Endocrine Abstracts

Introduction: In addition to the medication prescribed by their doctors, patients may recourse to natural medicine and take herbal medications without thinking about their potential side effects and interactions with other drugs.Case Report: A 39-year-old female, with personal history of iron deficiency anemia, regular menses but long-standing dysmenorrhea and polymenorrhea and reactive anxiety-depressive disorder, complained of frequent intermenstrual s...

Introduction/Aim: New oral anticoagulant drugs such as the factor Xa inhibitor rivaroxaban are often preferred to the classic coumarins because they do not need frequent blood-test monitoring and have fever interactions with other drugs and foodstuffs. They are not, however, interaction free. Rivaroxaban is metabolized by oxidative degradation catalyzed by CYP3A4/5 and CYP2J2; it is also a substrate of the P-gp and ABCG2 efflux transporter proteins. CYP3A4 activity enhancers s...

The GIRFT (Getting It Right First Time) visits, about which we have consulted the membership of the Society for Endocrinology and had positive feedback from many members, have now started. We have done four pilots in Birmingham, Leicester, Oxford and York. The objectives are to try to introduce a quantitative approach to help demonstrate best practice. It will explore surgical outcome data and complication rates with regard to thyroid, parathyroid, adrenal, pituitary and neuro...

John Connell, MRC Blood Pressure Group, Glasgow, UK AbstractJohn Connell graduated in medicine from Glasgow in 1977. After initial training in endocrinology, he was appointed as a Clinical Scientist to the MRC Blood Pressure Unit, Western infirmary, Glasgow in 1983. He held an MRC Travelling Fellowship in the Howard Florey Institute for Experimental Physiology and Medicine from 1987, working with Professor John Coghlan...

John S Bevan, Department of Endocrinology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK. AbstractJohn S Bevan is senior Consultant Endocrinologist at Aberdeen Royal Infirmary and Honorary Professor of Endocrinology at Aberdeen University. He qualified MB ChB, with Honours, from Edinburgh University in 1978 and his clinical training in Medicine & Endocrinology took place in Edinburgh, Oxford and Ca...

Animal and clinical models of GHRH excess suggest that GHRH provides an important trophic drive to pituitary somatotrophs. Mice in which GHRH neurons have been ablated using a novel viral ion channel transgene (GHRH-M2 mice) show marked anterior pituitary hypoplasia and GH deficiency although GH cells are present. GHRH-M2 mice are also deficient in prolactin which is surprising as GHRH has little or no direct effect on PRL synthesis or release (Le Tissier, Mol Endo 19). In mic...

The need for thyroid residue ablation in papillary thyroid cancer (PTC), classified with the TNM staging (AJCC, 2002) as pT1, with a maximum diameter comprised between 1 and 2 cm (pT1/1-2) and/or multifocal, is still debated. Aim of this study was to compare the outcome of pT1N0M0 patients submitted or not to postsurgical radioiodine ablation. Consecutive patients followed-up at this Institution from 1996 to 2010 were enrolled. All pT1/1-2N0M0 cases were radioiodine ablated be...

Women with Turner Syndrome (TS) often feel well but require detailed screening for potential sequelae, which may impact on their quality of life, morbidity and mortality. They may also have psychological issues around living with the condition. It is our opinion that women with TS benefit from attending a specialised clinic and consequently an Adult TS Clinic (ATSC) was set up, however the opinion of the women attending such a service is not known. A survey was therefore condu...

Background: The 3-year part of this trial investigated the effect of liraglutide 3.0 mg, as an adjunct to diet+exercise, in delaying onset of T2D (primary endpoint) in adults with prediabetes and obesity (BMI ≥30 kg/m2) or overweight (≥27 kg/m2) with comorbidities.Methods: Participants were randomised 2:1 to once-daily subcutaneous liraglutide 3.0 mg or placebo plus 500 kcal/day deficit diet and 150...

Uterine involution is a critical component of postpartum reproduction, which involves endometrial tissue repair, myometrial contraction and bacterial clearance. The uterus synthesises insulin-like growth factors (IGF-I and –II), IGF-I receptor (IGF-1R), and IGF binding proteins (IGFBPs -1 to -6) that regulate IGF bioavailability. This study used tissue from 12 multiparous Holstein-Friesian cows at day 14 postpartum to investigate expression of the uterine IGF system durin...