Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

ea0090p206 | Thyroid | ECE2023

Thyroid Pyramidal Lobe Detection by Ultrasound in 1275 Consecutive Patients

Mammadov Emin

Background: The thyroid pyramidal lobe (TPL) represents a normal anatomical variation of the thyroid gland. Intraoperative TPL identification is of paramount significance, taking into account that the remnant TPL leads to higher thyroglobulin, could contain thyroid carcinoma foci and lead to recurrence.Methods: We conducted a prospective single-center, single-operator study to identify TPL in 1275 consecutive patients undergoing thyroid ultrasound for an...

ea0090p207 | Thyroid | ECE2023

Thymic Hyperplasia and Graves’s Disease: A Non-Incidental Association

Pla Peris Begona , Abellan Galiana Pablo , Franch Salvador Sara , Gonzalez Boillos Margarita , Maravall Javier , Angel Merchante Alfaro Agustin

Introduction: Grave’s disease (GD) is an autoimmune disease characterized by the development of thyroid-stimulating hormone (TSH) receptor antibodies that have a stimulating effect on the thyroid gland. There is a rare but non-incidental and well-documented association between GD and thymic hyperplasia (TH). Nonetheless, this association is often underdiagnosed in routine clinical practice and the mechanisms behind this association have yet to be thoroughly elucidated. Th...

ea0090p208 | Thyroid | ECE2023

Novel Thyroid Hormone Receptor-β Agonist TG68: a polypharmacological approach for the treatment of obesity-associated diseases

Ricardi Caterina , Polini Beatrice , Dettori Cristina , Saponaro Federica , Chiellini Grazia

Obesity is a multifactorial disease in which environmental conditions and genetic factors play an important pathogenic role [1]. Interestingly, some of these obesogenic environmental and genetic conditions are shared with neurodegenerative diseases (NDD). The common biological mechanisms involved in obesity and NDD are insulin resistance, pro-inflammatory cytokines, and oxidative damage, in turn leading to cognitive dysfunction or cell death. In this aspect, a poly-pharmacolog...

ea0090p209 | Thyroid | ECE2023

The TNAPP web-based algorithm improves thyroid nodule management in clinical practice. A retrospective validation study

Lisco Giuseppe , Renzulli Giuseppina , Frasoldati Andrea , Guglielmi Rinaldo , Angelo Giagulli Vito , Guastamacchia Edoardo , R Garber Jeffrey , Triggiani Vincenzo , Papini Enrico

The detection of thyroid nodules has been increasing over time, resulting in an extensive use of fine-needle aspiration (FNA) and cytology. Tailored methods are required to improve the management of thyroid nodules, including algorithms and web-based tools. To assess the performance of the Thyroid Nodule App (TNAPP), a web-based, interactive algorithmic tool, in improving the management of thyroid nodules, we carried out a preliminary analysis on a cohort of outpatients. One h...

ea0090p210 | Thyroid | ECE2023

The role of 18F-DOPA-PET/CT in medullary thyroid cancer patients with biochemical incomplete response

Gambale Carla , Faranda Alessio , Matrone Antonio , Prete Alessandro , Brogioni Sandra , Bottici Valeria , Agate Laura , Volterrani Duccio , Elisei Rossella

Background: PET/CT scan with 18F-fluoro-dihydroxyphenylalanine (18F–DOPA) is an emerging useful tool in medullary thyroid cancer (MTC) patients with high calcitonin (CTN) values. The aim of this study is to evaluate the potential usefulness of 18F-DOPA-PET/CT in MTC patients with biochemical incomplete response (BiR) (detectable CTN values and negative/indeterminate findings at CT scan with i.v. contrast).Materials a...

ea0090p211 | Thyroid | ECE2023

Improving the surgical indication of the Indeterminate TIR3B nodules: a prediction model based on clinical, ultrasound and cytological features

Sparano Clotilde , Puccioni Matteo , Adornato Virginia , Zago Elena , Maggi Mario , Petrone Luisa

Introduction: Indeterminate cytology still puzzles clinicians, due to its wide range of oncological risks. The new Italian cytological classification introduced in 2014 by SIAPEC-IAP split this category into TIR3A and TIR3B, according to a different cancer risk of <10% and <30%, respectively. Consequently, TIR3B nodules still have a surgical indication, even if more than half of cases will not result in thyroid cancer. The present study aims to analyse a consecutive se...

ea0090p212 | Thyroid | ECE2023

Iodine supply and thyroid status of women with gestational diabetes mellitus and their impact on birth outcomes

Vitkova Hana , Kratky Jan , Brutvan Tomas , Jiskra Jan , Anderlova Katerina , Radimerska Veronika , Bilek Radovan , Springer Drahomira , Votava Felix , Potlukova Eliska

Introduction: Urinary iodine concentration (UIC) and neonatal thyroid stimulating hormone (neoTSH) concentrations can reflect changes in iodine status and serve as a sensitive marker of iodine intake in pregnancy. As gestational diabetes mellitus (GDM) requires some diet modification, the study aimed to map the situation of iodine intake in women with GDM compared to healthy pregnant women and explore a relationship to thyroid function.Methods: In the tw...

ea0090p213 | Thyroid | ECE2023

Patients with Covid-19 induced atypical thyroiditis have thyroid-resident memory T-cells specific for SARS-CoV-2

Muller Ilaria , Silvestri Ylenia , Clemente Francesca , Maioli Sara , Carelli Elena , Moschetti Giorgia , Espadas Alejandro , De Feo Tullia , Mantovani Giovanna , Arosio Maura , Bombaci Mauro , Pesce Elisa , Grifantini Renata , Abrignani Sergio , Salvi Mario , Geginat Jens

Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19) is associated with the onset of thyroid dysfunction via multiple mechanisms. Patients hospitalised for severe Covid-19 disease may develop painless atypical thyroiditis coexisting with non-thyroidal illness syndrome, which determines transient thyrotoxicosis with quick restoration of euthyroidism during the following weeks. However signs of thyroiditis at ultrasound and sci...

ea0090p214 | Thyroid | ECE2023

Depression among hyperthyroid patients and the impact of Graves’ orbitopathy

Marković Bojan , Stojkovic Mirjana , Janić Tamara , Klet Sanja , Nedeljkovic Beleslin Biljana , Ciric Jasmina , Zarkovic Milos

Background: Thyroid hormones have regulatory effect on serotonin and noradrenaline and thyroid dysfunction is closely linked to some mental disorders. Besides depression and anxiety, and increased risk for suicide is demonstrated in patients with Graves’ disease (GD).The aim: of our research was to determine the symptomatology of depression in patients with hyperthyroidism and Graves’ orbitopathy (GO) and compare it with hyperthyroid patients w...

ea0090p215 | Thyroid | ECE2023

Nonfunctioning thyroid nodules in graves’ disease – do they harbor a higher risk of malignancy?

Salome Serranito Maria , Cunha Nelson , Abegao Matias Alexandra , Sabino Teresa , Martins Diana , Palha Ana , Matos Lurdes , Silva-Nunes Jose

Introduction: The prevalence of palpable thyroid nodules in Graves’ disease (GD) is approximately 15%. Cytopathologic interpretation in GD is challenging due to frequent cytomorphologic changes, namely after radioactive iodine (RAI) therapy. Some of the few published studies regarding fine-needle aspiration (FNA) in patients with GD, suggest an increased risk of malignancy of thyroid nodules arising in GD patients. However, the results are inconsistent, and there is no co...

ea0090p216 | Thyroid | ECE2023

UPLC-Q-TOF/MS-based metabolomics explored the metabolic mechanisms of thyroid cancer in different background

Sun Danyang , Li Xue , Wang Xuan , Ji Yanhui , Meng Zhaowei , Zheng Wei

Thyroid papillary carcinoma (PTC) is the most common endocrine tumor, Hashimoto’s thyroiditis (HT) is considered to be closely related to PTC pathogenesis, but their relationship still needs verification and exploration. Aim of the study. To analyze the differences and similarities of the metabolic mechanism of thyroid papillary carcinoma in normal and HT background, and to explore the relationship between HT and PTC. The Ultra performance liquid chromatography-q...

ea0090p217 | Thyroid | ECE2023

Autoimmune thyroid disease: a risk factor for thyroid cancer?

Salome Serranito Maria , Cunha Nelson , Abegao Matias Alexandra , Sabino Teresa , Milheiro Adelaide , Silva-Nunes Jose

Introduction: Some studies suggest a possible link between autoimmune thyroid disease (AITD) and thyroid cancer (TC). However, existing data is inconsistent, and no consensus exists regarding this question.Objective: The aim of this study was to analyze the association between TC and AITD, namely Hashimoto’s thyroiditis (HT) and Graves’ disease (GD).Methods: We conducted a retrospective and observational study of all pati...

ea0090p218 | Thyroid | ECE2023

Sonographic pattern and risk factors and malignancy in indeterminate thyroid nodules

Riestra Maria , Dieguez Felechosa Marta , Gandara Gutierrez Carmen , Gonzalvo Rodriguez Pablo , Rodriguez Villar Diana , Mendez Lopez Lorena , Fernandez Morais Raquel , Sanchez Canteli Mario , Valdes Gallego Nuria

Introduction: Fine-needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules, but fails to classify thyroid nodules in 15% to 30% of cases (indeterminate thyroid nodules-ITN). ‘Rule out’ molecular testing improves the diagnostic accuracy, with high sensitivity and negative predictive value, ranging from 86 to 96%. However, these tests are not widely available, and notably increase costs. <p ...

ea0090p219 | Thyroid | ECE2023

Graves ophthalmopathy in HIV patient: a case report

Seremet Aristia , Vudu Stela , Vudu Lorina

Background: Graves disease is a resurgent autoimmune condition that is known to occur during treatment and immune reconstitution in HIV, and it is one of the commonly diagnosed endocrinopathies in these patients. Graves orbitopathy, on the other hand, is a situation that occurs less frequently. We report the clinical features and manifestations of thyroid-associated orbitopathy in a case of an HIV patient with Graves disease.Case Presentation: A 48-year-...

ea0090p220 | Thyroid | ECE2023

C-reactive protein level in patients with autoimmune hypothyroidism before and after levothyroxine treatment

Vudu Stela , Seremet Aristia , Vudu Lorina

Hypothyroidism is one of the most common endocrine disorders. The long-time debatable question is whether patients with subclinical hypothyroidism (SH) should be treated with levothyroxine. Data are contradictory and treatment decision depends on several factors: TSH level, anti-TPO level, age, presence of symptoms etc. Hypothyroidism is associated with cardiovascular disease. Even a minor increase in C-reactive protein (CRP) is considered a cardiovascular risk, therefore evid...

ea0090p221 | Thyroid | ECE2023

Effects of Growth Hormone Therapy on Thyroid Function in Adults with and Without Concomitant Central Hypothyroidism in Growth Hormone-Deficient Patients

Shankar Anand , Kumar Das Amit

Introduction: Numerous thyroid function disturbances have been linked to the administration of growth hormone (GH) to GH-deficient patients. There have been reports of anything from increased energy expenditure and improved peripheral thyroxine (T4) to triiodothyronine (T3) conversion to decreased thyrotropin (TSH) sensitivity to thyrotropin-releasing hormone (TRH) stimulation and induction of hypothyroidism.Objective: GH has an impact on thyroid structu...

ea0090p222 | Thyroid | ECE2023

Prediction and Classification models for Hashimoto’s thyroiditis risk using clinical and paraclinical data

Corlan Ana-Silvia , Diogen Babuc , Flavia Costi , Darian Onchis

Background: Hashimoto’s thyroiditis (HT) is the most common autoimmune disorder and, also, the leading cause of hypothyroidism in iodine-sufficient areas. In recent years, a concept emerged, that thyroid autoimmunity could be associated with low-grade chronic inflammation, which may result in future cardiovascular comorbidities, independent of thyroid function. It is therefore essential to diagnose Hashimoto’s thyroiditis as early as possible and to test for thyroid ...

ea0090p223 | Thyroid | ECE2023

The Association of Iodothyronine Deiodinase Gene Polymorphisms and Hashimoto’s Thyroiditis: Does Free T3 Play a Role?

Armağan Turan Cem , Elbasan Onur , Apaydin Tugce , Gozaydınoğlu Buşra , Ilgin Can , Akalan Hande , Yaşar Şirin Duygu , Bircan Rıfat , Ilıksu Gozu Hulya

Introduction: Hashimoto’s thyroiditis (HT) is caused by a variety of genes, cytokines, receptors, and environmental factors. A series of enzymes known as type 1 and type 2 deiodinases (D1, D2) are in charge of converting thyroxine (T4) into triiodothyronine (T3). It is believed that the low free T3 (fT3) levels caused by D2 polymorphism may result in thyroid autoimmunity through the induction of inflammation. However, iodothyronine deiodinase (DIO) gene polymorphism and H...

ea0090p224 | Thyroid | ECE2023

PAX8-PPARγ rearrangement, galectin-3 immunoreactivity and risk of deep vein thrombosis (DVT) in patients with metastatic follicular thyroid cancer (FTC)

Katalinic Darko , Aleric Ivan , Primorac Dragan , Vcev Aleksandar

Introduction: Follicular thyroid cancer (FTC) account for approximately 15% of all thyroid malignancies, with about 65 % being conventional and 35 % Huürthle cell type. Recently a PAX8-PPARγ gene fusion was detected in a significant portion of FTCs, some with a chromosomal translocation t(2;3)(q13;p25). The t(2;3) rearrangement leads to an in-frame fusion of the PAX8 gene, which encodes a transcription factor, with the peroxisome proliferator-activa...

ea0090p225 | Thyroid | ECE2023

Clinical Characteristics of Differentiated Thyroid Carcinoma with Obesity and Glucose Metabolism

Wang Xuan , Zheng Wei , Li Xue , Sun Danyang , Ji Yanhui

Objective: To explore the association between body mass index (BMI) and plasma glucose level with pathological features and clinical outcomes of differentiated thyroid cancer (DTC).Methods: Clinical data of 1264 consecutive DTC patients treated with total thyroidectomy and enrolled at the time of the first 131I treatment from April 2016 to July 2020. The clinicopathological findings were compared in the groups were categorized according to BMI...

ea0090p226 | Thyroid | ECE2023

A retrospective study on the immunocitochemistry profile of benign thyroid nodules unresponsive to thermal ablation

Bernardi Stella , Taccogna Silvia , D'Angelo Martina , Giudici Fabiola , Mauri Giovanni , Raggiunti Bruno , tina doris , Zanconati Fabrizio , Papini Enrico , Negro Roberto

Objective: Thermal ablations (TA) are gaining ground as alternative options to conventional therapies for symptomatic benign thyroid nodules. Little is known on the impact of nodule biology on the outcomes of TA. The aim of our study was evaluating the baseline immunocytochemistry profile of thyroid nodules that are poorly responsive to TA, in order to identify potential predictors of treatment response.Methods: we retrospectively selected by propensity ...

ea0090p227 | Thyroid | ECE2023

Radioactive Iodine Treatment in Hyperthyroidism is Associated with Increased Body Weight

Al Jumaah Ali , Gohil Shailesh , Levy Miles J , Reddy Narendra

Introduction: Definitive treatment of hyperthyroidism with Radioactive Iodine (RAI) ablation therapy has been associated with weight gain from RAI induced hypothyroidism. Literature on weight data of post-RAI patients following normalisation of thyroid function is equivocal.Objective: We undertook a retrospective study to evaluate the effect of RAI on weight in Hyperthyroid patients in University Hospitals of Leicester NHS Trust (UHL). <p class="abst...

ea0090p228 | Thyroid | ECE2023

The role of thyroid autoimmunity in assisted reproduction outcome-not yet solved puzzle

Medenica Sanja , Garalejic Eliana , Abazovic Dzihan , Bukumiric Zoran , Arsic Biljana , Zarkovic Milos

Background: hyroid autoantibodies cross blood-follicle barrier in titer dependent manner and may change oocyte microenvironment with adverse effects on implantation or post-implantation period. Thyroid autoimmunity (TAI) interfers with pregnancy course and newborn anthropometry in pregnancy achieved by assisted reproduction (ART).Objective: To light upon pregnancy course outcomes and newborn anthropometric characteristics regarding TAI in ART programme.<...

ea0090p229 | Thyroid | ECE2023

Severe malnutrition associated with amyloid goiter: A case report

Jareno Martinez Carlos , Prats Custal Ariadna , Franco Borras Cristina , Martinez Guasch Laia , Michalopoulou Alevras Theodora , Naf Cortes Silvia , Castellote Caixal Manel , Samitier Pastor Alejandro , Raventos Estelle Antoni , Megia Colet Ana

Background: Amyloidosis is defined as the accumulation of amorphous, proteinaceous material in different parts of the body. It can be primary or secondary, having decreased the incidence of this last one due to the current therapeutic landscape of infectious and autoimmune diseases. This material can be deposited in the thyroid gland resulting in an enlargement known as Amyloid goiter. Although amyloid infiltration in thyroid is common, the occurrence of clinically enlarged th...

ea0090p230 | Thyroid | ECE2023

Exogenous Testosterone May Have A Effect on Thyroid Volume İn Trans-Men

Imre Eren , Akcay Seckin , Dincer Yazan Ceyda , Elbasan Onur , Yorguner Neşe , Ustay Ozlem

Purpose: Thyroid autoimmune diseases occur more frequently in women than men. A previous study reveals that exogenous testosterone may have a protective effect on thyroid autoimmunity in men with Hashimoto’s thyroiditis. But no study has determined whether sex hormones produce any effect on thyroid antibody titreş in women. The primary study aim was to assess whether exogenous testosterone affects thyroid autoimmunity in trans-men with increasing testosterone levels....

ea0090p231 | Thyroid | ECE2023

Differences between Unilateral and Bilateral Graves’ Orbitopathy. An observational study

Boutzios Georgios , Chatzi Sofia , Mina Areti , Fanouraki Maria , Giovannopoulos Ilias , Karampela Athina , Goules Andreas , Tzioufas Athanasios

Introduction: Graves’ Orbitopathy (GO), the most common extrathyroidal manifestation of Graves’ disease (GD), usually presents bilateral disease. However, a minority of patients present with unilateral disease, the prevalence of which is between 4,5% and 14%. The aim of our study is to evaluate the specific demographic and clinical characteristics and potential differences between bilateral and unilateral GO, and the association with disease activity and severity.</p...

ea0090p232 | Thyroid | ECE2023

Efficacy and Safety of Ultrasound-Guided Percutaneous Polidocanol Sclerotherapy Vs Percutaneous Ethanol Injection in Benign Cystic Thyroid Nodules: Preliminary Results

Ghazi Hossam , Gouda Sherihan , Saleh Mayada , Harb Dina

Introduction: Percutaneous Ethanol Injection (PEI) is well known treatment for benign cystic thyroid nodules; however, local pain is common side effect. Objective: To compare between efficacy and safety of Percutaneous Polidocanol Sclerotherapy (PPS) vs PEI.Patients and methods: We included 60 patients -with mean age 32 years- have benign thyroid nodules (9 of them were males). They were divided into 2 groups; group 1 with...

ea0090p233 | Thyroid | ECE2023

Impact of SARS-COV-2 infection on the endocrine system: a case series

Cristiana Calin , Florentina Burcea Iulia , Dobre Ramona , Dumitriu Roxana , Trifanescu Raluca , Poiana Catalina

Introduction: There is evidence that SARS-COV-2 infection can result in development of endocrine disturbances. Expression of the angiotensin-converting enzyme 2, which is postulated to be at the center of the pathogenesis of COVID-19, has been reported in various endocrine tissues.Case Series: We retrospectively analyzed 12 patients with recent history of SARS-COV-2 infection: 5 cases with subacute thyroiditis (SAT), 2 cases with Graves’ disease, 2 ...

ea0090p234 | Thyroid | ECE2023

Lower expression of miR-21 is related to multifocal lesions of papillary thyroid carcinoma

Kondrotienė Aistė , Daukša Albertas , Pamedytyte Diana , Kazlauskienė Mintautė , Žvirblienė Aurelija , Daukšienė Dalia , Simanavičienė Vaida , Klimaitė Raimonda , Šarauskas Valdas , Verkauskienė Rasa , Žilaitienė Birutė

Introduction: Multifocality empirically is often treated as a risk factor for aggressive course of papillary thyroid carcinoma (PTC), encouraging aggressive treatments. However, inconsistency and even contradiction in a literature is present concerning the role of tumor multifocality in clinical outcomes of PTC. Therefore, the prognostic value of multifocality of PTC remains controversial, creating a difficulty in the current clinical management.Methods....

ea0090p235 | Thyroid | ECE2023

Role Of liothyronine+Levothyroxine combination therapy in 70 overweight/obese patients with TSH between 2.5-5 unable to loose weight

Gupta Vishal , Teli Vaishali

Aim: To asses the role of Liothyronine (T3)+Levothyroxine combination (T4) therapy in 70 overweight/obese patients with Thyrotropin Stimulating Hormone (TSH mIU/ml) between 2.5-5 who were unable to lose weight. Methods: Between Jan’ 20 - Jan’ 21, 70 overweight/obese patients with TSH 2.5 -5 performed on &pm; 2 occasions &pm; 4 weeks apart were retrospectively analyzed. 24% {17/70} had TSH 2.5-2.99, 37% {26/70} had TSH 3-3.99 & 39% {27/70} h...

ea0090p236 | Thyroid | ECE2023

Clinical and Biochemical Comparative Evaluation of Thyroid Hormone Replacement in Patients with Hypothyroidism Due to Autoimmune Thyroiditis and Total Thyroidectomy

Akgul Kızılcay Zeynep , CAKIR İlkay , Kural Alev , Mert Meral

Aim: Hypothyroidism is a common chronical disease worldwide, leading to a lifelong metabolic slowdown that can have a significant negative impact on the quality of life, both physiologically and psychologically. Despite achieving euthyroidism with replacement, there is evidence that symptoms persist. In this study, we aim to examine the effectiveness of thyroid hormone replacement and the effect of autoimmunity from a clinical-biochemical point of view by evaluating the euthyr...

ea0090p237 | Thyroid | ECE2023

Analysis of types of thyroid surgery before and after COVID19 pandemics

Abdurakhmanov Humoyunxon , Ismailov Said , Rahmonberdieva Matluba , Shamansurova Zulaykho

Introduction: Thyroid surgery usually performed in 20% when traditional drug therapy was not effective, or development severe complications, or high risk/presence of cancer. New infection COVID19 affected whole body and probably thyroid results changes in clinical future and treatment. The aim of our study were investigate if frequency and type of thyroid surgery affected by COVID19 pandemics. Material and methods: We analysed and compared data from one ...

ea0090p238 | Thyroid | ECE2023

May Concomitant Thyroid Autoimmunity be Associated with Better Prognosis in Thyroid Papillary Carcinoma?

Celik Eliş Dilan , Cakir İlkay , Cem Dural Ahmet , Mert Meral

Aim: The association between thyroid autoimmunity and thyroid cancer has long been suggested, in addition whether and how the concurrent thyroid autoimmunity with Papillary Thyroid Carcinoma (PTC) affects clinicopathological features and prognosis is a matter of debate. In the present study, we aimed to evaluate the laboratory data, cancer characteristics and prognosis of PTC patients with and without thyroid autoimmunity.Materials and Methods: Data of 2...

ea0090p239 | Thyroid | ECE2023

2D-SWE PLUS in the assessment of thyroid malignancy

Borlea Andreea , Dana Stoian

Our study assesses the diagnostic performance of 2D shear-wave elastography plane-wave ultrasound (2D-SWE PLUS) in detecting thyroid cancer. Using conventional ultrasound (2B-mode) and 2D-SWE PLUS with SuperSonic Mach30 equipment, 270 thyroid nodules were assessed (Supersonic Imagine, France). In every instance, the outcomes and the pathology reports were compared. 69 (or 25.5%) of the 270 nodules were malignant. 2D-SWE PLUS parameters demonstrated great diagnostic accuracy. T...

ea0090p240 | Thyroid | ECE2023

Fatal bleeding and thrombosis in a patient with autoimmune primary hypothyroidism

Elomma Mrabet Houcem , Belkhiri Malak , Fadia Boubaker , Elloumi Yesmine , Baha Zantour , Wafa Alaya , Mohamed Habib Sfar

Introduction: Thyroid diseases have been known to cause haemostatic changes, either tendency to bleeding or thrombosis. We report a case of a patient with primary hypothyroidism presenting with spontaneous bleeding and jugular thrombosis.Case report: An 85-year old patient with no medical history was admitted to the endocrinology department with primary auto-immune hypothyroidism. Hypothyroidism was suspected because of severe loss of weight and appetite...

ea0090p241 | Thyroid | ECE2023

Investigations on fibroblast growth factor 21 and lipid parameters in patients with Hashimoto thyroiditis

Bak-Csiha Sara , Hutkai David , Lőrincz Hajnalka , Harangi Mariann , Bodor Miklos , Katko Monika , Nagy Endre , Paragh Gyorgy , Eszter Berta

Background: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. Enhanced FGF21 production in diabetes and obesity reduces the level of LDL-C and triglycerides by suppression of hepatic SREBP-2. Hypothyroidism has also been shown to have unfavorable effects on atherogenesis and dyslipidemia. To date, the association of lipid p...

ea0090p242 | Thyroid | ECE2023

Thyroid manifestations in two different genetic syndromes

Shoaib Zaidi Muhammad

Introduction: The sensitivity of tissues to thyroid hormones can be impaired rarely, either due to the genetic anomalies of the thyroid hormone metabolism and transport. Consequently, the relative triiodothyronine(T3), thyroxine(T4), and reverseT3(rT3) levels get disturbed and different clinical manifestations ensue. Two recently admitted cases are briefly described.First Case: A 32 yrs old Saudi housewife, had been admitted to our hospital on 05.01.2023...

ea0090p243 | Thyroid | ECE2023

Amiodarone-Induced Thyroid Disorders Not Uncommon

Khan Alaina , Lowe Miriam , Hayat Maisha , Ahuja Sanjali , English Robert , Hamid Kedir , Saleem Muhammad , Mahamud Bashir , Mohamed Ayan , Ramachandran Kirtanya , Mohammed Mohammed , Mlawa Gideon

Introduction: Amiodarone is a highly effective drug, used for the treatment of arrhythmias. However, it can cause either hypothyroidism or thyrotoxicosis. It leads to alterations in thyroid gland function or thyroid hormone metabolism, due to its high iodine content. Amiodarone-induced hypothyroidism is common in countries with high iodine dietary intake, and Amiodarone-induced thyrotoxicosis is more prevalent in regions with low iodine dietary intake. A large amount of iodide...

ea0090p244 | Thyroid | ECE2023

Graves’ Disease and Muscle Paresis

Francaitė-Daugėlienė Miglė

Background: Graves’ disease is medical condintion requiring early diagnosis and urgent management, which can be challenging due to diverse clinical presentations. The presence of muscle paresis is rare. Case Presentation: We report a 38-year-old female who presented with muscle paresis, urine and fecal incontinence, because of thyrotoxicosis due to Graves’ disease. Clinical manifestation: general weakness, body tremor, tachycardia, palpitations...

ea0090p245 | Thyroid | ECE2023

Large rapidly developing goiter and Acute Leukemia

Ben Hadj Slama Nassim , Saad Ghada , Asma Gorchene , Elfekih Hamza , Kacem Maha , Molka Chadli

Introduction: Many thyroid conditions are associated with the development of a rapidly progressing goiter and should evoke several diagnoses, some of which may be of poor prognosis.Case-presentation: A 47-year-old female patient with no previous pathological history presented with a large goiter associated with a deteriorated general condition that had been evolving for 3 weeks On examination, she presented with a fever at 39°C, multiple cervical ad...

ea0090p246 | Thyroid | ECE2023

Hidden central hypothyroidism in an elderly patient following radioiodine therapy

Aycha Ghachem , Elfekih Hamza , Bnina Molka Ben , Saad Ghada , Kenza Houd , Hasni Yosra , Chadli Chaieb Molka

Introduction: Thyrotropin deficiency is a rare etiology of hypothyroidism. The diagnosis can be easily confirmed in case of low FT4 level associated with normal or low TSH value. In patients with peripheral hypothyroidism treated by levothyroxine, this biochemical profile become difficult to find. Herein, we describe the case of a patient with peripheral hypothyroidism due to radioiodine therapy in whom the diagnosis of central hypothyroidism was made.Ob...

ea0090p247 | Thyroid | ECE2023

Noise Level, Salivary Cortisol Levels and Surgical Team Stress During Thyroidectomy in An Endocrine Surgery Operating Room

Idrees Sarrah , Mayilvaganan Sabaretnam , Bhargav Panchangam Ramakanth , Chan Gyan , Mishra Anjali , Agarwal Gaurav

Introduction: Noise in the operating room is an ongoing problem and impacts the outcome of surgery. Noise as stressor can produce a startle reaction and activate fight or flight response of the autonomic and endocrine system. The psychobiology of the stress as assessed by salivary cortisol level is a sensitive measure of allostatic load. In this study, we correlated salivary cortisol levels of the surgical team with noise measurement and also whether the noise in OR subjective...

ea0090p248 | Thyroid | ECE2023

Individual experiences and patients’ lives: Place of the narrative approach in the therapeutic education plan for thyroid cancer patients

Mouhaymen Missaoui Abdel , Hamza Fatma , Soomauroo Siddiqa , Ben Ahmed Khawla , Belabed Wafa , Abid Mohamed

Objective: To describe the experience of patients with differentiated thyroid carcinoma (DTC) since their diagnosis.Patients and Methods: Cross-sectional study including 25 patients with DTC who integrated the therapeutic education program (TPE) on DTC at the Nuclear Medicine Center, Sfax, Tunisia. Each participant recounted his or her experience during collective meetings (narrative approach). Results: Our group was composed of 19...

ea0090p249 | Thyroid | ECE2023

Papillary Thyroid Carcinoma with Abdominal Desmoid-Type Fibromatosis – A Case Report

Poshi Klodiana , Haxhiraj Adela , Kermaj Marjeta , Hoxha Violeta , Ylli Dorina , Toti Florian , Shehu Tea , Muja Ardita , Cerma Adishah , Zotaj Ina , Ylli Agron

Introduction: Papillary Thyroid Carcinoma is the most frequent malignant tumour of the thyroid gland. It usually progresses slowly and is rarely metastatic. On the other side, fibromatosis are usually benign tumours with infrequent malignant appearances, which affect musculoaponeurotic structures. The aetiology remains unclear, although various possible factors are linked to it such as trauma, genetic predisposition, β-catenin heterozygous mutation, hormone disbalance etc...

ea0090p250 | Thyroid | ECE2023

Coexistence of Atypic Parathyroid Tumor and Metastatic Thyroid Papillary Carcinoma

Kostek Hatice , Yener Ozturk Feyza , Kuver Begum , Abul Rabia , Doğan İpek Fatma , Canat M. Masum , Erol Selvinaz , Cil Sen Esra , Kostek Mehmet , Taner Unlu Mehmet , Cihangiroglu Gulcin , Ozel Alper , Altuntas Yuksel

Introduction: Atypical parathyroid tumour (APT) is a rare cause of primary hyperparathyroidism (PHPT) with a frequency of 1.2-1.3%. APT is a lesion with suspicious clinical and histological features of malignancy which does not completely respect the World Health Organization (WHO) criteria for diagnosis of Parathyroid Carcinoma (PC). There is a well-known association with PHT and medullary thyroid carcinoma for multiple endocrine neoplasia. However, concurrence of thyroid pap...

ea0090p251 | Thyroid | ECE2023

Dwarfism of the Laron type with normal high affinity serum growth hormone-binding protein

Chandra Abhishek , Kumar Singh Vijay

Introduction: An autosomal recessive illness called the syndrome of familial GH-resistant short stature is characterized by a phenotype that is similar to that of isolated GH deficiency, but with normal or excessive GH production and decreased IGF-I synthesis. When these individuals are treated with GH, neither growth nor a rise in blood somatomedin/IGF-I activity—the mediator of GH’s growth-promoting effects—are stimulated. This suggests that the cause of the g...

ea0090p252 | Thyroid | ECE2023

Role of Ayurveda based novel ‘Thyroid detoxification program’ in the management of hypothyroid patients

Vikrant Patil Dr , Patil Dr. Sushama , Menkudale Bhavana , Naik Ninad

Background: The aim of study was to determine the effectiveness of Thyroid detoxification program therapy in patients of hypothyroidism, attending TATC clinic in Maharashtra. According to the clinical survey from various studies on thyroid disease, it has been estimated that about 32% of people suffer from thyroid diseases in India out of which 10.7 % of people have hypothyroidism. According to health experts, even though hypothyroidism is easy to detect and inexpensive to tre...

ea0090p253 | Thyroid | ECE2023

Interplay between thyroid, amiodarone and heart - case presentation

Hrabar Mirna , Matijaca Ana

Background: Amiodarone is a commonly used antiarrhythmic drug, but because of its abundance with iodine and a direct toxic effect on the thyroid, it can have side effects like hypo- and hyperthyroidism. There are two types of amiodarone-induced thyrotoxicosis (AIT). We present a case which demonstrates the importance of timely diagnosis and appropriate treatment of amiodarone-induced thyrotoxicosis in patients with serious cardiac comorbidities.Case pres...

ea0090p254 | Thyroid | ECE2023

Endocrine adverse events associated with immune checkpoint inhibitors - A case series

Anne-Marie Stefan Andreea , Iulia-Florentina Burcea , Roxana Ioana Dumitriu , Ramona Dobre , Nicoleta Baculescu , Ionela Baciu , Radian șerban , Cristina Căpățină , Trifanescu Raluca , Poiana Catalina

Background: Immune checkpoint inhibitors (ICIs) are a novel group of drugs, used for treatment of various types of malignancies. The receptors cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1) or its ligand (PDL-1) are targeted by those inhibitors. They are associated with immune-related adverse events (irAEs). Endocrinopathies are the most frequent irAEs with a prevalence of approximately 10%. Case study: We retrospect...

ea0090p255 | Thyroid | ECE2023

Two-year case series of a thyroid consultation at a hospital unit

Silva Maria Helena F. , Serejo Portugal Rita , Matos Goncalves Andre , Nagirnyak Volodymyr , Gabriel Oliveira Baltazar , Marques Carlos , Cabeleira Joana , Rita Sanches Ana , Cunha Martins Sonia , Sousa Carvalho Margarida

This paper aims to describe the followed population in the consultation, through a retrospective study in a hospital unit. This retrospective study was carried out during February 2020 to February 2022, and analyses the clinical processes of the patients that were followed in this consultation, and later analysing the data using Microsoft Excel® Over these two years, 395 patients were observed. These patients age average 61 years old, ranging from 17 to 93 years of age. M...

ea0090p256 | Thyroid | ECE2023

Non-secreting pheochromocytoma or adrenal metastasis of medullary thyroid cancer? When the differential diagnosis is difficult

Bouchenna Amira , Kablia Samia Ould

Introduction: Medullary thyroid cancer (MTC) accounts for 5-10% of thyroid cancers.25% of cases may be hereditary related to multiple endocrine neoplasia type 2 A (MEN2A) and associated with pheochromocytoma. Metastases from CMT are preferentially lymph node chains. However, other localizations are possible such as adrenal metastases which remain exceptional.Observation: We report the case of a 35-year-old patient with CMT for which he underwent thyroide...

ea0090p257 | Thyroid | ECE2023

Fear of recurrence of differentiated thyroid cancer in patients in remission

Mouhaymen MissaouI Abdel , Hamza Fatma , Soomauroo Siddiqa , Ben Ahmed Khawla , Belabed Wafa , Abid Mohamed

Objective: to evaluate the fear of recurrence of differentiated thyroid cancer (DTC) in patients in complete remission. Patients and Methods: Cross-sectional study of 41 patients in complete remission after treatment of DTC, followed up at the Nuclear Medicine Centre of Sfax, Tunisia. The evaluation was based on the administration of a shortened version of the Fear of Cancer Recurrence Inventory (FCRI-SF) to all patients (maximum score 36 points)<p c...

ea0090p258 | Thyroid | ECE2023

Widely invasive follicular thyroid carcinoma. A case report

Contreras Pascual Cristina , Gonzalez Lazaro Paloma , Zhao Montero Benitez Maria , Jimenez Torrecilla Pedro , Almendra Alvarado Rosas Karol

Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer, making up about 10 to up to 15% of all thyroid cancers. It is called a ‘well differentiated’ thyroid carcinoma, like papillary thyroid cancer, but it is typically more aggressive than this. We report the case of a 75-year-old man with personal history of Type 1 Diabetes since he was 25 years old, with severe nonproliferative diabetic retinopathy (blindness) and multinodular goiter. I...

ea0090p259 | Thyroid | ECE2023

Male with Graves Disease and Primary Thyroid Cancer in the Thyroglossal Cyst

Logwin Sergio , Ruiz Diaz Daisy , Jimenez Violeta , Bueno Elvio , Romero Fabiola

Introduction: The malignancy of the thyroglossal duct cyst is infrequent, 0.7 to 1% of the thyroglossal duct cysts, predominantly in women and euthyroid subjects, some associated with Hashimoto’s Thyroiditis. Clinical case: Male, 42 years old, with a 5-year history of a large anterior cervical tumor, diagnosed with Graves’ disease and thyroid orbitopathy. Cervical ultrasound reports right submandibular region mixed tumor mass 36 x30. mm with no...

ea0090p478 | Thyroid | ECE2023

Mouse model of Graves’ ophthalmopathy induced by the immunization with TSHR A and IGF-1Rα subunit gene

Zheng Wei , Wu Ruixin , Li Ning , Wang Xuan , Wang Shen , Tan Jian

Background: The study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ ophthalmopathy (GO; GD+GO) that can represent the clinical disease characteristics.Methods: A eukaryotic expression plasmid of insulin-like growth factor 1 receptor (IGF-1R) α subunit (pcDNA3.1/IGF-1Rα) and a thyrotropin receptor (TSHR) A subunit plasmid (pcDNA3.1/TSHR-289) were injected in female BALB/c mice to induce a GD+GO model. Grouping w...

ea0090p479 | Thyroid | ECE2023

Clinical significance of IgG4 serum concentration in Graves Disease – a pilot study

Olejarz Michał , Szczepanek-Parulska Ewelina , Hernik Aleksandra , Sawicka-Gutaj Nadia , Ruchala Marek

Background: Immuglobulin 4 (IgG4) is the least common subtype of Immoglobulin G. However due to its unique characteristic it has been the focal point of many research projects, which eventualy led to the discovery of the sytemic fibro-inflammatory disorder called IgG4-Related Disease. The potential role of IgG4 in the pathogenesis of autoimmune thyroid diseases has been also suggested. However, the amount of evidence is still limited, especially in Graves Disease (GD).<p c...

ea0090p480 | Thyroid | ECE2023

A Prospective Comparitive Study on Cardiovascular Dysfunction and its Reversal After Treatment in Patients with Graves and Toxic Multi Nodular Goitre

Sankaran Muthukumar , Krishnan Ravikumar , Salmon Mohammad , Sundarram Thalavaai , Sadacharan Dhalapathy , Ibrahim, Syed

Cardiovascular dysfunction (CVD) is a well recognized complication in patients with hyperthyroidism and is the major cause of mortality. To date there has been no studies which had clearly evaluated the CVD and its recovery pattern between patients with Graves and Toxic multi nodular goitre(TMNG). Hence we intended to compare treatment outcomes in patients with Graves and TMNG. Patients with hyperthyroidism were grouped into, Group 1 [n=133, age<6...

ea0090p481 | Thyroid | ECE2023

CytoFoam core device: an innovative support for immunocytochemical assessment in cytologically indeterminate thyroid nodules

Novizio Roberto , Taccogna Silvia , guglielmi rinaldo , Persichetti Agnese , Papini Enrico

Background: Fine needle aspiration (FNA) is the procedure of choice in the evaluation of thyroid nodules. Nodules with indeterminate cytological categories, Bethesda III and IV, pose challenges in clinical practice and are frequently submitted to diagnostic surgery. Immunohistochemistry provides complementary information to cytological findings but its reliable use on FNA samples is hampered by technical problems. CytoFoam Core (CFCS), an absorbent foam device inserted into th...

ea0090p482 | Thyroid | ECE2023

Sonographic and clinicopathological differences between non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and minimally invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC)

Erturk Banu , Gaye Guler Yesim , Gurlek Alper

Background: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly described indolent thyroid tumor with well-defined histopathological diagnostic criteria. Even though the histopathologic features and diagnostic criteria for NIFTP are well-established, preoperative diagnosis using sonographic or fine needle aspiration findings has yet to be confirmed. The aim of this study is to compare the clinical, sonographic, and cytological charac...

ea0090p483 | Thyroid | ECE2023

Cytokine levels and the effect of the Covid-19 pandemic on the course of Graves’ disease under antithyroid treatment

Sarıbeyliler Goktuğ , Oyacı Yasemin , Merve Ok Ayşe , Şenturk Ciftci Hayriye , Pehlivan Sacide , Yarman Sema

Objective: Graves’ disease (GD) occurs as a result of genetic and environmental factors that trigger autoimmunity. Some pro-inflammatory cytokines have already been linked to an increased susceptibility of developing GD. Recently, it has been reported that Covid-19 infection and SARS-CoV-2 vaccination trigger the emergence of new GD cases or disease recurrence as environmental factors due to the pandemic. However, there is no data in the literature reporting the effects o...

ea0090p484 | Thyroid | ECE2023

Normative Values for the Hypoparathyroidism Patient Questionnaire (HPQ28) in the General German Population

Blaschke Martina , Wilde Deborah , Schulz Maxi , Herrmann-Lingen Christoph , Siggelkow Heide

Introduction: Patients with hypoparathyroidism (hypoPT) suffer from a number of complaints and reduced quality of life (QoL) besides having serum values for disease-specific parameters in the target range. To be able to quantify symptoms in hypoPT patients we lately developed a disease-specific questionnaire, the Hypoparathyroidism patient questionnaire with 28 items (HPQ28). The aim of this study was to present normative values for the HPQ28.Methods: A ...

ea0090p485 | Thyroid | ECE2023

Graves’ Disease in A Patient with Thyroid Hormone Resistance

Copuroğlu Esra , Baykal Gokhan , Dibeklioğlu Bilge , Nasiroglu Imga Narin , Dirikoc Ahmet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: While Graves’ disease is a common cause of thyrotoxicosis, tyroid hormone resistance (THR) is a rare cause of high thyroid hormones. Coexistence of Graves’ disease and THR which can cause quite a lot of difficulties in diagnosis and treatment was reported very rarely in the literature. Here, we report a patient with THR and Graves’ disease in whom remission was achieved with medical therapy.Case: A 38-year-old woman applied t...

ea0090p486 | Thyroid | ECE2023

History of Goiter in The Mother is Associated with Thyroid Volume, TSH and Thyroid Heterpogeneity in Women at Midlife

Dilek Erzengin Zeynep , Kale Banu

Family history of thyroid disease (Karger 2010) and family history of goiter (Singer 2011, Knudsen 2003, Gebremichael 2020) were found to be associated with risk of goiter though some did not observe this association (Phitayakorn 2006). On participants of the Isparta Menopause and Health (IMH) Study, we measured TSH (n=1099) and thyroid sonographic parameters (n=994) including TV, thyroid nodularity (TN) and heterogeneity (TH). Health related factors and hist...

ea0090p487 | Thyroid | ECE2023

Is there a paradigm shift for the evaluation and treatment of isthmic thyroid nodules?

Babayid Yagmur , Gokcay Canpolat Asena , Ceyhan Koray , Corapcioğlu Demet , Şahin Mustafa

Introduction: Although the thyroid isthmus seems like a structure that connects bilateral lobes, it is an undiscovered area that needs to be explored. Currently, the data is evolving that the increase in the risk of malignancy is higher in the isthmic nodules, and extrathyroidal extensions and lymph node metastases are more common in isthmic-derived malignant thyroid nodules. Therefore, we aimed to compare the malignancy rate of isthmic and lobar nodules, the ultrasonographic ...

ea0090p488 | Thyroid | ECE2023

Evaluation of Factors Determining Iodine Refractoriness in Thyroid Carcinoma

Erten Aslı , Abidin Sayıner Zeynel , Koroğlu İpek , Oğuzkan Balcı Sibel , Akarsu Ersin

Introduction: Radioiodine-resistant thyroid carcinoma is an important milestone in the treatment and follow-up of thyroid cancers. The biological defects of iodine uptake in thyroid cancer cells should be well known. In this study, we aimed to evaluate the clinical and pathological features and SLC5A5 gene expression status of iodine-refractory papillary thyroid carcinoma patients. Material-Method: We studied SLC5A5 expression in 83 papillary thyroid car...

ea0090p489 | Thyroid | ECE2023

Microscopic Calcifications Isolated from Thyroid Nodule Fine Needle Aspiration Can Serve as Biomarkers of Thyroid Nodule Malignancy

Yoel Uri , Fraenkel Merav , Gotnayer Lotem , Aranovich Dina , Vidavsky Netta

Background: When US characteristics and the diameter of a thyroid nodule (TN) justify further evaluation to rule out or to establish the diagnosis of thyroid cancer (TC), fine needle aspiration (FNA) biopsy for cytology (FNAC) is indicated. A major limitation of FNAC is the high rate of indeterminate significance (~30%) results, which require further evaluation. Although recently introduced molecular testing contributed to the ability to differentiate benign from malignant TNs...

ea0090p490 | Thyroid | ECE2023

Challenges in the management of endocrine complications after hematopoietic stem cell transplantation – could it be reconstitution Graves’ disease?

Grosu Iustina , Dumitrache Sabina-Maria , Stan Raluca , Zubaci Ana , Iliescu Marina , Tarna Mihaela , Jercan Cristina , Colita Anca , Nicoleta Cima Luminita , Fica Simona

Background: The rapid advancements in the field of allogenic hematopoietic stem cell transplantation (allo-HSCT) and better management of acute postprocedural complications have led to increased life expectancy, but at the same time to higher incidences of long-term complications. Conditioning regimens (chemotherapy, total body irradiation), immunosuppresive treatments and immune dysregulation threaten endocrine and metabolic functions, leading to late effects, including hypog...

ea0090p491 | Thyroid | ECE2023

A life threatening manifestation of severe hypothyroidism

Seshadri Shyam , Nata Raja

A 29 year old lady with a past history of seronegative rheumatoid arthritis, Vitamin B12 deficiency, autoimmune hypothyroidism and fibromyalgia who had feeling unwell with a left sided headache for a few days had a fall at home witnessed by her friend. She was noted to be in peri arrest state by ambulance crew on their arrival. Agonal breathing was noted and monitor revealed VF. She was given 5 DC shocks with return of spontaneous circulation and regained consciousness. She wa...

ea0090p492 | Thyroid | ECE2023

Resistance to Thyroid Hormone Beta in a 12-Year-Old Patient: Clinical, Laboratory, and Molecular Characteristics

Lozovanu Vera , Alina Silaghi Cristina , Emanuela Georgescu Carmen

Background: Resistance to thyroid hormone beta (RTHβ) is an inherited syndrome of reduced tissue responsiveness to thyroid hormones (THs). It is driven in 85% of cases by mutations in the thyroid hormone receptor beta (THRb). The estimated incidence is 1:40.000 to 1:19.000 live births. We report the clinical, laboratory, and genetic analysis of a patient with this disorder.Case report: A 12-year-old boy with a history of Attention-Deficit/H...

ea0090p493 | Thyroid | ECE2023

Role of thyroid hormones in the development of neurodegeneration in rats

Mustafakulov Muhammadjon , Saatov Talat , Ishankhodjaev Takhir , Yalalova Ilmira , Shamansurova Zulaykho

Introduction: Neurodegeneration is one of the most common condition accompanied Diabetes Mellitus, Parkinson’s and Alzheimer’s diseases. Although its mechanisms intensively studied for many years, some questions of pathogenesis remain unclear. The aim of the study was investigate the effects of thyroid hormones and some neurotransmitters on the cerebral cortex of rats with experimental neurodegeneration. Materials and methods: Series of experim...

ea0090p494 | Thyroid | ECE2023

The utility of salivary thyroid hormones in assessment of thyroid function

Sawicka-Gutaj Nadia , Glinicki Piotr , Nijakowski Kacper , Bromińska Barbara , Ostrowska Magdalena , Szatko Alicja , Sobol Zuzanna , Kowalski Konrad , Wilk Paweł , Zgliczyński Wojciech , Ruchala Marek

Introduction: Saliva is an interesting alternative to blood in clinical evaluation of endocrine function. Certain advantages of saliva collection must be considered, when comparing with conventional blood sampling. Vital arguments are that procedure is easy, non-invasive and stress-free. The studies on correlation between salivary and serum thyroid hormones are scarce and contradictory. The goal of our research was to assess if salivary thyroid hormone levels reflect serum con...

ea0090p495 | Thyroid | ECE2023

Weight Variability with the Treatment of Graves’ Disease in Adults

Lopes Leonor , Tavares Bello Carlos , Cunha Clara , Antunes Carolina , Limbert Clotilde , Manuel Sequeira Duarte Joao

Introduction: Graves disease (GD) is a frequent cause of primary hyperthyroidism and often presents with weight loss. Weight gain beyond the premorbid state is often reported and could be a challenge during patient’s management. Treatment modalities, disease remission and biochemical parameters at the diagnosis have been described as predictors of weight changes in patients with GD. Objectives: To evaluate the determinants of weight changes in GD tr...

ea0090p496 | Thyroid | ECE2023

Amyloid Goiter, Papillary Thyroid Microcarcinoma and Diffuse Thyroid Lipomatosis – a case report of a rare association

de Assuncao Guilherme V. , Fonseca Liliana , Couto de Carvalho Andre , Freitas Claudia

Introduction: Amyloidosis is a disease characterized by the accumulation of an amorphous proteinaceous material, known as amyloid, in various organs and tissues of the body. Amyloid goiter is a remarkably rare pathologic condition due to thyroid massive amyloid infiltration of amyloid light chain (primary) or amyloid A (secondary amyloidosis) proteins. Case: 54 year-old male, with known history of chronic tophaceous gout medicated with anakinra and predn...

ea0090p497 | Thyroid | ECE2023

Course of Papillary Thyroid Carcinoma Diagnosed in Childhood and Adolescence and Followed Through Adulthood: Experience from a Tertiary Referral Center

Hacisahinogullari Hulya , Inan Balci Elif , Yenidunya Yalin Gulsah , Soyluk Selcukbiricik Ozlem , Bas Firdevs , Kubat Uzum Ayse , Poyrazoglu Sukran , Gul Nurdan

Introduction: Differentiated thyroid cancer accounts for 1.5% of all pediatric malignancies. Papillary thyroid cancer (PTC) is the most common subtype and is associated with more advanced disease at diagnosis compared to adults. The aim of this study was to identify long-term outcomes of pediatric PTC.Methods: Records of 30 patients with PTC diagnosed in childhood and adolescence and followed up at Istanbul Faculty of Medicine were reviewed retrospective...

ea0090p498 | Thyroid | ECE2023

Performances of ABEI-based automated immunoassays thyroid function tests

Gruson Damien

Background: Diagnosis and monitoring of thyroid diseases rely on thyroid function tests. Testing for Thyroid Stimulating Hormone (TSH) and free thyroxin (FT4) are frontline assays for the diagnosis of hyper- and hypothyroidism. Measurement of TSH receptor autoantibodies (TRAB) is pivotal for the diagnosis of Graves’ disease. Our study objective was to determine the performances of ABEI-based automated immunoassays for measurement of TSH, FT4 and TRAb.<p class="abstext...

ea0090p499 | Thyroid | ECE2023

Radioiodine therapy outcomes in benign thyroid disease at the University Hospital of Wales, UK

Nagarajah Kalyani , Jones Elizabeth , Witczak Justyna , Taylor Peter , Lansdown Andrew

Background: Radioiodine therapy (I-131) is commonly prescribed for benign thyroid disease in keeping with recommended guidelines.Aims: To determine the effectiveness of I-131 in treating benign thyroid disease and the rates of hypothyroidism following treatment and by diagnosis.Methods: We identified 100 patients who received radioiodine therapy between November 2013 and June 2015 from a database held in the Medical Physics Departm...

ea0090p500 | Thyroid | ECE2023

The iodine study in pregnancy: no correlation between serum thyroglobulin and urinary iodine concentration

Žabkova Kristyna , Kratky Jan , Jiskra Jan , Krausova Adela

Background: Despite obligatory iodination of salt in the Czech Republic, pregnant women with higher demands on iodine intake may be at risk of iodine deficiency with potentially negative consequences for the course of pregnancy and foetal development. Determination of urinary iodine concentration (UIC) is a conventional but not widely available method used to estimate the iodine status. Based on previous studies, serum thyroglobulin (Tg) could serve as a more convenient marker...

ea0090p501 | Thyroid | ECE2023

An unremarkable presentation but signs of Grave danger: Never forget the thyroid function

Essame Jenna , M Williams David , Shaikh Ayesha , Atkinson Michael , Udiawar Maneesh , Boregowda Kusuma

Introduction: Profound thyrotoxicosis commonly presents with heat intolerance, sweating, weight loss, palpitations, tremor, goitre and eye signs in the case of Grave’s disease. Typically, thyroid storm is differentiated by marked volume depletion, congestive cardiac failure, cardiac arrhythmias, confusion, nausea and vomiting, often with extreme agitation. The wide-ranging and systemic manifestations associated with profound hyperthyroidism are mediated through the thyroi...

ea0090p502 | Thyroid | ECE2023

Long-Term Effects of Radioiodine Treatment on Thyroid Functions, Thyroid Volume, Nodule Volume and Ultrasonographic Features in Patients with Toxic Adenoma and Toxic Multinodular Goitre

Koc Ilgın , Begum Bahcecioglu Mutlu Adile , Avcı Merdin Fatma , Araz Mine , Erdogan Murat

Background: Radioiodine(RAI) has been used to treat hyperthyroidism for more than seven decades. Effects of RAI treatment on thyroid function tests(TFT), risk of hypothyroidism, gland and autonomous nodule volumes and on ultrasonographic features in toxic adenoma (TA) and toxic multinodular goitre TMNG patients, have been previously studied by ourselves and other. However, studies evaluating ultrasonographic changes in thyroid and toxic nodule volumes usually have a follow-up ...

ea0090p503 | Thyroid | ECE2023

Thyroid status in patients after COVID19 in iodine deficiency region

Karimova Mukima , Shamansurova Zulaykho

Introduction: Coronavirus infection COVID19 spread by Sars-Cov-2 virus were announced by WHO as a pandemics in the end of 2019. As shown in many studies virus affects whole body, particularly endocrine system. There were information about thyroid disturbances after COVID19 infection. Fergana valley of Uzbekistan is an endemic region with high degree of iodine deficiency. The aim of our study were investigate impact of COVID19 on thyroid function in people living in iodine defi...

ea0090p504 | Thyroid | ECE2023

Incidence of congenital hypothyroidism in Lithuania: data from the National New-born screening program, 2002-2019

Zabuliene Lina , Miglinas Marius , Brazdziunaite Deimante , Smirnova Marija , Songailiene Jurgita , Bratcikoviene Nomeda , Banys Valdas , Macioniene Ernesta , Urbonas Mykolas , Utkus Alfgirdas

Background: Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation and intellectual disability. The overall incidence of CH ranges from 1 in 3,000 to 1 in 4,000 live births, with variation worldwide among different ethnicity [1]. During the period 1993–2000 the incidence of CH in Lithuanian population was estimated as 1 in 4800 live births [2]. The aim of present study was to determine the incidence of CH among new-borns in Lithu...

ea0090p505 | Thyroid | ECE2023

Thyroid hormones resistance, lipid profile and insulin resistance in autoimmune thyroiditis

Neves Celestino , Sergio Neves Joao , Goncalves Juliana , Pereira Miguel , Carvalho Davide

Introduction: Anomalies of glucose metabolism and insulin resistance are common in patients with hypothyroidism. Some studies suggests that euthyroid autoimmune thyroiditis (AIT) may also be associated with changes of glucose metabolism and insulin resistance. The role of thyroid hormones resistance in this context is still uncertain.Aim: To evaluate the relationship between thyroid hormones resistance, insulin resistance and lipid profile in euthyroid p...

ea0090p506 | Thyroid | ECE2023

A Rare Association of Thyroid Medullary Carcinoma with Paraneoplastic Cushing Syndrome: Effects of Multidisciplinary Approach

Alexandra Olariu Cristina , Marin Alexandra , Corneci Cristina , Badiu Corin

Introduction: Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the thyroid gland. While thyroid cancer is increasingly common worldwide, MTC still has a low incidence. We present a case of a seventy-one-years-old woman who presented in our unit after an axillary adenopathy biopsy which tested sparsely positive for KeratinPan, CK7, CEA, TTF1, Chromogranin, Snaptophysin and calcitonin, focal positive for EMA, PAX8, Ki67 30%. Also multi...

ea0090p507 | Thyroid | ECE2023

Prevalence and clinico-pathological correlations of BRAF V600E and TERT promoter mutations in differentiated thyroid cancer in Romania

Dobrescu Ruxandra , Schipor Sorina , Muresan Andrei , Ioachim Dumitru , Goldstein Andrei , Manda Dana , Vladoiu Suzana , Badiu Corin

Background: Differentiated thyroid cancer (DTC) encompases a wide spectrum of disease from clinically insignificant micro-tumors to aggressive cancers. The molecular signature can be used to predict tumor behaviour, and the co-existence of BRAF and TERT promoter mutations has been identified as a marker of adverse prognosis, but we have yet no available molecular data for the Romanian population.Objectives: To determine the prevalence of BRAF V600E and T...

ea0090p508 | Thyroid | ECE2023

The clinical significance of low dose biotin supplements (<300μg/day) in the treatment of patients with hypothyroidism: crucial or overestimated?

Angelopoulos Nikolaos , Paparodis Rodis , Androulakis Ioannis , Boniakos Anastasios , Karras Spyridon , Livadas Sarantis

Background: In the last decade, the combination of the widespread use of streptavidin-biotin technology and biotin–containing supplements (BCS) in the daily clinical practice, have led to numerous reports of erroneous hormone immunoassay results. However, there are no studies assessing the clinical and biochemical significance of that phenomenon, when treating patients with hypothyroidism. Therefore, a prospective study was designed to investigate the potential alteration...

ea0090p509 | Thyroid | ECE2023

Corticosteroid therapy in dysthyroid orbitopathy: about 53 cases

Charkaoui Sara , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Dysthyroid orbitopathy is an autoimmune disorder that occurs in the context of dysthyroidism. corticosteroid therapy is the main therapeutic option recommended by EUGOGO for the management of moderate and severe active forms.Goal of the Study: Describe the clinical, para-clinical and evolutionary characteristics of dysthyroid orbitopathy treated by bolus corticosteroid therapyMaterials and Methods: This is a descripti...

ea0090p510 | Thyroid | ECE2023

Adrenal and Lung Metastases of Papillary Thyroid Carcinoma

Celik Ozlem , Tuna Edizer Deniz , Aytac Erman , Tekin Ali , Unal Kemal , Demirkaya Ahmet , Caliskan Can , Behzatoglu Kemal , Anaforoglu İnan , Serter Ruştu

Objective: Distant metastases from papillary thyroid carcinoma (PTC) are relatively rare and may be associated with a poor prognosis. Herein, we describe a case report with adrenal and lung metastasis of follicular variant of PTC in the context of the review of the literature.Case Report: A 52-year-old male presented with complaints of swelling of his neck and cough. He had been diagnosed with multinodular goiter, obesity, pre-diabetes, and hypogonadism....

ea0090p511 | Thyroid | ECE2023

Retrospective analysis of diagnostic and therapeutic management in thyroid cancer patients in 2019- 2021 to assess the possibility of treatment de-escalation

Kolton Magdalena , Handkiewicz-Junak Daria , Krajewska Jolanta

Introduction: In recent years, there has been a significant increase in the detection of thyroid cancer (TC) and a number of thyroid surgeries. Both the ATA 2015 and 2022 Polish guidelines allow sparing treatment in low-risk TC, nevertheless, most patients are qualified for total thyroidectomy.Material and method: The present study analyzed how often a TC patient opts for sparing treatment and the relationship between the size of the primary focus and ri...

ea0090p512 | Thyroid | ECE2023

Predictive factors affecting prognosis in papillary thyroid microcarcinomas

Kayhan Yusuf , Azizova Leyla , Yilmaz Merve , Bakış Muhsine , Capkinoğlu Turk Sema , Gunduz Betul , Kılıc Kan Elif , Atmaca Aysegul , Colak Ramis

Background: Papillary thyroid microcarcinoma (PTMC) is a papillary thyroid cancer (PTC) type with a maximum diameter of ≤ 10 mm. Generally, PTMCs have good prognosis and low mortality risk. However, there are cases of PTMCs showing more biologically aggressive characteristics, such as lymph node (LN) involvement and distant metastasis.Objectives: Reveal the factors affecting the prognosis and aggressiveness of PTMCs.Methods: ...

ea0090p513 | Thyroid | ECE2023

Epidemiology of thyroid cancer in Tunisia

Mohsen Selma , Hyem Khiari , Emna Mziou , Achwak Mehrez , Olfa Berriche

Introduction: In 2020, Thyroid cancer was responsible for 586,000 cases worldwide, ranking in 9th place in terms of incidence. It is also the most common type of cancer of the endocrine system in 2020. According to the literature, thyroid cancer have reported an increase in the incidence worldwide. However, it varies greatly from country to country. The aim of this work was to evaluate the incidence of thyroid cancer and its trend in northern Tunisia between 1990 and 2019....

ea0090p514 | Thyroid | ECE2023

Incident gout attack precipitated by primary hypothyroidism: a case report

Lassoued Najoua , Belkhiri Malak , Baha Zantour , Wafa Alaya , Mohamed Habib Sfar

Introduction: Thyroid hormones in fluence kidney function and thereby might alter serum urate levels, a major risk factor for gouty arthritis. Previous research documented a high prevalence of elevated levels of Uric acid in primary hypothyroid patients. We present the case of an incident gout attack in a patient with primary hypothyroidism.Case report: A 72-year-old male was hospitalized for a primary hypothyroidism complicated by a rhabdomyolysis. Labo...

ea0090p515 | Thyroid | ECE2023

Multinodular Goitre followed by a new diagnosis of PTEN Hamartoma Tumor Syndrome in an adult patient- A Case report

Haddad Aiman , Chopra Tanya , Hyams Elizabeth , Joshi Shivani , Seechurn Shivashankar , Taufik Bara

Introduction: PTEN Hamartoma Tumor Syndrome (PHTS)is a rare genetic spectrum of disorders characterised by multiple hamartomas and increased risk of cancers including thyroid cancer. People with PHTS have an increased lifetime risk of differentiated thyroid carcinoma (DTC), estimated to be about 35% compared to the general population risk of below 1% (1). Case Presentation: We report a 38-year-old male who presented with a Goitre found on routine examina...

ea0090p516 | Thyroid | ECE2023

Hyalinizing trabecular tumor of the thyroid gland. A rare entity with atypical cytological features A case report

Boutzios Georgios , Tsourouflis Gerasimos , Gakioloulou Charikleia , Destouni Maria , Chatzi Sofia , Giovannopoulos Ilias

Introduction: Hyalinizing trabecular tumors are extremely rare and uncommon thyroid tumors, which were first described by Carney et al. Until now, their preoperative diagnosis based on cytological characteristics is not possible, because of the lack of specific features and molecular markers.Case presentation: We present a 38-year-old Caucasian female, non-smoker, with a disease-free medical history, with a right-sided clearly delimited large hy...

ea0090p517 | Thyroid | ECE2023

The relationship of Nodular Goiter Frequency and Iodine Consumption in University Students

Mantar Ferhan , Nur Altuntas Yurttas Elvan , Elghorab Ihab , Ozkul Ecenur , Goksu Feriha

Nodular Goiter Disease is very common, its prevalence varies between 26 and 67%. This rate is higher in iodine deficient regions. Recent data indicate that the incidence of both benign and malignant thyroid nodules is increasing. The most important factor in noduler guatr is iodine deficiency. The reported prevalence of nodular disease depends on which population is studied and the methods used to detect the nodules. There are other risk factors that lead to an increased incid...

ea0090p518 | Thyroid | ECE2023

Cerebral Vascular Accident in a patient presenting with a Thyroid Storm

Mohamed Ayan , Bashir Mahamud , Ramachandran Kirtanya , Etbinah Lubna , Mohammed Mohammed , Roy Juthi , Mlawa Gideon

Thyroid storm is rare life-threatening clinical manifestation of endocrine dysfunction originating from excess level of thyroid hormone leading to hypermetabolic state with an incidence of 0.57-0.76/1000,000. The increase demand of metabolic activity subsequently induces, palpitations, dyspnoea, exercise intolerance and congestive heart failure. Most common cardiovascular manifestation of thyroid storm is tachycardia and atrial fibrillation occurs in up to 15% of patients. In ...

ea0090p519 | Thyroid | ECE2023

Aspects and Evolution of the thyroid gland in Thyroid dyshormonogenesis

Haj Kacem Akid Faten , Mkaouer Samir , Belabed Wafa , Ayadi Younes , Dhieb Nesrine , Mnif Mouna , Rekik Majdoub Nabila , Elleuch Mouna , Abid Mohamed

Introduction: Congenital Hypothyroidism is the principal cause of preventable mental retardation. It is due to Thyroid dysgenesis in 85% of the cases and in 15% to thyroid dyshormonogenesis.Methods: We conducted a prospective study including 17 patients with familial congenital hypothyroidism due to thyroid dyshormonogenesis other than the features of thyroid gland by ultrasound. Other than the phenotype we evaluated the functionality by thyroid Scintigr...

ea0090p520 | Thyroid | ECE2023

Change in mucosal pigmentation following treatment with radioactive iodine

Verissimo David , Rombo Diogo , Ferreira Teresa , Donato Sara

Introduction: Treatment using radioactive iodine (RAI) is used in several thyroid diseases, including differentiated thyroid carcinoma (DTC). The most frequent adverse effects include acute gastrointestinal symptoms, sialadenitis, xerostomia, cervical pain, and cervical swelling. Chronic symptoms such as obstruction of the salivary ducts, pulmonary fibrosis or other primary malignant diseases are also described. A single case of change in tongue pigmentation / lingua villosa n...

ea0090p521 | Thyroid | ECE2023

A case of follicular thyroid cancer in a girl with Graves’ disease

Muratova Shakhlo

The combination of GD and FTS in children is extremely rare and is poorly understood. RSSPMC of Endocrinology named after Academician Y. Kh. Turakulov, a girl A.M., 12 years 11 months old, living in the Namangan region, was hospitalized for the purpose of diagnosis and correction of treatment. Complaints corresponded to the clinic of HT, also included bilateral protrusion of the eyeballs, lacrimation, reddening of the conjunctiva, feeling of a foreign body in the eyes, blurred...

ea0090p522 | Thyroid | ECE2023

Cardiovascular health status among thyroid cancer survivors

Kaouache Nadjib , Nouri Nassim

Background: Thyroid cancer have good global prognosis with survival rate exceeding 85% at 5 years. Survivors are exposed to higher cardiovascular morbidity and mortality than the general population. The objective of this study is to quantify the prevalence of cardiovascular health levels in an Algerian cohort of thyroid cancer survivors who were considered free of any classical cardiovascular risk factors or cardiovascular diseaseMethods: A cohort of pat...

ea0090p523 | Thyroid | ECE2023

Primary hyperparathyroidism and papillary carcinoma of the thyroid: about a case

Charkaoui Sara , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Primary hyperparathyroidism is a frequent pathology. Its association with non-medullary thyroid carcinoma is rare (2.3–4.3%). The aim of this work is to describe the particularities of this association based on an observation.Observation: This is a 67-year-old patient who was admitted to the department for exploration of primary hyperparathyroidism discovered during a pathological fracture. Biologically she hada calcemia at 130 mg/l a ...

ea0090p524 | Thyroid | ECE2023

Anti-cancer medication related hypothyroidism: Case report

Huseynova Aygun , Mirzazada Valeh

Here we present a patient who had been on various anti-cancer medications such as tyrosine kinase inhibitors and checkpoint immune inhibitors. Eventually, anti-cancer therapy caused thyroid disfunction. Male, 74 years old, presented with fatigue, somnolence, decreased appetite, diarrhea and depression. His medications included tyrosine kinase inhibitor Axitinib (Inlyta) 5 mg which he has been taking for 1 year and human monoclonal antibody Denosumab (Exgeva) 120 mg since 2016....

ea0090p525 | Thyroid | ECE2023

A rare association of hyperthyroidism with Darier disease: case report

Ben Yamna Hadami , Chiboub Marwa , Had Khadija , Gharbi Radhouen , Kandara Hajer , Kammoun Ines

Introduction: Darier disease, also known as dyskeratosis follicularis, is a rare autosomal dominant genodermatosis characterized by a persistent eruption of keratotic papules. It is caused by mutations in the ATP2A2 gene encoding sarcoendoplasmic reticulum Ca 2+ -ATPase isoform 2 in the endoplasmic reticulum. Since it is expressed in most tissues, other organs besides the skin may be involved in Darier disease. In this case, we report a patient treated for Darier disease who w...

ea0090p526 | Thyroid | ECE2023

Hypokalemic Thyrotoxic Periodic Paralysis. A case report

Mauricio Chavez Villegas Alvaro , Jimenez Lopez Noemi , Allo Miguel Gonzalo , Leon Sanz Miguel

Background: Hypokalemic Thyrotoxic Periodic Paralysis (HTPP) is a rare acquired muscular channelopathy that develops in the context of thyrotoxicosis. It consists of episodes of painless muscle weakness, precipitated by exercise, fasting, or high-carbohydrate meals. Men among ages 20-40 are more frequently affected than woman. Thyrotoxicosis (and its subsequent beta-adrenergic stimulation) increases the activation of the Sodium-Potassium ATPase channels, which leads to hyperpo...

ea0090p527 | Thyroid | ECE2023

Preoperative thyroid tumor markers significance - two case reports of misleading values

Fonseca Ricardo , Roque Catarina , Sofia Osorio Ana , Castro Oliveira Sofia

Background: Basal tumor markers are valuable in preoperative evaluation of medullary thyroid carcinoma (Calcitonin and CEA), but are insensitive and nonspecific for papilary thyroid cancer (thyroglobulin). Even if their utility is questionable or not recomended in the evaluation of thyroid nodules, in some cases refered to endocrinology department they are available and can be misleading. We present two cases of thyroid nodules with very high preoperative tumor markers.<p ...

ea0090p528 | Thyroid | ECE2023

A case of Kikuchi-Fujimoto disease with fluctuating thyroid autoantibodies

Nagarajah Kalyani , Lei Yin Win , Lansdown Andrew , Witczak Justyna

Introduction: Kikuchi-Fujimoto disease (KFD) is a benign self-limiting disease presenting with fever and lymphadenitis and mostly affecting adults younger than 40 years of age and of Asian descent. Its aetiology and pathogenesis are unknown though KFD often occurs in patients with concomitant autoimmune illness such as autoimmune thyroiditis or lupus erythematosus (SLE). We report a case of a patient with KFD and fluctuating thyroid function and thyroid autoantibody levels.</p...

ea0090p529 | Thyroid | ECE2023

Myxoedma coma and NAFLD secondary to poorly controlled Hypothyrodism

Mohammed Mohammed , Mohamed Ayan , Mahamud Bashir , Abumedian Mohammed , Saeed Yousif , Musa Awadelgeed , Mlawa Gideon

Myxoedema Coma with NAFLD secondary to poorly controlled hypothyroidism. Myxoedema coma is defined as severe hypothyroidism leading to decreased mental status, hypothermia, and other symptoms related to slowing function in multiple organs. It can culminate in severe, longstanding hypothyroidism or be precipitated by acute stressors such as infection, and surgery in patients with poorly controlled hypothyroidism. Moreover, there is a strong correlation between poorly controlled...

ea0090p530 | Thyroid | ECE2023

Coexistence of thyroid nodule and Graves’ disease: Is it a favorable factor for papillary thyroid cancer?

Yatkın Keleş Yağmur , Abidin Sayıner Zeynel , Koroğlu İpek , ozturk sadettin , Akarsu Ersin

Introduction: The incidence of papillary thyroid cancer (PTC) in the coexistence of Graves’ disease (GD) and thyroid nodule is not known clearly, and the pathophysiology of PTC development in these patients is still unclear. Aim: The aim of our study is to compare the clinicopathological features of GD patients with thyroid nodule + PTC and patients with euthyroid and non auto-immune thyroid nodule + PTC and investigate the clinicopathological featu...

ea0090p531 | Thyroid | ECE2023

Assessment of sleep quality in patients in remission from differentiated thyroid carcinoma: a case-control survey

Mouhaymen Missaoui Abdel , Hamza Fatma , Soomauroo Siddiqa , Ben Ahmed Khawla , Belabed Wafa , Abid Mohamed

Objective: To evaluate the quality of sleep in patients in remission of differentiated thyroid cancer (DTC) Patients and Methods: Comparative case-control study conducted at the Nuclear Medicine Center of Sfax, Tunisia including 99 individuals divided into 2 subgroups G1 (n=39) patients in remission from DTC G2 (n=60) healthy control subjects Sleep quality was assessed according to the 7 components of the Pittsburgh Sleep Quality Index ...

ea0090p532 | Thyroid | ECE2023

Transition from hypothyroidism to hyperthyroidism following R-CHOP treatment in mantle cell lymphoma patient

Zrilic Vrkljan Anamarija , Andric Jelena , Hrabar Mirna , Šamle Ivona , Marusic Srecko , Pandzic Jaksic Vlatka

The most common cause of primary hypothyroidism is Hashimoto’s disease, while the most common cause of hyperthyroidism is Graves’ disease; both conditions are autoimmune diseases. In clinical practice, the switch from hypothyroidism to hyperthyroidism is a rare phenomenon. So far, the etiology and mechanisms of conversion have not been determined. We present a case where we believe the monoclonal antibody rituximab was the primary cause of transition. A 58-year-old m...

ea0090p749 | Thyroid | ECE2023

A rare case of rapidly progressive Graves’ orbitopathy in an elderly patient with a new-onset hyperthyroidism

Pandozzi Carla , Tenuta Marta , Cozzolino Alessia , Feola Tiziana , Centello Roberta , Filice Alessia , Giannetta Elisa , Isidori Andrea M.

Background: Graves’ orbitopathy (GO) is the major extrathyroidal manifestation of Graves’ disease (GD). Even if usually mild and non-progressive, in its worst forms, GO can represent a major therapeutic challenge, because is not always responsive to the available medical treatments. First line treatment for moderate-to-severe and active GO relies on intravenous (i.v.) methylprednisolone. Optic neuropathy is a sight-threatening complication which can seriously impact ...

ea0090p750 | Thyroid | ECE2023

Treatment Response With VRDN-001, a Full Antagonist Antibody to IGF-1 Receptor, in Thyroid Eye Disease (TED): Phase 1/2 Clinical Study

Katz Barrett , Turbin Roger , Cockerham Kimberly , Tang Rosa , Nijhawan Navdeep , Ugradar Shoaib , O'Shaughnessy Denis J. , Summerfelt Rochelle M. , She Angela , Douglas Raymond

Purpose: IGF-1R antagonism reduces TED-related inflammation and proptosis. VRDN-001, a subnanomolar affinity full antagonist antibody to IGF-1R, is being evaluated in a phase 1/2 RCT (NCT05176639) at 3-20 mg/kg. We present results from the first cohort (10 mg/kg) of TED patients.Methods: Adults with active moderate-to-severe TED with clinical activity score (CAS) ≥4 were randomized to 2 infusions 3 weeks apart of either 10 mg/kg VRDN-001 or placebo...

ea0090p751 | Thyroid | ECE2023

Thyroglobulin Point of Care Assay for Rapid Detection of Metastatic Differentiated Thyroid Carcinoma- A Pilot Study

Yoel Uri , Angel Sagi , Bosin Emily , Elezra Miri , Marks Robert S. , Fraenkel Merav

Introduction: Fine needle aspiration (FNA) for thyroglobulin (Tg) measurement (FNA-Tg) and for cytology (FNAC) are recommended for the evaluation of cervical lymph nodes (LN) suspected as differentiated thyroid carcinoma (DTC) metastases. LN proven to represent a metastasis of thyroid origin, change the operation plan, both prior to surgery and while encountering suspicious LN during surgery.Aim: To assess the diagnostic accuracy of a novel point-of-care...

ea0090p752 | Thyroid | ECE2023

A Rare Case of Covid-19 Vaccine-Associated Subacute Thyroiditis Causing Thyroid Storm

Yagmur Sahin Alak Zehra , Uzgec Guller Pinar , Guclu Metin , Kiyici Sinem

Introduction: Subacute thyroiditis (SAT) has been reported after COVID-19 infection and SARS-CoV-2 vaccination. SAT has a mild and self-limiting course. This is the first reported case of thyroid storm following the SARS-CoV-2 vaccineCase: A 32-year-old female patient had mild anterior neck pain, fatigue, tremor 2 weeks after being administered with the second dose of COVID-19 mRNA vaccine BNT162b2 (Pfizer–BioNTech). Initial biochemical investigatio...

ea0090p753 | Thyroid | ECE2023

Assesing the effect of thyroid dysfunction during pregnancy on maternal and neonatal outcomes with guidelines and population-based gestation-specific reference intervals

Elbasan Onur , Turkal Rana , Armağan Turan Cem , Aytan Serenay , Cakmak Burcu , Gozaydınoğlu Buşra , Ceyda Takır Duygu , Unlu Ozan , Bahramzada Gunel , Faruk Tekin Ahmet , Cevlik Tulay , Esim Buyukbayrak Esra , Şirikci Onder , Ilıksu Gozu Hulya , Haklar Goncagul

Introduction: Adverse pregnancy outcomes have been associated with maternal thyroid dysfunction. However, optimizing the best threshold value to improve maternal and perinatal outcomes and alleviate complications by establishing population-based gestation-specific reference intervals (RIs) instead of using recommended universal cut-off values, especially for thyroid-stimulating hormone (TSH), is still an ongoing debate. The aim of this study was to compare the prevalence and r...

ea0090p754 | Thyroid | ECE2023

Pre-operative features of borderline thyroid lesions – outcomes of the sonographic and cytopathological analysis

Żyłka Agnieszka , Dobruch-Sobczak Katarzyna , Piotrzkowska-Wroblewska Hanna , Goralski Piotr , Gałczyński Jacek , Bakuła-Zalewska Elwira , Dedecjus Marek

Objectives: In the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors thyroid tumors are divided into several new categories that allow for a clearer understanding of the cell of origin, pathologic features, molecular classification, and biological behavior. According to this classification there are some borderline nodules -the group of low-risk follicular cell-derived neoplasms - such as noninvasive follicular thyroid neoplasm with papillary-like nu...

ea0090p755 | Thyroid | ECE2023

Abstract withdrawn...

ea0090p756 | Thyroid | ECE2023

Concordance between the ACR TIRADS ultrasound criteria, the BETHESDA cytopathology classification and final resection result in evaluation of thyroid nodules – Spanish tertiary hospital experience

Jalowiecka Izabela , Garzon Pastor Sandra , Sanz Martinez Olivia , Marti Ibor Encarna , Morillas Arino Carlos

Introduction and Aims: Thyroid lesions constitute a frequent consultation in the area of endocrinology. Fine-needle aspiration (FNA) cytology is a gold standard for the evaluation of thyroid lesions, while ultrasound examination according to various thyroid imaging reporting and data system (TIRADS) criteria is gaining importance in the field. The aim of our study was to compare the sensitivity and specificity of both techniques in patients attended in thyroid lesion unit of o...

ea0090p757 | Thyroid | ECE2023

68Ga-PSMA-PET vs 18F-FDG-PET in metastatic radio-refractory differentiated thyroid cancers

Colapinto Alessandra , Basso Cristina , Vicennati Valentina , Fanti Stefano , Tabacchi Elena , Golemi Arber , Calderoni Letizia , Vetrone Luigia , Lodi Rizzini Elisa , Nannini Margherita , De Biase Dario , Tallini GIovanni , Pagotto Uberto , Repaci Andrea

Introduction: Although 18F-FDG-PET has found wide application in the management of radio-refractory differentiated thyroid cancers (RAI-R-DTCs), alternative radiotracers, including 68Ga-PSMA have been recently evaluated. Prostate-specific membrane antigen (PSMA) is in fact overexpressed in the microvasculature of several solid malignancies including thyroid cancers.Aim: To compare the diagnostic performance between 68Ga-P...

ea0090p758 | Thyroid | ECE2023

Cancer rate and characterstics of nodules with macrocalcification

Tuğce Şah Unal Fatma , Gokcay Canpolat Asena , Halil Elhan Atilla , Sevim Selim , Dizbay Sak Serpil , Emral Rifat , Demir Ozgur , Gullu Sevim , Erdogan Murat , Corapcıoğlu Demet , Sahin Mustafa

Aim: The aim of this study was to determine the malignant potential of thyroid nodules with macrocalcifications and to evaluate the role of other sonographic findings in the diagnosis of malignancy in thyroid nodules besides macrocalcifications.Method: The findings of 8250 patients who applied to our outpatient clinic and underwent thyroid ultrasonography(US) between 2008 and 2021 were retrospectively reviewed. We included a total of 303 patients with 30...

ea0090p759 | Thyroid | ECE2023

Redifferentiation with Vemurafenib of BRAF-mutated Radioiodine Refractory Differentiated Metastatic Thyroid Cancer in two patients

Koukoula Chrysoula , Papalou Olga , Diamantopoulos Aristidis , Beka Aikaterini , Baikousi Dimitra , Antonopoulou Vasiliki , Ntali Georgia , Stratigou Theodora , Rontogianni Phoebe , Datseris Ioannis , Vassiliadi Dimitra , Tsagarakis Stylianos

Radioiodine treatment is the cornerstone of differentiated thyroid cancer (DTC) management. A number of thyroid cancers, however, become radioiodine-refractory (RAIR) and these represent about 60% of advanced DTCs and are responsible for the vast majority of DTC mortality. RAIR DTC has limited therapeutic options, mainly tyrosine kinase inhibitors that are associated with moderate efficacy and considerable toxicity. Reinducing NIS expression (redifferentiation) with the aim of...

ea0090p760 | Thyroid | ECE2023

Paraneoplastic Subacute Thyroiditis Secondary to Renal Cell Carcinoma

Cengiz Deniz

A 52 year old lady presented with a six month history of weight loss and fatigue. Physical examination showed mild abdominal discomfort on the right flank with signs of anemia. Blood pressure was 130/60 mmHg, pulse was 83 bpm regular. Tender goitre or tremor were not present. Laboratory tests revealed tsh: 0.008 mUI/l (0.37-4.45), fT4: 2.12 ng/dl (0.8-1.8), thyroglobulin 40 ng/ml (5-42), TPO-Ab <35 IU/ml and TgAb <20 IU/ml, sedimentation:72 mm/h, crp: 59 mg/dl with nor...

ea0090p761 | Thyroid | ECE2023

J – 131 therapy of autonomously functioning thyroid adenoma: the outcome of our 20 – years experience

Petrovski Zlatko

Objective: To investigate the results of J – 131 treatments in patients (pts) with autonomous thyroid adenomas in long period of follow up.Material and Methods: We enrolled 68 consecutive pts with Plummer’s disease (50 females, 18 males, mean age 54,7 yrs, range 21 – 79 yrs) for period 2000 – 2020 yrs. 87%(59/68) pts had a unifocal nodule, while 13% (9/68) pts had multifocal toxic autonomous nodules. Pts stopped antithyroid drugs for ...

ea0090p762 | Thyroid | ECE2023

Assesmement of An Artificial Intelligence-Based Decision Support System in The Thyroid Nodule Evaluation in Clinical Practice

Fernandez Velasco Pablo , Torres Torres Beatriz , Perez Lopez Paloma , Benito-Sendin Plaar Katia , De Luis Roman Daniel , Diaz Soto Gonzalo

Objective: To evaluate the impact of a decision support system (DSS) based on artificial intelligence (AI) -KoiosDS- on ultrasound (US) image analysis and risk stratification in thyroid nodules. Material and methods Retrospective US study of all thyroid nodules with histologic (AP) result from June 2020 to December 2021. Diagnostic performance of US with ACR-TIRADS, by four endocrinologists and DSS, before and after the use of AI was evaluated.Results: A...

ea0090p763 | Thyroid | ECE2023

Long term effects of 0.1 mg Recombinant Human Thyrotropin-Stimulated fix dose of radioiodine therapy in patients with recurrent multinodular goiter after surgery. A 10 year follow-up study

Angelopoulos Nikolaos , Iakovou Ioannis , Effraimidis Grigoris , Livadas Sarantis

Background: Several treatment options exist after thyroid malignancy has been ruled out in patients with multinodular goiter (MG). Surgery efficiently reduces the goiter size but carries a risk of both surgical and anesthetic complications while in recent years, levothyroxine suppressive therapy has been abounded. I131 therapy is the only nonsurgical alternative; however, the effectiveness diminishes with increasing goiter size and depends on iodine sufficiency in some areas. ...

ea0090p764 | Thyroid | ECE2023

Microwave ablation therapy in the treatment of benign thyroid nodules: A single center experience

Onder Elif , Anataca Gulden , Sonmez Suleyman , Peynirci Hande

Aim: Image-guided thermal ablation methods are gaining popularity in recent years for the treatment of benign and malignant thyroid nodules. It has also started to be performed more frequently in our country in the last few years, but few centers have published data on this subject. We aimed to assess the effectiveness and safeness of microwave ablation (MWA) technique in patients with benign thyroid nodules (TNs).Materials and Methods: This retrospectiv...

ea0090p765 | Thyroid | ECE2023

An Fifty Six Gene panel Next Generation Sequencing Study of Follicular differentiated Thyroid Cancer: An Indian Study

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Mayilvaganan Sabaretnam , Bangaraiahgari Rajesh , Kumar N Udaya , Bangaraiahgari Chakrapani

Background: Follicular differentiated thyroid cancer (FDTC) is the most common endocrine cancer, globally. Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput genetic sequencing in short time. This analysis offers useful information on tumor biology. NGS Studies on follicular differentiated thyroid cancer are scanty from South East Asia. In this context, we set out study the pattern of a genetic panel wide somatic mutations in thyroid cancer.<p cl...

ea0090p766 | Thyroid | ECE2023

Is it necessary to elevate TSH for FDG-PET/CT imaging in differentiated thyroid carcinoma patients with TENIS Syndrome?

Şahin Ertan , Abidin Sayıner Zeynel , Elboğa Umut

Objective: We aimed to compare the effectiveness of F-18 fluorodeoxyglucose in positron emission computed tomography (FDG-PET/CT) findings under elevated TSH levels (eTSH) and suppressed TSH levels (sTSH) in differentiated thyroid carcinoma patients with TENIS syndrome (Thyroglobulin-elevated Negative Iodine Scintigraphy).Methods: A total of 23 patients with differentiated thyroid carcinoma (DTC) who undergone total thyroidectomy and 131I ablation therap...

ea0090p767 | Thyroid | ECE2023

Analysis of curative effect after 131I treatment of familial differentiated thyroid cancer

Ji Yanhui , Sun Danyang , Zheng Wei

Objective: To analysis the clinical pathological characteristics and 131I curative responses of familial differentiated thyroid cancer(FDTC) and sporadic differentiated thyroid cancer(SDTC).Methods: A total of 112 FDTC patients(79 females, 33males, age(41.3&pm;15.6)) and 1000 SDTC (658 females, 342males, (44.2&pm;13.9)) who underwent 131I therapy in Department of Nuclear Medicine in our hospital between January 2011 and July 2021 we...

ea0090p768 | Thyroid | ECE2023

Effect of Tumor Size on Prognosis in Papillary Thyroid Microcarcinoma

Kayhan Yusuf , Azizova Leyla , Yilmaz Merve , Bakış Muhsine , Capkinoğlu Turk Sema , Gunduz Betul , Kılıc Kan Elif , ATMACA Aysegul , Colak Ramis

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually detected incidentally. They occur as a result of histological/microscopic examination of a thyroid removed especially for nodular goiter. Generally, the prognosis is good. However, it has been reported that lymph node (LN) metastasis is more common especially in PTMCs with tumor size > 5mm. In this study, it was aimed to show the effect of tumor size on prognosis by comparing clinicopathological data in pat...

ea0090p769 | Thyroid | ECE2023

The Efficiency of Ultrasound Surveillance in Papillary Thyroid Cancer Patients with Excellent Response to Therapy

Yazirli Bercemhan , Ardic Sinem , Unluturk Uğur

Aim: To investigate the efficiency of ultrasound surveillance in detecting papillary thyroid cancer recurrences in Dynamic Risk Stratification (DRS) subgroups. Methods: The study included 477 patients with papillary thyroid cancer (PTC) who underwent total or completion thyroidectomy and were followed for at least three ultrasound scans (US). The patients were categorized into DRS subgroups based on their first-year therapy response. The reports of conse...

ea0090p770 | Thyroid | ECE2023

Does targeting a TSH ≤ 2.5 mmol/l improve fertility in euthyroid women?

Nasri Ismail

Introduction: hypothyroidism is among the most frequent causes of infertility, our objective is to analyze this population in order to evaluate the effectiveness of treatment with levothyroxine.Patients and methods: this is a retrospective interventional study from September 2017 to September 2022.Inclusion criteria: infertility, TSH>2.5 mmol/lExclusion criteria: infertility for less than 1 year, age ≥ ...

ea0090p771 | Thyroid | ECE2023

Clinical, Laboratory and Imaging Findings in the Selection of Treatment and Determination of Relapse in Subacute Thyroiditis

Aytuğ Kuştaş Ali , Nur Korkmaz Fatma , Gokcay Canpolat Asena , Demir Ozgur

Subacute Thyroiditis (SAT) is a painful, self-limited inflammation of the thyroid gland. Guidelines recommend Non-Steroid Antiinflammatory Drugs (NSAIDs) for mild cases and steroids for moderate to severe cases. Early relapses can be seen in about 9-35%. The aim of this study was to investigate the clinical, laboratory, and imaging findings that may affect treatment selection and predict relapse.Materials and Methods: Forty SAT patients who applied to th...

ea0090p772 | Thyroid | ECE2023

Predictive factors for sufficient cytological result after first nondiagnostic thyroid fine-needle aspiration biopsy result

Dilek Dellal Kahramanca Fatma , Bestepe Nagihan , Meryem Kiran Merve , başer husniye , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Aim: To determine whether there is any factor that can predict sufficient results in second thyroid fine-needle aspiration biopsy (FNAB) after first nondiagnostic cytological result.Materials and method: Nodules with non-diagnostic result after first FNAB were included and separated into two groups as sufficient (Group-1) and insufficient (Group-2) second FNAB. Results: Second FNAB was performed on 643 nodules of 443 patients with ...

ea0090p773 | Thyroid | ECE2023

Does timing of repeat fine needle aspiration biopsy in thyroid nodules alter the adequate or AUS/FLUS cytology result?

Dilek Dellal Kahramanca Fatma , Sacikara Muhammed , Kilicarslan Aydan , Evranos Ogmen Berna , Aydin Cevdet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Aim: To determine whether early repeat fine needle aspiration biopsy(FNAB) has an effect on adequate or atypia of undetermined significance/follicular lesion of undetermined significance(AUS/FLUS) cytology rates in thyroid nodules with inadequate or AUS/FLUS in the first FNAB.Method: Nodules of patients who underwent repeat biopsy due to insufficient or AUS/FLUS cytology between 2019-2022 were included. Demographic data of the patients and ultrasonograph...

ea0090p774 | Thyroid | ECE2023

The role of oxidative stress in Hashimoto’s disease

Buczyńska Angelika , Sidorkiewicz Iwona , Wiatr Aleksandra , Adamska Agnieszka , Siewko Katarzyna , Krętowski Adam , Popławska-Kita Anna

Hashimoto disease, a chronic autoimmune lymphocytic thyroiditis, is the most common cause of hypothyroidism with a prevalence of 10–12% in the general population. Literature data suggests that persistently high levels of oxidative are considered as relevant risk factor in the occurrence and development of autoimmune diseases, including Hashimoto. The DNA and RNA are particularly valuable to the oxidative damage, and guanine is the most prone base to oxidation. Thus, the D...

ea0090p775 | Thyroid | ECE2023

Hypothyroidism in Glycogen Storage Disease Type 1b and Management

Atikcan Deniz , Bascil Tutuncu Neslihan , Turhan Iyidir Ozlem

Glycogen storage disease (GSD) type 1 is an autosomal recessive disorder in which there is problem in glucose 6 phosphatase system. Glucose-6-phosphate transport protein deficiency is found in GSD type 1b. There is disorder in glucose metabolism, lack of glucose production in liver. Hypoglycemia, seizures, lactic acidosis, hyperuricemia and hyperlipidemia are some of the components. Affected people may also have short stature, pancytopenia and inflammatory bowel disease. Our a...

ea0090p776 | Thyroid | ECE2023

Atezolizumab A PDL-1 Inhibitor Induced Severe Hypothyroidism Related Rhabdomyolysis

Abul Rabia , Erol Selvinaz , Cil Sen Esra , Yener Ozturk Feyza , Canat M. Masum , Kostek Hatice , Kuver Begum , Doğan İpek Fatma , Altuntas Yuksel

Introduction: Recently, Programmed cell death ligand 1 (PD-L1) inhibitors have been frequently used as promising treatment options for some advanced malignancies. Although immune-related side effects secondary to PD-1 inhibitor treatment are well defined in the literature, data on PD-L1 inhibitors are limited. Thyroid dysfunction was reported in 10% of patients in the clinical study of atezolizumab. We aimed to present a case of severe hypothyroidism-related rhabdomyolysis and...

ea0090p777 | Thyroid | ECE2023

Rapidly-Growing Thyroid Mass: is the Diagnosis Always Anaplastic Cancer?

Yiğit Koroğlu Ekin , Turan Kubra , Pınar Altay Feride , Karadayı Bilgehan , Kılıcarslan Aydan , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

A 87 year old woman admitted with complaints of hoarseness and a palpable mass which she noticed 1 week ago. She had hypothyroidism for 25 years. On examination, there was a hard and fixed palpable 4x4 cm mass on the right side of the neck. In laboratory evaluation, thyroid function tests were normal, thyroid auto-antibodies were positive, calcitonin was normal, C-reactive protein was 224 mg/l and liver and kidney function tests were normal. Thyroid ultrasonography revealed a ...

ea0090p778 | Thyroid | ECE2023

Severe post-amiodarone thyrotoxicosis: personalized approach for radical treatment in a life-threatening condition

Opalinska Marta , Pantoflinski Jacek , Sokołowski Grzegorz , Pach Dorota , Kostecka-Matyja Marta , Żabicka Katarzyna , Partyński Bartosz , Kieć-Klimczak Małgorzata , Sowa-Staszczak Anna , Buziak-Bereza Monika , Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja

Background: Despite increased awareness among cardiologists about the risk of amiodarone’s significant side effects, it is still a commonly used antiarrhythmic drug. Amiodarone may induced easy for management hypothyroidism which affect even 25% of patients or less frequent thyrotoxicosis (AIT) which causes a challenge for clinicians. Type 1 of AIT occurs on the basis of pre-existing thyroid diseases such as nodular goiter or latent Graves’ disease, type 2 results fr...

ea0090p779 | Thyroid | ECE2023

Autoimmune thyroid dysfunction induced by Alemtuzumab

Singh Andrada-Elena , Jones Bethany , Abdelrahim Emad , Randeva Harpal S. , Arun Tarunya , Machenahalli Pratibha

Background: Alemtuzumab is an anti-CD52 monoclonal antibody used in the treatment of relapsing and remitting Multiple Sclerosis (MS). It is a highly effective medication however common side effects of the treatment can include Autoimmune thyroid disease (Graves’ disease, Hashimoto’s thyroiditis), idiopathic thrombocytopenic purpura, anti-glomerular basement membrane disease, neutropenia, haemolytic anaemia, vitiligo being the most common presentation. This case highl...

ea0090p780 | Thyroid | ECE2023

Thyroid and ovarian cancers occurring a decade after treated Hodgkin’s disease

Hadj Sliman Chayma Bel , Sellem Dorra Ben , Syrine Cherif , Hend Rokbani , Bechir Letaief , Aida Mhiri

Introduction: Hodgkin lymphoma is a cancer that affects the lymphatic system. Treatment includes chemotherapy and radiation therapy, which can increase the risk of secondary cancers such as thyroid and ovarian carcinomas. We report a case of a patient who developed secondary thyroid and ovarian cancers after being treated for Hodgkin’s disease.Observation: Mrs LS was diagnosed with Hodgkin disease at the age of 34 and was treated with chemotherapy a...

ea0090p781 | Thyroid | ECE2023

Quality of Life in Patients with Papillary Thyroid Cancer Assessed with The Turkish Version of The Thyroid Related Patient-Reported Outcome Questionnaire ThyPRO: A Prospective Single Center Study

Cıkın Boztuğ Cansu , Begum Bahcecioglu Mutlu Adile , Gullu Sevim

Background: Although the survival rate of papillary thyroid cancer is over 95%, the diagnosis of ’cancer’ and fear of recurrence may impair the quality of life of patients. There is no specific scale for patients with thyroid cancer, scales that can be used in the course of all chronic diseases and include the concept of general health are used to evaluate the quality of life in these patients. We aimed to evaluate the validity of the Thyroid Specific Quality of Life...

ea0090p782 | Thyroid | ECE2023

The impact of lockdown on thyroid hormone metabolism in patients on levothyroxine replacement therapy residing in Adjara

Jashi Liana , Peshkova Tamar , Dundua Ketevan , Kamashidze Koba , Kvanchakhadze Rusudan , Beridze Sophio

Background: The Covid 19 pandemic has significantly changed people’s lives. For patients with chronic diseases, social isolation and distancing have become a provocative factor in metabolic control disorders of varying degrees. Patients avoided hospital visits as much as possible due to fear of infection. Also for the representatives of the medical field, the pandemic has become the basis for new ways of consulting patients (remote, teleconsultation). The aim of the study...

ea0090p783 | Thyroid | ECE2023

Antithyroid Drugs-Induced Angioedema

Al-Qaysi Amina , Chatterjee Sudesna

Introduction: Anti-thyroid drugs like Carbimazole and Propylthiouracil are widely used in the management of hyperthyroidism. These medications are associated with a spectrum of cutaneous, hematologic, teratogenic and hepatobiliary adverse effects.Case Report: A 65-year-old lady, known to have asthma on inhalers as needed and no history of allergies. She was diagnosed with Graves’ thyrotoxicosis after she presented to her General Practitioner with mo...

ea0090p784 | Thyroid | ECE2023

Methimazole induced agranulocytosis - A clinical case report

Menino Joao , Meira Ines , Pedro Jorge , Carvalho Davide , Freitas Paula

Introduction: Antithyroid drugs (ATDs) are generally safe and well tolerated, however, major side effects such as hepatotoxicity and agranulocytosis may occur and patients should be provided information on the major symptoms of these conditions. Although rare, agranulocytosis appears to be more likely with propylthiouracil (PTU) at any dose than with low-dose Methimazole (MMI). Clinical Case: We describe the case of a 70-year-old woman referred to Endocr...

ea0090p785 | Thyroid | ECE2023

Thyroid nodular disease in a patient with Neurofibromatosis type 1

Aycha Ghachem , Elfekih Hamza , Ghada Sabbagh , Saad Ghada , Kenza Houd , Hasni Yosra , Chadli Chaieb Molka

Introduction: Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease. Patients affected by NF1 have an increased risk of developing tumors other than neurofibromas, especially of endocrine origin, that’s why this patients should be screened for endocrine lesions. In this report, we describe a patient affected by NF1 who present a thyroid nodule.Observation: A 27-year-old woman was admitted in our department for endocrinological evaluati...

ea0090p786 | Thyroid | ECE2023

Graves’ disease presented simultaneously with subacute thyroiditis - A case report

Lumi Ema , Tare Rajmonda , Ylli Agron

Introduction: Graves’ disease is an autoimmune disease that leads to a generalized over activity of the entire thyroid gland (hyperthyroidism). It is caused by TRAb thyrotropin receptor antibodies (TRAb), which bind to receptors on the surface of thyroid cells and stimulate those cells to overproduce and release thyroid hormones. Subacute thyroiditis is presumed to be caused by a viral infection or a postviral inflammatory process. It is a self-l...

ea0090p787 | Thyroid | ECE2023

A rare case of autoimmune thyroiditis with frequent episodes of hashitoxicosis requiring thyroid surgery

Dzagania Ketevan , Vashakmadze Natia

19 years-old female was diagnosed with thyrotoxicosis for the first time in 2015; Severe hypothyroidism developed after 1 month thiamazole therapy, therefore medication was stopped and the patient was prescribed L-T4 that resulted in improvement of thyroid function tests. L-T4 was finally withdrawn and TSH returned to normal. Since then TSH was constantly monitored and the levels were normal. In 01/2020, the patient was presented with complains about increased heart rate, emot...

ea0090p788 | Thyroid | ECE2023

Etiological profile of hypothyroidism in transition to adult endocrinology

Gueddari Amine , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Hypothyroidism, congenital or acquired, is responsible for hypometabolism. It is the leading cause of preventable mental retardation in children. Its congenital form is common with 1 in 3500 births. The objective of our work was to describe the characteristics and etiologies of hypothyroidism.Patients and methods: Retrospective descriptive and analytical study on patients followed for hypothyroidism in transition consultation at the departm...

ea0090p789 | Thyroid | ECE2023

Treatment resistant Amiodarone-induced Thyrotoxicosis in a patient with laminopathy requiring salvage thyroidectomy

J Tansey David , Moran Carla

Background: Amiodarone induced thyrotoxicosis (AIT) is a potentially catastrophic situation for patients with cardiac disease who are at risk of life-threatening complications. We describe the protracted and challenging journey of a patient with Laminopathy and a significant cardiac history who developed AIT.Clinical Case: A 53-year-old man was referred with thyrotoxicosis (TSH <0.01mU/l, free T4 61 pmol/l, free T3 8.0 pmol/l) detected following comm...

ea0090p790 | Thyroid | ECE2023

Unusual coexistence of primary hyperparathyroidism with graves’ disease and papillary thyroid carcinoma: a case report

Myriam Baltagi , Najla Bchir , Hadj Sliman Chayma Bel , Benchhida Annam , Dorraelguiche Dorra , Chadia Zouaoui , Ouertani Haroun

Introduction: Papillary Thyroid Carcinoma (PTC) is the most frequent cancer of the thyroid. PTC may rarely coexist with Primary hyperparathyroidism (PHPT). Furthermore, the association of PTC and graves’ disease (GD) has been described and the existence of a link between these entities has long been investigated, but no clear correlation has been established. We report the case of a female patient who suffered from GD, PTC and PHPT.Observation: A 34...

ea0090p791 | Thyroid | ECE2023

Long-Term Effects of Radioiodine Treatment on Parathyroid Gland Functions in Patients with Benign or Malignant Thyroid Diseases

Avcı Merdin Fatma , Corapcıoğlu Demet , Sahin Mustafa

Background: Radioiodine (RAI) therapy has been used for a long time in benign and malign diseases of the thyroid gland. During the application of radioiodine treatment, parathyroid glands may also be exposed to radiation due to its close proximity to the thyroid gland. There is interest in the effects of RAI treatment on parathyroid functions in clinical studies. The aim of this study is to evaluate whether the dose of RAI treatment for benign or malignant thyroid diseases has...

ea0090p792 | Thyroid | ECE2023

Plasma Lipoprotein(a) Is Not Associated With Graves’ Ophthalmopathy

Sulu Cem , Dedeoglu Selin , Gonen Busenur , Gonen Sait

Aim: To investigate the relation of serum lipoprotein (a) (Lp(a)) and other serum lipids with presence of Graves’ Ophthalmopathy (GO). We also analyzed the correlation between serum lipids and GO activity.Methods: A cross-sectional investigation was conducted in consecutive patients with Graves’ Disease (GD) who came under the authors’ observation to receive antithyroid drug. A stratification was aimed at forming two distinct groups of pat...

ea0090p793 | Thyroid | ECE2023

Blood ethylenethiourea and disorders of the thyroid gland in Indian mango plantation workers

Kumar Manish , Sukrit Prakash Akhouri , Ahsan Sajjad

Introduction: A suspected human carcinogen and antithyroid substance, ethylenethiourea (ETU), is produced during the metabolism of ethylenebisdithiocarbamates (EBDCs). These fungicides are sprayed from above or while wearing a backpack. Ethylenethiourea (ETU), a Type II B carcinogen, and antithyroid chemicals are produced when EBDCs are broken down.Objective: The objective of conducting this research was to compare the occurrence of thyroid problems amon...

ea0090p794 | Thyroid | ECE2023

Leukopenia A Benign Comorbitidy and Early Sign of Autoimmunity in Hashimoto’s Thyroiditis

Athanassiou Lambros , Athanassiou Panagiotis , Tsakiridis Pavlos , Nikolakopoulou Sofia , Nikolidaki Maria , Mathiou Dimitra , Fortis Athanasios , Athanasiou Ifigenia Kostoglou

Introduction: Leukopenia is a manifestation of autoimmune diseases such as systemic lupus erythematosus (SLE). Leukopenia may be an early sign of autoimmunity and may be a comorbidity in patients with autoimmune Hashimoto’s thyroiditis. Aim: The aim was to present a cohort of 12 patients with autoimmune Hashimoto’s thyroiditis who presented with leukopenia.Methods: A cohort of 12 patients, aged 19-72 y, female, with autoi...

ea0090p795 | Thyroid | ECE2023

Nivolumab-induced hypothyroidism: a case report

Bestepe Nagihan , Aydogmus Yasar , Balsak Belma Tural , Hafizoglu Emre , Solmaz Kubra , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: Immune checkpoint inhibitors are relatively new and promising treatments for a variety of solid tumors. Nivolumab is an anti-cancer monoclonal antibody that inhibits anti-programmed death-1 (PD1) and modulates T-cell response. It has been shown to significantly improve survival in many types of cancer, but clinical studies have also reported an increased risk of developing immune-related adverse events. In particular, immune-related adverse events may be related ...

ea0090p796 | Thyroid | ECE2023

Assessement of Thyroid Function in An Obese Population

Jemai Chaima , Jemel Manel , Gharbi Radhouen , Kandara Hajer , Kammoun Ines , Berriche Olfa , Mahjoub Faten , Jamoussi Henda

Background: Obesity is an expanding pathology in the world and in Tunisia. We conducted this study to assess the thyroid function in a population of obese women and to investigate the relationship of thyroid status parameters with clinical and metabolic parameters.Methods: This is a cross-sectional retrospective study about 50 obese women carried out at the obesity unit of department A of the National Institute of Nutrition in Tunis. We collected body ma...

ea0090p797 | Thyroid | ECE2023

Congenital Hypothyroidism and Thyroid dyshormonogenesis: Clinical features and genetic findings

Mkaouer Samir , Haj Kacem Akid Faten , Ayadi Younes , Belabed Wafa , Khochtali Rihab , Noura Bougacha , Rim Chaaben , Ben Salah Dhoha , Abid Mohamed

Introduction: Thyroid dyshormonogenesis represents 15% of congenital hypothyroidism. It is a genetic disorder due to a trouble of Thyroid hormones synthesis. it implies many factors involved in this process mainly TPO Enzyme and NIS channel.Methods: We conducted a prospective study including 17 patients with Congenital Hypothyroidism belonging to 4 consanguine multigenerational Tunisian families. The thyroid dyshormonogenesis was diagnosed based on clini...

ea0090p798 | Thyroid | ECE2023

Anaplastic transformation of papillary thyroid carcinoma in lung metastases:A case report

Yarar Zeliha , Ozturk Yusuf , Kulaksizoglu Mustafa , Karakose Mellia , Karakurt Feridun , Oltulu Pembe , Tas Aycicek Seda

Introduction: Anaplastic thyroid carcinoma is a subtype of thyroid carcinomas with an aggressive form. Anaplastic thyroid carcinomas are thought to develop as a result of differentiation of well-differentiated thyroid cancers. Anaplastic transformation of well-differentiated papillary thyroid carcinoma is very rare and most commonly occurs in thyroid gland and regional lymph nodes, whereas occurrence at distant metastatic site is extremely rare. Here we report the case of a pa...

ea0090p799 | Thyroid | ECE2023

Idiopathic Intracranial Hypertension and Grave’s Disease

Zeguir Hadjer , Achir Safia , Arbouche Zakia

Introduction: Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure without a detactable cause. Risk factors for the development of this syndrome are obesity and young female population. IIH due to hyperthyroidism is rare in the literature, mentioned in few individual case reports. The exact mechanism of how hyperthyroidism causes IIH is not known. We are reporting the case of a young women with Graves’ disease presenting with symp...

ea0090p800 | Thyroid | ECE2023

Assessment of educational needs of thyroid cancer patients during ablative iratherapy sessions

Mouhaymen Missaoui Abdel , Hamza Fatma , Soomauroo Siddiqa , Ben Ahmed Khawla , Belabed Wafa , Abid Mohamed

Objective: To assess the educational needs of patients with differentiated thyroid carcinoma (DTC) undergoing ablative irradiation therapy (RAI131)Patients and Methods: Cross-sectional study including 25 patients operated for TDC who integrated the therapeutic education program (TPE) on DTC at the Nuclear Medicine Center, Sfax, Tunisia. An assessment questionnaire was filled by the patients before the RAI session131Results: Our gro...

ea0090p801 | Thyroid | ECE2023

Prevalence and factors associated with sleep disorders in patients with thyroid cancer

Mouhaymen Missaoui Abdel , Hamza Fatma , Soomauroo Siddiqa , Ben Ahmed Khawla , Belabed Wafa , Abid Mohamed

Objective: To determine the prevalence and factors associated with sleep disorders in patients with differentiated thyroid cancer (DTC)Patients and Methods: Analytical cross-sectional study of 39 patients followed for DTC at the Nuclear Medicine Center of Sfax, Tunisia. Sleep disorders were evaluated according to the 7 components of the Pittsburgh Sleep Quality Index (PSQI). Results: The average age of the patients at the time of t...

ea0090p802 | Thyroid | ECE2023

Graves’ disease associated with thymic hyperplasia: about a case

Bouchenna Amira , Kablia Samia Ould

Introduction: The association between Graves’ disease and thymic hyperplasia was first described in 1912. Hundreds of cases have since been described. This rare association doesn’t seem fortuitous. We report a case.Observation: A 30-year-old patient with no particular personal history who consults following the onset of dyspnea with chest tightness. A CT scan of the chest revealed thymic hyperplasia. The preoperative assessment found an hyperth...