Endocrine Abstracts

Background: Telemedicine use has increased rapidly during the COVID-19 pandemic, replacing many face-to-face (FTF) consultations. FTF consultations are associated with increased CO2 emissions (CO2em) from travel to clinics. This study evaluates the triple bottom line of children and young people’s (CYP) and parent or guardian experience of a new telemedicine service, estimated CO2em saving from reduced travel and cost saving to families.Methods: Dat...

Introduction: The aim of having an away day was to enhance relationships across three sites by improving the understanding of each other’s roles, their contributions and ways to provide mutual support. Also the intention was to establish parity through co-designing common practices of working effectively and developing quality improvement projects.Method: Staff members from three Paediatric Diabetes Teams within the same trust were invited to attend...

The skeletal dysplasias are a heterogeneous group of over 450 conditions characterised by abnormalities in growth, development, or differentiation of the skeleton. They are classified according to the International Nosology and Classification of Genetic Skeletal Disorders into 40 different classes reflecting the broad range of phenotypes which vary in severity from perinatal lethality to mild short stature. Broadly, they can be divided into conditions affecting bone mineral ho...

The Best Practice Tariff standards for paediatric diabetes state that each patient must have an annual assessment of their emotional health related to their diabetes. The assessment determines whether input to their care by a clinical psychologist is required and if so, they should have timely access to this or, as appropriate, children and young people’s mental health services. Locally a Systemic Psychotherapist (Family Therapist) rather than a clinical psychologist unde...

Several studies indicated that estrogen receptors (ERs) and vitamin D receptor (VDR), as well 1α-hydroxylase 25-hydroxy vitamin D (1OHase) are expressed in various normal and cancerous cell types. To date, there are no reported studies on the different expressions of VDR, 1OHase and ERs, in human thyroid normal and cancer cells. This study addresses these questions. Tissues harvested from papillary thyroid cancer (PTC) and normal glands explants were used throughout eithe...

Aim: To use experience based co-design to improve the Diabetes Transition Service.Design: Young people with diabetes (type 1 and 2) managed by a district general Paediatric Diabetes Team, were invited to attend a focus group. The focus group, held in a local café, afterschool, was facilitated by two members of the Paediatric Diabetes team and the Diabetes Psychologist. A graphic designer attended to support the young people to visually explore and c...

Introduction: Gestational diabetes insipidus (GDI) is a rare endocrinopathy whose incidence is around four cases per 100 000 pregnancies. It is a potentially life threatening state. We present a case of a 39 year old with GDI.Case report: A previously healthy 39-year-old woman in her 37th week of gestation presented dry oral mucosa with polydipsia and polyuria of 8 l over 24 h for approximately 2 month. The prenatal course of the pregnancy was uncomplica...

Introduction: The diabetes education program for schools and nurseries at an inner city hospital was introduced in 2010. The team offers 3 h sessions ~5–6×/year with the diabetes CNS and specialist diabetes dietician.Aims: To assess the uptake of the sessions; to look at how sessions were offered and delivered; to analyse the evaluation forms filled out by the participants with particular focus on good points and suggestions for improvement; an...

Introduction: Denosumab, a human monoclonal antibody that inhibits activation of osteoclasts provides sustained suppression of bone turnover in osteolytic bone disease. Denosumab has rarely been associated with late hypercalcaemia following therapeutic administration for bone tumours in children, bone metastases in adults and in children with Osteogenesis Imperfecta Type VI.Case report: A male child of Indian origin was referred for advice to GOSH from a...

Introduction: The chondrodysplasias are a heterogeneous group of genetic conditions affecting growth and form of the skeleton. As genetic knowledge has improved and genetic testing has become increasingly available, we hypothesize that over the past 10 years there has been an increase in the number of children where a genetic diagnosis is reached.Aims: To ascertain if there had been an increase in the number of chondrodysplasias confirmed by genetic test...