Endocrine Abstracts

Introduction: Inflammation has been involved in the physiopathology of diabetic ketoacidosis (DKA). Hematological inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and white blood cell count (WBC) can serve as predictive markers for a systemic inflammatory response. This study aimed to evaluate hematological inflammatory markers in T1DM patients with DKA and without-DKA in an uninfected state and to determine their role in the prediction of DKA.<p class="ab...

Introduction: In addition to its role in phosphocalcic metabolism, the vitamin D (vitD) seems to have anti-tumor effects, particularly in colorectal cancer (CRC). The active metabolite of vitD [1,25(OH)2D3], converted by the enzyme CYP27B1, inhibits proliferation and promotes differentiation of CRC cells which express vitamin D receptor (VDR) via the regulation of a high number of genes. The vitD metabolism seems also to regulate inflammatory processes in...

Introduction: Pheochromocytoma is a rare tumor originating from the embryonic neural crest and secreting high levels of catecholamines. The average pheochromocytoma size is 7 cm in the previous publications (1). Sometimes these tumors may be bigger. In this abstract, a case of pheochromocytoma with a huge size presented with unusual presentation.Case study: Fifty-six year-lady presented with an incidental finding of suprarenal mass 14.5 cm after an inves...

Thirty-eight years gentleman presented with DKA as the first presentation of his diabetes. His HbA1c was 12%. On exam, he showed features of Acromegaly and normal BMI. His Growth hormone and IGF-1 were very high in confirming the diagnosis of Acromegaly. His Anti GAD and Anti Islet cell antibodies are negative. MRI dedicated pituitary showed pituitary macroadenoma. Treatment of his DKA was difficult. He was discharged on insulin. Later, the patient was seen in the endocrine cl...

Background: In the majority of cases, the results of TFTs are straightforward. In significant subgroup of patients, the interpretation of TFTs is more challenging, either because. The results appear discordant with the clinical picture (e.g. normal TSH in a patient with suspected thyrotoxicosis), Or measurements appear to contradict each other (e.g. raised TH concentrations, but with non-suppressed TSH).Case presentation: 29 year old Caucasian female com...

Purpose: Coronary artery disease (CAD) is more common and severe in diabetic patients. The aim of this study is to assess the frequency of silent myocardial ischemia in asymptomatic diabetitics by myocardial perfusion scintigraphy and to correlate the results with risk fators.Methods: We prospectively studied 50 (25 men and 25 women) diabetic patients asymptomatic and without known history of CAD. The minimum duration of diabetes was 15 years for the typ...

Introduction: The diagnosis of hereditary hemorrhagic telangiectasia (HHT) is definite if 3 of the following criteria are present, possible or suspected if 2 are present and unlikely if fewer than 2 are present:• Epistaxis.• Telangiectasias.• Visceral lesions: gastrointestinal, pulmonary, hepatic, cerebral and spinal).• Family history: a first-degree relative with HH...

Introduction: Brown tumors or osteitis fibrosa cystica are benign bone tumors complicating uncontrolled primary or secondary hyperparathyroidism. They may behave aggressively and can be destructive. Their osteolytic aspect may be misinterpreted as skeletal metastases.Methods: A 37-year-old female patient with chronic renal failure on dialysis, presented with pain and swelling of her left knee for 10 days, with no associated trauma. She gave history of tu...

Isolated hyperreninemic hypoaldosteronism presents in infancy with failure to thrive, hyponatremia, hyperkalemia, markedly elevated plasma renin activity, and low or inappropriately normal aldosterone. It is usually caused by mutations in the CYP11B2 gene encoding aldosterone synthase. Patients have normal cortisol levels and no features of congenital adrenal hyperplasia. We report a patient who presented with hyperreninemic hypoaldosteronism in early infancy.<p class="abs...

Hashimoto’s thyroiditis (HT) is the most common inflammatory condition of the thyroid gland. In addition to the classic variant of HT, several other subtypes have been identified, such as the fibrous variant (HTFV).Case history: A 38 years old man noticed a rapidly enlarging lump in his neck month ago. This resulted in discomfort with choking sensation and mild dysphagia. He mentioned weight loss, tiredness and night sweats. He was a smoker and dran...