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18th European Congress of Endocrinology

Eposter Presentations

Thyroid (non-cancer)

ea0041ep966 | Thyroid (non-cancer) | ECE2016

What does matter for AUS/FLUS: size, sex or age?

Rafael Ana Alves , Silva Silvia , Marques Ricardo Rodrigues , Duarte Joao Sequeira , Fernandes Luis Viana

Background: The clinical attitude to the treatment of Bethesda System Category III lesions has been under controversy. Our aim was to analyse three variables and to establish a possible predictive value for carcinoma in patients with AUS/FLUS nodules.Methods: Retrospective study of 671 thyroid fine-needle aspirations (FNAs) classified as AUS/FLUS between January 2012 and June 2015. Size, sex and age were analysed, using SPSS.Result...

ea0041ep967 | Thyroid (non-cancer) | ECE2016

Clinical features and outcomes of thyroid storm: a retrospective study

Garcia Maria Laura , Rella Noelia G , Szuman Gabriela , Scioscia Maria Florencia , Panebianco Maria Victoria

Thyroid storm (TS) is a rare but life-threatening manifestation of thyrotoxicosis.Objective: To describe the clinical features and outcomes of patients admitted for TS according to Burch-Wartofsky’s score (BW).Methods: A retrospective review of subjects admitted to a single hospital from 2009 through 2015 was conducted.Results: 15 cases were identified. Etiology: autoimmune (n=8), factitious (<e...

ea0041ep968 | Thyroid (non-cancer) | ECE2016

Mean platelet volume (MPV) and platelet distribution width (PDW) in euthyroid woman with Hashimoto’s Thyroiditis

Bilge Muge , Adas Mine , Yesilova Aylia , Helvaci Aysen

Objective: Hashimoto’s thyroiditis (HT) is extremely common, particularly among women. Mean platelet volume (MPV) and platelet distribution width (PDW) are the measure of platelet size. We aimed to investigate MPV and PDW levels in euthyroid woman with HT.Methods: This was a retrospective study in which the data were obtained from a computerized patient registry database. We evaluated 145 women with HT and 60 matched healty controls, who applied to ...

ea0041ep969 | Thyroid (non-cancer) | ECE2016

Association between serum insulin-like growth factor-1 and thyroid nodules

Lee Jaehyuk , Yeob Shin Dong , Joon Kim Kwang

Background: Insulin-like growth factor-1 (IGF-1) is known to be closely related to the growth of thyroid cells and thyroid diseases. However, the association between IGF-1, thyroid nodule, and thyroid cancer has not been clearly established yet. Therefore, this study investigated the association between IGF-1 and thyroid nodule size.Methods: A total of 346 patients with thyroid nodules confirmed by ultrasonography were included. For all participants, the...

ea0041ep970 | Thyroid (non-cancer) | ECE2016

The immune status peculiarities depending on the level of thyroid peroxidase antibodies in Graves’ disease

Dogadin Sergey , Dudina Margarita , Savchenko Andrey , Matsynina Valentina

It is known that thyroid peroxidase is expressed on the apical surface of thyrocytes, where catalyze the iodination of thyroglobulin and may, also, be a surface-cell antigen, which involves in the complement-dependent cytotoxicity reactions. Objective: to study the immune status indicies depending on thyroid peroxidase (anti-TPO) antibodies in patients with Graves’ disease (GD). Materials and methods. The study included 35 women aged from 18 to 55 years, mean age of 39.1&...

ea0041ep971 | Thyroid (non-cancer) | ECE2016

25-Hydroxy vitamin D levels and inflammatory markers in patients with graves disease activation

Ersoy Mustafa , Akalın Aysen

Objective: By the definition of vitamin D receptors in many tissues, many functions of vitamin D other than calcium homeostasis and bone metabolism were shown. A role for vitamin D is suggested in the pathogenesis of Graves disease because of the effects of vitamin D on the immune system. In our study the role of vitamin D deficiency in the activation of Graves disease, development of autoimmune thyroid disease and the relationship between vitamin D and inflammatory markers we...

ea0041ep972 | Thyroid (non-cancer) | ECE2016

Inverse relationship between seasonal vitamin D variations and thyroid antibodies (TAb) and TSH

De Remigis Alessandra , Tomei Giammarco , Maria Lattanzio Franca , Occhuzzi Umberto , Teresa Natalini Maria , Rapino Daniele

Vitamin D has a role in the pathogenesis of thyroid autoimmunity.There is evidence in humans that serum levels of 1,25(OH) D3 were found to be significantly lower in patients with autoimmune thyroid diseases.We have evaluated all samples performed in the endocrine labs tested for vitamin D, AbTg, Ab-TPO and TSH from 2006 to 2015; 29216 samples for vitamin D and 41014 for TSH, AbTg and TPO were considered.We s...

ea0041ep973 | Thyroid (non-cancer) | ECE2016

Autoimmune thyroiditis: association with two common polymorphisms of the RAGE gene and oxidative stress

Giannakou Maria , Saltiki Katerina , Mantzou Emily , Loukari Eleni , Philippou Georgios , Terzidis Konstantinos , Lilly Kiriaki , Stavrianos Charalampos , Alevizaki Maria

Introduction: Polymorphisms of the receptor for advanced glycation end products (AGEs), RAGE, have been associated with autoimmune disorders and their complications. There are no studies concerning Hashimoto’s thyroiditis (HT); the aim of our study was to investigate the possible role of two RAGE polymorphisms (−429T>C, −374T>A) in combination with indices of oxidative status in women with HT.Design: We examined 300 euth...

ea0041ep974 | Thyroid (non-cancer) | ECE2016

Surgery of benign thyroid disease – Analysis of vocal fold paralysis in 3019 patients

Kohnen Bianca , Schurmeyer Christina , Schurmeyer Thomas H , Kress Peter

Methods: To evaluate factors influencing the relative risk (RR) for vocal fold paralysis we analyzed 3019 patients (69.5% female) having surgery for benign thyroid diseases (58.7% nodular goiter, 17.5% inactive nodes, 16.3% thyroid autonomy, 6.5% Grave’s disease). Operations were performed with intraoperative neuromonitoring by general surgeons (GS, n=1637) or physicians specially trained for ENT (n=1382). 19.2% of the procedures were carried out by resi...

ea0041ep975 | Thyroid (non-cancer) | ECE2016

Evaluation of incidental 18f-Fdg uptake of thyroid with ultrasonography and elastosonography

Tutal Esra , Karakose Melia , Sayki Arslan Muyesser , Apaydin Mahmut , Demirci Ayse , Demirci Taner , Cakal Erman , Sahin Mustafa , Ozbek Mustafa , Delibasi Tuncay

Introduction: Thyroid incidentaloma detected by FDG-PET/CT (flourodeoxyglucose positron emition tomography/computed tomography) is important because of high rate of malignancy. Elastosonograpghy has proven valuable in discriminating malign and benign thyroid lesions. In this study, we aimed to evaluate PET incidentalomas by ultrasonography and elastosonography and to compare cytopathological results with imaging findings.Methods: A total of 50 patients i...

ea0041ep977 | Thyroid (non-cancer) | ECE2016

Immunohistochemical expression of iNOS and eNOS in thyroid goiter

Segiet Oliwia , Michalski Marek , Piecuch Adam , Brzozowa-Zasada Marlena , Matysiak Natalia , Wojnicz Romuald

Introduction: Oxidative stress has been implicated in the pathogenesis of many thyroid diseases, such as non-toxic nodular goiter and Hashimoto’s thyroiditis. Nitric oxide synthases are responsible for the synthesis of nitric oxide from L-arginine. There are three isoforms of nitric oxide synthase (NOS): neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). They have important functions in inflammation and vasoregulation but their role in thyroid diseases ...

ea0041ep978 | Thyroid (non-cancer) | ECE2016

Factors associated with persistent atrial fibrillation after achievement of euthyroid state

Melki Amel , Yazidi Meriem , Barka Ines , Chaker Fatma , Chihaoui Melika , Rjeb Ons , Slimane Hedia

Introduction: Atrial fibrillation (AF) occurs in up to 15% of patients with hyperthyroidism. Although hyperthyroidism is usually regarded as a reversible cause of AF, spontaneous sinus conversion occurs in only 2/3 of patients upon the normalization of T4 levels. The aim of this study was to identify factors associated with persistent atrial fibrillation after restoration of euthyroid state.Methods: We conducted a retrospective study of 13 years. Twenty ...

ea0041ep979 | Thyroid (non-cancer) | ECE2016

Effect of smoking on thyroid function during pregnancy

Ruiz Ochoa David , Piedra Leon Maria , Alio Lavin Gomez Bernardo , Baamonde Calzada Carmela , Mateos Garcia Fatima , Teresa Garcia Unzueta Maria , Tejado Elviro Inigo , Antonio Amado Senaris Jose

Introduction: Smoking affects thyroid function, the magnitude and direction of the effect varies greatly with different studies. Less is known about the effect of smoking in thyroid function during pregnancy.Materials and methods: Healthy pregnant women with not known thyroid dysfunction were questioned about smoking habit in the first trimester of pregnancy. Blood samples for TSH, free T4 (fT4) and free T3 (fT3) were obtained in each trimester and for t...

ea0041ep980 | Thyroid (non-cancer) | ECE2016

Evaluation of ambulatory arterial stiffness index in hyperthyroidism

Turhan Iyidir Ozlem , Muhittin Yalcin Mehmet , Eroglu Altinova Alev , Arslan Emre , Uncu Ulu Bahar , Konca Degertekin Ceyla , Balos Toruner Fusun

Hyperthyroidism whether endogenous or exogenous in origin causes hemodynamic changes which associated with adverse cardiovascular outcomes. Ambulatory arterial Stiffness index (AASI) is a non invasive way of measuring arterial stiffness. Short term BP variability is derived from 24-hour ambulatory blood pressure monitoring (ABPM) recordings. BP variability and AASI are associtaed with increased cardiovascular risk.We aimed to investigate AASI and short t...

ea0041ep981 | Thyroid (non-cancer) | ECE2016

Herbal medicines used for thyroid disease in Turkey, and short-term effects of Anethum graveolens

Altay Mustafa , Ates Ihsan , Kaplan Efe Fatma , Karadag Ibrahim

Aim: To investigate the herbal medicines (HM) used for thyroid disease, their effects and use rates in Turkey.Materials and methods: A total of 547 patients (494 females and 53 males) had a thyroid disease were included in the study. The patients were questioned whether they used any alternative therapies or HM for their thyroid disease. The patients who used HM were asked about the kind of the HM, and duration of use. The data regarding the dose of the ...

ea0041ep982 | Thyroid (non-cancer) | ECE2016

The impact of the TIRAD system on medical tactics in patients with thyroid nodules

Ametov Aleksandr , Aleksandrov Yuri , Yanovskaya Elena

Widespread use of ultrasound has led an increase of patients with thyroid nodules. But individual scores of ultrasound images leads to different estimates of the results and the misunderstandings between specialists. A decision of problem is possible through standardization based on TIRADS.Purpose: Evaluated the impact the application of TIRADS and TBSRTC on medical assistance to patients with thyroid nodules. The examination dates of 4415 people was est...

ea0041ep983 | Thyroid (non-cancer) | ECE2016

Percutaneous laser ablation of benign thyroid nodules

Aleksandrov Yuri , Belyakov Ivan , Patrunov Yuri

Objectives: To define sonographic and color Doppler peculiarities of thyroid nodules influencing the efficacy and follow-up principles of percutaneous laser ablation (PLA).Methods: Three hundred forty-five thyroid nodules were treated with 1–3 PLA sessions and subsequently sonographically examined every three months within one year. Indication for PLA was increase sizes of nodules. All nodes were benign according to FNAB.Resul...

ea0041ep984 | Thyroid (non-cancer) | ECE2016

Incidence and prevalence of overt hypothyroidism and causative diseases in Korea as determined using claims data provided by the health insurance review and assessment service

Wook Kim Sun , Hoon Chung Jae , Jeong Kim Hye , Young Sohn Seo , Nam Kim Young , Lee You-Bin , Kim Hye-In , Lee Seung-Eun

Background: The incidence and prevalence of overt hypothyroidism have been reported to be 2 to 4/1,000 population/year and 8 to 13/1,000 population, respectively, in foreign countries. As there has been no nationwide survey to obtain data in Korea, the present study investigated the incidence and prevalence of overt hypothyroidism in Korea using claims data provided by the Health Insurance Review and Assessment Service. The proportions of causative diseases for hypothyroidism ...

ea0041ep985 | Thyroid (non-cancer) | ECE2016

Clinical, imaging and cytological differences between palpable and non-palpable thyroid nodules

Silva Joao , Paiva Sandra , Ribeiro Cristina , Melo Miguel , Gomes Leonor , Bastos Margarida , Carrilho Francisco

Introduction: The prevalence of palpable nodules varies between 3–7% and nodules diagnosed by ultrasonography between 20–76%. According to the American Thyroid Association’s guidelines it isn’t recommended to perform routine thyroid ultrasound for thyroid nodules diagnosis, unless they are palpable or there are any risk factors.Objective: Evaluation of sonographic and cytological differences between palpable and non-palpable thyroid n...

ea0041ep986 | Thyroid (non-cancer) | ECE2016

Selenium concentration in Korean patients with thyroid disease: a preliminary report

Wook Kim Sun , Hoon Chung Jae , Jeong Kim Hye , Young Sohn Seo , Nam Kim Young , Lee You-Bin , Kim Hye-In , Lee Seung-Eun

Background: Selenium is an important trace element for thyroid hormone metabolism and its deficiency can cause hypothyroidism. Serum or plasma selenium concentration has been known as best biomarker which reflects selenium intake and reserve. We preliminarily assessed the serum or urine selenium concentrations in patients with thyroid disease compared to healthy normal population. We also investigated the correlation of serum selenium concentration with urine selenium concentr...

ea0041ep987 | Thyroid (non-cancer) | ECE2016

Evaluation of TSH receptor antibodies and histopathological features in patients with toxic multinodular and toxic nodular goiter

Aydin Cevdet , Baser Husniye , Neslihan Cuhaci Fatma , Ozdemir Didem , Yalcin Samet , Ersoy Reyhan , Cakir Bekir

Introduction: Association between high thyrotrophin receptor antibodies (TRAb) and relapse of thyroid cancer in Graves’ patients was reported previously. In this study, we aimed to investigate possible relation between TRAb and thyroid malignancies in patients with toxic multinodular (TMNG) and toxic nodular goiter (TNG).Methods: Thyroidectomized patients with a preoperative diagnosis of TMNG, TNG and euthyroid multinodular or nodular goiter (MNG/NG...

ea0041ep988 | Thyroid (non-cancer) | ECE2016

Malignancy is associated with microcalcification and AP/T ratio in ultrasonography, but not with Hashimoto’s thyroiditis in histopathology in patients with thyroid nodules evaluated as Bethesda Category III (AUS/FLUS) in cytology

Topaloglu Oya , Baser Husniye , Cuhaci Neslihan , Sungu Nuran , Yalcin Abdussamed , Ersoy Reyhan , Cakir Bekir

Introduction: The predictors of malignancy are important for decision of appropriate management in nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS). Our aim was to determine the ultrasonographical, clinical and biochemical predictors of malignancy in these patients.Methods: A total of 427 patients with Bethesda Category III (AUS/FLUS) thyroid nodules were included in this retrospective study. We d...

ea0041ep989 | Thyroid (non-cancer) | ECE2016

Increased Serum Levels of IL-28 and IL-29 and Protective Effect of IL28B rs8099917 Polymorphism in Patients with Hashimoto’s Thyroiditis

Arpaci Dilek , Celik Sevim Karakas , Can Murat , Gunes Gunes Cakmak , Kuzu Fatih , Unal Mustafa , Bayraktaroglu Taner

Hashimoto’s thyroiditis is thought to result from the decreased of T helper type 2 (Th2) responses, leading to progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) is a recently described member of the IFN-λ family and has been shown to decrease production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in Hashimoto’s thyroiditis remain unkno...

ea0041ep990 | Thyroid (non-cancer) | ECE2016

The value of blood cell markers in patients with thyroid nodules including atypia of undetermined significance/follicular lesion of undetermined significance cytology

Arpaci Dilek , Cakmak Guldeniz Karadeniz , Emre Ali Ugur , Unal Mustafa , Kuzu Fatih , Bahadir Burak , Bilici Muammer , Bayraktaroglu Taner

Background: Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a heterogeneous that cannot be definitively diagnosed as benign, malignancy-suspect, or malignant. The estimated risk of AUS/FLUS malignancy is reported 5% to 15% according to the Bethesda System (BS). This study was conducted to evaluate the ability of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) to predict the malignant potential of nodules diag...

ea0041ep991 | Thyroid (non-cancer) | ECE2016

Neck lesions located outside the thyroid bed with similar echogenity of thyroid tissue

Dellal Fatma Dilek , Aydin Cevdet , Ozdemir Didem , Ersoy Reyhan , Ocal Berrak G. , Cakir Bekir

Introduction: We aimed to determine demographical, hormonal, ultrasonography(US) and cytological features of cases with neck lesions that are located outside the thyroid region and have similar echogenity with thyroid tissue.Method: Neck US reports of patients who underwent fine needle aspiration(FNAB) under US guidance in our clinic in a period of one year were reviewed retrospectively. Lesions having similar echogenity with thyroid tissue and defined a...

ea0041ep992 | Thyroid (non-cancer) | ECE2016

Increased chemiluminescence activity of blood neutrophilic granulocytes from patients with Graves’ disease

Dudina Margarita , Dogadin Sergey , Savchenko Andrey , Gvozdev Ivan

The cellular structures lipid peroxidation related to immune system dysfunction seems to have a key role in autoimmune theory of Graves’ disease (GD). Aim: to investigate chemiluminescent (CL) activity of blood neutrophilic granulocytes in patients with GD. Materials and methods: Twenty six women, mean age 40.7±13.2, with manifestation of GD up to antithyroid therapy and 30 sex- and age-matched healthy subjects were examined. Serum thyroid hormone concentrations were...

ea0041ep993 | Thyroid (non-cancer) | ECE2016

Effectiveness of radiofrequency ablation of the autonomously functioning benign thyroid nodules

Solovov Viacheslav , Vozdvizhenskiy Michael , Orlov Andrew , Makhonin Alexander

Introduction: The usual treatment for autonomously functioning benign thyroid nodules was surgery until the advent of new techniques such as radiofrequency ablation (RFA). This study aimed at estimating RFA efficacy of autonomously functioning benign thyroid nodules.Material and Methods: The analysis included the results of treatment of 108 patients with autonomously functioning benign tumors of the thyroid gland, received in the Samara Oncology Center. ...

ea0041ep994 | Thyroid (non-cancer) | ECE2016

Sorafenib-induced changes in thyroid hormone levels in patients with hepatocellular carcinoma

Beukhof Carolien , Bins Sander , van Doorn Leni , de Herder Wouter , Visser Theo , Mathijssen Ron , Peeters Robin

Background: Recent studies suggest enhanced peripheral thyroid hormone metabolism as an explanation for the changes in thyroid hormone levels in patient treated with Sorafenib.Methods: In this single centre, prospective, observational cohort study 60 patients with hepatocellular carcinoma were treated with Sorafenib. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) were measured at baseline (time-0), at 6 weeks (time-1) and at the end of therap...

ea0041ep995 | Thyroid (non-cancer) | ECE2016

Alterations of thyroid functions in obesity: is there any impact of co–existence of type 2 diabetes mellitus?

Topaloglu Omercan , Sumer Fatih , Cetin Sedat , Yologlu Saim , Kayaalp Cuneyt , Sahin Ibrahim

Objective: The number of studies that investigate thyroid functions in obese patients is limited, and little known about the effect of co-existence of type 2 diabetes mellitus on thyroid functions. In our study, we aimed to evaluate the spectrum of thyroid function in the both diabetic and non-diabetic obese patients.Materials-Methods: 145 obese patients who were admitted to our department of endocrinology and metabolism, between June 2014 and December 2...

ea0041ep996 | Thyroid (non-cancer) | ECE2016

Transforming growth factor β1 in postpartum thyroiditis

Zielinska Anna , Maciulewski Rafal , Siewko Katarzyna , Poplawska-Kita Anna , Kozlowska Gabryela , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Introduction and aims: TGF-β1 participates in the pathogenesis of autoimmune diseases e.g. diabetes, Hashimoto disease, autoimmune digestive system disorders. The aim of our study was to evaluate TGF-β1 levels during pregnancy and after childbirth in women who developed postpartum thyroiditis (PPT) in comparison to the healthy control group (CG) and women with positive anti-thyroid antibodies (ATA+) who did not develop PPT.Material and method: ...

ea0041ep997 | Thyroid (non-cancer) | ECE2016

Markers of apoptosis in thyroid goiter

Segiet Oliwia , Mielańczyk Łukasz , Michalski Marek , Matysiak Natalia , Klymenko Olesya , Helewski Krzysztof , Wojnicz Romuald

Introduction: Thyroid goiter may be present in different thyroid pathologies, such as non-toxic nodular goiter (NTNG) or Hashimoto’s thyroiditis (HT), as a result of focal hyperplasia of thyrocytes (nodal goiter) or generalized enlargement of thyroid (diffuse goiter). Previous studies have demonstrated that programmed cell death, known as apoptosis, plays an important role in the pathogenesis of many thyroid diseases, especially inflammatory conditions.<p class="abste...

ea0041ep998 | Thyroid (non-cancer) | ECE2016

Hemithyroidectomy seems to be a reasonable initial surgical approach for patients with cytologically Bethesda Category III (AUS/FLUS) thyroid nodules

Bilginer Cuneyt , Ozdemir Didem , Topaloglu Oya , Aydin Cevdet , Dumlu Gurkan , Dogan Hayriye , Ersoy Reyhan , Cakir Bekir

Introduction: Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) termed as Bethesda Category III constitute 15–30% of thyroid cytology. However, the risk of malignancy in this heterogenous category is estimated as 5–15%. The recent studies has been reported the malignancy rate in the wide range of 6–48%. This causes surgical approach variability between different centers. We aimed to evaluate the initial malignancy rate...

ea0041ep999 | Thyroid (non-cancer) | ECE2016

Risk Factors for the development of hypothyroidism after thyroid lobectomy

Barka Ines , Chaker Fatma , Bouzouita Hajer , Chihaoui Melika , Kilani Osman , Yazidi Mariem , Rejeb Ons , Slimane Hedia

Bakground: Thyroid-lobectomy is a frequent procedure performed in patients with a variety of thyroid conditions.The aim of this study is to determine the prevalence of post-operative hypothyroidism and the risk factors of hypothyroidism in patients undergoing thyroid-lobectomy.Patients and methods: We retrospectively reviewed patients who underwent a thyroid lobectomy for benign disease from january 2000 to 2014. Patients with known hypothyroidism before...

ea0041ep1000 | Thyroid (non-cancer) | ECE2016

Autoimmune thyroid diseases (AITD) and mental illness: An evaluation of parietal cell antibodies, intrinsic factor antibodies, vitamin B12 and psychiatric symptoms in patients with AITD and Non-AITD controls

Leineweber Doerte , Galling Britta , Schurmeyer Thomas H.

Introduction: Associations of autoimmune thyroid disease (AITD) with autoimmune gastri-tis and mental disorders have been suggested, but evidence for a connection is lacking.Methods: We compared the co-incidence of parietal cell antibodies (PCA>20 RE/ml), intrinsic factor antibodies (IFA>1.19 AU/ml), vitamin B12 plasma levels (<200 pg/ml) and mental illness in patients with AITD (n=398), e.g. active (TPO+), atrophic (TPO−) and ...

ea0041ep1001 | Thyroid (non-cancer) | ECE2016

Assessment of 25-Hydroxy vitamin D level in pre- and postmenopausal women with euthyroid Hashimoto’s thyroiditis

Bilge Muge , Adas Mine , Yesilova Aylia , Helvaci Aysen

Objective: Hashimoto’s thyroiditis is a common autoimmune disorder. A few studies have analyzed the association between serum vitamin D levels and Hashimoto’s thyroiditis and available data remains inconclusive. The aim of this study was to evaluate the association between serum 25-Hydroxy vitamin D levels in pre- and postmenopausal woman with Hashimoto’s thyroiditis.Methods: We evaluated 120 premenopausal women with euthyroid Hashimoto&#1...

ea0041ep1002 | Thyroid (non-cancer) | ECE2016

Occurrence of ATD-induced agranulocytosis and its treatment

Cepkova Jitka , Lasticova Martina , Cap Jan

Introduction: Agranulocytosis represents a serious complication of thyreostatic (ATD) treatment. The aim of our work was to determine how often did agranulocytosis occur in Graves’ disease patients admitted to the thyroid treatment department of our clinic for RAI treatment between the years 1999 and 2014.Patients and methods: We have retrospectively analysed 699 patients (572 women and 127 men at the average age of 51.5±12.9 years). 327 (47%) ...

ea0041ep1003 | Thyroid (non-cancer) | ECE2016

Does Immunosuppressive Therapy improve outcomes in Graves’ disease: Results from a Systematic Review and Meta-analysis

Struja Tristan , Gubelin Larissa , Kutz Alexander , Fehlberg Hannah , Muller Beat , Schutz Philipp

Objective: Whether additional immunosuppressive drugs to standard treatment with thyreostatic drugs reduce the risk for relapse in Graves’ disease is not well understood. We performed a systematic review and meta-analysis to study the effects of immunosuppressive drugs on relapse rate and treatment effect of patients with hyperthyroidism due to Graves’ disease.Methods: We searched PubMed, EMBASE and Cochrane in July 2015 for randomized-controll...

ea0041ep1004 | Thyroid (non-cancer) | ECE2016

Vitamin D levels in Graves’ disease with and without exophthalmos: a case-control study

Sheriba Nermin , Abushady Manal Mohamed , Abdelsalam Mona Mohamed , Eliwa Tamer Fahmy , Almasri Mohamed Samir

There is evidence that vitamin D has a variety of effects on immune system function, which may enhance innate immunity and inhibit the development of autoimmunity. It suppresses T-cell proliferation, and inhibits secretion of pro-inflammatory Th1- and Th2-related Cytokines. In Graves’ ophthalmopathy (GO), a diffuse infiltration of lymphocytes is seen in the orbital adipose tissues and extracellular muscles. Th1 and 2 appear to play a role GO.Aim: To...

ea0041ep1005 | Thyroid (non-cancer) | ECE2016

Amiodarone-induced thyrotoxicosis

Fonseca Ricardo , Duarte Joao Sequeira , Santos Francisco , Bello Carlos , Roque Catarina , Capitao Ricardo , Ferreira Rute , Serra Filipa , Vasconcelos Carlos

Background: Amiodarone is an antiarrhytmic drug used mainly in atrial fibrillation. Amiodarone-induced thyrotoxicosis (AIT) is less common than hypothyroidism, but it represents a true therapeutic challenge. AIT can be due iodine load (type 1) or a destructive thyroiditis (type 2).Methods: Retrospective study of patients with AIT, diagnosed between 2010 and 2015, in a central hospital. We reviewed medical records regarding age, gender, amiodarone therapy...

ea0041ep1006 | Thyroid (non-cancer) | ECE2016

Relationship of insulin sensitivity with HOMA-IR and QUICKI index in euthyroid woman with Hashimoto’s

Bilge Muge , Adas Mine , Yesilova Aylia , Helvaci Aysen

Objective: It is recognized that autoimmun thyroid dysfunction is associated with weight and metabolic changes, insulin resistance and type 1 diabetes. In this study, we aimed to investigate whether thyroid autoimmunity had an effect on insulin sensitivity in euthyroid woman with Hashimoto’s thyroiditis.Methods: Forty-seven newly diagnosed euthyroid woman with Hashimoto’ thyroiditis with a mean age of 43 years were included in the study. The co...

ea0041ep1007 | Thyroid (non-cancer) | ECE2016

Thyroid dyshormonogenesis: therapeutic data of a group of seventeen patients

Cheikhrouhou Nesrine , Mnif Mouna , Mnif Fatma , Salah Dhouha Ben , Abid Mohamed

Introduction: Thyroid dyshormonogenesis (TD) accounts for 15–20% of congenital hypothyroidism (CH). Levothyroxine is the treatment of choice with the immediate goal to raise the serum T4 as rapidly as possible. Surgical treatment is indicated in case of compressive or suspected goiter.Patients and methods: Seventeen patients with thyroid dyshormonogenesis belonging to 4 Tunisian families were included in a descriptive prospective study. They were fo...

ea0041ep1008 | Thyroid (non-cancer) | ECE2016

Soluble (Pro)rennin receptor levels in patients with graves disease

Mizuguchi Yuki , Yatabe Midori , Yatabe Junichi , Seki Yasufumi , Niyama Michita , Bokuda Kanako , Watabnabw Daisuke , Ando Takashi , Morimoto Satoshi , Ichihara Atsuhiro

Background: (Pro)renin receptor[(P)RR] is a multi-functioning transmembrane protein which plays key roles in the regulation of tissue renin-angiotensin system (RAS). (P)RR is cleaved by furin to generate soluble (P)RR[s(P)RR], which is secreted into extracellular space. We previously reported that high blood concentration of s(P)RR indicates poor organ prognosis in several diseases. In this way, s(P)RR is expected as a candidate biomarker for reflecting the tissue RAS status, ...

ea0041ep1009 | Thyroid (non-cancer) | ECE2016

Conjunctival impression cytology is worsened in Hashimoto’s thyroiditis without thyroid associated ophthalmopathy

Altay Mustafa , Sahin Tugba , Yildiz Zennure , Simsek Gulcin , Citirik Mehmet , Ates Ihsan , Bitiren Muharrem

Introduction: We aimed to investigate the conjunctival surface changes in Hashimoto’s thyroiditis (HT) patients and controls comparatively, and search the correlation of these changes with thyroid functions and thyroid autoantibody level in patients without thyroid associated ophthalmopathy (TAO).Methods: A total of 25 patients with HT and 33 healthy individuals were enrolled in the study. Serum TSH, fT4 and fT3 level, and anti...

ea0041ep1010 | Thyroid (non-cancer) | ECE2016

The effects of iodoprophylaxis on thyroid volume and nodular size during pregnancy in an iodine-sufficient area

Perez-Naranjo Susana , Abellan Pablo , Merchante Agustin Angel , Rubio Olalla , Querol Roser , Cubells Pilar

Introduction: During pregnancy, the thyroid volume (TV) increases by 20% to 35% in areas with iodine deficiency. In iodine-sufficient countries, while some studies showed an increase in TV by 10–15%, others did not observe any change in TV during pregnancy. Thyroid nodules may be present in up to 15–35% of pregnant women in areas with moderate iodine deficiency. However, in areas with iodine-sufficient, thyroid nodules were investigated in a few number of studies...

ea0041ep1011 | Thyroid (non-cancer) | ECE2016

Changes in thyroid ultrasound during the first trimester of pregnancy are not related to levels of TSH

Perez-Naranjo Susana , Merchante Agustin Angel , Rubio Olalla , Cubells Pilar , Querol Roser , Abellan Pablo

Introduction: The changes observed in thyroid ultrasound during pregnancy are related to the nutritional status of iodine, but its association with TSH levels or the presence of thyroid peroxidase antibodies (TPOAb) is unclear.Objective: To compare the relationship between the findings in thyroid ultrasound and thyroid function tests in the first trimester of pregnancy in an iodine sufficient area.Subjects and methods: We conducted...

ea0041ep1012 | Thyroid (non-cancer) | ECE2016

Central/Peripheral vascularization and resistance index at Doppler ultrasound examination of thyroid nodules: are they useful to differentiate between benign and malignant pathology?

Pacenza Nestor , Rosmarin Melanie , Blan Evelin , Serrano Sol , Cejas Claudia , Sforza Noelia , Serrano Leonardo , Campero Adriana , Frid Santiago , Faingold Maria Cristina , Brenta Gabriela

Thyroid Doppler ultrasound (TDUS) is highly used in the evaluation of thyroid nodules (TN). Malignant thyroid pathology has been more frequently associated with central vascularization of such nodules. There is controversy regarding the usefulness of the Resistance Index (RI) in the assessment of TN.Our aim was to analyze the utility of vascularization characteristics and RI at TDUS in the distinction of benign and malignant TN.Mat...

ea0041ep1013 | Thyroid (non-cancer) | ECE2016

Evaluation of thyroid function tests in patients with acute kidney injury

Ozkan Hanise , Okuturlar Yildiz , Kocoglu Hakan , Utku Irem Kirac , Demir Esra , Harmankaya Ozlem , Palaz Mehmet , Oztosun Bugra , Mert Meral , Kudu Aysegul , Yucel Sibel Kocak , Kumbasar Abdulbaki

Aim: Euthyroid sick syndrome can be described as abnormal findings on thyroid function tests that occur in the setting of a nonthyroidal illness (NTI) without preexisting hypothalamic-pituitary and thyroid gland dysfunction. In this study we tried to compare thyroid function tests between patients with acute kidney injury (AKI) and healthy controls.Materials and Methods: This study consisted of 31 patients with AKI and 26 healthy controls. All patients&#...

ea0041ep1014 | Thyroid (non-cancer) | ECE2016

Is there seasonality in the month of birth of patients with autoimmune thyroid diseases?

Ramos-Levi Ana M , Serrano-Somavilla Ana , Martinez-Hernandez Rebeca , Sampedro-Nunez Miguel , Vicuna Alicia , Vitales-Noyola Marlen , Marazuela Monica

Background: Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are common disorders with an autoimmune etiology, which are known as autoimmune thyroid diseases (AITD). A specific seasonal pattern of the month of birth has been suggested in several autoimmune disorders, supporting the hypothesis of a link between viral infections and the development of aberrant immune-regulatory mechanisms. However, there are few studies which specifically address this issue in AIT...

ea0041ep1015 | Thyroid (non-cancer) | ECE2016

Cardiovascular risk assessment using serum hs-CRP and Framingham risk score in newly diagnosed Graves’ disease patients

Martin Sorina , Betivoiu Minodora , Florea Suzana , Fica Simona

Introduction: In hyperthyroid patients mortality is increased by 20%, the major causes of death being cardiovascular disorders. Recent data suggest that subclinical or treated thyroid disease is associated with increased long-term vascular risk despite restoration of euthyroidism.Methods: We measured high-sensitivity C reactive protein (hs-CRP) in 116 newly diagnosed Graves’ disease (GD) patients, without prior antithyroid treatment. Levels of hs-CR...

ea0041ep1016 | Thyroid (non-cancer) | ECE2016

Total thyroidectomy in refractory amiodarone induced thyrotoxicosis: a case series of 12 patients

Drescher Tilman , Clerici Thomas , Kolb Walter , Brandle Michael , Bilz Stefan

Introduction: Amiodarone induced thyrotoxicosis (AIT) occurs in 5–10% of patients and may occur at any time throughout the course of treatment including months after discontinuation. Two distinct forms of AIT are distinguished and treated differently. Iodine-induced hyperthyroidism, typically seen in patients with underlying thyroid disease, is referred to as typ1 AIT and treated with high doses of thionamide antithyroid drugs and perchlorate. Type 2 AIT is a destructive ...

ea0041ep1017 | Thyroid (non-cancer) | ECE2016

Accuracy of repeated core biopsy (CB) after inadequate first CB in thyroid nodules

Paja Miguel , Zabala Rosa , Korta Igone , Zabalegui Alba , Dublang Maddalen , de Ciriza Maite Perez , Lizarraga Aitzol , Ugalde Aitziber

In our centre, thyroid core-biopsy (CB) has replaced fine needle aspiration biopsy (FNAB) in the study of thyroid nodules because its better accuracy. International guidelines recommend repeating the FNA in cases of inadequate or insufficient first specimen, but nothing is published about the case in failed CB.Objective: To study the differences between nodules with inadequate and diagnostic thyroid Core Biopsy and the accuracy of repeating a CB after a ...

ea0041ep1018 | Thyroid (non-cancer) | ECE2016

The prevalence of iodothyronine deiodinase genes and their association with neuropsychological status in Korean hypothyroid patients

Chung Jae Hoon , Kim Sun Wook , Kim Hye Jeong , Sohn Seo Young , Kim Young Nam , Lee You-Bin , Kim Hye-In , Lee Seung-Eun

Background: Three deiodinase genes (DIO) play an important role in thyroid hormone metabolism. Among them, type 2 iodothyronine deiodinase (DIO2) converts T4 to T3 in brain and impaired psychological well-being was reported in minor variants of DIO2. However, the prevalence of three DIOs and their relation to neuropsychological status has not been evaluated in Asian hypothyroid subjects.Methods: We prospectively enrolled 196 subjects who were taking levo...

ea0041ep1019 | Thyroid (non-cancer) | ECE2016

Anti neutiphil cytoplasmic antibodies & hyperthyroidism in fayoum (Egypt)

Mashahit Mohamed , Khattab Doaa

Background: It was noted in the last few years there was an increased incidence of vasculitis and vasculitic reactions in patients with thyrotoxicosis. Those vasculitic reactions ranged from simple purpuric skin lesion to sever intra-alveolar hemorrhage and even to Steven Johnson Syndrome, Most of those vasculitic reactions occurred in patients receiving propylthiouracil or methimazole. But many other cases were detected in thyrotoxic patients even be...

ea0041ep1020 | Thyroid (non-cancer) | ECE2016

Recurrent sub acute thyroiditis lacking diagnostic imaging features: atypical scenario

Rashid Muhammad , Naeemul Haq Muhammad , Islam Najmul , Khan Bella , Kiran Zareen

Introduction: Diagnosis of sub acute thyroiditis is readily considered in a patient presenting with classical history and characteristic clinical features. Confirmation of diagnosis is based on particular set of laboratory investigations and supported by characteristic imaging findingsof Tc-99 scan. However, prescence of sub acute thyroiditis with normal thyroid scintigraphy findings is exceedingly rare.Case report: 51 years old postmenopausal female wit...

ea0041ep1021 | Thyroid (non-cancer) | ECE2016

Evaluation of theurapeutic modalities of Graves’ disease

Saglam Fatma , Koseoglu Derya , Onal Eda Demir , Yalcin Yavuz , Berker Dilek , Guler Serdar

Objective: Radioiodine (RAI), surgical and anti-thyroid drug therapy are the main options to treat Graves’ disease (GD). The aim of this study was to investigate theurapeutic options, their efficacy and adverse reactions of prophilthiouracil (PTU) and methimazole (MMI).Design: A total of 650 patients with GD were evaluated retrospectively. Treatments, adverse reactions, clinical and laboratory results were recorded. After 18 months of primary medica...

ea0041ep1022 | Thyroid (non-cancer) | ECE2016

Changes in irisin, titin and dystrophin concentrations in patients with overt thyroid dysfunction

Zybek-Kocik Ariadna , Sawicka-Gutaj Nadia , Wrotkowska Elżbieta , Sowiński Jerzy , Ruchała Marek

Introduction: Many original research studies describes significant impact of thyroid hormones on muscle tissue. Hypo- and hyperthyroidism cause both functional and structural damage of muscles presented by many signs and symptoms of thyroid myopathy. Thus, it is interesting to compare the impact of thyroid dysfunction on hormones secreted by muscles – myokines.Aim: The main goal of the project is to assess serum concentration of three myokines &#150...

ea0041ep1023 | Thyroid (non-cancer) | ECE2016

Thyroid function parameters in Polish pregnant women

Trofimiuk-Muldner Malgorzata , Szybinski Zbigniew , Sokolowski Grzegorz , Stefanska Agnieszka , Buziak-Bereza Monika , Adamczewski Zbigniew , Lewinski Andrzej , Hubalewska-Dydejczyk Alicja

Thyroid function in pregnancy differs between populations. The aim of the study was to assess thyroid parameters in Polish pregnant women. It included 1095 pregnant volunteers aged 16–42 years (174, 501, 420 in the 1st, 2nd, and 3rd trimester, respectively), who gave their informed written consent. In each woman thyroid ultrasound was performed, 90.7% had TSH, fT4 and a-TPO measured, and 84.0% iodine urinary concentration (UIC) in urine spot sample estimated.<p class=...

ea0041ep1024 | Thyroid (non-cancer) | ECE2016

Skin autofluorescence and serum carboxymethyllysine levels in hypothyroid and hyperthyroid patients

Yavuz Dilek Gogas , Yazici Dilek , Temizkan Sule

Levels of thyroid hormones may effect the levels of the glycation product and those of the oxidation products.Objective: To evaluate the relationship between skin autofluorescence (SAF), and serum advanced glycation end products (AGEs) parameters in hypothyroid and hyperthyroid patients.Method: Newlydiagnosed or untreated 100 overt and subclinical hypothyroid patients (42±13 yrs) and 50 overt-subclinical hyperthyroid patients ...

ea0041ep1025 | Thyroid (non-cancer) | ECE2016

Ectopic thyroid tissue in the midline of the neck coexisting with a normally located thyroid gland

Marin Veronica , Trifanescu Raluca , Dumitrascu Anda , Ioachim Dumitru , Goldstein Andrei , Poiana Catalina

Introduction: Ectopic thyroid tissue (ETT) is a rare entity; it is more frequent in women (80%) and is usually located along the obliterated thyroglossal duct. ETT in the midline is even rarer (1.79%). Incidence of malignancy in this group is lower than in orthotopic thyroid nodules.Case report: A 40 years old woman, resident in iodine sufficient area, but originating from an iodine deficient area, presented for a midline neck mass. TSH and FT4 were meas...

ea0041ep1026 | Thyroid (non-cancer) | ECE2016

Depression and anxiety in hashimoto thyroiditis after long-term levothyroxine replacement

Djurovic Marina , Pereira Alberto , Jemuovic Zvezdana , Vasovic Olga , Pavlovic Dragan , Petakov Milan , Miljic Dragana , Damjanovic Svetozar

Introduction: Thyroid dysfunction may cause various psychiatric symptoms and disturbances. In addition, many factors affect the variable responses to hormone replacement. Many patients treated for Hashimoto thyroiditis(HT) report persistent impairments in general well-being despite long-term L-thyroxine (LT4) replacement and restoration of biochemical euthyroidism.Aim: To investigate the prevalence of depression and anxiety in patients with HT on long-te...

ea0041ep1027 | Thyroid (non-cancer) | ECE2016

Follow-up of serum selenium concentrations in patients receiving selenium supplementation

Molnar Jeannette , Balazs Csaba

Selenium (Se) supplementation has been adopted as treatment for patients with elevated autoantibodies or in patients with mild Graves’ orbitopathy. However, serum Se concentrations or other markers of Se status are usually not determined during treatment. The aim of our study was to measure serum Se concentrations at regular intervals during treatment and to register any side effects.Twenty patients with mild orbitopathy and twenty patients with act...

ea0041ep1028 | Thyroid (non-cancer) | ECE2016

Is the high mean platelet volume associated with inflammation in subacute thyroiditis?

Simsek Eda , Yildiz Faruk , Ademoglu Esra , Durmaz Senay Arikan , Filiz Murat , Bingol Fatih , Bingol Buket , Baykan Emine Kartal , Aydin Unsal , Sanibas Ahmet Veli , Carlioglu Ayse

Introduction and aims: Subacute thyroiditis (ST) is a spontaneous remitting inflammatory disease of thyroid gland. Although there is no clear evidence for its specific etiology, multiple factors may responsible for this inflammatory reaction. Mean platelet volume (MPV) is a new important inflammatory marker that indicates disease activity. Aim of this study is to evaluate MPV value in patients with subacute thyroiditis.Materials and methods: Thirty-one p...

ea0041ep1029 | Thyroid (non-cancer) | ECE2016

Increased levels of bisphenol a in euthyroid autoimmun thyroiditis

Ademoglu Esra , Keskin Muge , Gorar Suheyla , Carlioglu Ayse

Introduction: Autoimmune thyroiditis (AIT), also called Hashimoto thyroiditis or chronic lymphocytic thyroiditis is characterized by destruction of the thyroid gland involving apoptosis of thyroid epithelial cells. It usually presents as euthyroidism or subclinically hypothyroidism, rarely as overt hypothyroidism. The cause of Hashimoto’s thyroiditis is thought to be a combination of genetic susceptibility and environmental factors. Bisphenol A (BPA), an endocrine-disrupt...

ea0041ep1030 | Thyroid (non-cancer) | ECE2016

Acute suppurative thyroiditis caused by burkholderia cepacia

Tarkun Ilhan , Akyay Ozlem Zeynep , Canturk Zeynep , Cetinarslan Berrin , Selek Alev , Catan Fatma Tugba

Introduction: The thyroid is generally resistant to infections due to its encapsulated location, high iodine concentration, hydrogen peroxide production, and high levels of blood and lymphoid circulation therefore acute suppurative thyroiditis is rarely seen. The most common agents are Staphilococcus and Streptococcus. In this case we present acute suppurative thyroiditis caused by Burkholdeira cepacia, that is a rare infectious agent in adults.Case: 34 ...

ea0041ep1031 | Thyroid (non-cancer) | ECE2016

Immunohistochemical expression of coagulation and fibrinolysis markers in thyroid goiter

Mielańczyk Łukasz , Segiet Oliwia , Deska Mariusz , Buła Grzegorz , Piecuch Adam , Kowalczyk-Ziomek Grażyna , Wojnicz Romuald

Introduction: Endocrine disorders can influence the hemostatic balance. Various abnormalities of coagulation-fibrinolytic system have been reported in patients with thyroid dysfunction. The aim of the study was to assess the immunohistochemical expression and distribution of coagulation and fibrinolysis markers in follicular cells of thyroid goiter.Materials and methods: 20 patients with thyroid goiter were included in the study: 11 cases with non-toxic ...

ea0041ep1032 | Thyroid (non-cancer) | ECE2016

Thyroid scintigraphy findings in patients without thyroid tissue in the ultrasonography

Tastekin Gungor , Kaya Ahmet , Kulaksizoglu Mustafa , Saglam Bugra , Atabek Emre , Turan Elif

Introduction: Patients that were suspected to have thyroid agenesis on imaging procedures were retrospectively evaluated.Methods: Totally 4155 patients had scintigraphy imaging between years of 2010–2015 in our university. 4021 (96.77%) patients were adults (>18 years) and 134 patients (3.22%) were in the pediatric population. Among adult population, 3060 (76.1%) were female, and 1095 (27.2%) were male. In the pediatric population, 85 (63.4%) pa...

ea0041ep1033 | Thyroid (non-cancer) | ECE2016

Immunohistochemical assessment of catalase in lesions of thyroid gland

Michalski Marek , Segiet Oliwia , Piecuch Adam , Brzozowa-Zasada Marlena , Helewski Krzysztof , Harabin-Słowińska Marzena , Wojnicz Romuald

Introduction: Catalase is an enzyme, which functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. It is responsible for protecting the cell from oxidative damage by reactive oxygen species. Catalase promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells, and normal and transformed fibroblast cells. Nevertheless, the role of this enzyme in thyroid pathologies i...

ea0041ep1034 | Thyroid (non-cancer) | ECE2016

Abnormal thyroid function tests following thyroidectomy

Serap Yalin A. , Turemen Erdem , Biyikli Mithat , Erdemir Ayhan , Kucukercan Inci , Cakmakci Metin

Introduction: Permanent hypothyroidism is a common side effect of thyroidectomy. Thyroxine binding globulin (TBG) deficiency is characterized with low total thyroid hormones (TH) in the presence of normal free THs and thyroid stimulating hormone (TSH).Case report: A previously healthy 37-year-old man underwent annual health check-up. Thyroid US revealed a 24×14×19 mm isoechoic solid nodule in the left lobe. TSH was 1.4 (0.27–4.2 μIU/m...

ea0041ep1035 | Thyroid (non-cancer) | ECE2016

Propylthiouracil induced ANCA-associated vasculitis

Souteiro Pedro , Freitas Joana , Amaral Susana , Belo Sandra , Nogueira Claudia , Pereira Rodrigues , Meirinho Ivone

Introduction: Propylthiouracil is a drug used in the treatment of hyperthyroidism and autoimmunity phenomena have been described as a side effect of its use. Despite anti-neutrophil cytoplasmic antibodies (anca) positivity is frequent in patients treated with propylthiouracil, the occurrence of clinically evident vasculitis is rare.Case report: A 65-year-old woman, diagnosed with hyperthyroidism 2 years ago and treated with propylthiouracil (50+...

ea0041ep1036 | Thyroid (non-cancer) | ECE2016

An inverse relationship between weight and free thyroxine middle gestation

Outas Mariana Costache , Procopiuc Camelia , Costache Cosmina , Fica Simona

Evaluation of the thyroid function in pregnant women is of extreme importance for maternal and neonatal health. The reference interval of thyroid function tests in pregnant women differs from that of the general population and among trimesters in the same patient. Trimester-specific thyrotropin (TSH) reference ranges for pregnant women are recommended in order to avoid misclassification of the thyroid dysfunction during pregnancy.Less data about the free...

ea0041ep1037 | Thyroid (non-cancer) | ECE2016

Cytological evaluation of thyroid nodules by fine-needle aspiration performed by endocrinologists. Our clinical experience in 2014.

Fernandez-Ladreda Mariana Tome , Bautista Carmen , Rojas Rocio , Duarte Daniel Gonzalez

Introducción: Thyroid nodule is a very frequent pathology that affects 4-8% of population. Fine-needle aspiration (FNA) guided by ultrasound (US) is considered the gold standard test in diagnostic evaluation of thyroid nodules. This technique is being assumed more and more frequently by endocrinologists.Description of Methods: We conducted a retrospective study that included all thyroid US-guided FNA performed in 2014. We considered the following va...

ea0041ep1038 | Thyroid (non-cancer) | ECE2016

At least 15 mCi radioactive iodine dose should be considered in Graves’ disease with larger goiter: A sonographic volumetric study

Kim Jungmin , Jeong Yunah , Yoon Jee Hee , Kim Hee Kyung , Kang Ho-Cheol

Background: Fixed-dose radioactive iodine therapy (RAI) is one of the standard therapy for Graves’ disease (GD). However, optimal RAI dose to achieve hypothyroidism in GD has been controversial.Methods: The clinical outcome of 124 patients with GD treated with a RAI between Apr. 2004 and Dec. 2014 was analyzed retrospectively. Responder group was defined as patients who were rendered hypothyroid by the RAI. Thyroid volume (TV) was assessed with sono...

ea0041ep1039 | Thyroid (non-cancer) | ECE2016

Comparison of thyroid nodule prevalence in two population-based studies in Bulgaria: 2006 and 2012

Shinkov Alexander , Borissova Anna-Maria , Kovatcheva Roussanka , Dakovska Lilia , Vlahov Jordan , Vukov Mirtcho

The nodular goiter is the most prevalent thyroid disorder. Its prevalence increases with age and reaches over 70%. The aim of the study was to compare the nodule prevalence in two population-based studies, carried in Bulgaria in 2006 and 2012.Material and methods: Two thousand four hundred and two subjects (1347 female and 1053 male, age range 20–94 years) were included in 2006 and 2022 (1073 female and 949 male, 20–88 years) in 2012. All subje...

ea0041ep1040 | Thyroid (non-cancer) | ECE2016

Prevalence of autoimmune thyroid disorders in kin/relatives with those diseases

Carsote Mara , Ratcu Mihaela , Gharibafshar Payman , Oprisan Bogdan , Staicu Dana Cristina , Peretianu Dan

AbstractAim and objectives: To investigate the prevalence of relationships between kin/relatives with a known thyroid immune disorder related to Hashimoto thyroiditis.Material and method: 1. Thyroid disease diagnosis: a. ATPO > 34 u/ml = Hashimoto thyroiditis (HT); b. ATPO = normal but with high antithyroglobuline (ATG) = thyroiditis with only hyper-ATG (T-ATG); c. hypothyroidism without high ATPO/ATG = idiopat...

ea0041ep1041 | Thyroid (non-cancer) | ECE2016

Drug-induced hepatitis in a patient with Graves’ disease

Yahia Seifeldin , Sommers Nicola

A 52 year old lady presented with a history of weight loss, tachycardia and tremor. She was diagnosed with primary hyperthyroidism; TFTs were TSH <0.02 mU/l and FT4 >100 pmol/l, LFTs were mildly deranged (ALT 79 u/l, ALP 101 u/l). TSH receptor antibodies were positive, suggestive of Graves’ disease.The patient was started on carbimazole, initially at 10 mg TDS which was titrated down to 5 mg TDS. Repeat LFT showed ALP at 219 u/l and a fluctu...

ea0041ep1042 | Thyroid (non-cancer) | ECE2016

A case of concurrent Riedel’s disease and Hashimoto’s thyroiditis

Oueslati Ibtissem , Khiari Karima , Elfeleh Emna , Mchirgui Nadia , Bchir Najla , Abdallah Nejib Ben

Introduction: Riedel thyroiditis is a rare form of infiltrative and fibrotic disease of the thyroid which may involve neighbouring tissues. The main differential diagnosis of Riedel thyroiditis includes malignant tumors and fibrosing Hashimoto’s thyroiditis.Herein, we report a case of concurrent Riedel’s disease and Hashimoto’s thyroiditis.Observation: A 45-year-old woman was diagnosed with goiter and hypothyroidism....

ea0041ep1043 | Thyroid (non-cancer) | ECE2016

Ophthalmopathy occurrence after two years of thyroidectomy on account of papillary thyroid microcarcinoma

Altay Mustafa , Colbay Mehmet , Arslan Metin

Introduction: Thyroid ophthalmopathy occurs generally due to Graves’ disease. Only a few cases were reported about ophthalmopathy in the years following a thyroidectomy and RAI therapy or metastatic papillary thyroid cancer.Case: A forty-six-year-old female patient was operated on for the fine needle aspiration biopsy (FNAB) result of a suspicious follicular neoplasia. A pathology examination showed a papillary microcarcinoma and Hashimoto thyroidit...

ea0041ep1044 | Thyroid (non-cancer) | ECE2016

Technique of story-telling in patients undergoing thyroid surgery

Mayilvaganan Sabaretnam , Chand Gyan , Mishra Saroj , Agarwal Amit , Agarwal Gaurav , mishra Anjali , Verma AK , Warsi Dabeer

Introduction: In the modern day busy clinical practice the communication between patient and care giver is at minimal level. The patients feel apprehensive when advised about the surgical intervention. In such situation they feel the need of detail information from the care givers.Story telling is a tool which can be used for this problem. We intended to study the efficacy of storytelling technique on patients undergoing Hemithyroidectomy for benign cytology.<p class="abst...

ea0041ep1045 | Thyroid (non-cancer) | ECE2016

Hypothyroidism: a reversible cause of heart failure

Shah Nisarg , Miaskiewicz Stasia

Introduction: Hypothyroidism is characterized by a decrease in oxygen and substrate utilization by major organ systems of the body. Hence patients with angina have fewer symptoms if they become hypothyroid. Hypothyroidism also results in bradycardia and weakening of myocardial contraction. Cardiac preload is decreased, afterload is increased, and chronotropic and inotropic functions are reduced. The impairment of these measures leads to a reduction in cardiac output.<p cla...

ea0041ep1046 | Thyroid (non-cancer) | ECE2016

Exophthalmos as the first manifestation of mantle cell lymphoma of the patient with Hashimoto thyroiditis

Marczewski Krzysztof , Boniek-Poprawa Dorota , Tomaszewski Piotr , Kawałko Agnieszka , Maciejewski Marek

Introduction: The diagnosis of thyroid orbitopathy is based on clinical symptoms and typical changes in laboratory tests confirming thyroid disease. In approximately 5% it is Hashimoto’s thyroiditis. Typical treatment is primarily steroids administered intravenously. But one disease does not exempts the other, and the drugs can not read. Therefore, we would like to present the history of our patient.Case report: 55 year-old man was admitted to the E...

ea0041ep1047 | Thyroid (non-cancer) | ECE2016

Rhabdomyolysis case based on hypothyroidism

Ates Ihsan

Muscle involvement in hypothyroidism is a rare complication. These patients are often present with decreased muscle mass, cramps and myalgia. With these clinical symptoms increasing muscle enzyme suggests the rhabdomyolysis table. Rhabdomyolysis based on hypothyroidism is not a common condition. In this report, a case which detected rhabdomyolysis based on deep hypothyroidism will be discussed.Seventy-two years old male patient applied to our clinic with...

ea0041ep1048 | Thyroid (non-cancer) | ECE2016

The relationship between thyroid function and type 1 diabetes Mellitus duration

Rizov Cristina , Vudu Lorina

Thyroid disease is common among the population, and the prevalence increases with age. In patients with type 1 diabetes mellitus (T1DM) the risk of thyroid dysfunction and thyroid autoimmunity is increased. The aim of this study was to investigate the relationship between thyroid function and T1DM duration. There were evaluated 110 patients (71 women and 39 men) with T1DM between 2013 and 2015 and were appreciated antibodies against thyroid peroxidase (ATPO) (normal values...

ea0041ep1049 | Thyroid (non-cancer) | ECE2016

Surgical treatment Graves disease: long term results and their predictions

Makarov Igor , Galkin Rudolf , Sidorov Aleksandr , Shibanov Victor

The incidence of Graves disease in different regions of Russia ranges from 20 to 50 cases per 100000 population.Purpose: To improve the results of surgical treatment of patients with Graves disease by identifying the optimum amount of remaining thyroid tissue and prediction of thyroidal status in the long term.Methods and design: The 138 patients with Graves disease operated over the past 10 years: 131 women (94.9%) and 7 men (5.1%...

ea0041ep1050 | Thyroid (non-cancer) | ECE2016

Relation between Serum 25-hydroxy-vitamin D Levels and TSH receptor antibody seropositivity

Saglam Fatma , Koseoglu Derya , Berker Dilek , Guler Serdar

Objective: Vitamin D is an immune-modulator that may play a role in thyroid related autoimmunity. But the relation between Vitamin D and Graves’ disease (GD) is not well defined yet. The aim of this study was to investigate the association of 25-hydroxy-vitamin D (25[OH]D) levels and TSH receptor antibody (TRab) levels in GD.Design: A total of 429 GD patients were analyzed retrospectively. 122 of 429 patients had vitamin D levels were enrolled in th...

ea0041ep1051 | Thyroid (non-cancer) | ECE2016

Long-term follow-up results of benign nodular goiter in a rural district of east Japan

Kunori Takao , Nemoto Noriko , Kawaguchi Shinya , Shinya Fumiaki

Introduction: Surgery for benign nodular goiter (NOD) is currently limited to cancer or cosmetic deformities. Most patients are, in principle, followed up for years or decades. The long-term outcome, however, is not always clear.Patients and methods: NOD was diagnosed as benign in 1,825 patients (1990–2015). 102 patients (5%) were treated by surgery. 95% returned to home doctors (69%) or continued to visit our clinic (518 patients, 31%). Follow-up e...

ea0041ep1052 | Thyroid (non-cancer) | ECE2016

Long-term universal salt iodization has resulted now in more than adequate iodine intake and consequent chronic autoimmune thyroiditis in school-age children living in some localities from Mures and Harghita Counties, Romania

Szanto Zsuzsanna , Reti Zsuzsanna , Gall Anna , Ballok Iolanda , Csiszer Attila , Nagy Előd , Croitorescu Zsuzsanna , David Anna , Hadnagy Margit , Barbara Laszlo Emőke , Zier Hella , Tanko Zsuzsa , Gal Zsuzsanna , Zoltan Kun Imre

Introduction: In Romania universal salt iodization was implemented into practice since 2002, and iodine content of salt was gradually increased afterward. The efficiency and sustainability of this nationwide program were evaluated among school children from endemic regions of Mures and Harghita Counties. During these studies thyroid ultrasound characteristic for chronic autoimmune thyroiditis was observed in a considerable number of cases.Objective: To e...

ea0041ep1053 | Thyroid (non-cancer) | ECE2016

Can routine steroid cover during radioiodine therapy of patients with Graves’ disease (GD) prevent the onset of de novo Graves’ orbitopathy (GO)?

Kowalska Aldona , Palyga Iwona , Gasior-Perczak Danuta , Mikina Estera , Szymonek Monika , Piwowar Monika , Gadawska-Juszczyk Klaudia , Trybek Tomasz , Mezyk Ryszard , Gozdz Stanislaw

Introduction: Radioiodine therapy is considered as a risk factor for the development of Graves’ orbitopathy (GO) de novo or worsening of pre-existing orbitopathy. This risk is estimated in the available literature as up to 15–20%. Steroid cover is considered to eliminated this risk.Objective: The aim of our study was to established the relationship between the occurrence of GO and treatment with radioiodine. And the analysis of the time of appe...

ea0041ep1054 | Thyroid (non-cancer) | ECE2016

Prevalence of anti-thyroid antibodies (TAb) in relationship with high TSH levels at different ages

De Remigis Alessandra , Tomei Giammarco , Maria Lattanzio Franca , De Remigis Pierluigi , Occhiuzzi Umberto , Rapino Daniele

Some authors observed lower thyroid antibodies titers (AbT) in children than in the adult population. The aim of this work was to consider the prevalence of positive results in AbT and elevated TSH levels. We have considered AbT and TSH measurements in a large population. We divided samples in 7 age groups 0–18, 18–20, 20–40, 40–50, 50–60, 60–70 and >70 years old. Cut-off positivity for AbTg and AbTPO was 50 and for TSH was 10 mUI/ml.<p cl...

ea0041ep1055 | Thyroid (non-cancer) | ECE2016

Thyroid dysfunction and insulin resistance

Mohamed Mohamed , El Toukhy Hala

Background Insulin resistance (IR) is a state in which a given concentration of insulin produces biological effect less than expected and IR actually make up a broad clinical spectrum, including obesity, glucose intolerance, DM, and the metabolic syndrome that are associated with various endocrine, metabolic, & genetic conditions. There is an association of IR with thyroid abnormalities. Evidence for a relationship between T4 and T3 and glucose metabolism appeared over 100...

ea0041ep1056 | Thyroid (non-cancer) | ECE2016

ThyPROgr: translation and validation in Greek of the thyroid-specific quality of life questionnaire ThyPRO

Mintziori Gesthimani , Watt Torquill , Pournaras Dimitrios , Tzortzis Emmanouil , Kita Marina , Goulis Dimitrios

Introduction: Assessing the quality of life of patients with thyroid disease does represent a challenge. ThypRO questionnaire has been developed recently and comprises a reliable and valid scale structure of a patient-reported outcome measuring thyroid-specific quality of life.Material and methods: The standard methodology for translation of patient-reported outcomes was followed. Two independent translators, Greek native speakers, fluent in english, wer...

ea0041ep1057 | Thyroid (non-cancer) | ECE2016

Antithyroid arthritis syndrome

Paepegaey Anne-Cecile , Mavromati Maria , Chanson Philippe , Salenave Sylvie

The most frequent side effects of antithyroid drugs are skin reactions (6%), gastrointestinal effects (5%) and arthralgia (5%). Other complications such as antithyroid arthritis syndrome (1%), agranulocytosis (0.5%) and hepatitis (0.2%) occur rarely.We describe the case of a 20-year-old woman with Graves’ disease. Two weeks after the beginning of carbimazole therapy, she developed an urticarial reaction that led to discontinuation of treatment. Neve...

ea0041ep1058 | Thyroid (non-cancer) | ECE2016

Relapse subacute thyroiditis: atypical symptoms

Peretianu Dan , Carsote Mara , Voicu Gabriela , Neamtu Daniela , Goldstein Andrei , Valea Ana

Introduction: Subacute thyroiditis (ST) is a self limited condition; relapse is rarely seen. Anterior cervical complains and inflammatory syndrome is highly suggestive.Aim: We report a series of female cases associating arelapse of ST which was confirmed after the admission for atypical distant symptoms as diffuse headache or ear pain.Material and Methods: The endocrine profile is presented.Results: A 48-year...

ea0041ep1059 | Thyroid (non-cancer) | ECE2016

Hoffmann syndrome: a case report

Barka Ines , Maaroufi Amel , Badr Wafa , Hasni Yosra , Kacem Maha , Chadli Chaieb Molka , Ach Koussay

Background: Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudo-hypertrophy. Here, we report a case of Hoffman syndrome aggravated by statin therapy.Case report: We describe the case of a 60 year old woman with primary hypothyroidism who presented with fatigue, cold intolerance, constipation, exertional breathlessness, progressive proximal muscle weakness and swelling of th...

ea0041ep1060 | Thyroid (non-cancer) | ECE2016

Thyrolipoma: a rare entity of the thyroid gland

Ekiz Bilir Betul , Ozturk Ozlem , Bilir Bulent , Soysal Atile Neslihan , Ozkan Hakan

Introduction: Thyrolipoma (focal adenolipoma of thyroid gland) and thyrolipomatosis (diffuse lipomatosis in the gland) are rarely encountered pathologies in daily practice. We reported a case of small thyrolipoma incidentally diagnosed in a multinodular goiter patient.Case report: A 56 year-old man was admitted to our out-patient clinics with the complaint of a lump in his cervical region. His thyroid function tests were normal. In physical examination, ...

ea0041ep1061 | Thyroid (non-cancer) | ECE2016

A retrospective analysis of the relationship between obesity and thyroid nodule size

Oz Gul Ozen , Cander Soner , Sisman Pinar , Erturk Erdinc , Ersoy Canan

Objective: The prevalence of overweight and obesity has been increasing for several decades. Few studies have recently showed functional and morphological changes of the thyroid gland in relation to obesity. The aim of this study was to correlate thyroid nodule size with body mass index (BMI), waist-hip ratio (WHR) and thyroid stimulating hormone (TSH) levels.Methods: A total of 119 patients diagnosed with euthyroidic nodular goiter were included in this...

ea0041ep1062 | Thyroid (non-cancer) | ECE2016

A nonspecific complaint such as diarrhea in elderly with hyperthyroidism: evaluation with a case

Sarac Sefa , Tutuncuoglu Pelın , Savas Sumru , Sarac Fulden

Introduction: Hyperthyroidism in the elderly can present with subtle nonspecific complaints. Patients with long-standing goiter can develop autonomous nodules resulting in toxic nodular goiter.Case report: An 86 year old women was referred from gastroenterologist for thyroid disease because of low TSH. She had diarrhea with five to eight bowel movements a day for six months. She denied palpitations, heat intolerance or muscle weakness. She had been noted...

ea0041ep1063 | Thyroid (non-cancer) | ECE2016

Autoimmune thyroid disease among type 2 diabetic Egyptian female patients

El Ibrashy Ibrahim , El Meligi Amr , Rashed Laila , Fayez Randa , Youssef Elham , Fathy Shaimaa

Background: High prevalence of thyroid disorders is more common in T1 compared to T2 Diabetes Mellitus due to the associated autoimmunity, with hypothyroidism being the most common disorder.Objectives: The aim of this study is to assess the prevalence of autoimmune thyroid dysfunction among T2 diabetic Egyptian females and to find the correlation between the metabolic syndrome components and autoimmune thyroid dysfunction.Methods: ...

ea0041ep1064 | Thyroid (non-cancer) | ECE2016

Autoimmunity as a cause of goiter, obesity and miscarriage in north of Iran, an iodine sufficient area

Bazrafshan Behnaz , Sarmadi Payam , Bazrafshan Hamidreza , Nematollahi Nemat , Stalla Gunter

Introduction: The thyroid gland plays an important role in metabolism of human body. Abnormal growth of this gland is called Goiter. Iodine deficiency was thought to be the main cause of goiter. However, despite years of salt iodization, goiter continues to be a major public health, worldwide. As the thyroid gland is the most common organ affected by autoimmune diseases, it is suggested that autoimmunity can disturb thyroid function and develop to goiter. This study tries to i...

ea0041ep1065 | Thyroid (non-cancer) | ECE2016

Large thyroid cysts

Augustina Gheorghisan-Galateanu Ancuta , Carsote Mara , Tupea Claudiu , Dumitrascu Anda , Valea Ana , Petrova Eugenia , Goldstein Andrei , Ghemigian Adina

Introduction: Thyroid fluid-filled cavities are mostly resulted from degenerating thyroid adenomas but blood vessel anomalies are also described. Despite the typical benign behavior the local anatomical effects may require fine needle aspiration or directly surgery.Materials and methods: This is series of cases presenting intermittent breathing problems leading to the diagnosis of thyroid cysts. Thyroid evaluation included ultrasound, computed tomography...

ea0041ep1066 | Thyroid (non-cancer) | ECE2016

Hypertrophic Hashimoto’s thyroiditis mimicking thyroid lymphoma

Alexandru Niculescu Dan , Iorgulescu Radu , Dumitrascu Anda , Poiana Catalina

Introduction: Hashimoto’s thyroiditis (HT) is a well known risk factor for thyroid lymphoma. A rapidly enlarging goiter accompanied by lymph nodes pressure on surrounding structures usually suggest the development of thyroid lymphoma.Case report: An 85 years old hypertensive women presented for a massive goiter extending from the lower jaw to clavicle which increased in size for the last 5 months. She also complained of dysphagia, hoarseness and sho...

ea0041ep1067 | Thyroid (non-cancer) | ECE2016

The level of awareness on thyroid disorders

Ocak Serin Sibel , Ilhan Muzaffer , Ahci Seda , Okuturlar Yildiz , Koc Guven , Eyupgiller Tulay , Sivritepe Ridvan , Ucak Sema

Objective: To evaluate the level of awareness among patients with thyroid disorders presenting to our hospital and determine patient profiles.Design: The present study was conducted using a survey technique on patients aged between 18 and 75 years, who were admitted to our hospital for follow-up between December 1, 2014 and December 31, 2014. The pregnant women and those with a thyroid malignancy and patients who did not consent for the study were exclud...

ea0041ep1068 | Thyroid (non-cancer) | ECE2016

Glomerular filtration rate in euthyroid Hashimoto’s patients

Coskun Firat Yasemin , Timur Ozge , Sevinc Can , Yildiz Faruk , Kartal Baykan Emine , Aydin Unsal , Emin Budak Mehmet , Gozcu Hakan , Arslan Abdulmuttalip , Sevimli Hakan , Carlioglu Ayse

Thyroid hormones influence renal development, kidney structure, renal hemodynamics, glomerular filtration rate, the function of many transport systems along the nephron and sodium and water homeostasis. Patients with hypothryoidism can have clinically important reductions in glomerular filtration rate (GFR). 41 patients (mean age 31.5±11 years) newly diagnosed as Hashimoto thyroiditis with presence of high thyroid autoantibodies with gland heterogenity in ultrasound and a...

ea0041ep1069 | Thyroid (non-cancer) | ECE2016

The efficacy of Radioiodine Therapy in Patients with Graves’ Disease

Dabrowska Anna , Kijek Jolanta , Tarach Jerzy , Torun-Jurkowska Anna , Chrapko Beata , Kurowska Maria

Introduction: Radioiodine (RAI) has been used for the treatment of Graves’ hyperthyroidism since 1940s. It is relatively safe and considered as one of the definitive therapies. Achievement of hypothyroidism or euthyroidism is defined as a successful therapy.Methods: The study was conducted in 366 patients (80.60% of women) with Graves’ disease (GD), aged 46.76±13.52 years. We analyzed retrospectively hormonal and imaging findings (scintigr...

ea0041ep1070 | Thyroid (non-cancer) | ECE2016

The course of chronic autoimmune thyroiditis in pregnant women during iodine and selenium therapy

Szanto Zsuzsanna , Csiszer Attila , Kun Imre Zoltan , Croitorescu Zsuzsanna

Introduction: In iodine deficient regions maternal iodine supply is indispensable for the normal development of the fetus, but it might aggravate autoimmune thyroid diseases in the mother during pregnancy and postpartum. Selenium might be beneficent in these thyroid diseases by defending against the harmful effect of iodine on maternal thyroiditis.Objective: To study the course of Hashimoto’s thyroiditis in pregnant women, under combined therapy wit...

ea0041ep1071 | Thyroid (non-cancer) | ECE2016

Ectopic Thyroid Tissue: Imagery Findings versus Pathological Report

Gheorghisan-Galateanu Ancuta Augustina , Carsote Mara , Dumitrascu Anda , Valea Ana , Geleriu Andreea , Terzea Dana , Ghemigian Adina

Introduction: Accessory thyroid tissue is a part of thyroid dysgenesis and sometime represents an incidental adult finding displaying a normal function.Material and Methods: This is a case presentation of an adult admitted for an atypical anterior cervical aspect which could not be recognized as accessory thyroid tissue only after surgery. Thyroid evaluation used imagery like ultrasound, computed tomography (CT), assays as TSH (Thyroid Stimulating Hormon...

ea0041ep1072 | Thyroid (non-cancer) | ECE2016

Iodine status and thyroid volume in pregnant women

Dolores Ollero M , Toni Marta , Martinez Juan Pablo , Pineda Jose Javier , Espada Mercedes , Anda Emma

Introduction: Adequate iodine intake is important in pregnant women.Objective: To determinate iodine status and thyroid volumen (TV) in healthy pregnant women from Navarra (Spain), and to evaluate possible influence of diet.Methods: A cross-sectional study of 144 women in the first trimester of pregnancy (single pregnancies) was carried during 2014. We measured thyroid-stimulating hormone (TSH), free thyroxine (fT4) and antithyroid...

ea0041ep1073 | Thyroid (non-cancer) | ECE2016

Efficacy and safety of radioiodine therapy for mild Graves’ ophthalmopathy in dependence on nicotine consumption

Czarnywojtek Agata , Komar-Rychlicka Krzesislawa , Zgorzalewicz-Stachowiak Malgorzata , Wolinski Kosma , Stangierski Adam , Torlinska Barbara , Florek Ewa , Waligorska-Stachura Joanna , Ruchala Marek

Introduction: Graves ‘Orbitopathy (GO), is an autoimmune disease associated with Graves’ thyrotoxicosis (GT). The therapy is largely dependent on the severity and activity of ocular changes. Additionally, the severity of GO is influenced by exogenous factors, such as thyroid dysfunction, cigarette smoking or radioiodine therapy (RIT). The aim of the study was to indicate how radioiodine therapy (RIT) influences on GO in smoking and non-smoking patients.<p class="...

ea0041ep1074 | Thyroid (non-cancer) | ECE2016

What is the cut-off level for commercial kits for antithyroperoxydase antibody

Carsote Mara , Ratcu Mihaela , Gharibafshar Payman , Paduraru Denis , Staicu Dana Cristina , Peretianu Dan

Aim: The biological diagnostic of Hashimoto thyroiditis (HT) is based on higher than normal levels of antithyroperoxydase antibodies (ATPO). Our goal was to establish the cut-off limit of normality (the upper limit) for ATPO in our thyroid normal patients. This limit and not that of the laboratory, should be used as diagnosis of Hashimoto thyroiditis.Material and method: 1. ATPO was investigated in patients with normal level of thyroid hormones (euthyroi...

ea0041ep1075 | Thyroid (non-cancer) | ECE2016

Toxic adenoma as a cause of dementia

Dyrmishi Blertina , Olldashi Taulant , Ranxha Eris , Fureraj Thanas , Ylli Agron , Puca Entela

Background: Psychiatric symptoms have been reported quite frequently in thyroid disease. Dementia associated with hyperthyroidism is less well documented.The case: We present the case of a 62 years old woman, who initially presented for a neurological consultation about her symptoms suggested Alzheimer’s disease. The patient had been under treatment for more than seven years for type 2 diabetes and developed frequently episodes of hypoglycemia. She ...

ea0041ep1076 | Thyroid (non-cancer) | ECE2016

Secondary hypothyroidism and the tarsal tunnel syndrome

Dyrmishi Blertina , Olldashi Taulant , Borici Neritan , Fureraj Thanas , Ylli Agron

Clinical Case: We referred one case with primary hypothyroidism and tarsal tunnel syndrome. The boy 11 6/12 years old was presents in our clinic with fatigue, obesity, difficulty during walking, low performance in school, hyposthenia and dementia. His weight was 48 kg +3.8 DS; height 153 cm +2 DS; the patient has bilateral symptoms of the tarsal tunnel syndrome and his foot symptom was aggravated by walking. The hormonal values were: TSH 2.3 mUI/ml (0.35–4.04); FT4 0.54 n...

ea0041ep1077 | Thyroid (non-cancer) | ECE2016

Assessment of thyroid function during the three trimesters of pregnancy in alexandria region (Egypt)

Amara F E , Megalaa M H , Oraif Y I , Moawad M G , Korani M A , Amara M F , El-Sheikh S

Introduction: Pregnancy is associated with significant reversible changes in thyroid functions due to certain hormonal changes e.g. HCG and estrogen.Objective: To study thyroid functions in different trimesters of pregnancy compared to control age matched non pregnant women.Design and Methods: Cross sectional study of 90 pregnant women divided into three groups in the three trimesters of pregnancy compared to 30 ages matched non-pr...

ea0041ep1078 | Thyroid (non-cancer) | ECE2016

Relationship to TSH, and interleukin levels patients with Hashimoto’s Thyroiditis

Guleryuz Bedia , Akin Fulya , Topsakal Senay , Yaylalı Guzin Fidan , Turgut Sebahat , Ata Melek Tunc , Dalyanoglu Mukaddes Mergen

Background: Hashimoto’s Thyroiditis (HT) is the most common clinical expression of thyroid dysfunction and result from organ-specific autoimmune reaction. Cytokines are play an important role in autoimmunity, by stimulating B and T cells.The aim of this study is to examine the relationship between cytokines and thyroid function tests in patient with Hashimoto’s ThyroiditisMethods: 139 cases with HT included this study. Su...

ea0041ep1079 | Thyroid (non-cancer) | ECE2016

Evaluation of ovarian reserve in terms of ovarian volume, antral follicule count and hormonal tests in Hashimoto’s thyroiditis

Mete Turkan , Ozbalci Aysu Basak , Kan Elif Kilic , Duman Gulhan , Yavuz Halise Cinar , Kucuk Gultekin Ozan , Ozer Ismail , Kurt Hacer Pinar Ozturk , Atmaca Aysegul

Introduction: Our aim is to investigate whether ovarian reserve is decreased in patients with euthyroid Hashimoto’s thyroiditis (HT).Method: Our study included 110 euthyroid HT patients and 72 age matched healthy women (controls; C). In all patients FSH, LH E2, and P levels were measured from blood samples, and ovarian volumes (OV) and antral follicule count (AFC) were measured using ultrasonography at 3rd day of menstruation....

ea0041ep1080 | Thyroid (non-cancer) | ECE2016

Thyroid screening in pregnancy –preliminary data from our outpatient clinic

Palenikova Patricia , Kollerova Jana , Bednarova Adriana , Kuzma Martin , Payer Juraj

Introduction: The adverse impact of overt hypothyroidism that complicates pregnancy outcomes is well-established. In order to eliminate these complications has long been discussion about the need for early detection of the disease of the thyroid gland in the population of women planning pregnancy, respectively in early pregnancy. In Slovakia, this effort resulted in the approval of screening for thyroid diseases in pregnancy and has been enshrined in a legislative in 2009. Obl...

ea0041ep1081 | Thyroid (non-cancer) | ECE2016

The efficacy of radioiodine therapy in patients with hyperfunctioning thyroid nodules

Dabrowska Anna , Kijek Jolanta , Tarach Jerzy , Torun-Jurkowska Anna , Chrapko Beata , Kurowska Maria

Introduction: Radioiodine (RAI) is used as a definitive therapy of hyperthyroidism due to toxic adenoma (TA) as well as toxic multinodular goiter (TMG). Achievement of hypothyroidism or euthyroidism is defined as a successful therapy.Methods: The study was conducted in 666 patients – 484 with TA and 182 with TMG (85.58% of women), aged 56.19±13.88 years. We analyzed retrospectively hormonal and imaging findings (scintigraphy, ultrasonography), ...

ea0041ep1082 | Thyroid (non-cancer) | ECE2016

Clinical and epidemiological profile of patients with hyperthyroidism and hypothyroidism that receive endocrinological services from a medical institution in Medellín (Colombia) between 2013 and 2015

Velasquez Paula , Osorio Felipe , Ramirez Sergio , Jaramillo Laura , Molina Juliana , de los Angeles Rodriguez Maria , Martinez Lina

Introduction: Endocrine Illnesses have high prevalence on a global level due to multiple etiologies that can lead alterations to this system.Objective: Determine the epidemiological profile of hyperthyroid and hypothyroid patients that receive endocrinological services from a medical institution in Medellin (Colombia) between 2013 and 2015.Methodology: A descriptive, retrospective study was conducted and included the clinical recor...

ea0041ep1083 | Thyroid (non-cancer) | ECE2016

The beneficial effect of L-thyroxine on lipid parameters in mild form of subclinical hypothyroidism

Nakova Valentina Velkoska , Krstevska Brankica , Pemovska Gordana , Milenkovikj Tatjana , Vaskova Olivija

Introduction: Overt hypothyroidism and severe subclinical hypothyroidism (ScH) are associated with dyslipidaemia, and its condition is reversible after thyroid replacement therapy. We investigated the effect of levothyroxine therapy on lipid parameters in patients with mild form of subclinical hypothyroidism (ScH).Material and methods: Fifty-seven patients with newly diagnosed ScH with TSH levels below 10 mU/l and 30 age and sex-matched healthy subjects ...

ea0041ep1084 | Thyroid (non-cancer) | ECE2016

Princess and the Pea

Srbova Libuse

Introduction: Subacute (de Quervainś) thyroiditis is an uncommon altough not a rare condition. Pain in the thyroid and ill-defined hypoechogenic thyroid lesions in ultrasonography are typicall findings, occasionaly are increased thyroid hormones levels. Often preceded by upper respiratory tract infection. The disease is self-limited and often resolves spontaneously, usually without subsequent thyroid function abnormalities, or it may improve with anti-inflammatory drugs a...

ea0041ep1085 | Thyroid (non-cancer) | ECE2016

Delayed diagnosis of small bowel adenocarcinoma due to thyroiditis induced thyrotoxicosis in a healthy young adult

Park Tae Sun , Lee Kyung Ae , Kim Yu Ji , Baek Hong Sun

Objectives: Various systemic symptoms may occur in patients with thyrotoxicosis. Gastrointestinal manifestations such as hyperphagia or frequent defecation, often coexist with other thyrotoxic symptoms. Vomiting also has been mentioned.In this setting, systemic symptoms of underlying malignancy may be confused with those of thyrotoxicosis leading to a delay in diagnosis.Methods: We report a case with delayed diagnosis of small bowe...