Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Eposter Presentations

Thyroid cancer

ea0041ep1086 | Thyroid cancer | ECE2016

External beam radiation therapy: a promising tool to enhance mesenchymal stem cell migration towards tumors

Schug Christina , Wechselberger Alexandra , Urnauer Sarah , Schmohl Kathrin A , Muller Andrea M , Schwenk Nathalie , Lauber Kirsten , Nelson Peter J , Spitzweg Christine

The tumor-homing property of mesenchymal stem cells (MSC) has led to their use as delivery vehicles for therapeutic genes such as the sodium iodide symporter (NIS), which has convincingly been demonstrated by our recent studies of systemic NIS gene delivery using MSCs as delivery vehicles in both subcutaneous and orthotopic xenograft mouse models. External beam radiation therapy (EBRT) represents a promising tool in the application of engineered MSC (eMSCs)-based gene therapy ...

ea0041ep1087 | Thyroid cancer | ECE2016

Comparisons of Endothelial Dysfunction, Inflammation and Insulin Resistance in Differentiated Thyroid Cancer Patients According to Their Radioactive Iodine Treatment Status

Dinc Mustafa , Baskoy Kamil , Yildiz Ramazan , Tapan Serkan , Alagoz Engin , Yesildal Fatih , Ozturk Erkan , Taslipinar Abdullah , Aydogdu Aydogan , Deveci Salih , Arslan Nuri , Azal Omer , Sonmez Alper

Objective: Radioactive iodine (RAI) treatment has been reported to be associated to increased cardiovascular events and death compared to the general population, but the mechanism is not fully understood. Endothelial dysfunction, inflammation, and insulin resistance play important roles in the pathogenesis of atherosclerotic events. We aimed to compare papillary thyroid carcinoma patients receiving levothyroxine suppression therapy after bilateral total thyroidectomy with or w...

ea0041ep1088 | Thyroid cancer | ECE2016

Benefits of anti-thyroid peroxidase antibody and anti- thyroglobulin antibody for the prediction of differentiated thyroid cancer in Hashimoto thyroiditis

Ozmen Sevilay Akalp , Cadırcı Kenan , Altunkaynak Konca , Calık İlknur , Yıldız Faruk , Laloğlu Esra , Sevimli Hakan , Gozc Hakan , Arslan Abdulmuttalip , Kaya Yasemin , Keskin Havva , Carlıoğlu Ayşe

Purpose: The association between differentiated thyroid cancers and autoimmune thyroid diseases is well known. Therefore, we aimed to investigate the importance of thyroid peroxidase antibody (anti-TPO) and thyroglobulin antibody (Anti-Tg) in patients followed with the diagnosis of Hashimoto’s thyroiditis regarding the development of differentiated thyroid cancer.Methods: A total of 56 patients including 22 Hashimoto’s thyroiditis patients oper...

ea0041ep1089 | Thyroid cancer | ECE2016

Malignancy in AUS/FLUS: can we create a predictive score?

Silva Silvia , Rafael Ana , Marques Ricardo , Fernandes Luis

Background: Thyroid AUS/FLUS lesions continue to be a grey area regarding the surgery to be carried out. Our aim was to create a predictive malignancy score to help in surgical decision.Methods: Retrospective study of 2981 patients and 3557 thyroid Fine-needle aspirations (FNAs) between January 2012 to December 2014. Ultrasound and cytological findings considered suspicious by the ATA guidelines were analyzed. Malignant group was compared with a control ...

ea0041ep1090 | Thyroid cancer | ECE2016

Differential expression of mRNA of the vitamin D receptor, 1α-hydroxylase 25-hydroxy vitamin D and estrogen receptors in human explants and cell cultures of thyroid cancer and normal tissues

Somjen Dalia , Sharon Orli , Knoll Esther , Aizic Abraham , Fliss David , Limor Rona , Stern Naftali , Izkhakov Elena

Several studies indicated that estrogen receptors (ERs) and vitamin D receptor (VDR), as well 1α-hydroxylase 25-hydroxy vitamin D (1OHase) are expressed in various normal and cancerous cell types. To date, there are no reported studies on the different expressions of VDR, 1OHase and ERs, in human thyroid normal and cancer cells. This study addresses these questions. Tissues harvested from papillary thyroid cancer (PTC) and normal glands explants were used throughout eithe...

ea0041ep1091 | Thyroid cancer | ECE2016

Bethesda classification is highly predictive especially for the diagnoses of aggressive variants of papillary thyroid carcinoma

Evranos Berna , Polat Sefika Burcak , Baser Husniye , Ozdemir Didem , Kilicarslan Aydan , Yalcin Abdussamed , Ersoy Reyhan , Cakir Bekir

Background: Fine needle aspiration biopsy (FNAB) has proven to be the most valuable diagnostic procedure for preoperative discrimination of benign and malignant nodules. Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized reporting and cytomorphological criteria in aspiration smears. In this study, we aimed to determine malignancy rates in nodules with different cytology results and diagnostic value of TBSRTC for variants of papillary thyroid carcinom...

ea0041ep1092 | Thyroid cancer | ECE2016

Strain ultrasound elastography in the diagnostic evaluation of thyroid nodules

Siderova Mira , Hristozov Kiril , Krasnaliev Ivan

Objectives: The aim of the study was to determine different types of thyroid nodules according to their elasticity and to evaluate the diagnostic accuracy of strain elastography in detection of thyroid cancer. 114 thyroid nodules in 84 patients were examined prospectively with conventional B-mode US, color Doppler, strain elastography (SE) and fine needle aspiration biopsy (FNAB). 72 nodules in 50 patients were submitted to surgery and histologically assessed. For final diagno...

ea0041ep1093 | Thyroid cancer | ECE2016

Usefulness of Day 5 sampling in thyroid cancer patients for radioactive iodine therapy with recombinant human thyrotropin

Sohn Seo Young , Lee Eun Kyung , Lee You Jin , Hwangbo Yul , Jun Hae Jin , Park Dae Yoon , Kim Ji Hyun , Ryu Junsun

Background: We evaluated the impact of several anthropometric parameters on serum peak TSH levels after standard two-dose of recombinant human thyrotropin (rhTSH) injection and assessed the usefulness of repeated measurement of TSH and thyroglobulin (Tg) levels at 24 and 72 h after rhTSH injection (Day 3 and 5) to confirm stimulated Tg level.Methods: We retrospectively reviewed 270 differentiated thyroid carcinoma patients who underwent rhTSH stimulation...

ea0041ep1094 | Thyroid cancer | ECE2016

Thyroid nodule ultrasound: which indication for FNA? a prospective study

Riganti Fabrizio , Bonelli Nadia , Rossetto Ruth , Pacchioni Donatella , Viberti Laura , Maccario Mauro , Ghigo Ezio , Garberoglio Roberto

Introduction: Thyroid nodules are discovered by ultrasound (US) in a large percentage of population. In most cases they are benign and asymptomatic. When to perform or not a fine-needle-aspiration (FNA) is still matter of debate. Aim of this study was to evaluate the usefulness of a easy-to-use US classification, based on three US classes.Methods: We prospectively evaluated US features of 1118 thyroid nodules, allocating each nodule in one of three class...

ea0041ep1095 | Thyroid cancer | ECE2016

Clinical usefulness of dynamic risk stratification in medullary thyroid cancer

Han Ji Min , Kwon Hyemi , Kim Won Gu , Jeon Min Ji , Kim Tae Yong , Kim Won Bae , Shong Young Kee

Purpose: To detect persistent/recurrent disease of medullary thyroid carcinoma (MTC) after initial surgery is important. The Tumor-Node-Metastasis (TNM) staging system is useful for predicting disease-specific mortality, but it is static and does not include postoperative serum calcitonin levels. We focused on the clinical usefulness of dynamic risk stratification (DRS) using the best response to initial therapy in patients with MTC.Methods: A total of 1...

ea0041ep1096 | Thyroid cancer | ECE2016

Sitagliptin use and thyroid cancer risk in patients with type 2 diabetes

Tseng Chin-Hsiao

Background: Whether sitagliptin use in patients with type 2 diabetes mellitus may affect the risk of thyroid cancer requires further investigated.Methods: The reimbursement database of the National Health Insurance in Taiwan was used. Patients with newly diagnosed type 2 diabetes mellitus within 1999–2008 were recruited and followed for at least 6 months for thyroid cancer until December 31, 2011. Patients were divided into those who were newly trea...

ea0041ep1097 | Thyroid cancer | ECE2016

Immunohistochemistry as alternative to DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas

Paja Miguel , Del Cura Jose L , de Ciriza Maite Perez , Oleaga Amelia , Ugalde Aitziber

Objective: To compare the results of immunohistochemistry (IHC) and DNA sequencing in detection of BRAF V600E mutation in papillary thyroid carcinomas (PTC). BRAF V600E mutation is the most common genetic alteration in papillary thyroid carcinomas and is associated with worse prognosis. Direct sequencing is usually performed, but less expensive immunohistochemistry can be used instead.Methods: Study was performed in 54 consecutive PTCs during 2014–2...

ea0041ep1098 | Thyroid cancer | ECE2016

Sequence defined cMET/HGFR-targeted polymers as gene delivery vehicles for the theranostic sodium iodide symporter (NIS) gene

Urnauer Sarah , Morys Stephan , Levacic Ana Krhac , Muller Andrea M , Schug Christina , Schmohl Kathrin A , Schwenk Nathalie , Zach Christian , Carlsen Janette , Bartenstein Peter , Wagner Ernst , Spitzweg Christine

The sodium iodide symporter (NIS) in its role as well characterized reporter and therapy gene represents an outstanding tool to target different cancer types allowing non-invasive imaging of functional NIS expression by 123I-scintigraphy and therapeutic application of 131I. Based on its overexpression on the surface of the vast majority of cancer types, the cMET/Hepatocyte growth factor receptor (HGFR) serves as an ideal target for tumor-selective gene de...

ea0041ep1099 | Thyroid cancer | ECE2016

Are there any differences between demographic characteristics, preoperative ultrasonographic findings, and cytological results of patients with thyroid tumors of uncertain malignant potential and papillary thyroid carcinoma of classical and non-encapsulated follicular variants?

Baser Husniye , Topaloglu Oya , Tam Abbas Ali , Alkan Afra , Kilicarslan Aydan , Ersoy Reyhan , Cakir Bekir

Introduction: Thyroid tumors of uncertain malignant potential (TT-UMP) has been accepted as a subgroup of follicular-patterned thyroid tumors for which benignancy or malignancy cannot be assessed exactly. We aimed to evaluate demographic characteristics, ultrasound (US) findings, and cytological results of patients with TT-UMP and compare these findings with the classical variant of papillary thyroid carcinoma (CV-PTC) and non-encapsulated follicular variant of PTC (NEFV-PTC) ...

ea0041ep1100 | Thyroid cancer | ECE2016

Comparison of the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with differentiated thyroid carcinoma

Wolinski Kosma , Czepczynski Rafal , Stangierski Adam , Trojanowski Maciej , Rewaj-Losyk Magdalena , Ziemnicka Katarzyna , Bęczyk Maciej , Dyzmann-Sroka Agnieszka , Ruchala Marek

Introduction: According to a limited number of specialized hospital beds for radioiodine therapy in some countries, fractionated dose of radioiodine may be considered as the ablation therapy of differentiated thyroid cancer (DTC). Aim of the study was to compare the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with DTC.Patients and metods: Patients with DTC treated with one (131)I dose of 2.2 GBq or fracti...

ea0041ep1101 | Thyroid cancer | ECE2016

Papillary thyroid carcinoma in a thyroglossal duct Cyst (TDC) without a thyroid primary

Canturk Zeynep , Catan Fatma Tugba , Cetinarslan Berrin , Tarkun Ilhan , Selek Alev , Akyay Ozlem Zeynep

Introduction: Thyroglossal duct cyst (TDC) is a developmental abnormality of the thyroid gland. Malignancy arising from this duct is very rare. Due to embryological remnants of thyroid tissue located in the TDC, all malignant tumors which develop in the thyroid gland may also develop in the TDC. In case of malignancy, the most probable diagnosis is papillary thyroid carcinoma.Case report: We present a 27-year-old female patient complaining of a midline n...

ea0041ep1102 | Thyroid cancer | ECE2016

Management and transcendence of incidental thyroid 18FDG-PET focal uptake (PEToma)

Roman Anna Casteras , Liopis Carles Zafon , Burillo Amparo Garcia , Rosciolesi Diego Villasboas , Pujanell Maite Salcedo , Duran Jaime Monturiol , Conesa Joan Castell , Manteca Jordi Mesa

Introduction: Incidental focal uptake in the thyroid gland is detected in 1%–2% of 18FDG-PET examinations. FNA is recommended due to an increased risk of malignancy (25–50%), but these figures are extracted from the studied cases (about a half). Moreover there is controversy about the maximum standardized uptake value (Suvmax) ability to discriminate between benign or malignant nodules.Methods: We retrospectively reviewed 4207 FDG-PE...

ea0041ep1103 | Thyroid cancer | ECE2016

The association between Nlo and Mhr in differentiated thyroid cancer

Cadırcı Kenan , Yıldız Faruk , Keskin Havva , Kızıltunc Hilal , Durmaz Şenay , Carlıoğlu Ayşe

Purpose: Papillary and follicular cancers are classified as differentiated thyroid cancers. Recently, it has been revealed that Neutrophile/lymphocyte ratio (NLO) and the ratio of monocyte/lipoprotein cholesterol with high density (MHR) are the strong indicators of oxidative stress and systemic inflammation. In this study, we intend the evaluation of all these indicators in our patients diagnosed with differentiated thyroid cancers.Method: This study inc...

ea0041ep1104 | Thyroid cancer | ECE2016

Thyroid cancer in hyperthyroid patients treated by surgery

Domingues A L , Rodrigues E , Saavedra A , Matos Lima L , Carvalho D

Introduction: The association of hyperthyroidism and thyroid cancer (TC) is controversial with prevalences in the literature varying from 1.6 to 32.8%. The aim of this work was to evaluate the prevalence of TC in hyperthyroid patients submitted to surgery and to find differences between the tumors according to the type of hyperthyroidism.Material and methods: retrospective study to evaluate clinical and histopathological data of all hyperthyroid patients...

ea0041ep1105 | Thyroid cancer | ECE2016

The increased coexistence of autoimmune thyroiditis (AIT) in children and adolescents with thyroid carcinoma (TC) in years 2001–2015 compared to years 1996–2000

Niedziela Marek , Flader Maciej , Harasymczuk Jerzy , Trejster Ewa , Breborowicz Danuta , Rabska-Pietrzak Barbara , Kurzawa Pawel , Breborowicz Jan

Introduction: In years 1996–2000, the predominance of papillary thyroid carcinoma (PTC) (70.3%) compared to follicular thyroid carcinoma (FTC; 27.0%) and medullary thyroid carcinoma (MTC; 2.7%) was observed in our region. AIT coexisted in 1 PTC (2.7% of all cancers and 3.8% in PTC group).Aim: The aim of retrospective study was to analyze the coexistence of AIT and TC in years 2001-2015 in relation to years 1996–2000.Mater...

ea0041ep1106 | Thyroid cancer | ECE2016

Biochemical effects of levothyroxine withdrawal in patients with differentiated thyroid cancer

Papadakis Georgios , Kalaitzidou Styliani , Triantafillou Eleni , Kakava Kassiani , Drosou Aspasia , Sapera Aggeliki , Dogkas Nikolaos , Pappa Theodora , Kaltzidou Victoria , Villiotou Vassiliki , Tertipi Athanasia

Background: Many patients with differentiated thyroid cancer (DTC) are treated with radiodine (I-131) after thyroidectomy, while they are hypothyroid and all are submitted to withdrawal of LT4 periodically for the evaluation of their disease. Among the tests used for follow-up is serum thyroglobulin (Tg) as a tumor marker, and occasionally, total body scan with I-131. Maximal sensitivity of the aforementioned tests is established in the hypothyroid state, under elevated thyrot...

ea0041ep1107 | Thyroid cancer | ECE2016

Baicalein induces cell apoptosis via the MAPK pathway in FRO anaplastic thyroid cancer cells

Kim EunSook , Han SeEun , Nam-Goong IlSung , Kim YoungIl

Baicalein induces cell apoptosis via the MAPK pathway in FRO anaplastic thyroid cancer cells.Anaplastic thyroid cancer is one of the most aggressive forms of malignancies which grow very rapidly. Although several conventional medications have been applied for the treatment of anaplastic thyroid cancer, but current therapies still rather limited and novel therapeutic strategies are required. Baicalein is a flavone, a type of flavonoid, originally isolated...

ea0041ep1108 | Thyroid cancer | ECE2016

Ultrasonographical, clinical and histopathological features of 1264 nodules with papillary thyroid carcinoma and microcarcinoma based on tumor size

Cuhaci Neslihan , Baser Husniye , Topaloglu Oya , Ozdemir Didem , Kilicarslan Aydan , Ersoy Reyhan , Cakir Bekir

Introduction: In recent years, due to the improvements in ultrasonography (US), it has become possible to gain more information about the papillary throid carcinoma (PTC) and papillary tyroid microcarcinoma (PTMC). However, whether PTC and PTMC exhibit the same ultrasonographic features and behave same features is controversial. We aimed to evaluate the patients diagnosed with PTC and PTMC in terms of clinical, ultrasonographical (US) and histopathological features and their r...

ea0041ep1109 | Thyroid cancer | ECE2016

Screening and follow up of an extended Hungarian family with familial medullary thyroid cancer

Valkusz Zsuzsanna , Sepp Krisztian , Gardi Janos , Patocs Attila

Medullary thyroid carcinoma (MTC) originates from the parafollicular or C cells of the thyroid gland and represents approximately 10% of all thyroid malignancies. The operational classification of FMTC is four or more family members with MTC without objective evidence of pheochromocytoma (PC) and parathyroid hyperplasia. In multiple endocrine neoplasia type 2A (MEN 2A) and familial medullary thyroid cancer (FMTC), the majority of germline mutations are restricted to specific p...

ea0041ep1110 | Thyroid cancer | ECE2016

Comparisson between two differnet protocols for the management of patients with differnetiated thyroid cancer

Crisosto Nicolas , Inostroza Vjeroka , Campos Cristian , Gajardo Francisca , Invernizzi Pamela , Vasquez Felix , Hernandez Paola , Pereira Cecilia , de Guevara Amanda Ladron , Dominguez Miguel , Diaz Erika

Introduction: New techniques such as etapification ecotomography (EE) have led to less invasive surgeries in Differentiated Thyroid Cancer (DTC). The trend in recent years has been to a reduction in the doses of radioiodine administered. Our hospital in 2013 incorporated these features to protocolize the administration of radioiodine depending on the characteristics of the tumour and the initial thyroglobulin levels, which may have had an impact in the response to treatment (R...

ea0041ep1111 | Thyroid cancer | ECE2016

Thyroid medullary and papillary carcinoma, a rare combination

Suveran Mustafa , Sisman Pinar , Akkurt Aysen , Gul Ozen Oz , Cander Soner , Erturk Erdinc , Ersoy Canan

Introduction: Thyroid papillary carcinomas originate from thyroid follicular epithelia and are the most frequent thyroid differentiated carcinomas. Medullary thyroid carcinomas originate from thyroid parafollicular C cells and %25 are a component of Multiple Endocrine Neoplasia (MEN) syndromes. Co-incidence of the two condition on the same patient is so rare.Case: 78 years old female patient who has had simple goiter for 10 years, was investigated about ...

ea0041ep1112 | Thyroid cancer | ECE2016

“Modified thyroidectomy difficultly score” for goiters in Iodine deficient population

Mayilvaganan Sabaretnam , Bansal Naval , Mishra Anjali , Agarwal Gaurav , Agarwal Amit , Mishra SK

Introduction: Thyroid surgery was initially considered as “horrid butchery” due to associated high morbidity and mortality, however with the advent of safe surgical techniques and improved understanding of thyroid physiology, thyroid surgery has become safer. Still there are certain intra-operative factors, as described in Difficulty Thyroidectomy Scale (DTS)which are thought to be associated with adverse outcome. However anatomical parameters also need to be address...

ea0041ep1113 | Thyroid cancer | ECE2016

Role of early 18F-FDG PET/CT in the management of differentiated thyroid cancer patients with negative 131I scan and elevated thyroglobulin levels

Sohn Seo Young , Lee Jae Hyuk , Cho Yoon Young , Chung Jae Hoon , Kim Sun Wook

Background: Early detection of residual or recurrent cancer in patients with differentiated thyroid cancer (DTC) is important, especially, when they do not uptake 131I uptake because these tumors do not likely benefit from radioiodine therapy (RAIT). We aimed to evaluate the usefulness of FDG-PET/CT as an early diagnostic work up in DTC patients with negative radioiodine whole body scan (I-WBS) and elevated stimulated Tg (sTg) levels.Methods: ...

ea0041ep1114 | Thyroid cancer | ECE2016

Markers predicting the contralateral lobe involvement in patients with multifocal papillary thyroid carcinoma: An instutional case series of 914 patients

Polat Sefika Burcak , Cakir Bekir , Ogmen Berna , Baser Husniye , Cuhaci Neslihan , Aydin Cevdet , Ersoy Reyhan

Background: The characteristics of multifocal PTC remain controversial. Surgical approach to multifocal tumor changes between centers. In cases that the initial procedure was lobectomy, most clinicians would suggest for completion thyroidectomy since the risk of PTC in the contralateral lobe is significant. This study aimed to evaluate the incidence of bilateral involvement, predictive factors for bilaterality and whether or not bilaterality was related with more aggressive hi...

ea0041ep1115 | Thyroid cancer | ECE2016

Abstract withdrawn....

ea0041ep1116 | Thyroid cancer | ECE2016

Thyroid nodules classified as bethesda 3: final diagnosis

Barrera-Martin Ana , Moreno-Moreno Paloma , Rebollo-Roman Angel , Bahamondes-Opazo Rodrigo , Herrera-Martinez Aura-Dulcinea , Prior-Sanchez Maria-Inmaculada , Segui-Alpizcueta Pedro , Galvez-Moreno Maria-Angeles

Introduction: The Bethesda System classifies suspicious thyroid nodules or those with a large size after fine-needle aspiration (FNA) depending on the risk of malignancy through its cytology study. Bethesda category 3 (B3) implies atypia of uncertain significance or follicular lesion of undetermined significance. Objectives: To determine the final diagnosis of category B3 nodules and the number of cases in which a second or third FNA results in a conclusive category (B2, B4, B...

ea0041ep1117 | Thyroid cancer | ECE2016

Association of multifocality, tumor number and total tumor diameter with clinicopathological features in papillary thyroid cancer

Tam Abbas Ali , Ozdemir Didem , Cuhaci Neslihan , Baser Husniye , Aydin Cevdet , Kilicyazgan Aylin , Ersoy Reyhan , Cakir Bekir

Introduction: In this study, we aimed to evaluate impact of multifocality, tumor number and total tumor diameter on clinicopathological features of PTC.Methods: Medical records of 912 patients who underwent thyroidectomy and diagnosed with PTC were reviewed retrospectively. Patients were grouped into 4 according to number of tumoral foci; N1 (1 focus), N2 (2 foci), N3 (3 foci) and N4 (≥ 4 foci). The diameter of the largest tumor was considered as t...

ea0041ep1118 | Thyroid cancer | ECE2016

Medullary thyroid cancer (MTC): descriptive analysis and prognostic factors in a multicenter study

Alcazar Victoria , Blanco Concepcion , Alvarez-Escola Cristina , Guijarro Guadalupe , Estrada Javier , De Miguel Paz , Palacios Nuria , Duran Alejandra , Carmen Montanes M. , Abad Ainhoa , Lecumberri Beatriz , Civantos Soralla , Aller Javier

Introduction: MTC accounts for 5% of thyroid cancers and can occur sporadically or as part of the multiple endocrine neoplasia type 2 syndrome (MEN 2). The objective of our study is to evaluate the prognostic factors and outcomes of patients with MTC in the community setting.Methods: Retrospective descriptive multicenter study of patients with histological diagnosis of MTC. Descriptive, bivariate analyses (Student t for cuantitative and ...

ea0041ep1119 | Thyroid cancer | ECE2016

Visualization of kallikreins in thyroid epithelial and carcinoma cells

Kroll Eileen , Pejkovska Anastasija , Rehders Maren , Lesner Adam , Dubin Grzegorz , Kantyka Tomasz , Fuhrer Dagmar , Potempa Jan , Brix Klaudia

Human tissue kallikreins (KLKs) are serine proteases expressed in various organs including thyroid hormone-generating and target tissues. Besides their involvement in important physiological processes, KLKs are mainly recognized for their association with pathological conditions like cancer. Previously, KLK2 and KLK3 transcripts were detected in normal thyroid and carcinoma tissue, while the levels and subcellular distribution of KLK proteins remained largely elusive. Since th...

ea0041ep1120 | Thyroid cancer | ECE2016

Management of thyroid cancer in outpatient practice

Zabuliene Lina , Einikyte Ruta , Urboniene Jurgita

The incidence of thyroid cancer (TC) is increasing over time. Follow up and adequate treatment of patients with TC is important in everyday routine practice. The aim of the study was to evaluate peculiarities of clinical and pathologic characteristics of patients with TC, and their management after surgery.Material and methods: We conducted retrospective review of medical records of 116 patients with TC after thyroid surgery followed up in Vilnius Antaka...

ea0041ep1121 | Thyroid cancer | ECE2016

One thyroid, three tumors within: a case of three collision tumors

Selalmatzidou Despoina , Adamidou Fotini , Mintziori Gesthimani

Introduction: Collision tumors of the thyroid are neoplasms of distinct histology located within the same gland. Although rare, the most commonly described collision tumors of thyroid origin are medullary and papillary carcinomas. We describe a case of co-existence of a benign follicular adenoma in a dominant nodule with a micropapillary and a micromedullary carcinoma in a patient carrying a heterozygous germline RET polymorphism.Case report: A 74-year-o...

ea0041ep1122 | Thyroid cancer | ECE2016

A study on age and nodule size in affecting decision for repeat thyroid FNAC after one benign cytology

Keat Cheah Seong , Pierce Brian , Kumar Anusha , Kyaw Tun Tommy , Sreenan Seamus , McDermott John , Hickey Neil , Leen Eamon , Sabah Muna , Walsh Thomas

Introduction: Fine needle aspiration cytology (FNAC) is a widely adopted pre-operative investigatory tool for thyroid nodules. The British Thyroid Association (BTA) recently updated guidelines recommending that an FNAC that initially yields benign cytology (Thy2) should be repeated if there is any clinical or ultrasound (US) suspicion (1). We postulate that there is a tendency for a more conservative approach in older age groups with smaller thyroid nodules on US studies.<...

ea0041ep1123 | Thyroid cancer | ECE2016

Analysis of BRAF and RAS genetic alterations in thyroid cancer in the Greek population

Kostoglou-Athanassiou Ifigenia , Argyropoulou Marilena , Karanatsiou Pagona , Papoutsidakis Georgios , Papadopoulou Alexandra , Loukou Kalliopi , Manolakelli Aikaterini , Synadaki Eleni , Vilaras George , Karameris Andreas , Liadaki Kalliopi

Introduction: Thyroid cancer is one of the most common malignancies of the endocrine system and displays a variety of histological patterns. The understanding of the molecular pathogenesis and the identification of molecular markers which will be used for diagnosis and prognosis is of high clinical significance. The most common molecular alterations include BRAF and RAS point mutations and RET/PTC and PAX8/PPARγ rearrangements. The pres...

ea0041ep1124 | Thyroid cancer | ECE2016

Adjuvant metformin (M) therapy in differentiated thyroid carcinoma (DTC)

Balestra Margherita , Gay Stefano , Pera Giorgia , Mortara Lorenzo , Monti Eleonora , Giusti Massimo

M shows an antiproliferative effect. In vivo, M reduces TSH in type 2 diabetes mellitus (T2DM) and DTC aggressiveness in DTC with T2DM. The aim of the study was to evaluate in DTC diabetic (Gr1, n=30 under M 1500 mg/day) and non-diabetic without (Gr2, n=83) or under M (gr3, n=84; M 1000 mg/day) the adjuvant role of M. Clinical and laboratory examinations were performed up to 24 months. At baseline the DTC groups were similar for age, gender, tumor st...

ea0041ep1125 | Thyroid cancer | ECE2016

Anaplastic thyroid carcinoma masquerading as subacute thyroiditis

Vainikonyte-Kristapone Jelena , Jakuboniene Neli , Barsiene Lina , Sarauskas Valdas , Kuprionis Gintaras

Anaplastic thyroid carcinoma (ATC) is a rare form of thyroid carcinoma that is associated with an extremely poor prognosis. Ultrasonography (US) and subsequent fine needle aspiration biopsy (FNAB) are the first diagnostic methods in the assessment of a palpable thyroid mass. Nevertheless, some clinical and US features of ATC are not specific. Here, we report on an extremely rare case of ATC masquerading as subacute thyroiditis (SAT).A 40-year-old woman w...

ea0041ep1126 | Thyroid cancer | ECE2016

From thyroidectomy to thyroid cancer: epidemiological data from 2004 to 2014

Anyfantakis Anastasios , Vourliotaki Eirini , Foukaki Eirini Michaela , Alexaki Sophia , Avloniti Maria , Chatziriga Aikaterini , Stamataki Aikaterini

Background and aims: To evaluate the evolution of thyroid cancer epidemiological characteristics from 2004 to 2014.Materials and methods: Retrospective analysis of histological data from thyroidectomies performed in our hospital in the period 2004–2014.Results: From 2004 to 2014, 2725 thyroidectomies (women 81% vs men 19%) were performed in our hospital. In 1083 of these (40%) histologic examination revealed thyroid cancer.</p...

ea0041ep1127 | Thyroid cancer | ECE2016

Baseline serum TSH and risk of thyroid microcarcinoma in non-toxic nodular thyroid disease

Askitis Dimitrios , Efremidou Eleni I , Karanikas Michael , Tripsianis Gregory , Polychronidis Alexandros , Liratzopoulos Nikolaos

Aim: Thyroid cancer comprises the most common endocrine malignancy and a variety of studies have examined the role of TSH as an independent risk factor for the manifestation of differentiated thyroid cancer in otherwise benign thyroid disorders. Objective of the current retrospective study was the assessment of a possible relation between baseline serum TSH and thyroid microcarcinoma in a patient cohort with non-toxic thyroid disorders and without preoperative cytological esta...

ea0041ep1128 | Thyroid cancer | ECE2016

Nuclear cysteine cathepsins in thyroid carcinomas

Al-Hashimi Alaa , Tedelind Sofia , Szumska Joanna , Dierkes N Kim , Pinzaru Alexandra , Burden Roberta , Scott Christopher , Fuhrer Dagmar , Brix Klaudia

Cysteine cathepsins are endo-lysosomal proteases that play crucial roles in thyroid physiology. However, in thyroid cancer, cathepsin B is overexpressed and secreted into the extracellular space, thus promoting migratory phenotypes of thyroid carcinoma cells through excessive extracellular matrix degradation. In addition, we have shown that N-terminally truncated forms of cathepsins B and V which lack the signal peptide and parts of the pro-peptide are localized to the nuclei ...

ea0041ep1129 | Thyroid cancer | ECE2016

The diagnostic value of FNAB for early diagnosis of thyroid cancer: a Greek center experience

Triantafillou Eleni , Papadakis Georgios , Manitarou Paraskevi , Panagiotidi Evgenia , Kanouta Fotini , Drosou Aspasia , Kaldrymidis Philippos , Kaltzidou Victoria , Tsouma Eleni , Alexiadou Anastasia , Plyta Styliani , Tertipi Athanasia

Introduction: Fine needle aspiration biopsy (FNAB) is the initial investigation of choice for thyroid nodules.Methods: A total of 563 patients (106 males/457 females) underwent FNAB for the same number of thyroid nodules. Their mean age was 56.1±14.1 years. We correlated the demographic profile (age and gender) and sonographic features of these nodules with the FNAB outcome. The Bethesda system for reporting thyroid cytopathology was used.<p cla...

ea0041ep1130 | Thyroid cancer | ECE2016

Diagnostic and prognostic aspects of immunomorphology of post-chernobyl encapsulated follicular thyroid tumours

Abrosimov Alexander , Dvinskikh Nina , Lushnikov Eugeny

Background: An increased incidence of thyroid cancer among young population of contaminated territories of Russia after Chernobyl accident made very important morphological verification of diagnosis. Many epidemiological and molecular studies of post-Chernobyl thyroid cancer conducted by various research teams required an independent review of tumour histology. The International Pathology Panel formed consensus diagnosis for each case of post-Chernobyl thyroid tumours and prop...

ea0041ep1131 | Thyroid cancer | ECE2016

Fine needle thyroid biopsy – time to change of indications?

Maciejewski Marek , Sawicka Agnieszka , Slomian Michal , Budzynska-Nosal Renata , Kozlowska Beata , Marczewski Krzysztof

Introduction: After a period of enthusiasm for the early detection of cancer, apparently we are entering a period of skepticism, questions and side effects in the form of unnecessary operations and their complications and costs. This also applies to thyroid cancer, and actually nodules and lesions visible only in ultrasoundMethod. Prospective observation of consecutive patients in one centre.Results: In Years 2013 and 2014 we have performed 2189 ultrasou...

ea0041ep1132 | Thyroid cancer | ECE2016

Ultrasonographic scoring index can be useful in the prediction of thyroid malignancy in subcentimeter and supracentimeter thyroid nodules

Cuhaci Neslihan , Ogmen Berna , Tam Ali , Aydin Cevdet , Topaloglu Oya , Kilic Yazgan Aylin , Dumlu Gurkan , Ersoy Reyhan , Cakir Bekir

Introduction: The increased rate of thyroid malignancy as well as incidental and subcentimeter thyroid nodules have been attributed to increasing use of high-resolution US which can detect the non-palpabl or subcentimeter (maximum diameter ≤1 cm) thyroid nodules. We aimed to evaluate the sonographic features of the tyroid nodules between ≤1 cm and > 1 cm according the histopathology results and to determine the ultrasonographical predictive factors for malignan...

ea0041ep1133 | Thyroid cancer | ECE2016

Thyroglobulin (Tg) levels post initial treatment predict the recurrence risk in differentiated thyroid carcinoma (DTC)

Ruiz de Azua Teresa , Gonzalez Blanca , Gonzalez Pedro , Javier Santamaria Francisco , Gaztambide Sonia

Aim: To know if Tg levels after treatment (total thyroidectomy and radioiodine ablation) in the DTC can predict their prognosis in the long term.Material and methods: Basal Tg and Tg after rh-TSH were measured in 229 patients with DTC without any evidence of residual tumour (negative neck ultrasonography) after treatment. The group was followed until tumour recurrence or, if recurrence was not found, a minimum of 12 month (mean ± SD =63±37 mont...

ea0041ep1134 | Thyroid cancer | ECE2016

Cerebellar metastasis from follicular thyroid carcinoma

Rojas Martelo Giovani , Iglesias Lozano Pedro , Jose Diez Gomez Juan , Rodriguez Berrocal Victor , Pian Arias Hector , Jimenez Zapata Daniel

Differentiated thyroid carcinoma (DTC) is the most frequent endocrine neoplasm. Follicular thyroid carcinoma (FTC) is the second histological variant in frequency after papillary thyroid carcinoma (PTC). Cerebellar metastases from DTC are extremely rare, corresponding about 1% of all cerebellar metastases, and being the majority metastases from PTC. To the best of our knowledge there have been no reported cerebellar metastases from CFT so far. We present here the first clinica...

ea0041ep1135 | Thyroid cancer | ECE2016

Can ratio of primary tumor diameter to total tumor diameter be a new parameter in the differential diagnosis of agressive and favorable multifocal papillary thyroid microcarcinoma?

Ali Tam Abbas , Ozdemir Didem , Cuhaci Neslihan , Baser Husniye , Dirikoc Ahmet , Aydin Cevdet , Kilicyazgan Aylin , Ersoy Reyhan , Cakir Bekir

Introduction: In this study, we aimed to evaluate the usefulness of ratio of primary tumor diameter to total tumor diameter as a new parameter for the differentiation of agressive and favorable papillary thyroid microcarcinomas (PTMC).Methods: The diameter of the largest tumor focus was taken as the primary tumour diameter (PTD). For multifocal tumors, total tumor diameter (TTD) was calculated as the sum of the maximal diameter of each lesion. A ratio wa...

ea0041ep1136 | Thyroid cancer | ECE2016

Overview of differentiated thyroid cancer in a tertiary health care center in the Canary Islands

Darias-Garzon Ricardo , Garcia-Fernandez Javier , Francisco Garcia-Bray Bruno , Emilio Rivero-Melian Benigno

Introduction: Our objective is to determine the profile of patients with differentiated thyroid cancer (DTC) attended in our center and the therapeutic approach employed.Methods: Retrospective review of medical records from patients treated for DTC during the years 2013 and 2014.Results: Data from 387 patients, 84% female, 96% Caucasian, mean follow up of 10.82 years. The average age at diagnosis was 44.24 years, 77% had normal thy...

ea0041ep1137 | Thyroid cancer | ECE2016

Fine-needle aspiration of thyroid nodules: our experience before and after Bethesda

Andrada Ioana Iulia , Gleeson Tadhg , Murphy Maurice , Yousif Obada

Introduction: Thyroid nodules are common. Fine-needle aspiration cytology (FNAC) has an essential role in the evaluation of thyroid nodules, but results may be nondiagnostic. A standardised (FNAC) reporting system: Bethesda system for reporting thyroid cytology (BSRTC) is widely used.Purpose: The aim of this study was to assess the diagnostic accuracy of (FNAC) of thyroid nodules performed at our Hospital before and after the introduction of (BSRTC)....

ea0041ep1138 | Thyroid cancer | ECE2016

The prevalence of thyroid malignancy incidentally detected by ultrasound in patients with non-thyroidal head and neck cancer

Joo Yun E , Young Yoon D , Jung Kim Y , Won Oh K

Thyroid cancer is one of the common head and neck malignancies and may be found incidentally with other head and neck cancers. The purpose is to evaluate the prevalence and risk of malignancy in incidental thyroid lesions identified by ultrasound (US) in patients with head and neck cancer. We retrospectively reviewed medical records of all patients with head and neck cancer other than of thyroid origin between January 2004 and January 2012. A total of 697 patients (542 men and...

ea0041ep1139 | Thyroid cancer | ECE2016

Our experience with low doses of radioactive iodine (30 mCi) in patients with differentiated thyroid cancer

Prior-Sanchez Inmaculada , Munoz Jimenez Concepcion , Moreno Moreno Paloma , Rebollo Roman Angel , Barrera Martin Ana , Moreno Ortega Estefania , Antonio Vallejo Casas Juan , Angeles Galvez Moreno Maria

Background: The management of patients with differentiated thyroid cancer (DTC) has been changing in recent years and aggressiveness of treatment depends on the risk of persistent or recurrent disease.Objective: The aim of this study was to assess the efficacy of low doses of Radioactive Iodine (RAI;131I) therapy in patients with DTC.Methods: We retrospectively evaluated all patients who were diagnosed with DTC (n</e...

ea0041ep1140 | Thyroid cancer | ECE2016

A giant lung metastasis of thyroid papillary carcinoma

Karadeniz Yusuf , Gungor Adem , Gokkaya Naile , Bilen Arzu , Bilen Habib

Introduction: Papillary thyroid carcinoma (PTC) patients with distant metastasis (DM) have variable clinical forms. PTC mostly metastasizes to the regional cervical lymph node. Metastasis rate is approximately 20–90% available when diagnosed. In addition, the overall incidence of DM is approximately 10%. DM are usually to the lungs, bone and brain. Furthermore rarely liver, pancreas, skeletal muscle, adrenal gland, ovaries, sphenoid sinuses and submandibular gland metasta...

ea0041ep1141 | Thyroid cancer | ECE2016

Relation of F-18 FDG PET/CT positivity with tumor cytopathology and molecular markers in malignant and benign thyroid tumors

Cakmak Guzin , Imge Aydogan Berna , Gullu Sevim

Introduction: The role of F-18 FDG PET/CT in follow-up of differentiated thyroid cancer (DTC) is well established. Molecular markers were shown to be related with malignancy risk of thyroid nodules and prognosis of DTC. The goal of this study was to assess the relation of molecular markers such as NIS, Galectin-3, PTEN, Ki-67, p53 with PET positivity and malignancy of thyroid.Methods/design: We evaluated patients who had 18-FDG uptake in thyroid gland at...

ea0041ep1142 | Thyroid cancer | ECE2016

Accuracy of fine-needle aspiration biopsy in Albanian experience

Golemi Ersida , Ylli Dorina , Alimehmeti Mehdi , Hysi Gerond , Nelaj Ermir , Spahiu Edi , Ylli Agron

Background: Fine-needle aspiration biopsy (FNAB) is the gold standard in detecting thyroid cancer. The overall incidence of thyroid cancer is 9–13% in patients with thyroid nodule that are eligible for FNAB. If the sample taken is sufficient, a negative FNA-B response eliminates the carcinoma risk in 98–99% of cases.The aim of the study: To access the role of FNAB in the early diagnosis of thyroid cancer in Albania.Materi...

ea0041ep1143 | Thyroid cancer | ECE2016

Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumour: a case report

Alphan Uc Ziynet , Gorar Suheyla

Introduction: Medullary thyroid carcinoma (MTC) is a relatively uncommon tumour of the thyroid as compared with papillary thyroid carcinoma (PTC). Concurrent of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in a single patient is a rare.Case: Forty-nine year-old male patient was referred to endocrinology for multinodular goiter evaluation. He had no palpable nodules. There was no apparent family history of endocrine disorders or...

ea0041ep1144 | Thyroid cancer | ECE2016

Clinical evaluation and outcome of indeterminate (Thy 3) thyroid nodules

Monti Eleonora , Balestra Margherita , Mortara Lorenzo , Gay Stefano , Pera Giorgia , Adorno Alberto , Giusti Massimo

In thyroid nodules with indeterminate cytology, presurgical evaluations for risk management comprise biochemical tests, ultrasonography (US), elastography-US (USE), contrast-enhanced US (CEUS) and mutation analysis. The cytology of 130 Thy 3 nodules was reviewed according to the BTA 2014 classification. Nodules were divided into Thy 3a and Thy 3f categories. Histology was available in 97 nodules. Malignancy was the final diagnosis in 19% of surgically treated nodules. No signi...

ea0041ep1145 | Thyroid cancer | ECE2016

Brain metastasis from follicular thyroid carcinoma as first manifestation of the disease

Marquez-Pardo Rosa , Garcia-Garcia-Doncel Lourdes , Gloria Baena-Nieto M , Cayon-Blanco Manuel , Lopez-Velasco Rosario , Torres-Barea Isabel

Introduction: The prevalence of brain metastasis from differentiated thyroid carcinoma is 1%. Brain metastasis as the first manifestation of the disease is extremely uncommon.Case report: We present a case of 44-year-old woman with headache and a tumor in right parietal zone. The patient has had multinodular goiter for 15 years, with two dominant nodules in left thyroid lobe. Both of them were isoechoic with hypoechoic halo and measured 2 cm. Fine-needle...

ea0041ep1146 | Thyroid cancer | ECE2016

Coexisting papillary thyroid carcinoma and renal cell carcinoma: 4 cases

Celik Mehmet , Ayturk Semra , Yilmaz Bulbul Buket , Can Nuray , Tastekin Ebru , Sezer Atakan , Ustun Funda , Guldiken Sibel

Papillary thyroid cancer (PTC) constitutes 85% of all differentiated thyroid cancers. PTC is usually sporadic, but may occur in a familial form. Familial cancer syndromes such as Cowden’s syndrome and familial adenomatous polyposis are associated with PTC. Lal et al. recently published a study in which subsequent thyroid cancer was most common among the patients with renal cell cancer (RCC). RCC is a common malignancy of uroepithelial region, which constitutes about 3% of...

ea0041ep1147 | Thyroid cancer | ECE2016

Multi-directional approach for mean platelet volume in differentiated thyroid cancer

Kiziltunc Ozmen Hilal , Askin Seda , Simsek Eda , Carlioglu Ayse , Arikan Senay

Background: Differential thyroid cancer (DTC) is classified into papillary, follicular and papillary micro thyroid cancer. Also, mean platelet volume (MPV) is an independent risk factor for cardiovascular disease. The aim of the present study was to investigate MPV values in DTC patients.Materials and methods: The levels of MPV were assessed in 183 patients with DTC 44 papillary thyroid cancer (mean age 43.±13.9) 34 papillary micro thyroid cancer (m...

ea0041ep1148 | Thyroid cancer | ECE2016

Preoperative predictors of malignancy in lesions classified as BETHESDA IV

Polat Sefika Burcak , Ogmen Berna , Baser Husniye , Sungu Nuran , Dumlu Gurkan , Ersoy Reyhan , Cakir Bekir

Background: Differential diagnosis of a thyroid nodule is difficult if it is a follicular lesion. Follicular lesions include follicular adenoma (FA) or a malign neoplasm (follicular cancer (FC) or follicular variant of papillary thyroid carcinoma (FVPTC)). Cytology can’t separate benign from malignant condition in follicular lesions. Differential diagnosis is important because patients often undergo less than ideal interventions, such as a total thyroidectomy for a benign...

ea0041ep1149 | Thyroid cancer | ECE2016

Burkitt lymphoma of the thyroid (A rapidly growing painless thyroid mass during pregnancy)

Bellarbi Dhiya Eddine , Si-youcef Hafsa , Azzoug Said , Amalou Mustapha , Boudia Fethi Merad , Chentli Farida

Introduction: Primary thyroid lymphomas (PTL) are rare tumors, accounting for 2.5% of all non-Hodgkin’s lymphomas and fewer than 2% of all malignant thyroid tumors. Primary thyroid’s Burkitt lymphoma represents a very unusual type of PTL. Only very few cases of primary thyroid’s Burkitt lymphoma have been reported during pregnancy.Observation: We present a 30 years old female patient who developed a rapidly enlarging painless neck mass. Th...

ea0041ep1150 | Thyroid cancer | ECE2016

Can we predict malignancy in AUS/FLUS by measuring TSH?

Marques Ricardo Rodrigues , Rafael Ana Alves , Santos Francisco Sousa , Silva Silvia Sofia , Duarte Joao Sequeira , Fernandes Luis Viana

Background: Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules and differentiating benign from malignant disease. According to Bethesda System Classification, the rate of AUS/FLUS is between 3–6% of all FNA. The malignancy risk is of 5–15%. TSH levels might be associated to the likelihood of malignancy in thyroid nodules according to some studies. Our aim was to establish a possible correlation between TSH level and malignanc...

ea0041ep1151 | Thyroid cancer | ECE2016

Neutrophil-Lymphocyte Ratio (Nlr) and Platelet -Lymphocyte Ratio (Plr) may be superior to C-Reactive Protein (Crp) for predicting the occurrence of differentiated thyroid cancer

Ozmen Sevilay , Timur Ozge , Calik Ilknur , Altinkaynak Konca , Zipak Elif , Simsek Eda , Yildiz Faruk , Sevimli Hakan , Gozcu Hakan , Arslan Abdulmuttalip , Carlioglu Ayse

Aim: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are prognostic markers of differentiated thyroid cancers. In our study we evaluated NLR, PLR and C-reactive protein for predicting the occurence of differentiated thyroid cancer. This is the first study that compares NLR and PLR to C-reactive protein indifferantiated thyroid cancer not only papillary cancer but also folliculer cancer.Materials and Method: This study includes 51 pa...

ea0041ep1152 | Thyroid cancer | ECE2016

Local classification of differentiated thyroid cancer: does it help to discriminate the response to treatment?

Gajardo Francisca , Pereira Cecilia , Campos Cristobal , Inostroza Vieroska , Diaz Erika , Invernizzi Pamela , Vasquez Felix , Crisosto Nicolas , de Guevara Amanda Ladron , Hernandez Paola , Dominguez Miguel

Introduction: The prediction of the risk of recurrence in differentiated thyroid cancer (dtc) in chile is different from ata. The use of the stimulated thyroglobulin (tg) post-surgery in the prediction of the risk is controversial. We present a cohort applying a new local protocol that includes the tg for supporting the discrimination of the patients for offer low doses or radio iodine.Objective: Asses if the local risk classification (lc) allow us to di...

ea0041ep1153 | Thyroid cancer | ECE2016

Thyroid cancer in a patient with neurofibromatosis type 1: von recklinghausen disease

Karaitianos Ioannis , Athanassiou Panagiotis , Tsomidou Christiana , Kostoglou-Athanassiou Ifigenia

Introduction: Neurofibromatosis type 1 or von Recklinghausen disease is a systemic hereditary disease characterized by disorders regarding the skin, neural and skeletal systems. Osteoporosis is one of the skeletal manifestations of neurofibromatosis type 1, being associated with increased fracture risk. Neurofibromatosis type 1 is associated with a propensity for the development of cancer, breast cancer in particular being associated with neurofibromatosis type 1.<p class=...

ea0041ep1154 | Thyroid cancer | ECE2016

Collision thyroid tumors among patients diagnosed with thyroid carcinomas

Mintziori Gesthimani , Adamidou Fotini , Selalmatzidou Despoina , Kita Marina

Introduction: Collision thyroid tumors are defined as independent and histologically distinct tumors that coexist within the thyroid gland. Collision thyroid tumors are rare and their prevalence is unknown.Methods: A retrospective, registry-based study was performed by reviewing the electronic medical records of the Department of Endocrinology, Ippokratio General Hospital of Thessaloniki, Greece. All patients with thyroidectomy and thyroid cancer diagnos...

ea0041ep1155 | Thyroid cancer | ECE2016

Second primary malignancies in patients with differentiated thyroid carcinoma

Baldys-Waligorska Agata , Kolodziej Maciej , Buziak-Bereza Monika , Hubalewska-Dydejczyk Alicja

Introduction: It has been shown that thyroid cancer has a significant correlation with cancers originated from other organs. The aim of this study was to investigate the association between synchronous primary cancers in patients with thyroid cancer.Material and Method: A retrospective analysis of medical records of 560 thyroid cancer patients treated in the years 2007–2013 and followed up over 2–8 years, was performed. In 38 patients (6.7%), 5...

ea0041ep1156 | Thyroid cancer | ECE2016

A case of thyroid cancer followed by metachronous cancers and a pituitary tumour

Baldys-Waligorska Agata , Skalniak Anna , Piętkowski Jakub , Sowa-Staszczak Anna

Introduction: Based on cancer registries, the risk of second primary malignancies in patients with DTC increases by 30%. In our case report we aimed at understanding the patomechanism of metachronous primary tumours in patients with thyroid cancer.Case: In a 71-year old female surgery of nodular goitre (1988), followed by papillary thyroid cancer (pT3NxMx) surgery (2008) and complementary 131-I treatment (2009), were performed. In diagnostic WBS (2010) n...

ea0041ep1157 | Thyroid cancer | ECE2016

Benign and malignant thyroid gland diseases in the patients with primary hyperparathyroidism

Celik Mehmet , Guldiken Sibel , Ayturk Semra , Bulbul Buket Yilmaz , Tastekin Ebru , Can Nuray , Sezer Atakan , Ustun Funda , Kucukarda Ahmet

Aim: This study aimed to evaluate concurrently detected thyroid pathologies in the patients who underwent surgery for primary hyperparathyroidism.Materials and Methods: In this study, we retrospectively analyzed the files of the patients who underwent surgery for primary hyperparathyroidism between 2012–2015. Pre-operative and post-operative laboratory examination results and the results of pre-operative radiological and nuclear medicine studies of ...

ea0041ep1158 | Thyroid cancer | ECE2016

Hyalinizing trabecular tumor of thyroid in a patient with suspicious for papillary cancer in fine needle aspiration biopsy: a case report

Tam Abbas Ali , Aydin Cevdet , Ozdemir Didem , Dogan Hayriye Tatli , Korukluoglu Birol , Ersoy Reyhan , Cakir Bekir

Introduction: Hyalinizing trabecular tumor is a very rare neoplasm of thyroid and can be misinterpreted as papillary or medullary cancer in fine needle aspiration biopsy (FNAB).Case report: Multinodular goiter was detected in a 65 years old woman using metformin and L-thyroxine for impaired blood glucose and Hashimoto thyroiditis, respectively. FNAB was performed in two nodules and reported as suspicious for malignancy and benign. She underwent total thy...

ea0041ep1159 | Thyroid cancer | ECE2016

Case of papillary carcinoma occasionally found in young patient and the importance of immediate radical therapy

Katamadze Natia , Burnadze Iakob , Butbaia Nino

Introduction: The number of thyroid cancer is progressively increasing and the majority of those diagnosis are papillary thyroid cancer- the most common type of thyroid cancer. Females are more likely to have thyroid cancer. Thyroid cancer can occur in any age group, although it is most common after age 30, and its aggressiveness increases significantly in older patients. Thyroid cancer does not always cause symptoms. Often the first sign of thyroid cancer is a thyroid nodule....

ea0041ep1160 | Thyroid cancer | ECE2016

Three siblings with familial nonmedullary thyroid carcinoma

Rashid Muhammad , Haq Muhammad Naeemul , Islam Najmul , Kiran Zareen

Introduction: Nonmedullary carcinoma of thyroid is most common of thyroid carcinoma with familial predisposition and very low incidence.We describe cases of three brothers with familial nonmedullary thyroid carcinoma diagnosed over a span of six years clinical follow up.Case: 58 years male with swelling in neck for 5 days. On examination he had left thyroid nodule. Ultrasound thyroid showed multinodular goiter while fine needle aspiration cytology (FNAC)...

ea0041ep1161 | Thyroid cancer | ECE2016

Differentiated thyroid papillary carcinoma with cerebellar metastasis, case report

Turan Elif , Kaya Ahmet , Kulaksizoglu Mustafa , Zamani Aysegul , Kozacioglu Sumeyye

Introduction: Differentiated thyroid cancer has usually good prognosis and long-term survival. Distant metastasis ratio is 5–15%. Metastasis to cerebrum, breast, liver, kidney, muscle, and skin is relatively rare. The study of molecular mechanisms of PTC has demonstrated that BRAFV600E gene mutation is a significant event in the process of this disease.Case: 55-year-old-male patient who had multinodular goiter showed malignant cytology in fine-needl...

ea0041ep1162 | Thyroid cancer | ECE2016

The efficacy and safety of sorafenib treatment on iodide refractory metastatic differentiated thyroid carcinomas

Sisman Pinar , Suveran Mustafa , Sahin Ahmet Bilgehan , Gul Ozen Oz , Cander Soner , Erturk Erdinc , Ersoy Canan

Introduction: Differentiated thyroid carcinomas (DTC) are originated from thyroid follicular epithelial cells and comprises %90 of all thyroid carcinomas. Researches indicate that sorafenib is more efficacious than other chemotherapeutic agents on metastatic iodide refractory DTCs.Material and methods: In our center, between 2013 and 2015, sorafenib was applied to six patients who had iodide refractory metastatic DTC. Five of the patients were female. Th...

ea0041ep1163 | Thyroid cancer | ECE2016

Biphasic synovial sarcoma: an exceptional rare cervical mass

Ghemigian Adina , Carsote Mara , Petris Rodica , Dumitrascu Anda , Valea Ana , Terzea Dana , Paun Diana Loreta

Introduction: Synovial sarcoma represents a type of cancer derived from soft tissues; young males are more affected.Material and methods: This is a case report of a male with a cervical mass confirmed as sarcoma. Later on the investigations lead to the discovery of a thyroid nodule challenging the differential diagnosis. We assessed thyroid ultrasound, computed tomography (CT) at the cervical, thorax, mediastinum and abdomen; TSH (Thyroid Stimulating Hor...

ea0041ep1164 | Thyroid cancer | ECE2016

Bone metastatsis from differentiated thyroid cancer treated successfully with I131: case report

Puca Entela , Olldashi Blertina , Lumi Ema , Dhima Arben , Koza Kadir Burak , Bitri Sonila , Ylli Agron

Differentiated thyroid cancer (DTC) in general has a good prognosis when ist diagnosed early. Late stage disease with bone metastasis may cause severe complications, increases mortality rate, decreases the quality of life, and shortens the patients’ survival. The treatment is still controversial. Surgery or radioiodine therapy alone is usually unsatisfactory.Case presentation: We report a case of a 40-year-old female presented, in August 2012, with ...

ea0041ep1165 | Thyroid cancer | ECE2016

An unusual case in endocrinology practice: suture granuloma

Cansu Guven Baris , Taskiran Bengur , Bakar Tulay , Cengiz Betul Peker

Background: Suture granuloma, the rare complication of thyroidectomy, results from use of nonabsorbable suture materials. Despite its typical ultrasound images and benign course, it carries utmost importance in differential diagnosis of lymph nodes, recurrent nodules, and recurrence in case of thyroid cancers.Case report: A 54-year-old female patient, who underwent bilateral thyroidectomy in July 2010, was diagnosed with multinodular goiter and incidenta...

ea0041ep1166 | Thyroid cancer | ECE2016

Sonographic findings that can be mistaken for thyroid cancer

Kim Tae Hyun , Jo Shin Hyoung , Kim Soonho

Introduction: Thyroid nodule is a common disease that is found in 50% of the adult population; of total, 5% of thyroid nodule cases are diagnosed as thyroid cancers. Thyroid ultrasonography is the most sensitive diagnostic imaging method for the diagnosis of thyroid cancer. The ultrasonographic findings that indicate malignancy are taller than wider, speculate margins, marked hypoechoic lesion, microcalcification, and macrocalcification. In contrast to findings indicating pure...