Endocrine Abstracts

Introduction: Type 2 diabetes, obesity and fatty liver disase are the most common comorbidities at the orgin of metabolic syndrome. Treatment of these conditions overlaps significantly. The most recent innovation in the armamentarium of pharmacotherapy of type 2 diabetes is Glp 1 agonist, More recent research on the effect of GLP-1 receptor agonist on weight loss, metabolic parameters and fatty liver disease are promising. The weight reduction offered by GLP-1 agonist treatmen...

Introduction: In 2013 Trouillas et al. reported a new prognostic clinicopathological classification of pituitary adenomas. This classification analyses the impact of the intensity of proliferation and invasiveness of the tumor on patients’ prognosis. The aim of the study was to review this new classification in giant pituitary adenomas (GPAs) treated with endoscopic transsphenoidal approach.Material and methods: The study is a retrospective...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females of reproductive age. It is frequently associated with metabolic disturbances and insulin resistance, that occurs in about 50–70%. Evidences were reported about the association between vitamin D and osteocalcin with cardiovascular risk factors, regulation of insulin secretion and sensitivity.Objectives: Evaluation of the association between of low 25-hydroxyvitamin...

Background: X-linked adrenoleukodystrophy (X-ALD) is a hereditary disease that occurs in boys in childhood and adolescence, with cases being rarer in adulthood. Primary adrenal insufficiency (PSI) is present in more than 50% of patients and in 10% it is the only manifestationCase report: 24-year-old male, diagnosed with primary adrenal insufficiency as a child. The pathological history included dyslipidemia, obesity, prediabetes and parietospastic gait a...

Does Iodide Modulate The Biological Outcome of Activating Thyrotropin Receptor Mutations?Dr. F. Al-Khafaji and Dr. M. LudgateHyperthyroidism is caused by pathogenic activation of the thyrotropin receptor (TSHR) either by the thyroid stimulating antibodies of Graves' disease (GD) or activating TSHR mutations. These produce nodular goitre or familial hyperthyroidism. The pathogenic mechanism predominating varies according to the iodide intake, with nodular goitre account...

IntroductionOvulation involves rupture of the ovarian surface, and thus the ovarian surface epithelium (OSE) is subjected to serial injury and repair with each ovulatory cycle. Inflammation is integral to the process of ovulation, but importantly, inflammatory damage is also thought to be a potential mechanism of ovarian tumour development. We have examined OSE responses to an inflammatory stimulus associated with ovulation, Interleukin-1alpha (IL1alpha)...

Introduction: Hirsutism is a frequent reason for consultation, it is defined by the presence of terminal hair with male distribution in women, it is however essential to determine the cause, since it can reveal a serious underlying pathology and as it may be due to a benign cause see idiopathic in some cases. Idiopathic hirsutism is second in line to polycystic ovary syndrome in the etiological search for hirsutism. The objective of this study is to describe the clinical and p...

Introduction: Turner syndrome is one of the most common chromosomal abnormalities, with a reported prevalence of one in every 2.500 live-born girls. The phenotype includes short stature, primary ovarian failure, and other characteristics resulting from the consequences of fetal lymphedema and skeletal abnormalities. Turner syndrome can be associated with multiple defects: cardiovascular, renal, auditory, and skeletal. The aim of our study was to detect the prevalence of cardia...

Introduction: Hirsutism is a condition featuring an excessive growth of terminal hair at the woman’s androgen-dependent areas, which develops in a distribution model similar to that of men. It is one of the most common disorders in women during reproductive age. It affects up to 1 in 7 women. The objective of this work was to study the clinical and etiological aspects of hirsutism.Material and Methods: This is a retrospective descriptive study invo...

Introduction: Turner Syndrome is a genetic disorder linked to the total or partial absence of an X chromosome. The clinical presentation is heterogeneous, associating a small stature with a dysmorphic syndrome that varies from one person to another.The aim of this study was to determine the prevalence of autoimmune diseases in our Turnerian patients.Material and method: This is a retrospective descriptive study collecting 15 cases ...