gastritis, and gav...

Background and aims: Diabetes insipidus (DI) is a common complication after transsphenoidal surgery (TSS), but resolves in the majority of patients. We determined the osmolalities and timing of DI most that best predicted long-term outcome.Methods: Case series study randomly including 54 patients out of total 99 patients who underwent transsphenoidal surgery over 18 months. Follow up information was ascertained from clinic review or by telephone intervie...

A 31 year-old lady presented to clinic with an acute, three-week history of rapidly worsening polyuria and polydipsia. She described an eighteen month history of dysmenorrhoea with no galactorrhoea and reported no change in her vision. Her past medical history included alopecia areata one year previously from which she made a full recovery. Clinical examination was normal including full visual fields to red-pin confrontation. Biochemistry identified serum sodium of 141 mmol/l,...

Introduction: Di George’s syndrome is a rare congenital disease that is usually diagnosed in childhood due to its presentation with velo-cardio-facial abnormalities.Case report: A 42-year-old man was incidentally found to be hypocalcaemic (corrected calcium 1.71 mmol/l) during a ‘well-man check’. A subsequent parathyroid hormone (PTH) was inappropriately low at 0.8 pmol/l (reference range 0.5–4.4 pmol/l).He was ...

Case History: We present a very interesting and challenging case of a 71-year-old male, with a significant medical history including Bipolar affective disorder, drug-induced parkinsonism, benign prostatic hyperplasia (BPH), and hypothyroidism. The admission was prompted by a catheter-associated urinary tract infection and subsequent hypernatremia secondary to lithium induced Diabetes Incipidus. Despite initial therapeutic interventions, such as amiloride therapy, the patient c...