Late-Breaking

ea0090p260 | Late-Breaking | ECE2023

Effects of semaglutide, PYY3-36, and empagliflozin on the adrenal gland transcriptome in diet induced obese rats

Kloock Simon , Oertel Marie , Kohlhaas Michael , Nickel Alexander , Fassnacht Martin , Christian G. Ziegler , Dischinger Ulrich

Background: An activation of the hypothalamic-pituitary-adrenal (HPA) axis is a common observation in obese individuals. GLP-1 agonists, such as semaglutide, and SGLT-2 inhibitors, such as empagliflozin, are well known to be beneficial in obesity, while other incretins, like peptide tyrosine tyrosine 3-36 (PYY 3-36), might be also useful for the treatment of obesity. However, the effect of these substances on the adrenal gland is largely unknown. We directly compared the effec...

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ea0090p261 | Late-Breaking | ECE2023

Factored aldosterone can help distinguish mineralocorticoid resistance from aldosterone deficit hypoaldosteronism

Gabriel Ruiz Sanchez Jorge , Calle Alfonso , Angel Rubio Herrera Miguel , Paz de Miguel Novoa Maria , Gomez Hoyos Emilia , Runkle Isabel

Introduction: Hypoaldosteronism can be induced by a deficit of aldosterone production (AldDef) or a mineralocorticoid resistance (MinRes). Experts have proposed to use hyperkalemia-based aldosterone values for this purpose. However, there is no a range of aldosterone values indicating one of this type of hypoaldosteronism. In 2008, Adam W. R.1 hypothesized that the factored aldosterone (FAldo) could be useful differentiating hypoaldosteronism secondary to MinRes fro...

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ea0090p262 | Late-Breaking | ECE2023

Define cell-type-specific disease signatures regulating white adipose tissue of women with polycystic ovary syndrome

Li Congru , Eriksson Gustaw , Lu Haojiang , Vannay Alana , Lindgren Eva , Hirschberg Linden Angelica , Deng Qiaolin , Stener-Victorin Elisabet

White adipose tissue (WAT) is a dynamic and heterogeneous organ composed of different cell types involved in a wide array of biological processes. We know that women with polycystic ovary syndrome (PCOS) suffer from insulin resistance and type 2 diabetes which is associated with pathological white adipose tissue (WAT) function and expansion characterized by hypertrophic adipocytes, altered production and release of lipids and adipokines, and chronic low-grade tissue inflammati...

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ea0090p263 | Late-Breaking | ECE2023

Are severe obese patients aging faster? The impact of severe obesity on different markers of biological age

Dudek Alicja , Zapała Barbara , Tylec Piotr , Ciszek Karol , Cyranka Katarzyna , Zgliczyński Wojciech , Major Piotr

Obesity is defined as a state of chronic low-grade inflammation. It is associated with pro-inflammatory activity of visceral adipose tissue, regarded as a neuroendocrine organ that secretes cytotoxins and other pro-inflammatory factors, impairing metabolic pathways. The corollary of these changes is the risk of developing comorbidities. There are many similarities in the mechanisms of ageing and in obesity. The process of ageing leads to the accumulation of pro-inflammatory fa...

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ea0090p264 | Late-Breaking | ECE2023

Investigating the role of deubiquitinases in adrenocortical carcinoma

Louise Marnet Victoria , Hartmann Oliver , Reissland Michaela , Pahor Nikolett , Landwehr Laura-Sophie , Fassnacht Martin , Teresa Fuss Carmina , Elmar Diefenbacher Markus

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy presenting with an incidence of 1 per million per year and an overall 5-year survival rate under 35%. Currently, curative treatment is limited to full surgical resection, while the adrenolytic drug mitotane remains the only approved medical therapy option leaving a huge demand for innovative therapeutic strategies. Genetic alterations observed in ACC commonly lead to activation of Wnt/β-Catenin signaling most f...

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ea0090p265 | Late-Breaking | ECE2023

Genetic profile of bone metabolism and immunity modulators in bone metastasis in castration-resistant prostate cancer

Janeiro Matthew , Matos Andreia , Medeiros Rui , Bicho Manuel , Ribeiro Ricardo

Introduction: Prostate cancer is a neoplasm with high incidence and prevalence in the elderly population in western countries. Androgen deprivation therapy (ADT) has been used in locally advanced or metastatic disease, although most relapse, becoming hormone resistant, which is a poor prognostic event.Objectives: The aim of this study was to evaluate the association of genetic polymorphisms NOS2, GPRC6A, VKORC1, ARGI and ARGII in prostate cancer, particu...

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ea0090p266 | Late-Breaking | ECE2023

Risk of Impulse Control Disorders in Cabergoline-Treated Cushing’s Disease: A Cross-sectional Study

Sulu Cem , Gul Nurdan , Ciftci Sema , Tanrikulu Seher , Yener Ozturk Feyza , Mefkure Ozkaya Hande , Cagri Poyraz Burc , Kadioglu Pinar

Aim: To determine the prevalence of impulse control disorder (ICD) in patients with Cushings disease (CD) treated with cabergoline (CBG) compared to CBG-naive patients with CD.Methods: We performed a cross-sectional study in patients with CD followed at 5 referral centers based in Istanbul. Eligible patients with CD were those with current CBG treatment for ≥ 3 months. Eligible controls were CBG-naive patients with CD that were matched for ag...

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ea0090p267 | Late-Breaking | ECE2023

Surgical outcomes in acromegaly: The influence of sex and menopause

Carreira Ana , Martins Ferreira Mafalda , Cardoso Luis , Guelho Daniela , Gomes Leonor , Melo Miguel , Paiva Isabel

Introduction: Oestrogens and androgens modulate the effects of growth hormone (GH). Sex differences have been described in acromegaly, with conflicting results in different populations. Additionally, data on sex differences in tumour histopathology are scarce.Aims: To analyse the influence of sex and menopause status in tumour characteristics and surgical outcomes in patients with acromegaly.Materials and methods: Retrospective coh...

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ea0090p268 | Late-Breaking | ECE2023

Salivary Alpha-Amylase Activity in Patients with Acromegaly: A Preliminary Report

Erol Selvinaz , Cil Sen Esra , Yener Ozturk Feyza , Kara ZMY , Sarac Zeynep , Altuntas Yuksel

Objective: It has been argued that salivary alpha-amylase (sAA) is a potential indirect sympathoadrenal medullary (SAM) system activity marker. This study aimed to look at sAA to assess the sympathetic nervous system in acromegaly patients.Subjects and Methods: A total of 31 individuals with acromegaly and 30 controls were enrolled in this prospective, single-center investigation. Saliva samples were taken from individuals with acromegaly and controls in...

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ea0090p269 | Late-Breaking | ECE2023

Overlapping syndromes - Turner and X-linked Kabuki associated with Short Stature

Chelaru Nicoleta , Vasiliu Ioana , Puscasu Irina , Nita Diana-Elena , Starcea Iuliana-Magdalena , Preda Cristina , Florescu Alexandru

Introduction: Kabuki syndrome (KS) is a rare congenital, multisystemic disorder caused by pathogenic variants of KMT2D or KDM6A genes, causing autosomal dominant KS type 1 (more than 80%) and X-linked KS type 2 respectively. The phenotype spectrum is highly variable, consisting of a mixture of any of the five cardinal features (facial dysmorphic features, skeletal defects, dermatoglyphic abnormalities, various degrees of intellectual and growth retardation) with structural dis...

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ea0090p270 | Late-Breaking | ECE2023

Monitoring serum estradiol levels in clinical practice: a retrospective study in transgender AMAB subjects

Federici Silvia , Garofalo Chiara , Parazzoli Chiara , Amer Myriam , Delle Donne Elisa , Persani Luca , Bonadonna Stefania , Bonomi Marco

The Standards of Care version 8 (SOC 8) for transgender and gender diverse people suggest maintaining estradiol (E2) levels between 100-200 pg/ml in Assigned Male at Birth (AMAB) subjects who desire a complete feminization during gender affirmation hormone therapy (GAHT). However, data about estrogen dose therapy and corresponding serum concentrations are scarce, especially regarding gel formulations. Our aim was to retrospectively compare E2 serum levels in AMAB patients unde...

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ea0090p271 | Late-Breaking | ECE2023

Predictors of Quality of Life in Treated Hypothyroidism

Bakos Bence , Solymosi Tibor , Szili Balazs , Vincze Agnes , Meszaros Szilvia , Armos Richard , Kiss Andras , Lakatos Peter , Takacs Istvan

Background: Despite receiving biochemically adequate levothyroxine replacement, many patients with primary hypothyroidism suffer from persistent symptoms and a reduced quality of life (QoL). The underlying causes of this phenomenon are not fully understood, but psychological factors, autoimmune inflammation, and variations in thyroxine conversion have all been suggested as potential contributors. At this time, however, there is no consensus on the root cause.<p class="abst...

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ea0090p272 | Late-Breaking | ECE2023

Management of Thyroid Nodules- a single centre experience/ a district Hospital Experience

Lin Htut Thein , Mlawa Gideon , Mahmood Rabia , Hein Thura , Sadulah Dalya , Sreejith Gopika , Latif Yasser

Background: A thyroid nodule is a discrete lesion within the thyroid gland, which can serve as a prelude to a spectrum of conditions ranging from a benign incidental growth to a full-blown invasive carcinoma. Thyroid nodules are very common in adult population. About 15% of the UK population have clinically detectable goitres or thyroid nodules, and the lifetime risk of developing a thyroid nodule is around 5 to 10%. In addition, there is increasing risk of thyroid cancers in ...

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ea0090p533 | Late-Breaking | ECE2023

St. John’s wort as an example of the naturalistic fallacy: natural things are not necessarily good things

Rios-Gomez Carlos , Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Santana-Ojeda Borja , Arnas-Leon Claudia , Kuzior Agnieszka , Acosta-Calero Carmen , del Pino Ortiz-Hernandez Catherine , Maria Perez-Rivero Jennifer , Javier Martinez Martin Francisco

Introduction/Aim: New oral anticoagulant drugs such as the factor Xa inhibitor rivaroxaban are often preferred to the classic coumarins because they do not need frequent blood-test monitoring and have fever interactions with other drugs and foodstuffs. They are not, however, interaction free. Rivaroxaban is metabolized by oxidative degradation catalyzed by CYP3A4/5 and CYP2J2; it is also a substrate of the P-gp and ABCG2 efflux transporter proteins. CYP3A4 activity enhancers s...

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ea0090p534 | Late-Breaking | ECE2023

Functional and morphologic aspects of fetal adrenal before/after freezing/thawing and 14 days in organotypic culture

Renault Lucie , Labrune Elsa , Giscard d'Estaing Sandrine , Bidault Valeska , Schneider Gregoire , Mure Pierre-Yves , Lalli Enzo , Doghman Mabrouka , Dijoud Frederique , Lejeune Herve , Plotton Ingrid

Introduction: The human fetal adrenals (HFA) produce high levels of steroids. The gland is distinguishable from the 7th gestational week and can be separated in two zones: the fetal zone in the center which correspond of 80 % of the gland and the definitive zone in the periphery. At this time of the development, neural crest cells are reaching the adrenal primordium, producing catecholamines. A third zone, the transitional zone appears later in the early 2nd</s...

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ea0090p535 | Late-Breaking | ECE2023

Occurrence of thyroid autoimmunity, metabolic disorders and malignancy in patients with primary, non-syndromic hyperparathyroidism

Kardalas Efstratios , Ntali Georgia , Argyro Vassiliadi Dimitra , Tsagarakis Stylianos

Background/aim: Primary hyperparathyroidism (pHPT) is a relatively common endocrine disorder, which is often asymptomatic and thus diagnosed during routine biochemical testing. Emerging scientific data supports the theory that non-syndromic pHPT patients may be at increased risk for thyroid autoimmunity, metabolic disorders and malignancy.Materials and methods: A cohort of 227 pHPT (61 male and 166 female) and 244 non-pHPT (75 male and 169 female) patien...

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ea0090p536 | Late-Breaking | ECE2023

Role of insulin therapy in weight gain: lessons from islet transplantation in type1 diabetes

Romain Bulois , Jannin Arnaud , Defrance Frederique , Mapihan Kristell Le , Mikael Chetboun , Julie Kerr-Conte , Francois Pattou , Vantyghem Marie-Christine

Background: Weight gain in type 1 diabetes (T1D) patients has become a clinical problem due to less strict diets and more stringent glycemic targets. Thus, the number of overweight T1D in the USA increased from 3.4% in 1988 to 22.7% in 2007. Hyperinsulinism is involved in the genesis of obesity but in T1D, the impact of insulin therapy in weight gain is not established. Islet transplantation, now reimbursed in France, makes it possible to interrupt insulin. The aim of this wor...

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ea0090p537 | Late-Breaking | ECE2023

Abstract withdrawn...

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ea0090p538 | Late-Breaking | ECE2023

How did COVID-19 pandemic affect the glycemic regulation of patients with type 1 diabetes mellitus and continuous insulin infusion systems? Experience of a single diabetes center

Kardalas Efstratios , Katechakis Nikolaos , Argyro Vassiliadi Dimitra , Tsagarakis Stylianos

Background and Aims: The COVID-19 pandemic severely affected the glycemic regulation of adult patients with type 1 diabetes (T1D). The aim of this study was to evaluate the impact of this pandemic on glycemic control in T1D patients with continuous subcutaneous insulin infusion (CSII) systems.Methods: A cohort of adult T1D patients with CSII was retrospectively evaluated. Data regarding number visits to our diabetes clinics, total daily insulin dose (TDI...

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ea0090p539 | Late-Breaking | ECE2023

Somatic RET M918T variant can modify the natural history of MEN2 related medullary thyroid carcinoma: a case report and literature review

Sahakian Nicolas , Romanet Pauline , Cinzia Paladino Nunzia , Mirebeau-Prunier Delphine , Castinetti Frederic , Barlier Anne

Background: Multiple endocrine neoplasia type 2 associated medullary thyroid carcinoma (MTC) is driven by a strong genotype-phenotype correlation, the risk of aggressiveness being defined by the germline RET pathogenic variant (American Thyroid Association (ATA) guidelines). Based on this classification, the germline c.2370G>C, p.Leu790Phe (L790F) RET variant is considered to be of moderate risk of aggressive MTC, while the germline c.2753T>C, p.Met918Thr (M9...

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ea0090p540 | Late-Breaking | ECE2023

Systemic inflammation in paragangliomas and pheochromocytomas

Ozer Ozge , Apaydin Kayer Merve , Yilmaz Evrim , Nur Kebapci Medine , Akalin Aysen , Efe Belgin , Fuat Acikalin Mustafa , Yorulmaz Goknur

Background: Paragangliomas (PGLs) and pheochromocytomas (PCCs) arise from chromaffin cells. We evaluated the inflammatory markers. The pan-immune-inflammation value (PIV) has recently been used as a new marker. Therefore, we evaluated the PIV association in patients with PGLs/PCCs.Methods: In the study, the data of 82 patients with PGLs/PCCs who applied between 2005 and 2020 were collected retrospectively from the records. NLR (neutrophil/lymphocyte rati...

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ea0090p541 | Late-Breaking | ECE2023

In silico approaches advocates the sensitivity of adrenal gland against EDCs shown in male Wistar rats

Ahmad Shahzad , Raisuddin Sheikh

Adrenal gland is a less focused endocrine organ for the endocrine disrupting effect of endocrine disrupting chemicals (EDCs). The effects of two extensively used phthalate esters viz. di-ethyl hexyl phthalate (DEHP) and di-butyl phthalate (DBP) on adrenal gland were observed in Wistar rats in the present study to check the susceptibility of adrenal gland against the exposure of these extensively used plasticizers which are well known EDCs. Wistar rats were divided into seven g...

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ea0090p542 | Late-Breaking | ECE2023

Characterization of RNA expression and clinical outcomes in patients with aggresive pituitary tumors treated with temozolomide

Venegas Moreno Eva , Remon Pablo , Dios-Fuentes Elena , Pinar Gutierrez Ana , Manuel Canelo Juan , Oliva Rosario , Alonso-Garcia Miriam , Cardenas Eugenio , Kaen Ariel , G-Garcia Miguel E. , Cano Gonzales David , Luque Raul M. , Soto-Moreno Alfonso

Methods: Descriptive retrospective study of the clinical outcomes and RNA expression in aggressive pituitary tumors treated with temozolomide. RNA expression was studied in tumor samples normalized to housekeeping genes including GH, POMC, PRL, αsub, FSH, LH, TSH, sst1, sst2, sst3, sst5, sst5b, sst5c, DR1, DR2T, DR2L, DR4, DR5, Ghrelin, In1-Ghrelin, GOAT, GHRR1b, AVPR1b, GHRH-R, GnRH-R, Ki-67, PTTG1, CRHR1.Results: Ten patients were treated. 30% (3)...

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ea0090p543 | Late-Breaking | ECE2023

Synovial sarcoma in a patient with long-standing acromegalia: Causal vs. coincidental

Jose de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Santana-Ojeda Borja , Rios-Gomez Carlos , Arnas-Leon Claudia , Acosta-Calero Carmen , Kuzior Agnieszka , Perdomo-Herrera Esperanza , Lucia Tocino-Hernandez Alba , Javier Martinez Martin Francisco

Introduction: Acromegaly is associated with many different types of benign and malign neoplasm, putatively because of the chronic elevation of IGF-1. Colorectal, thyroid and breast neoplasms are well-established associations; there are many other possible ones, such as prostatic and uterine neoplasms, meningioma, leukemia, lymphoma, renal, pulmonary, esophageal and gastric tumors. Also in the context of MEN-1, parathyroid and pancreatic neoplasms are associated with acromegaly...

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ea0090p544 | Late-Breaking | ECE2023

Pituitary ACTH Secreting Carcinoma or metastasized Small Cell Pulmonary Carcinoma?

Lopes Sara , Margarida Monteiro Ana , Sa Juliana , Matos Catarina , Machado Catarina , Ribeiro Pedro , Almeida Rui , Marques Olinda

Pituitary carcinomas are rare and represent a challenge in clinical practice. Most secondary tumour localizations are intracranial and spinal, followed by liver, cervical lymph node, bone and, rarely, lung. PC frequently exhibit resistance to most usual therapies and the mean survival time is usually <4 years once metastases have been identified. Ectopic ACTH Syndrome is, in up to 50% cases, caused by lung tumours including carcinoids or Small Cell Lung Carcinomas (SCLC). ...

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ea0090p545 | Late-Breaking | ECE2023

AMH in men: Higher serum levels associated with healthy male aging

Tandl Veronika , Haudum Christoph W. , Eberhard Katharina , Hutz Barbara , Kolesnik Ewald , Schmidt Albrecht , Zirlik Andreas , von Lewinski Dirk , Scherr Daniel , Verheyen Nicolas , Pieber Thomas R. , Obermayer-Pietsch Barbara

Anti-Müllerian hormone (AMH), known for its role in fetal development and female reproduction, is also present in adult and elderly men in considerable amounts. In recent years, controversial findings regarding relations to age, other hormones, and BMI (possibly based on a dilutional effect due to higher blood volume) have been discussed. To date, little is known of its clinical relevance in this population. We aimed to further investigate AMH levels in an aging male popu...

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ea0090p546 | Late-Breaking | ECE2023

Polycythemia vera and feminizing hormone treatment in an individual Assigned Male at Birth (AMAB): a prickly situation

Parazzoli Chiara , Delle Donne Elisa , Federici Silvia , Amer Myriam , Persani Luca , Bonomi Marco , Bonadonna Stefania

Introduction: Feminizing hormone therapy (HT) for male-assigned at birth (AMAB) includes estrogens, often in combination with anti-androgens. Several studies have reported an increased incidence of cardiovascular diseases and venous thromboembolism in AMAB receiving estrogens. Indeed, procoagulant changes induced by estrogen-based HT occur in transwomen as well as in cisgender individuals. Therefore, using estrogen in gender-affirming HT is relatively contraindicated in those ...

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ea0090p803 | Late-Breaking | ECE2023

A case of functional hypercortisolism associated to alcohol abuse in a 43-year-old male

Santana-Ojeda Borja , Rios-Gomez Carlos , Jose de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Kuzior Agnieszka , Arnas-Leon Claudia , Acosta-Calero Carmen , Gonzalez-Diaz Paula , del Pino Ortiz-Hernandez Catherine , Javier Martinez Martin Francisco

Objective: Functional hypercortisolism associated with alcohol abuse is an infrequently diagnosed entity of unknown prevalence. Ethanol elicits hypothalamic oversecretion of CRH with subsequent increase in ACTH and cortisol. It may simulate Cushings disease both clinically and biochemically but there are no anatomic lesions and the diagnosis is confirmed by normalization of the biochemical pattern after at least 1 month of abstinence from alcohol. We hereby report a clin...

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ea0090p804 | Late-Breaking | ECE2023

Insulin Pump Therapy in Pregnant Women with type 1 Diabetes: Flash Glucose Monitoring vs Sensor Augmented Pump

Mariaca Riveros Karla , Milad Camila , Roca Daria , Amor Antonio , Gimenez Marga , Bellart Jordi , Vinagre Irene

Objectives: Pregnant women with type 1 diabetes (T1D) are associated with an increased risk of maternal fetal complications. Continuous subcutaneous insulin infusion [CSII] has been shown to improve metabolic control and perinatal morbidity. Few studies have compared the use of CSII with SAP (sensor augmented pump) therapy to flash glucose monitoring (FSL) in pregnant women with T1D. We aim to evaluate the possible differences between both monitoring systems associated with CS...

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ea0090p805 | Late-Breaking | ECE2023

Does the ‘obesity paradox’ have an expiration date? A bigdata retrospective cohort

Elkan Matan , Kofman Natalia , Minha Sa'ar , Rappoport Nadav , Zaidenstein Ronit , Koren Ronit

Background: Although obesity and overweight are associated with increased morbidity and mortality, higher body mass index (BMI) has been shown to be a protective factor from mortality in patients with acute infectious disease, also known as the obesity paradox. However, it is unknown whether these effects persist at long-term follow-up. Objective: To investigate the relationship between BMI and mortality after hospitalization with an infectio...

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ea0090p806 | Late-Breaking | ECE2023

Reduction of urinary albumin excretion with empagliflozin in patients with type 2 diabetes and uncontrolled hypertension

Arnas-Leon Claudia , Hernandez-Lazaro Alba , Santana-Ojeda Borja , Rios-Gomez Carlos , Jose de Leon-Durango Ricardo , Acosta-Calero Carmen , Kuzior Agnieszka , Maria Perez-Rivero Jennifer , Quintana-Arroyo Sara , Javier Martinez Martin Francisco

Introduction: Empagliflozin has a well-established anti-albuminuric effect in patients with T2DM, but in almost all available trials the baseline blood pressure was well controlled with SB P<140 mmHg. We analyzed the impact of empagliflozin treatment in patients with T2DM and uncontrolled hypertension, and its relationship with the changes in HbA1c and SBP.Methods: Retrospective analysis of the albuminuria, SBP and HbA1c data in patients wit...

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ea0090p807 | Late-Breaking | ECE2023

Retinal quantitative traits as prognostic factors for diabetic cardiomyopathy in people with type 2 diabetes: A scoping review

Sandoval Garcia Emmanuel , Stephani Hellwege Rubi

Introduction: Heart failure (HF) morbidity and mortality are increasing at an alarming rate in people with type 2 diabetes (T2D). Myocardial dysfunction may develop without ischemic heart disease (IHD), hypertension, or valvular pathologies, and which is defined as diabetic cardiomyopathy (DCM). Although the pathophysiology of DCM is unclear, DCM is initially characterised by myocardial fibrosis, dysfunctional remodelling, and associated diastolic dysfunction, later by systoli...

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ea0090p808 | Late-Breaking | ECE2023

Effects of oral semaglutide on the lipid profile of patients with type 2 diabetes mellitus and obesity: Are they mediated by body weight loss?

Kuzior Agnieszka , Santana-Ojeda Borja , Jose de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Rios-Gomez Carlos , Arnas-Leon Claudia , Acosta-Calero Carmen , Gonzalez-Diaz Paula , Maria Fernandez-Trujillo-Comenge Paula , Javier Martinez Martin Francisco

Introduction: It has been reported that patients with obesity and T2DM treated with oral semaglutide not only have a reduced total caloric input, but they also tend to reduce the proportion of fatty and sweet foodstuffs in an ad libitum diet. A modest improvement in the lipid profile of patients with obesity and T2DM treated with oral semaglutide has been reported, but its dependence on weight loss is not well established. We undertook to study the mediation effect of...

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ea0090p809 | Late-Breaking | ECE2023

Somatostatin Analogues or Active Surveillance in Sporadic and MEN1 associated Non-functioning Pancreatic Neuroendocrine Tumors

Raia Salvatore , Chiloiro Sabrina , Grazia Maratta Maria , Maiorano Brigida , Rossi Ernesto , Gabriella Brizi Maria , Rufini Vittoria , De Marinis Laura , Pontecorvi Alfredo , Tortora Giampaolo , Rindi Guido , Schinzari Giovanni , Bianchi Antonio

Introduction: Non-functioning (NF), sporadic and MEN1 associated, G1-G2 pancreatic neuroendocrine tumors (PanNETs) usually display an indolent course. Surgery is the first-choice treatment for localized tumors >2 cm. Unresectable or metastatic PanNETs expressing somatostatin receptors (SSTRs) are treated with somatostatin analogs (SSAs). The standard treatment for patients with PanNETs ≤ 2 cm is active surveillance (AS). Yet no evidence of the value of SSA treatment ...

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ea0090p810 | Late-Breaking | ECE2023

Evaluation with Dynamic Contrast Enhancement (DCE)-MRI in Patients with Acromegaly

Toygar Kalkan Ahmet , Ozer Ozge , Toprak Ugur , Efe Belgin , Akalin Aysen , Nur Kebapci Medine , Yorulmaz Goknur

Acromegaly is a rare disease with high morbidity and mortality associated with excessive secretion of growth hormone due to adenoma of somatotroph cells in the pituitary gland. In patients with acromegaly, residue may remain after surgical treatment, and disease control is attempted with surgery, medical treatment or radiotherapy for these patients. Pituitary imaging, IGF-1 and GH measurement are used in the follow-ups. Dynamic Contrast Enhancement perfusion MRI provides infor...

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ea0090p811 | Late-Breaking | ECE2023

Comparison of Metyrapone, OSilodrostat and KEToconazolE in the short-term thERapy of endogenous Cushing’s syndrome: preliminary results of the MOSKETEER study

Detomas Mario , Simeoli Chiara , Ceccato Filippo , Aulinas Maso Ana , Dolce Pasquale , Rubinstein German , Antonini Simone , Stelmachowska-Banaś Maria , Minnetti Marianna , Corsello Andrea , Dischinger Ulrich , Di Paola Nicola , Voltan Giacomo , Santos Vives Alicia , Braun Leah , Mazzarella Alessandro , DEUTSCHBEIN Timo , Lania Andrea , Isidori Andrea , Reincke Martin , Carla Scaroni , M Webb Susan , Pivonello Rosario , Fassnacht Martin , Altieri Barbara

Background: Steroid synthesis inhibitors, like metyrapone, osilodrostat, and ketoconazole are used as second-line treatment in all types of endogenous Cushings syndrome (CS). However, a direct comparison of these three drugs is missing. This study aimed to compare these drugs in the short-term therapy of CS.Design: Retrospective multicenter study involving 15 European centers.Methods: Patients with CS treated with metyrapone,...

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ea0090p812 | Late-Breaking | ECE2023

Importance of HLA in Grave’s orbitopathy development in Caucasian population

Stasiak Magdalena , Zawadzka-Starczewska Katarzyna , Tymoniuk Bogusław , Stasiak Bartłomiej , Lewinski Andrzej

Introduction: Graves disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. We have recently demonstrated novel, previously not reported association between a presence of alleles HLA-B*39:06, -B*37:01, -C*14:02, -C*03:02, -C*17:01, -DRB1*14:01 and GD. These alleles are independent risk factors, with no linkage disequilibrium with other,...

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ea0090p813 | Late-Breaking | ECE2023

Subacute thyroiditis development and its clinical course are HLA-dependent

Stasiak Magdalena , Tymoniuk Bogusław , Zawadzka-Starczewska Katarzyna , Stasiak Bartłomiej , Lewinski Andrzej

Introduction: Subacute thyroiditis is a thyroid inflammatory disease, triggered mainly by viral factors in genetically susceptible individuals. Up to 2020, only HLA-B*35 was confirmed as SAT-related. However, obviously in HLA-B*35-negative patients, some other genetic background occurs. Material and Methods: We performed HLA-typing using high resolution NGS method in different groups of patients with SAT and demonstrated the new association between HLA a...

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ea0090p814 | Late-Breaking | ECE2023

Is Patient Anxiety A Risk Factor for FNAB Sample Adequacy?

Can Senoymak Mustafa , Hale Erbatur Nuriye , Engin İsmail , Yonem Arif

Aim: Currently, imaging tools are increasing the frequency of thyroid nodules to 50%, and thyroid cancer risk is 7-15%. The most cost-effective, accurate diagnosis method is fine-needle aspiration biopsy (FNAB). However, non-diagnostic (ND) results can delay diagnosis, cause different procedures, raise costs, and distress patients. In addition, FNAB sample adequacy is affected by advanced age, nodule size (<5-10mm), cystic dominating nodules, macrocalcification, and hypo-e...

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ea0090p815 | Late-Breaking | ECE2023

Abstract withdrawn...

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25th European Congress of Endocrinology

BiosciAbstracts