Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Poster Presentations

Calcium and Vitamin D metabolism

ea0032p111 | Calcium and Vitamin D metabolism | ECE2013

The relationship between low maternal serum 25-hydroxyvitamin D level and gestational diabetes mellitus according to the severity of 25-hydroxyvitamin D deficiency

Zuhur Sayid Shafi , Erol Rumeysa Selvinaz , Kuzu Idris , Altuntas Yuksel

Introduction: The results of publications investigating the relationship between low maternal serum 25-hydroxyvitamin D (25OHD) level and gestational diabetes mellitus (GDM) are controversial and none of these publications have investigated this relationship according to the severity of 25OHD deficiency. Therefore, this study was conducted to assess the relationship between low maternal serum 25OHD and GDM according to the severity of 25OHD deficiency.Me...

ea0032p112 | Calcium and Vitamin D metabolism | ECE2013

Effects of vitamin D fortified bread on muscle strength

Mocanu Veronica , Costan Anca Roxana , Vulpoi Carmen

Background: Vitamin D deficiency is common in elderly nursing home residents. It has been associated with low bone mineral density, muscle weakness, increased body sway and falls. Evidence indicates that supplementation of vitamin D in these individuals helps to improve locomotor function and general health.Patients and methods: We evaluated, in a 12 months interval, the effects of vitamin D supplementation on grip strength in 45 nursing home residents (...

ea0032p113 | Calcium and Vitamin D metabolism | ECE2013

Evaluation of two routinely used 25OHD assays and serum variables in patients on dialyses

Locsei Zoltan , Kovacs Laszlo , Balogh Dora , Szijarto Adrienn , Kalman Bernadette , Kovacs Gabor L , Toldy Erzsebet

The total 25-hydoxy-vitamin-D (t25OHD) level can be assessed by various methods and reflects vitamin D intake. Results are influenced by the serum variables affected by dialyses.Aims: To examine t25OHD and bioavailable vitamin D (b25OHD) by two methods in patients on peritoneal-(PD) and hemodialysis (HD).Methods: We studied 37 HD (64±15 years) and 36 PD (63±18 years) patients. The t25OHD was assessed by chemiluminescence ...

ea0032p114 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D supply in healthy women with different reproductive stages: is there any relationship with DBP levels?

Toldy Erzsebet , Locsei Zoltan , Horvath Dora Eszter , Koppany Csaba , Kovacs Klaudia , Tancsics Emanuela , Kalman Bernadette , Racz Karoly

The total 25-hydoxy-vitamin-D (t-25OHD) level reflects the supply of vitamin D, but is also influenced by the levels of 25OHD binding proteins (DBP). We aimed studying t-25OHD and bioavailable 25OHD (bio-25OHD) levels in healthy females with different reproductive ages.Methods: t-25OHD, bio-intact parathormone (PTHi-1–84) (ECLIA, cobas e411, Roche), DBP (turbidimetry, Dako), calcium and albumin (Alb) levels were measured by routine methods (Modular,...

ea0032p115 | Calcium and Vitamin D metabolism | ECE2013

Cinacalcet in patients with primary hyperparathyroidism (PHPT): comparison between sporadic and MEN1 PHPT

Prete Michela Del , Marotta Vincenzo , Ramundo Valeria , Marciello Francesca , Carratu Anna Chiara , di Roseto Chiara De Luca , Esposito Raffaella , Di Sarno Antonella , Colao Annamaria , Faggiano Antongiulio

Introduction: PHPT is a common endocrine disease characterized by hypercalcemia and different degree of osteoporosis and nephrolithiasis. PHPT arises in the context of an inherited disease in 5% of cases. Multiple endocrine neoplasia type 1 (MEN1) is the commonest cause of inherited PHPT. The main therapeutic approach for PHPT is surgery, however many patients refuse or have contraindications for surgery while others, in particular those with MEN1 PHPT, have persistent/relapsi...

ea0032p116 | Calcium and Vitamin D metabolism | ECE2013

Efficacy of vitamin D on COPD exacerbation: a double blind randomized placebo-controlled clinical trial

Sanjari Mojgan , Soltani Akbar , Khorasani Abdolrahim Habibi , Shokoohi Mostafa , Zareinejad Maryam

Background: Exacerbations are an important feature and outcome measure in chronic obstructive pulmonary disease (COPD). The objective of this study was to investigate the effect of supplementation of standard treatment (inhaled long-acting β2 agonists, anticholinergics and corticosteroids) with vitamin D on pulmonary function tests in patients with COPD exacerbation.Methods: Patients referred to hospital were divided into three groups receiving 0.25...

ea0032p117 | Calcium and Vitamin D metabolism | ECE2013

Lower CD4 lymphocyte counts in HIV/HCV co-infected patients with liver fibrosis on long term HAART and low vitamin D level

Cayon Manuel , Garcia-Figueras Carolina , Bancalero Patricia , Terron Alberto

Introduction: Vitamin D insufficiency (D-INSUFF) has been associated with impaired immune response in human inmunodeficiency virus (HIV) patients and a worse prognosis in patients with liver fibrosis. Nevertheless, few studies have explored the influence of D-INSUFF in immunological response and liver parameters in HIV and hepatitis C virus co-infected patients (HIV/HCV) on long term highly active antiretroviral therapy (HAART) with successful immune and virological response. ...

ea0032p118 | Calcium and Vitamin D metabolism | ECE2013

Replenishment of reduced vitamin D levels: how much vitamin D is necessary?

Jungmann Eckart , Jungmann Gisela

Reduced vitamin D levels are a prevalent clinical finding that is clearly associated with increased morbidity and mortality. There is considerable controversy, however, as to how much vitamin D is required for the effective vitamin D replenishment in patients with reduced vitamin D levels.Therefore, we decided to evaluate the effectiveness of 1000 to 3000 U qd of vitamin D and of vitamin D receptor agonists (VDRA) in 161 patients with vitamin D levels &#...

ea0032p119 | Calcium and Vitamin D metabolism | ECE2013

Changes in anxiety and depression symptoms in patients with chronic fatigue syndrome treated with vitamin D

Plescheva Anastasia , Pigarova Ekaterina , Dzeranova Larisa

Introduction: Vitamin D is involved not only in the regulation of calcium–phosphorus metabolism; it also plays an important role in maintaining the immune system, muscle strength and neuromuscular conduction. Lack of vitamin D is assumed as one of the mechanisms of autoimmune and infectious diseases. Chronic fatigue syndrome (CFS) – is a syndrome manifesting with a severe chronic physical, mental weakness, psychological disturbances such as anxiety and depression, th...

ea0032p120 | Calcium and Vitamin D metabolism | ECE2013

The effects of vitamin D therapy on thyroid functions, thyroid autoantibodies, TNF-α, IL6 and IL1b in patients with autoimmune thyroiditis

Acibucu Fettah , Dokmetas Hatice Sebila , Kilicli Fatih , Celik Cem , Aydemir Mustafa

Vitamin D has immunomodulatory features and its deficiency is associated with the development of autoimmune diseases. The relation between vitamin D deficiency and autoimmune thyroiditis has not been investigated much. In the present study, our aim was to study the relation between vitamin D therapy and autoimmune thyroiditis.Fifty-four patients having newly diagnosed Hashimoto thyroiditis (HT) and vitamin D deficiency but requiring no thyroid hormone re...

ea0032p121 | Calcium and Vitamin D metabolism | ECE2013

Genetic analysis of AIP genes in familial primary hyperparathyroidism

Saponaro Federica , Borsari Simona , Pardi Elena , Banti Chiara , Vignali Edda , Meola Antonella , Picone Antonella , Mastinu Marco , Mariotti Stefano , Marcocci Claudio , Cetani Filomena

Primary hyperparathyroidism (PHPT) is usually a sporadic disorder, but in <10% of cases occurs as part of hereditary syndromes, including multiple endocrine neoplasia types 1 and 2A (MEN1 and MEN2A), hyperparathyroidism–jaw tumor syndrome (HPT–JT) and familial isolated hyperparathyroidism (FIHP).MEN1 is an autosomal dominant disorder characterized by tumours in multiple endocrine glands, most commonly parathyroid, enteropancreatic and anter...

ea0032p122 | Calcium and Vitamin D metabolism | ECE2013

A986S or the R990G polymorphism in CASR does not explain hypercalciuria and low normal serum calcium

Rasmussen Anne Qvist , Jorgensen Niklas Rye , Tfelt-Hansen Jacob , Bevilacqua Maurizio , Schwarz Peter

The calcium receptor (CASR) serves as one of the main regulators of the calcium homeostasis. CASR is expressed in among other tissues parathyroid chief cells and kidney tubule cells. It has been hypothesized that CASR gene variations are responsible for low circulating calcium levels together with hypercalciuria and thereby increased risk of kidney stones. The CASR gene polymorphism A986S has been shown associated to elevated serum calcium levels in vivo<...

ea0032p123 | Calcium and Vitamin D metabolism | ECE2013

Early measure of postoperative iPTH and corrected calcium as predictors of future hypoparathyroidism: which, when and why?

Paja Miguel , Moreno Cristina , Ugarte Estibaliz , Oleaga Amelia , Gutierrez Ma Teresa , Izuzquiza Ana J , Etxeberria Eider , Iglesias Natalia C , Lizarraga Aitzol , Martinez-Mate Maria P

Introduction: Intraoperative parathyroid hormone assay (ioPTH) has been validated as a useful tool for predicting postoperative hypocalcaemia (hypoCa) after thyroid surgery and has been proposed as a guide to early discharge from hospital. Its value to predict the risk of future hypoparathyroidism (hypoPT) has not been analyzed in detail. We evaluate this role in our recent surgical series.Description of methods/design: Patients with total thyroidectomy ...

ea0032p124 | Calcium and Vitamin D metabolism | ECE2013

Serum sclerostin and Dkk1 in patients with parathyroid disorders

Viccica Giuseppe , Borsari Simona , Pardi Elena , Chiavistelli Silvia , Albertini Sonia , Centoni Roberta , Cetani Filomena , Marcocci Claudio

The ‘canonical’ Wnt/β-catenin pathway plays an important role in the development and patterning of bone. Dkk1 (Dickkopf1) and sclerostin are competitive soluble inhibitors of this pathway. Serum sclerostin is decreased in patients with primary hyperparathyroidism (PHPT) compared to the healthy subjects and hypoparathyroid (HypoPT) patients. No data are currently available on Dkk1 serum level in PHPT.We evaluated serum Dkk1 and sclerostin l...

ea0032p125 | Calcium and Vitamin D metabolism | ECE2013

An observational study reveals that neonatal vitamin D is primarily determined by maternal contributions: implications of a new assay on the roles of vitamin D forms

Karras Spyridon , Shah Iltaf , Petroczi Andrea , Goulis Dimitrios , Bili Helen , Papadopoulou Fotini , Anagnostis Panagiotis , Persinaki Aggeliki , Tarlatzis Basil , Naughton Declan

Introduction: Vitamin D concentrations during pregnancy are measured to diagnose states of insufficiency or deficiency. The aim of this study is to apply accurate assays of vitamin D forms (single hydroxylated (25(OH)D2, 25(OH)D3), double-hydroxylated (1α,25(OH)2D2, 1α,25(OH)2D3), epimers (3-epi-25(OH)D2, 3-epi-25(OH)D3)) in mothers (serum) and neonates (umbilical cord) i) to expl...

ea0032p126 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D and sarcopenia in HIV-infected patients

de Villar Noemi Gonzelez Perez , Perez Vicente Estrada , de Rivera Jose M Pena Sanchez , Gaviria Antonio Zapatero , Vicente Rosa Villar , Molina Gloria Canovas , Minchot Emilia Cancer , Robles Azucena Rodriguez , Larrad M Teresa Martinez , Rios Manuel Serrano

Introduction: Sarcopenia, an age-associated loss of skeletal muscle mass and function, has been related to higher mortality in general population as well as in HIV-infected patients. In elderly, sarcopenia is a marker of frailty. The aim of our study was to describe the prevalence of sarcopenia and related factors in HIV-infected population.Methods: Skeletal muscle mass (SMM), total fat mass and body fat distribution were measured by DXA scan. Muscle mas...

ea0032p127 | Calcium and Vitamin D metabolism | ECE2013

Lithium-associated hyperparathyroidism: a case report

Marcelino Mafalda , Silva Joao , Lopes Luis , Salgado Lucilia , Lopes Carlos , de Castro Joao Jacome

Introduction: Lithium therapy is commonly used in bipolar disorder treatment. Alongside the increasing prevalence of goiter and hypothyroidism, the sustaining use of lithium therapy is associated with several metabolic disorders, such as hypercalcemia and hyperparathyroidism (HPT).Case report: A 64-year-old woman with history of bipolar disorder treated with lithium for several years was referred to our department for evaluation of recurrent hypercalcemi...

ea0032p128 | Calcium and Vitamin D metabolism | ECE2013

Late-onset hypoparathyroidism 15 years after thyroidectomy

Nunes Joana Menezes , Rodrigues Elisabete , Carvalho Davide

Introduction: Post-surgical hypoparathyroidism is a well known complication of total thyroidectomy. It may occur as transitory hypoparathyroidism that spontaneously recover within a few weeks/months and as permanent hypoparathyroidism needing long-term treatment. Only few cases of hypoparathyroidism newly diagnosed many years after surgery have been reported. We present a patient with hypoparathyroidism that became clinically evident 15 years after the thyroid surgery.<p c...

ea0032p129 | Calcium and Vitamin D metabolism | ECE2013

Does recognition of vitamin D deficiency affect the indication for surgical treatment in asymptomatic primary hyperparathyroidism?

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Cassibba Sara , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: Current guidelines for the management of asymptomatic primary hyperparathyroidism (A-pHPT) recommend that 25-hydroxyvitamin D levels should be assessed in all patients and vitamin D deficiency (VDD) should be cautiously corrected. It is unknown whether VDD affects the probability to meet surgical criteria currently proposed for A-pHPT. Aim of study was to evaluate whether VDD recognition affects the probability to meet surgical criteria in A-pHPT patients.<p ...

ea0032p130 | Calcium and Vitamin D metabolism | ECE2013

Fahr’s disease with dystonia: a case report

Aydogan Berna Imge , Unluturk Ugur , Can Ferda , Sahin Mustafa , Uysal Ali Riza

Background: Fahr’s disease is a rare degenerative disorder characterized by symmetrical and bilateral intracranial calcification. Movement disorders are the most common symptoms of Fahr’s disease and dystonia is an uncommon presentation which accounts for only 8% of symptomatic patients.Case report: A 47 years old female admitted to emergency department with involuntary movements of extremities and anxiety. Neurological examination was normal e...

ea0032p131 | Calcium and Vitamin D metabolism | ECE2013

Predictive factors of postoperative hypoparathyroidism after total thyroidectomy

Paja Miguel , Etxeberria Eider , Calles Laura , Exposito Amaia , Ugarte Estibaliz , Moreno Cristina , Lizarraga Aitzol , Espiga Javier , Oleaga Amelia

Introduction: Hypoparathyroidism (hypoPT) is the most frequent complication after thyroid surgery, usually as transient hypocalcaemia. Permanent parathyroid lesion is less frequent, but it can extend hospital stay and complicate postoperative management. Several preoperative factors predicting the development of hypoPT have been identified, including advanced age, hyperthyroidism, surgical experience and others. We evaluate the role of some potentially predictive factors in ou...

ea0032p132 | Calcium and Vitamin D metabolism | ECE2013

Normocalcemic primary hyperparathyroidism: an Italian epidemiologic study

Vignali Edda , Meola Antonella , Centoni Roberta , Maria Gibilaro Rosa , Daniello Giuseppe , Cetani Filomena , Chiavistelli Silvia , Saponaro Federica , Marcocci Claudio

Primary hyperparathyroidism (PHPT) is defined by hypercalcemia and high PTH levels. In recent years a variant of PHPT has been described, namely normocalcemic PHPT (NPHPT), which is characterized by normal serum calcium and high PTH levels, in the absence of other causes of secondary hyperparathyroidism. The epidemiology of NPHPT is poorly understood. We performed a survey in the early fall in a small Southern Italian village, in which all adult residents (n=1811) wer...

ea0032p133 | Calcium and Vitamin D metabolism | ECE2013

Plasma lipid levels in relation to the status of vitamin D sufficiency

Gonzalez-Molero Inmaculada , Rojo Gemma , Dominguez Marta , Morcillo Sonsoles , Rubio Eleazara , Gutierrez CArolina , de Adana MArisol Ruis , Almaraz Maria Cruz , Soriguer Federico

Introduction: Several studies have investigated a possible action of vitamin D metabolites on different lipid fractions but the possible mechanism by which they could act remain unknown, with varying results in observational and intervention studies.Objective: To study the relation between vitamin D levels and lipids levels.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects w...

ea0032p134 | Calcium and Vitamin D metabolism | ECE2013

Primary hyperparathyroidism and vitamin D deficiency. therapeutic implications

Kostoglou-Athanassiou Ifigenia , Athanassiou Panagiotis , Gkountouvas Anastasios , Xanthakou Eleni , Keramidas Ioannis , Chatjimarkou Fotini , Kaldrymidis Philippos

Primary hyperparathyroidism is a rather frequent disorder characterized by high plasma PTH and calcium. Vitamin D deficiency is prevalent in all areas of the world. Vitamin D deficiency has been described in patients with primary hyperparathyroidism. When present, vitamin D deficiency may be associated with large size parathyroid adenomas and musculoskeletal pain.The aim was to describe two cases of primary hyperparathyroidism and vitamin D deficiency.</...

ea0032p135 | Calcium and Vitamin D metabolism | ECE2013

Prevalence and correlates of vitamin D deficiency in Turkish adults

Satman Ilhan , Ozbey Nese , Boztepe Harika , Kalaca Sibel , Omer Beyhan , Tanakol Refik , Tutuncu Yildiz , Genc Sema , Alagol Faruk

Enormous evidence suggests that vitamin D deficiency could be linked to several chronic diseases, including cardiovascular disease, diabetes, obesity, depression and cancer. The purpose of this study was to examine the prevalence of vitamin D deficiency and its correlates to test the hypothesis that vitamin D deficiency was common among adult Turkish population, particularly in women. The Turkish Diabetes, Hypertension, Obesity and Endocrine Disease Survey (TURDEP-II) Jan to J...

ea0032p136 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficiency in urban adult population of south-eastern Poland

Trofimiuk-Muldner Malgorzata , Kiec-Klimczak Malgorzata , Hubalewska-Dydejczyk Alicja

Vitamin D deficiency has been recognized as a common public health issue in many countries, however its prevalence and impact on calcium metabolism parameters has not been extensively studied in Poland yet.The aim of the study was to assess the vitamin D status in sample of Polish urban population.Material and methods: Study included 273 healthy volunteers (76 males, 197 females, median age 58 years) living in city Krakow in south-...

ea0032p137 | Calcium and Vitamin D metabolism | ECE2013

The effects of lactose intolerance and lactose intolerance associated diseases on serum vitamin D levels, bone metabolism markers, bone mineral density and bone fractures

Csupor Emoke , Acs Bence , Acs Orsolya , Ferencz Viktoria , Meszaros Szilvia , Toth Edit , Farkas Gabor , Horvath Csaba

Introduction: Lactose intolerance itself is linked with lower peak bone mass (PBM) and with decreased bone mineral density (BMD) which may decrease further with lactose intolerance associated comorbidities. The aim of our study was to examine how bone metabolic parameters are affected (change of bone metabolism markers, BMD and frequency of fractures) in lactose intolerance which was accompanied by previously diagnosed hyperlipidemia or by hypothyroidism.<p class="abstext"...

ea0032p138 | Calcium and Vitamin D metabolism | ECE2013

Normocalcemic hyperparathyroidism

Kesraoui Mourad , Azzoug Said , Lounis Lydia , Aissa Nassima Belhadj , Chentli Farida

Introduction: In the whole world normocalcemic hyperparathyroidism (NC HPT) is an emerging entity and a growing problem. This disease is characterized by high levels of intact parathyroid hormone with normal total or ionized serum calcium. Our aim is to analyze its clinical and biological profile and its etiologies.Subjects and methods: We have studied 18 subjects with NC HPT. They all had routine analyses, plasma calcium and phosphorous, and assessment ...

ea0032p139 | Calcium and Vitamin D metabolism | ECE2013

Familiar hypocalciuric hypercalcemia a rare cause of hypercalcemia

Belo Sandra , Magalhaes Angela , Capela Joao , Carvalho Davide

Introduction: Familial hypocalciuric hypercalcemia (FHH) is caused by inactivating autosomal dominant mutations with high penetrance of CaSP gene. Contrary to severe neonatal hyperparathyroidism, caused by homozygous inactivation of the gene, familial hypocalciuric hypercalcemia is usually associated with inactivating variants in heterozygoty.Case: Male patient, 73 years, with history of Behçet’s disease and pulmonary sarcoidosis, was refered f...

ea0032p140 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficiency in lithuanian school graduates females

Zabuliene Lina , Urboniene Jurgita , Skendelyte Gitana , Barakauskas Svajunas

Background: There are evidences that young adults are at risk for poor vitamin D nutritional status. The objective of this study was to investigate the level of vitamin D in school graduates females and the factors associated with vitamin D status.Material and methods: School graduates females from three Lithuanian cities were enrolled into the project from March to June of 2012. General health, nutrition, physical activity status was assessed by questio...

ea0032p141 | Calcium and Vitamin D metabolism | ECE2013

Does vitamin D status predict handgrip strength in young adult women?

Sahin Ibrahim , Sezgin Salih , Keskin Lezzan , Taskapan Cagatay , Yavuz Dilek , Felek Selma Aydin , Karaca Zuhal , Taskapan Hulya

Introduction: Increasing evidence suggesting an integral role of vitamin D in skeletal muscle function. The relationship between muscle strength and vitamin D status has been investigated to some degree in older populations, however there has been very little research in younger adult women. This study aims to measure the effects of vitamin D on handgrip strength in young adult women.Method: A total of 141 healthy women with mean age of 33.8±6.8 wer...

ea0032p142 | Calcium and Vitamin D metabolism | ECE2013

Influence of preoperative characteristics in the result of Tc99m-sestaMIBI scan in patients with primary hyperparathyroidism

Egana Nerea , Lizarraga Aitzol , Paja Miguel , Elorza Ramon

Primary hyperparathyroidism (PHP) is a common endocrine disorder. It is due to a single parathyroid adenoma in 80% of cases, most of the remainder due to hyperplasia of all four parathyroid glands. The only curative procedure is parathyroidectomy, but preoperative localization can be difficult. Isotope scanning with sestaMIBI is considered to be useful in localizing any parathyroid adenoma to help guided surgery. The aim of this study is demonstrated the influence of biochemic...

ea0032p143 | Calcium and Vitamin D metabolism | ECE2013

Cystic parathyroid adenomas: ultrasonography features

Karbek Basak , Karakose Melia , Caliskan Mustafa , Bozkurt Nujen Colak , Aslan Muyesser Sayki , Delibasi Tuncay

Introduction: Parathyroid adenomas appear typically as homogeneous, hypoechoic lesions compared to the thyroid on the ultrasonography examination. They can be detected easily when they are more than 1 cm. However, cystic parathyroid adenomas are rare. When present, they appear as decreased echogenic areas in the gland. Extrathyroidal feeding from an artery at one pole of the gland is characteristic which is seen on Doppler imaging. We aimed to present a case series including s...

ea0032p144 | Calcium and Vitamin D metabolism | ECE2013

Primary hypoparathyroidism and autoimmune endocrine disorders

Martins Ana , Martins Joao Martin , Vale Sonia , Gomes Ana , Miltenberger-Miltenyi Gabriel , Carmo Isabel

Introduction: Primary hypoparathyroidism (PH) is a rare condition. After surgery and chronic alcoholism, an autoimmune disease is the most common etiology and must specifically be considered in the context of a patient with other autoimmune endocrine diseases.Case report: MASD a male caucasian patient aged 31, was admitted to the emergency department because of perioral and hand paresthesias, and carpal spasm, in the context of a generalized anxiety reac...

ea0032p145 | Calcium and Vitamin D metabolism | ECE2013

Experience in the treatment of primary hyperparathyroidism with cinacalcet: data after 12 months of treatment

Luque-Fernandez Ines , Garcia-Martin Antonia , Luque-Pazos Alessandra , Sastre-Marcos Julia , Vicente-Delgado Almudena , Marco-Martinez Amparo , Canovas Barbara

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 20 patients with primary hyperparathyroidism who had complete at least 12 months of treatment with cinacalcet for different reasons (eight patients r...

ea0032p146 | Calcium and Vitamin D metabolism | ECE2013

Primary hyperparathyroidism in people under 30

Saida Fedala , Farida Chentli

Introduction: Primary hyperparathyroidism (HPT) is usually observed in old people. It is very rare in children and young adults. Our aim is to analyze clinical, biological aspects, and outcome in six subjects under 30.Methods: The six subjects were chosen among 36 people hospitalized for primary HPT from 2009 to 2012. All had clinical examination, routine analyses, biological (blood and urinary calcium and phosphorus, and vitamin D) and hormonal (at leas...

ea0032p147 | Calcium and Vitamin D metabolism | ECE2013

An extensive precipitation of calcium in subcutaneous tissue in patient with juvenile dermatomyositis

Boskovic Olivera , Borozan Sanja , Vujosevic Snezana , Kavaric Sreten , Djogo Aleksandar , Kazic Koviljka , Medenica Sanja

Introduction: Juvenile dermatomyositis may be associated with advanced calcinosis but the mechanism that leads to their development remains unclear.Case report: A female patient admitted to the hospital at the age of 17 for skin rash, malaise and pain in peripheral joints and muscles. Congenital bilateral hip dysplasia. After evaluation a syndrome overlap with dominant atypical dermatomyositis and SLE was suspected and treatment with prednisolone and cho...

ea0032p148 | Calcium and Vitamin D metabolism | ECE2013

Measurement of 25-hydroxyvitamin D: evaluation of the new DIAsource ELISA assay

Huvelle Sophie , Lepoutre Thibault , Heureux Nicolas , Gruson Damien

Background: Vitamin D is an important contributor to musculoskeletal health and its potential involvement has recently been underlined in several non-skeletal diseases. Measurement of circulating levels of 25-hydroxyvitamin D (25OHD) represents the most reliable assessment of vitamin D status. Several assays are available but are not commutable because of a lack of of standardization. The aim of our study was to evaluate the performance of a new ELISA for measurement of 25OHD ...

ea0032p149 | Calcium and Vitamin D metabolism | ECE2013

Persistent primary hyperparathyreoidism

Kotova Irina , Gadzyra Alexander , Alayev Dmitry , Martino Elena

Introduction: Achievement of stable normocalcemia (88–98.8%) is considered a criterium of efficiency of surgical operations for primary hyperparathyroidism (PHPT) (P.Goudet et al. 2001, Zeiger 1997). In 1–15% of cases, persistence of PHPT is noted (Mariani et al. 2003, Mariette et al. 1998).Description of methods: In 110 of 175 patients (aged 14–72 years), parathyroid adenoma was verified, in 57 – hyperplasi...

ea0032p150 | Calcium and Vitamin D metabolism | ECE2013

Prevalence of multiple endocrine neoplasia type 1 syndrome in primary hyperparathyroidism

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: To assess the prevalence of multiple endocrine neoplasia type 1 (MEN1) in patients with symptomatic primary hyperparathyroidism (PHPT).Methods: A retrospective analysis of 75 consecutive patients with symptomatic PHPT from January 1994 to July 2012 was done, who underwent parathyroid surgery at our centre. Five patients had MEN1 syndrome. Among them 1 was familial MEN1. The patients with MEN1 were analyzed based on clinical presentation, bioch...

ea0032p151 | Calcium and Vitamin D metabolism | ECE2013

Does the severity of vitamin D deficiency affect the prevelance of gastrointestinal polyps?

Yonem Ozlem , Ataseven Hilmi , Dokmetas Sebila , Ozer Hatice , Kilicli Fatih

Introduction: The beneficial effects of vitamin D against gastrointestinal polyps and cancer in the gastrointestinal system as a whole remain unknown and relevance in repeat populations remain contraversial. Also in most studies the role of accompanying hypocalcemia itself is often neglected. For this reason we included only patients with low vitamin D levels and investigated the presence of gastric and colonic polyps.Methods/design: Between March 2011 a...

ea0032p152 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficit and metabolic syndrome

Molero Inmaculada Gonzalez , Rojo GEmma , Dominguez-Lopez Marta , Rubio Eleazara , Gutierrez Carolina , Morcillo Sonsoles , Esteva Isabel , Ruiz de Adana Marisol , Soriguer Federico

Background and aims: To assess the relationship between 25-hydroxyvitaminD levels and prevalence and incidence of metabolic syndrome.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a standardized clinical examination with an oral glucose toleran...

ea0032p153 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficiency predicts incidence of obesity

Gonzalez-Molero Inmaculada , Rojo Gemma , Dominguez-Lopez Marta , Rubio Eleazara , Gutierrez Carolina , Morcillo Sonsoles , lmaraz Maria Cruz , Ruiz de Adana Marisol , Esteva Isabel , Soriguer Federico

Background and aims: To assess the relationship between obesity and the incidence of hypovitaminosis D and investigate the relationship between 25-hydroxyvitamin D levels and incidence of obesity.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a...

ea0032p154 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficiency in morbid obesity before and after bariatric surgery

Gonzalez-Molero Inmaculada , Gonzalo-Marin Montserrat , Dominguez Marta , Arnes Juan Garcia

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to various factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study the prevalence of vitamin D deficiency in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 72 morbidly obese...

ea0032p155 | Calcium and Vitamin D metabolism | ECE2013

The association of low serum 25-hydroxyvitamin D and serum osteocalcin levels with the metabolic syndrome in females with polycystic ovary syndrome in Al-Baha region, Saudia Arabia: a case–control study

el Sagheer Ghada , Guddah Latifa , Saad el Deen Ahmad

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females of reproductive age. It is frequently associated with metabolic disturbances and insulin resistance, that occurs in about 50–70%. Evidences were reported about the association between vitamin D and osteocalcin with cardiovascular risk factors, regulation of insulin secretion and sensitivity.Objectives: Evaluation of the association between of low 25-hydroxyvitamin...

ea0032p156 | Calcium and Vitamin D metabolism | ECE2013

MSIA–SRM assay for parathyroid hormone and vitamin D binding protein: correlation with clinical immunoassay methods and application to clinical samples

Moniz Caje , Couchman Lewis , Krastins Bryan , Lopez Mary , Prakash Amol , Sarracino David , Vogelsang Mary , Peterman Scott , Vadali Gouri , Robinson Sarah

Parathyroid hormone is involved in calcium homeostasis through interactions with vitamin D. Because intact and truncated forms of PTH vary in their biological activity, assays that can accurately quantify the ratio of intact hormone to its fragments are of increasing significance in the diagnosis of endocrine, renal and bone diseases. Vitamin D and its metabolites circulate tightly bound to vitamin D-binding protein (DBP). Because DBP concentrations are altered in pregnancy, l...

ea0032p157 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficiency, secondary hyperparathyroidism and it’s influence on bone mineral density

Povoroznyuk Vladyslav , Balatska Nataliya

Introduction: The consequences of vitamin D deficiency are secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures, mineralization defects, which may lead to osteomalacia in the long term, and muscle weakness, causing falls and fractures.Objectives: The aim of the research was to determine the frequency of vitamin D deficiency, secondary hyperparathyroidism and it’s influence on bone mineral density in people of different ...

ea0032p158 | Calcium and Vitamin D metabolism | ECE2013

Comparative study of bone metabolic parameters and vitamin D levels of fertile aged women, suffering from different bone metabolism altering diseases

Acs Orsolya , Acs BenceT , Horvath Csaba , Ferencz Viktoria , Meszaros Szilvia , Toth Edit , Csupor Emoke

Introduction: Polycystic ovary syndrome (PCOS), lactase deficiency, nephrolithisasis and thyroid diseases are considered endemic. The aim of our study was to evaluate which of the above-mentioned diseases affect the most the bone metabolic parameters, bone mineral density (BMD) and the prevalence of bone fractures in fertile aged women.Materials and methods: A total of 92 fertile aged women (32.6±5.2 years) were divided into four groups (23 in each)...

ea0032p159 | Calcium and Vitamin D metabolism | ECE2013

Structure and frequency of clinical manifestations of primary hyperparathyroidism

Brutskaya-Stempkovskaya Elena , Shepelkevich Alla , Bilodid Irina , Kliausova Ekaterina , Lobashova Veronika

Introduction: Primary hyperparathyroidism (PHPT) is a result of overproduction of parathyroid hormone with pathologically changed parathyroid glands (PTG) and calcium-phosphorus metabolism disorders. Until now, PHPT is often detected late (in countries where there is no screening for hypercalcemia), when there are irreversible complications it manifested.Materials and methods: One hundred and nine patients with PHPT (mean age: 52.2±8.7 year...

ea0032p160 | Calcium and Vitamin D metabolism | ECE2013

A case report: hypoparathyroidism, nephrocalcinosis, and replacement therapy

Boysan Serife Nur , Ozgen Zeren , Sahin Tuna

Introduction: There is a risk of hypercalcemia, nephrolithiasis, nephrocalsinosis, and renal failure in the treatment of hypoparathyroidism. We present a case who has an improvement of this complication after changing large doses of vitamin D to physiological doses of 1,25(OH)2D itself.Case report: A 50 years old man was admitted to hospital. He had idiopathic hypoparatyhroidism from the age of 24. He was using oral 1,25(OH)2D 0.25 ...

ea0032p162 | Calcium and Vitamin D metabolism | ECE2013

The prognostic value of peripheral neuropathy for the mortality and its relation to secondary hyperparathyreoidism: a 10-month follow up of 97 patients with end-stage renal disease

Tesic Dragan , Curic Nikola

Introduction and objectives: The aim of this study was to evaluate the risk of death in relation to hemodialysis.Material and methods: We performed a 10-month follow up study of hemodialysed patients attending our Center. A total of 97 patients were evaluated: 37 (38.1%) nephroangiosclerosis, 28 (28.9%) diabetic nephropathy, 18 (18.6%), and glomerulonephritis 14 (14.4%) other causes. Somatic sensory neuropathy (PN) was documented using the Neuropathy Dis...

ea0032p163 | Calcium and Vitamin D metabolism | ECE2013

Postsurgical hypoparathyroidism with ‘normal’ PTH

Azevedo Teresa , Martins Teresa , Lemos Manuel , Cunha Nuno , Valido Frederico , Rodrigues Fernando

Introduction: Hypoparathyroidism is characterized by hypocalcemia and low or inappropriately normal levels of PTH. The most common cause of hypoparathyroidism is iatrogenic due to anterior neck surgery. In recent years it was documented that vitamin D insufficiency is widespread.Aim: To investigate the cause of hypocalcemia in thyroidectomized patients with PTH within the reference range.Methods: Retrospective review of clinical re...

ea0032p164 | Calcium and Vitamin D metabolism | ECE2013

Evaluation of concentration 25OH vitamin D3 selected patient population: preliminary report

Nowak Justyna , Koszowska Aneta , Puzon Anna Bronczyk , Kulpok Agata , Szkodzinska Barbara Zubelewicz , Jagielski Pawel

Introduction: Vitamin D in the human body plays a very important role.Aim: The aim of the study was identify the differences in concentration of 25OH vitamin D3 in blood and compared with anthropometrics and biochemicals results of researched group of people.Materials and methods: To research were included 212 patients hospitalized on Endocrinology Department of Hospital in Poland in 2012. Patients were divided into thre...

ea0032p165 | Calcium and Vitamin D metabolism | ECE2013

Evaluation of concentration 25OH vitamin D3 in the population over 65 years old: preliminary report

Puzon Anna Bronczyk , Nowak Justyna , Koszowska Aneta , Kulpok Agata , Just Joanna Przybylska , Szkodzinska Barbara Zubelewicz , Jagielski Pawel

Introduction: Old age is defined as late adulthood and is an important part of human’s life. This is the time of life, when exist the real risk of 25OH vitamin D3 deficiency.Aim: The aim of the study was find out the connections between concentration of 25OH vitamin D3 in blood and anthropometrics and biochemical results depending on diseases in persons above 65 years.Materials and methods: The research w...

ea0032p166 | Calcium and Vitamin D metabolism | ECE2013

Cardio-metabolic risk factors in subjects with Vit D deficiency

Azzoug Said , Aissa Nassima Belhadj , Kesraoui Mourad , Lounis Lydia , Chentli Farida

Introduction: Vitamin D (Vit D) is known for its action on bone metabolism. But recently more ubiquitous actions have been discovered. Vit D deficit is now considered as a world health problem because of it frequency and its consequences. Vit D deficiency seems to be involved in diabetes mellitus, and in autoimmune, neoplastic and cardio-metabolic diseases. The aim of our study was to analyze the incidence of cardio-metabolic diseases in a group of patients with vitamin D defi...

ea0032p167 | Calcium and Vitamin D metabolism | ECE2013

Hyperparthyroidism: are male forms more or less aggressive?

Azzoug Said , Lounis Lydia , Aissa Nassima Beldj , Kesraoui Mourad , Chentli Farida

Introduction: Hyperparathyroidism (HPT) is a common disease prevailing in females (F). Male (M) forms are rare and their impact on the body is less studied than in females. Our aim is to see if male HPT is more or less aggressive than the female one.Subjects and methods: It is a retrospective study that took in account 62 HPT (46F, 16M) over a period of 7 years (2005–2012). All were questioned, examined, and had routine analyses, biological assessme...

ea0032p168 | Calcium and Vitamin D metabolism | ECE2013

A clinical case of complicated hyperparathyroidismwith diagnosis delay due to vitamin D deficiency

Novac Roxana , Constantinescu Georgiana , Oprea Andreea , Mogos Voichita , Branisteanu Dumitru D

We present the case of a 75-year-old woman with a 10-year history of nephrolithiasis, for which she endured several sessions of extracorporeal shockwave lithotripsy (ESWL). She was directed to the Endocrinology unit for further investigations, due to persistent albeit minor increased values of blood calcium (10.48 mg/dl, normal 8.4–10.2 mg/dl). Here, the clinical supposition of primary hyperparathyroidism was confirmed. The tests revealed a mild hypercalcemia with hypopho...

ea0032p169 | Calcium and Vitamin D metabolism | ECE2013

Impact of vitamin deficiency and oF GH–IGF1 on cardiovascular risk in hypopituitaric patients

Savanelli Maria Cristina , Scarano Elisabetta , Vuolo Laura , Brunelli Vincenzo , Rubino Manila , Colao Annamaria , Di Somma Carolina

To determine a correlation between Vitamin D, GH, IGF1 and cardiovascular risk we enrolled. 41 GHD patients (22 M, 19 F, age 18–84 years) and 41 controls. In all we determined: anthropometric parameters, blood pressure (BP), lipid and glucose profile, PTH, 25-OH-vitamin D, GH peak after GHRH+ARG, IGF1. Metabolic syndrome (MS) was evaluated by the IDF criteria.The vitamin D were lower in patients than in controls (21.3±12.3 vs 28.2±9.4, <em...

ea0032p170 | Calcium and Vitamin D metabolism | ECE2013

Primary hyperparathyroidism in patients with urolithiasis: prevalence and predictors

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: To know the prevalence of primary hyperparathyroidism (PHPT) in urolithiasis and predictors of PHPT in urolithiasis.Methods: This cross sectional study was conducted between July 2005 and July 2012 in department of endocrinology and urology at our hospital. In this study a total of 165 consecutive patients with urolithiasis with radioopaque stones were evaluated for clinical and biochemical profile. Stones retrieved were analyzed for type of s...

ea0032p171 | Calcium and Vitamin D metabolism | ECE2013

Could PHPT be diagnosed at early stages even more frequently?

Siprova Helena , Sipr Kvetoslav , Frysak Zdenek

Primary hyperthyroidism (PHPT) is one of the diseases which are usually diagnosed in asymptomatic period nowadays. Even though considerable success was achieved, in some cases PHPT is not found out before complications were developed. A prospective study focuses on diagnostics and therapy of PHPT has been in progress at two tertiary centers of endocrinology in the Czech Republic since January 1st, 2007, with early diagnosis of PHPT being one of its aims. In a 6-year period, th...

ea0032p171.1 | Calcium and Vitamin D metabolism | ECE2013

Relation between carotid intima media thickness and vitamin D in hypertension

Taskiran Bengur , Bahadir Eylem , Mutluay Ruya

Introduction: Hypertension is associated with increased risk of vascular disease. There is possible relation between low vitamin D levels and subclinical atherosclerosis defined as increased carotid intima media thickness (CIMT). Vitamin D deficiency is defined as levels below 20 ng/ml. In this study we aimed to find out the relation between 25 hydroxy D vitamin level and CIMT and the presence of atherosclerotic plaques.Methods: A total number of 163 pat...