Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Poster Presentations

Cardiovascular Endocrinology & Lipid Metabolism

ea0032p172 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Lipid levels in acromegaly

Kostoglou-Athanassiou Ifigenia , Gkountouvas Anastasios , Keramidas Ioannis , Xanthakou Eleni , Chatjimarkou Fotini , Kaldrymidis Philippos

Acromegaly is known to be associated with increased cardiovascular risk. Additionally, acromegaly is known to be associated with disordered carbohydrate metabolism. Lipid levels in acromegaly have not been extensively studied. The aim was to study lipid levels in acromegaly.Methods: In 32 patients with newly diagnosed acromegaly lipid levels were studied. In particular total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride levels were measu...

ea0032p173 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Testosterone stimulates cholesterol metabolism and efflux from human macrophages via liver X receptor

Kilby Elizabeth , Jones Hugh

Low testosterone is associated with an increased prevalence of cardiovascular (CV) disease. Testosterone replacement improves several CV risk factors including lowering cholesterol and may protect against atherogenesis. Macrophage liver X receptor α (LXRα) stimulates cholesterol efflux which is a therapeutic target for the treatment of atherosclerosis. It was therefore proposed that the anti-atherogenic effect of testosterone may be mediated via LXRα. THP-1 macr...

ea0032p174 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Testosterone differentially regulates liver X receptor expression and targets of lipid and glucose metabolism in liver, muscle and adipose tissue of the testicular feminised mouse

Kelly Daniel , Akhtar Samia , Muraleedharan Vakkat , Brooke Johnathan , McLaren David , Channer Kevin , Jones T Hugh

Testosterone deficiency increases risk for cardiovascular disease (CVD) and type 2 diabetes. Testosterone replacement (TRT) improves insulin resistance, glycaemic control and cholesterol in hypogonadal men. Liver X receptor (LXR) is a nuclear receptor which regulates lipid and glucose metabolism. LXR agonists protect against atherosclerosis but cause hepatic steatosis. We have previously shown that TRT protects against hepatic steatosis and atherosclerosis in high-fat diet-fed...

ea0032p175 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Oxytocin, a new regulator of cardiomyocyte hypertrophy

Gutkowska Jolanta , Menaouar Ahmed , Jankowski Marek

We have uncovered the cardioprotective functional oxytocin (OT) system in the rat and human heart. In rat model of heart infarct, OT treatment significantly reduced infarct size, decreased cardiomyocytes (CM) diameter, increased expression of atrial natriuretic peptide (ANP) and improved parameters of heart function. Consequently, in this report we investigated hypothesis that OT-related mechanism of ANP synthesis or release, plays a role in the control of CM hypertrophy.<...

ea0032p176 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Long QT interval in Turner syndrome: a high prevalence of LQTS gene mutations

Trolle Christian , Mortensen Kristian Havmand , Pedersen Lisbeth Norum , Jensen Henrik Kjaerulf , Andersen Niels Holmark , Gravholt Claus Hojbjerg

Objective: QT interval prolongation of unknown aetiology is common in Turner syndrome (TS). This study set out to explore the presence of known pathogenic long QT (LQT) mutations in TS and to examine the corrected QT interval (QTc) over time and relate the findings to the TS phenotype.Methods: Adult females with TS (n=102) were examined thrice with a mean follow-up of 4.7±0.5 years, and 68 age-matched healthy controls were examined once. QT...

ea0032p177 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Osteoprotegerin and RANKL levels in instable coronary artery disease

Gurban Camelia , Balas Melania , Amzar Daniela , Golu Ioana , Stana Loredana , Zosin Ioana

Introduction: Osteoprotegerin (OPG) and receptor activator for nuclear factor-κB ligand (RANKL) are cytokines that increase in cardiovascular diseases. Serum OPG levels are high in vascular calcifications, while RANKL is expressed by atherosclerotic lesions. The aim of the study was to assess the OPG and RANKL concentrations in patients with stable coronary artery disease.Material and methods: The study included 38 patients diagnosed with ischemic c...

ea0032p178 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Intestinal cholesterol-transport gene expression is associated with abnormalities in post-prandial endothelial function and carotid intima-media thickness independent of insulin resistance

Widdowson W Matthew , McGowan Anne , Phelan James , Boran Gerard , Reynolds John , Gibney James

Introduction: Intestinal cholesterol absorption is known to be important in post-prandial lipid levels, and implicated in the development of vascular disease. This study evaluated the effect of intestinal gene expression on markers of early vascular disease in a cohort of diabetic and non-diabetic subjects.Methods: Subjects were identified from routine upper GI lists and enrolled as per local ethics approval. Intestinal gene expression was measured on du...

ea0032p179 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Mediterranean diet modulates the effect of rs1761667 in the CD36 gene on FFA concentration and BMI in a high cardiovascular risk population

Ortega-Azorin Carolina , Godoy Diego , Carrasco Paula , Asensio Eva M , Zanon-Moreno Vicente , Corella Dolores , Sorli Jose V

Introduction and objective: CD36 is a scavenger receptor that facilitates the membrane transport of long chain fatty acids into muscle and adipose tissue. Polymorphisms in this gene have been related to abnormal serum fatty acids and obesity-related phenotypes with inconsistent results. Gene-diet interactions could modulate these associations. Our aim was to study whether a common functional variant (rs1761667) in this gene will associate with anthropometric variables and plas...

ea0032p180 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

The effect of aerobic exercise on ectopic lipids intramyocellular, intrahepatocellular, and intracardiomyocellular lipids in physically active, healthy individuals

Kruesi Marion , Bucher Julie , Kreis Roland , Ith Michael , Zueger Thomas , Stettler Christoph , Boesch Chris , Christ Emanuel

Introduction: Ectopic lipids are fuel stores in non-adipose tissues (i.e. skeletal muscle (IMCL), liver (IHCL), and heart (ICCL)). It is recognized that IMCL can be depleted by physical activity and repleted by dietary fat intake indicating metabolic flexibility. In contrast, preliminary data suggested that aerobic exercise increases IHCL. Data on the acute effect of aerobic exercise on ICCL is scarce.Increased IMCL and IHCL have consistently been relate...

ea0032p181 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Can hypothyroidism manifest as ischemic heart disease in elderly patients with the absence of significant coronary atherosclerosis?

Yaroslavskaya Elena , Kuznetsov Vadim , Parato Maurizio , Krinochkin Dmitryi , Pushkarev Georgyi , Gorbatenko Elena

In elderly patients with symptoms of ischemic heart disease (IHD) coronary angiography often fails to reveal significant atherosclerosis. The causes of the absence of significant coronary atherosclerosis (SCA) in these patients have not been determined.Purpose: To determine predictors of SCA absence in the elderly IHD patients.Methods: This is a retrospective study of consecutive 10 713 patients who underwent coronary angiography a...

ea0032p182 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Short-term changes in serum sex steroid levels and cardiac function in healthy young men

De Smet Maarten , Lapauw Bruno , De Backer Tine , Ruige Johannes

Introduction: Male obesity is associated with an increase in estradiol (E2) and a decrease in testosterone (T). And, although sex steroids are associated with cardiovascular disease, direct effects on cardiac structure and function are hardly investigated in humans.Methodology: Twenty healthy men aged 20–40 years were randomized into two groups. One group was given an aromatase inhibitor (letrozole) only, thus obtaining a high testosteron...

ea0032p183 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality

Haring Robin , Teumer Alexander , Volker Uwe , Dorr Marcus , Nauck Matthias , Biffar Reiner , Volzke Henry , Baumeister Sebastian , Wallaschofski Henri

Background: Prospective studies showed that low serum testosterone concentrations are associated with various cardiometabolic risk factors and mortality. But the causal nature of these associations is controversial.Methods: We studied 1882 men aged 20–79 years with serum testosterone concentrations and genotyping data from the longitudinal population-based Study of Health in Pomerania.Testosterone concentrations were cross-sec...

ea0032p184 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Adults with GH deficiency have subclinical longitudinal left ventricular dysfunction, without significant vascular function impairment, suggesting intrinsic myocardial disease

Badiu Corin , Mihaila Sorina , Mincu Raluca , Dobrescu Ruxandra , Vinereanu Dragos

Aims: GH deficiency (GHD) is associated with increased cardiovascular events. We aimed to evaluate cardiac, arterial, and endothelial function, by conventional and 2D speckle tracking echocardiography (STE), and biomarkers (proBNP and troponin I), in GHD patients by comparison with normal individuals with similar cardiovascular risk profile.The study included 52 GHD patients (46.9±15.6, 36 males), free of cardiovascular disease, severe hypertension ...

ea0032p185 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Mechanism of oxytocin-mediated cardiomyocyte protection

Jankowski Marek , Gonzalez-Reyes Araceli , Gutkowska Jolanta

Oxytocin (OT) treatment improves heart functional recovery in rat model of myocardial infarct. We investigated in the H9c2 cell line (cardiomyocytes model), mechanism of OT action in simulated ischemia - reperfusion (sI-R). H9c2 cells were suspended in warm ischemic buffer and placed inside an anoxic chamber for 2 h at 37 °C, then ‘reperfused’ under normal nutrients and oxygen conditions for 2 h. OT presence during ischemia increased cell viability by 9.7±2...

ea0032p186 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

The effect of testosterone replacement on endothelial dysfunction, inflammation and insulin resistance in male hypogonadotrophic hypogonadism

Sonmez Alper , Taslipinar Abdullah , Aydogdu Aydogan , Tapan Serkan , Meric Coskun , Basaran Yalcin , Sertoglu Erdim , Yilmaz Mahmut I , Serdar Muhittin A , Ozgurtas Taner , Bolu Erol , Kutlu Mustafa

Objective: Metabolic disorders are common in patients with hypogonadism. Testosterone replacement therapy (TRT) significantly improves symptoms of testosterone deprivation such as mood, libido or musculoscelatal power. However, whether the metabolic and cardiovascular risk is improved is not clearly known. We aimed to search for the metabolic and cardiovascular effects of TRT.Design: Prospective study, performed in the outpatient units of Gulhane Medical...

ea0032p187 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

TSH and arterial stiffness in healthy postmenopausal women

Armeni Eleni , Stamatelopoulos Kimon , Rizos Demetrios , Georgiopoulos Georgios , Kazani Maria , Alexandrou Andreas , Deligeoroglou Efthymios , Livada Alexandra , Psychas Charalampos , Creatsa Maria , Bouboulis George , Alevizaki Maria , Lambrinoudaki Irene

Introduction: Thyroid dysfunction, whether overt or subclinical, has a significant effect on the cardiovascular system. On the other hand, fluctuation of thyroid hormones within the normal range has been associated with long-term health risks, and might have an impact on the vasculature. This study assessed the effect of thyroid hormones on surrogate markers of arterial structure and function in a sample of euthyroid postmenopausal women.Methods: This cr...

ea0032p188 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

A potential predict value of circulating osteoprotegerin in diabetic patients with asymptomatic coronary artery disease

Berezin Alexander , Kremzer Alexander

Background: Osteoprotegerin (OPG) is a bone-related glycopeptide produced by vascular smooth muscle cells due to arterial damage. OPG is considered as an independent predictor of cardiovascular disease in diabetic populations.The aim of this study was to evaluate the interrelation between circulating OPG and coronary vasculature damage in type 2 diabetes mellitus patients.Methods: One hundred and twenty six subjects with stable dia...

ea0032p189 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Metabolic profile of transsexual persons on cross-sex hormonal therapy in a multi-center prospective intervention study

Van Caenegem Eva , Wierckx Katrien , Taes Youri , Kaufman Jean-Marc , Schreiner Thomas , T'Sjoen Guy

Introduction: Gender differences in insulin resistance, body composition and lipid profile are well known and related to sex steroid hormones. In this study, we examine the metabolic profile of transsexual persons undergoing drastic sex steroid changes, during the first year of hormonal therapy.Design: This research is part of a prospective intervention study conducted in several European gender teams (Ghent, Oslo, Amsterdam, and Florence).<p class="...

ea0032p190 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Changes in lipid profile and markers of metabolic syndrome after 3 years of testosterone-therapy in female-to-male transsexuals

Becerra Antonio , Menacho Miriam , Perez-Lopez Gilberto , Villar Rosa , Del Rey Jose Manuel , Asenjo Nuria , Lucio Maria Jesus , Rodriguez-Molina Jose Miguel , Llopis Jose Luis

Introduction: Different studies have published that testosterone therapy in men and women results in decreased HDL cholesterol and increased LDL cholesterol, and therefore an increased cardiovascular risk.Aims: To determine whether testosterone therapy has this effect on lipid parameters and markers of metabolic syndrome (MetSyn) in female-to-male transsexuals (FMT).Material and methods: We studied 50 FMT, aged 27.8±7.6 years,...

ea0032p191 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

Szkodzinski Janusz , Hudzik Bartosz , Danikiewicz Aleksander , Pietka-Rzycka Anna , Lekston Andrzej , Zubelewicz-Szkodzinska Barbara

Introduction: Pentraxin-3 (PTX3) is an acute-phase reactant that shares structural and functional homology with C-reactive protein (CRP). However, unlike CRP, which is synthesized mainly in the liver, PTX3 is produced at the site of inflammation. It has been suggested that PTX3 plays the same role in the periphery that CRP does in circulation. PTX3 may represent a rapid marker for local inflammation.Methods: Fifty three patients with stable coronary arte...

ea0032p192 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Effect of cross-sex hormone treatment on lipid profile in transsexual individuals: experience in a specialized unit in Catalonia

Lopez Carmen Quiros , Patrascioiu Ioana , Porta Mireia Mora , Beatriz Gloria , Velazquez Aranda , Hanzu Felicia , Gil Esther Gomez , Sieso Teresa Godas , Rabinovich Irene Halperin

Objectives: To assess baseline differences on lipid profile in individuals with gender identity disorder (male to female, M2F and female to male, F2M) in relation to prior cross-sex hormone treatment (CHT) or not, and changes in the lipid profile after 24 months of treatment and follow-up in our unit.Methods: Transversal study by revision of medical records of 235 patients visited for first time in our service from 2006 to 2010. Clinical and analytical r...

ea0032p193 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

HDL cholesterol subfractions and the effect of testosterone replacement in hypogonadism

Bolu Erol , Sonmez Alper , Tapan Serkan , Taslipinar Abdullah , Aydogdu Aydogan , Meric Coskun , Basaran Yalcin , Uckaya Gokhan , Serdar Muhittin A , Kurt Ismail , Azal Omer

Metabolic disorders and cardiovascular events are increased in hypogonadism. Serum HDL composition is a better cardiovascular predictor than the HDL counts. However, there is no information about the HDL subfractions in patients with hypogonadism. We designed a prospective study to investigate the HDL subfractions in treatment naïve subjects with hypogonadism and the effects of two different testosterone replacement regimens on the HDL subfractions. Seventy young male pat...

ea0032p194 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

The activity of inflammation and the blood redox status in patients with coronary heart disease and type 2 diabetes mellitus

Buko Inna , Mokhort Tatiana , Konstantinova Helena , Tsapaeva Natalia , Moiseenok Andrey

To determine the relationship between indicators of inflammation and the blood redox status of type 2 diabetic (T2DM) patients with and without coronary heart disease (CHD).Forty four patients with T2DM and CHD (group 1), 67 patients with T2DM without cardiovascular complications (group 2), 89 healthy subjects (group 3) were included in this study. Serum concentrations of IL6 and IL8 were determined by ELISA using commercial kits. Concentrations of thiob...

ea0032p195 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Utility of N-terminal pro-brain natriuretic peptide in the evaluation of patients with high clinical probability of non-ST segment elevation acute coronary syndrome

Pascu Alina Mihaela , Radoi Mariana , Bisoc Alina , Moga Marius Alexandru

Introduction: The study aimed to analyze the efficiency of a concomitant N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac high-sensitivity troponin T (hs-cTnT) testing in diagnosing non-ST-segment-elevation myocardial infarction (NSTEMI) in patients initially negative for the standard fourth-generation assay of cardiac troponin T (cTnT), but with high clinical probability of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS).Meth...

ea0032p196 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Perturbed sympatho-vagal balance in Turner syndrome: relation to phenotype and aortic dilation

Trolle Christian , Mortensen Kristian Havmand , Hjerrild Britta , Andersen Niels Holmark , Gravholt Claus Hojbjerg

Objective: The risk of aortic dissection is 100-fold increased in Turner syndrome (TS). Increased blood pressure (BP) and heart rate is present as well as an increased risk of ischemic heart disease and diabetes. This study aimed to prospectively assess heart rate variability (HRV) in TS and its relation to aortic dimensions.Methods: Adults with TS (n=91, aged 37.4±10.4 years) recruited through the Danish National Society of Turner Syndrome...

ea0032p197 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Impact of subclinical thyroid dysfunction on mortality among patients presenting with cardiovascular events

Nacpil Paulette , Arkoncel Ma Luisa , Ryan Ardena Gregory Joseph , Jimeno Cecilia

Introduction: The possible clinical impact of subclinical thyroid dysfunction on patients with cardiovascular events is important if one considers the high incidence of a mildly altered thyroid hormone pattern in this population. This study aims to determine the prevalence of subclinical thyroid dysfunction among patients presenting with cardiovascular events in Philippine General Hospital, and its impact on mortality.Methodology: A cross sectional, pros...

ea0032p199 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Lipid levels in patients with rheumatoid arthritis and the effect of rituximab

Kostoglou-Athanassiou Ifigenia , Xanthakou Eleni , Tzanavari Aikaterini , Gkountouvas Anastasios , Dadiras Nicolaos , Koutsika Eirini , Athanassiou Panagiotis

Rheumatoid arthritis (RA) is known to be associated with cardiovascular comorbidity. In particular, patients with RA are known to be at increased for the development of atherosclerosis. Treatment with biological agents in RA may affect lipid levels.Aim: The aim was to study the effect of rituximab treatment on lipid levels in RA patients.Methods: In a cohort of 20 patients with RA lipid levels were studied before, 6 and 12 months a...

ea0032p200 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Linear growth and IGF1 concentrations in children cyanotic and acyanotic congenital heart disease before vs after intervention

Soliman Ashraf , Ellithy Khaled , Khella Ayman , Yassin Haytham , Shatla Emad , Sabt Aml , Elalaily Rania

Objectives: To measure linear growth of patients and the magnitude of catch-up growth and changes and IGF1 concentration.Design: This prospective study recorded the anthropometric data and measured the IGF1 of 32 infants and children with congenital acyanotic heart disease (CAHD) with left to right shunt (14 VSD, 10 ASD, and 8 PDA) without heart failure, and 15 with cyanotic heart disease (CCHD) before (B) and a year after (A) surgical or catheter interv...

ea0032p201 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Changes of expression of regulators of calcification in different stages of atherosclerosis in vasculature and bone

Schweighofer Natascha , Aigelsreiter Ariane , Graf-Rechberger Martina , Hacker Nicole , Schweiger Martin , Trummer Olivia , Pieber Thomas , Ulbing Matthias , Muller Helmut , Obermayer-Pietsch Barbara

Calcification is physiologically present in bone but also pathophysiologically in the vasculature, favouring cardiovascular diseases. Our aim was to investigate changes in the expression of calcification regulators (CR) during vascular calcification in bone and vasculature. Gene expression levels of OPG, RANKL, OPN, MGP, BSP-II and RUNX2 were determined in bone, aorta and arteria ilica externa tissue samples of 22 transplant donors. Gene expression levels during atheroscleroti...

ea0032p202 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Dyslipidemia associated with m-TOR inhibitors treatment

Couto Joana , Martins Raquel , Carneiro Filipa , Santos Ana Paula , Torres Isabel

Introduction: Therapeutic approach of patients (pts) with metastatic renal cell carcinoma (mRCC) may include the use of biological agents such as m-TOR inhibitors: temsirolimus (TM) and everolimus (EV). Its use is associated with metabolic dysfunction, especially with everolimus: hyperglycemia (37% TM treated pts vs 72% EV treated pts), hypercholesterolemia (25% TM treated pts vs 81% EV treated pts) and hypertriglyceridemia (30% TM treated pts vs 73% EV treated pts). Discontin...

ea0032p203 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Rising prevalence of fatty liver in India and its correlates

Gopal Jayashree , Usha R

Among individuals who came for master health check up to Apollo hospitals, Chennai between June 2011 to November 2011, 750 patients were recruited based on the inclusion and exclusion criteria. Those who showed fatty liver on ultrasonography were compared with those who had normal liver parenchyma. People with acute medical illness, known hepatic disease, known renal disease, people who consume excessive alcohol (>20 g/day), patients on medications that cause hepatotoxicit...

ea0032p204 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

CNR1 polymorphisms and metabolic disorders in woman with PCOS-preliminary report

Milewicz Andrzej , Laczmanski Lukasz , Lenarcik Agnieszka , Kuliczkowska Justyna , Trzmiel-Bira Anna , Stachowska Barbara , Jedrzejuk Diana , Sadowska Ewa , Kolackov Katarzyna , Pawlak Maurycy , Arkowska Anna , Dorobisz Urszula , Hirmle Lidia , Lwow Felicja

The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. Insulin resistance play important role in etiology in PCOS. The aim of our study was developed the role of CNR1 polymorphisms (rs806368, rs12720071, rs1049353, 806381, rs10485170, rs6454674, rs2023239) in metabolic disorders in woman with PCOS. 88 woman (20–35 years old) with PCOS (recognized using Rotterdam criteria) and 77 woman (20–3...

ea0032p205 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Oleic vs linoleic effects on hepatic sex hormone-binding globulin production

Lopez Cristina Saez , Hernandez Cristina , Simo Rafael , Selva David M

Low plasma SHBG is an independent risk factor of cardiovascular disease. Our recent work has shown that SHBG gene expression can be regulated indirectly through HNF4α gene expression. In this regard, we have identified that an increase in hepatic palmitate induced by high carbohydrate diets and pro-inflammatory cytokines (TNFα and IL1β) was able to reduce hepatic HNF4α protein levels which, in turn, decreased SHBG production. The Mediterranean diet, in whic...

ea0032p206 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Post prandial responses in insulin, free fatty acid and endothelial function following to Malaysian vs Mediterranean meals among healthy subjects

Wahab Norasyikin A , Yusoff Yusniza , Razali Amiliyaton Mohd , Zainudin Suehazlyn , Ghani Rohana Abd , Sukor Norlela , Mustafa Norlaila , Shah Shamsul Azhar , Yusof Barakatun Nisak Mohd , Kamaruddin Nor Azmi

Introduction: Refined carbohydrates, which constitute the staple diet in most cultures may exaggerate postprandial responses in term of insulin, free fatty acid and vascular function. These changes may contribute the onset of metabolic syndrome and diabetes among those at high risk of developing these diseases.Objective: To determine the postprandial insulin, free fatty acids levels and endothelial function responses in healthy subjects to two different ...

ea0032p207 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Subclinical atherosclerosis and cardiovascular risk in healthy, young menopausal women

Armeni Eleni , Stamatelopoulos Kimon , Georgiopoulos Georgios , Kouskouni Evangelia , Creatsa Maria , Alexandrou Andreas , Papamichael Christos , Lambrinoudaki Irene

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

ea0032p208 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Comparative effects of atorvastatin and rosuvastatin on vitamin D levels, glucose metabolism and systematic inflammation in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study

Anagnostis Panagiotis , Adamidou Fotini , Slavakis Arisitidis , Polyzos Stergios , Panagiotou Athanasios , Selalmatzidou Despina , Karathanasi Eleni , Poulasouchidou Maria , Kita Marina

Introduction: Low levels of 25-hydroxy-vitamin D [25(OH)D] have been recognized as a new cardiovascular disease risk factor. Conflicting data exist regarding the effect of statins on 25(OH)D levels and glucose metabolism.Methods/design: This was an open-label randomized prospective comparative study evaluating the effects of atorvastatin and rosuvastatin at equivalent doses on 25(OH)D levels, glucose homeostasis and systemic inflammation in non-diabetic ...

ea0032p209 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Clinical experience with exenatide and liraglutide in the internal medicine service two of hospitals in Valencia

Tamarit-Garcia Juan Jose , Roig-Espert Belen , Balaguer-Catalan Marta , Lozano-Cebrian Amparo , Ruiz-Garcia Ana , Vizcaino-Castillo Belen , Sacie-Reyes Patricia , Artero-Mora Atruro

Background and objective: The upcoming new marketing presentations GLP1 analogues with a dosage more comfortable for patients, we wanted to revise the two we currently have on the market. The target of this study is to determinate glicated hemoglobin (HbA1c) at 6 months of treatment, changes in weight, body mass index (BMI) and tolerance.Design and methods: Observational study that included 60 patients with diabetes mellitus type 2 followed in two Intern...

ea0032p210 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Effect of one session resistance exercise on C-reactive protein and cardio metabolic risk factors in trained and untrained healthy students

Mansouri Masoume , Hasani-Ranjbar Shirin , Keshtkar Abasali , Larijani Bagher

Introduction: We designed this study, to investigate the effect of a single resistance exercise session on serum C-reactive protein (CRP) and cardiometabolic riskfactors in trained and untrained young healthy male students and to evaluate whether regular training may affect the response of these markers to exercise.Method: According to training status 34 healthy male students divided to 19 trained and 15 untrained groups. Each group was then randomly div...

ea0032p211 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Combination therapy in diabetic patients with insulin glargine and exenatide in the internal medicine service two of hospitals in Valencia

Roig-Espert Belen , Tamarit-Garcia Juan Jose , Sacie-Reyes Patricia , Vizcaino-Castillo Belen , Ruiz-Garcia Ana , Lozano-Cebrian Amparo , Balaguer-Catalan Marta , Artero-Mora Arturo

Background and objective: Combination therapy in diabetic patients is seeking better clinical outcomes by acting on different targets in the pathophysiology of the disease.Insulin glargine provides excellent glycemic control, especially in the fasting glucose control, in spite of a increasing in weight, compared with exenatide which is more effective in controlling postprandial glycemic and in reducing insulin resistance, plus a reducing effect on the we...

ea0032p212 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Metabolic disorders in a group of Algerian hypersomatotropic subjects

Chentli Farida , Haddad Meriem , Daffeur Katia , Saraoui Fatima , Kalafate Nadia , Akkache Lina , Meskine Djamila

Introduction: Glucose metabolism disorders are well known in subjects with GH excess, but little is known about other metabolic abnormalities. Our aim is to analyze metabolic complications in subjects with acromegaly and pituitary gigantism.Subjects and methods: Records of 111 subjects were retrospectively examined, mean GH=62 ng/ml (n<5), mean age=39.11 (14–60). All had routine analysis for fasting blood glucose, cholesterol, triglycer...