Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Poster Presentations

Reproductive and Developmental Endocrinology

ea0090p170 | Reproductive and Developmental Endocrinology | ECE2023

RANKL signalling in female reproduction: a novel role of RANKL outside the skeleton?

Bech Arting Liv , Kooij Ireen , Krarup Knudsen Nadia , Hjorth Andreassen Christine , Juel Mortensen Li , Juul Anders , Blomberg Jensen Martin

Background and Purpose: Infertility affects 15% of couples globally, and only few treatment options are available. Gonadotropins are classic and potent regulators of ovarian and female reproductive function, but novel endocrine crosstalk appears to exist between gonads and the skeleton that may influence female fertility. One of the new players include the RANKL signalling system, which consists of the receptor activator of nuclear factor κβ ligand (RANKL), the recep...

ea0090p171 | Reproductive and Developmental Endocrinology | ECE2023

Chronic Unpredictable Stress (CUS) Induced Abnormal Sperm Morphology Associated with Male Reproductive Hormones and Phoenixin Expression in Male Rats

Isnaini Mohamed Zahra , K Radhakrishnan Ammu , Asnawi Zainal Abidin Syafiq , Jaafar Faizul

Introduction: Chronic stress caused by prolonged emotional pressure may cause to multiple physiological problems including reproductive dysfunction. There is no doubt that infertility can cause chronic stress. However, the effect of chronic stress-induced reproductive dysfunction is still debatable. Thus, this study aims to demonstrate CUS effect on reproductive system.Methodology: Sprague Dawley (SD) rats (n=16) were divided into two groups: i)...

ea0090p172 | Reproductive and Developmental Endocrinology | ECE2023

Ketoacidosis in Type 1 Diabetics: Epidemiological and Clinico-Biological Profile: About 423 Patients

Ouhessaine Sofia , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Diabetic ketoacidosis (DKA) is a serious metabolic complication of diabetes with an annual incidence between 4.6 and 8 episodes per 1000 diabetic patients, it is responsible for a considerable socio-economic impact, however its mortality remains low.Objectives: The objective of the study is to clarify the epidemiological and clinico-biological profile of type 1 diabetic patients hospitalized and followed for diabetic ketoacidosis.<p cla...

ea0090p173 | Reproductive and Developmental Endocrinology | ECE2023

Iodine deficiency in pregnancy reflected by ioduria and mother-child pairs thyroid status

Filipowicz Dorota , Ada Mikulska-Sauermann Aniceta , Karaźniewicz-Łada Marta , Szczepanek-Parulska Ewelina , Głowka Franciszek , Ruchała Marek

Background: Iodine deficiency disorders are a global health problem partially eliminated by salt iodization national programmes. In Poland, this micronutrient shortage diminished over the last two decades, however in some particularly vulnerable groups like pregnant and breastfeeding women additional supplementation of iodine is beneficial for both mother and newborn. The programme’s effectiveness should be regularly evaluated. The matter of concern remains the optimal re...

ea0090p174 | Reproductive and Developmental Endocrinology | ECE2023

Congenital Adrenal Hyperplasia – When does Gender Identity Begin?

Lopes Sofia , Ferreira Mafalda , Araujo Barbara , Ruas Luisa , Paiva Sandra , Oliveira Patricia , Paiva Isabel

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic condition which impairs enzymatic steroidogenesis of the adrenal cortex, leading to excessive androgen production. CAH phenotype is heterogeneous. In the mildest forms, it can present with hirsutism, acne and menstrual irregularities. Problems related to gender identification arise in about 5% of people with CAH with a 46,XX karyotype.Objective: We present the case of a young female-to-male ...

ea0090p175 | Reproductive and Developmental Endocrinology | ECE2023

Women with preeclampsia show altered cortico- and sex steroid profiles

Trummer Olivia , Stern Christina , Reintar Sharmaine , Tandl Veronika , Mayer-Pickel Karoline , Cervar-Zivkovic Mila , Fassnacht Martin , Kurlbaum Max , Huppertz Berthold , Fluhr Herbert , Obermayer-Pietsch Barbara

Background: Preeclampsia (PE) is a complex condition of pregnancy, associated with substantial perinatal morbidity and mortality, affecting 2% to 8% of pregnancies worldwide. Its hallmarks are high blood pressure (hypertension) and endothelial dysfunction, leading to potential end-organ injury. Affected organ systems include liver, blood, kidneys, brain and placenta. In the present study, we investigated steroid hormones such as progestagens, estrogens, androgens, and glucocor...

ea0090p176 | Reproductive and Developmental Endocrinology | ECE2023

Machine learning algorithm for predicting polycystic ovary syndrome based on voice samples

Stogowska Ewa , Jamiołkowski Jacek , Kondraciuk Marcin , Kucharski Michał , Paszcza Paweł , Ziołko Bartosz , Kamiński Karol , Kowalska Irina

Introduction: Several investigations proved the presence of receptors for androgens, estrogens and progesterone in vocal folds. The most common endocrine disorder causing alterations in the aforementioned hormones concentrations is polycystic ovary syndrome (PCOS), which, according to several studies, can cause voice changes, especially deepening of its timbre. Over last few years, vocal changes accompanying many different disorders have been a subject of research with the use...

ea0090p177 | Reproductive and Developmental Endocrinology | ECE2023

Hyperandrogenism-related metabolic changes in drug-naive transmen compared to cisgender women: A case-controlled study

Erel Pnar , Elbasan Onur , Yorguner Neşe , Imre Eren , Ustay Ozlem

Introduction: The etiology of gender dysphoria is still unclear. Although prior studies have shown trans men have higher androgen levels than cisgender women, they all concluded unselected populations. Our purpose to perform this study is to evaluate transmen’s hormone profile and metabolic status to compare cisgender women in a more selected population. This is the first case-controlled study to compare anthropometric, metabolic, and endocrinological parameters of drug-n...

ea0090p178 | Reproductive and Developmental Endocrinology | ECE2023

Are there Differences Between Androgens When Studying Androgenisation in the Transgender Patient?

Latorre Mesa Carlos , Velasco de Cos Guillermo , Villar Bonet Aurelia , Moyano Martinez Ana , Alexandra Zapata Maldonado Gabriela , Ormazabal Monterrubio Maialen , Alio Lavin Gomez Bernardo , Teresa Garcia-Unzueta Maria

Introduction: In gender affirming therapy of the transgender male, increasing doses of testosterone are administered and as the androgen dose increases, various biochemical parameters such as haematocrit, creatinine and PSA increase. It is not known whether any parameters have advantages in monitoring this androgenisation. Our study evaluates the correlation between the increase in androstanediol glucuronide, testosterone, free testosterone and free androgen index (FAI) with t...

ea0090p179 | Reproductive and Developmental Endocrinology | ECE2023

Characteristics of dilated aortas in patients with Turner syndrome: clinical, histological and cytogenetic analysis

Donadille Bruno , Alexander Valent , Kisaki Amemiya , Nicolas Rive-le-gouard , tatiana lecot-connan , Laurence Iserin , Paul Achouh , Salenave Sylvie , Patrick Bruneval , Jean-Pierre Siffroi , Christin-Maitre Sophie

Turner syndrome (TS) is a rare condition with a high frequency of aortic dilatation (AD) and a risk of aortic dissection. Our objective was to evaluate the characteristics of the aorta in patients with TS.Methods: Analyses of aortic walls were obtained during prophylactic aortic replacement. Histological description and measurement of a standardized media degenerative score (MDC) were performed. Cytogenetic analysis quantified the level of monosomy X in ...

ea0090p180 | Reproductive and Developmental Endocrinology | ECE2023

Vitamin D and IVF/ICSI outcome: Are we measuring the right metabolites?

Kooij Ireen , Gry Kristensen Stine , Bentin-Ley Ursula , Lorenzen Mette , Krog Hans , Juul Anders , Holt Rune , Blomberg Jensen Martin

Background: Numerous studies have suggested that optimal vitamin D status increases treatment success of women undergoing assisted reproductive treatments. However, conflicting data exist, and the relationship remains controversial, prompting the need for more comprehensive studies investigating all the metabolites of vitamin D in women undergoing IVF/ICSI treatment. Objective: To investigate the relationship between follicular fluid levels of the three ...

ea0090p181 | Reproductive and Developmental Endocrinology | ECE2023

In Vitro Fertilization in Polycystic Ovary Syndrome: Treatment Individualization Based on Genetic Singularities

Carreira Ana , Vieira Ines , Reis Sandra , Carvalho Alexandra , Dias Conceicao , Fernandes Silvana , Ferreira Ana , Rodrigues Dircea , Sousa Ana , Ramalho-Santos Joao , Cortesao Paulo , Almeida-Santos Teresa , Ramalhinho Ana , Moura-Ramos Mariana , Melo Miguel , Paiva Isabel

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Polymorphisms in genes related to follicular recruitment and development, such as the follicle-stimulating hormone receptor (FSHR) and the oestrogen receptor 1 (ESR1) genes, and their impact on biochemical phenotype and response to controlled ovarian stimulation in women with PCOS have been studied in different populations, with inconsistent results.<p class="abstext...

ea0090p182 | Reproductive and Developmental Endocrinology | ECE2023

Sublingual estradiol only, offers no apparent advantage over combined oral estradiol and cyproterone acetate, for Gender Affirming Hormone Therapy (GAHT) of treatment-naïve transwomen: Results of a prospective pilot study

Gindis Guy , Yaish Iris , Greenman Yona , Moshe Yaffa , Arbiv Mira , Buch Asaf , Sofer Yael , Shefer Gabi , Tordjman Karen

Background: The standard approach for Gender-Affirming Hormone Therapy (GAHT) of transgender women (TW) in Israel is oral estradiol (OE) combined with the potent anti-androgen cyproterone acetate (CA). Recently, many of our non-binary patients have requested sublingual estradiol (SLE) without CA, under the unproven belief it preserves erectile function, and does not induce depression. Preliminary data in a few subjects, who self-practiced this approach, suggested it also maint...

ea0090p183 | Reproductive and Developmental Endocrinology | ECE2023

Misdiagnosis of 46, XY DSD in a childhood Bone Marrow Transplantation survivor

Thayyil Sheena , Hamed Rama , Omer Tahir , Prouten Jennifer

Introduction: Endocrine late effects can manifest in hemopoietic stem cell transplantation survivors who were exposed to myelosuppressive conditioning treatment. These include dysfunction of the hypothalamic/pituitary, thyroid, and gonads leading to premature ovarian insufficiency and primary amenorrhoea. In addition, metabolic dysregulation and increased risk of diabetes have been observed in these patients. The investigation for primary amenorrhoea in this condition can rare...

ea0090p184 | Reproductive and Developmental Endocrinology | ECE2023

Human muscle fibers in previous users of anabolic steroids display persistent increased myonuclei number years after cessation

Rasmussen Jon , Nielsen Jakob , Frandsen Mikkel , Bulut Yeliz , Brandt-Jacobsen Niels , Aagaard Per , Kistorp Caroline

Background and Objective: Information on the long-term effects of anabolic androgenic steroids (AAS) use on the myocellular properties of human skeletal muscle is scarce, despite being the primary target of AAS. Animal studies suggest persistence of upregulated myonuclei numbers following AAS discontinuation. Few human studies have investigated the effects of AAS on human skeletal muscle cell morphology and exclusively focused on current AAS users. No data exist elucidating th...

ea0090p185 | Reproductive and Developmental Endocrinology | ECE2023

Fear of Hypoglycemia in Parents of Young Type 1 Diabetic Patients and Impact on Glycemic Control

Ouhessaine Sofia , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Hypoglycemia is the most frequent iatrogenic acute complication in type 1 diabetics, it is a potentially serious complication, which can lead to coma. Many advances in new generation insulins, self-monitoring methods and therapeutic education have reduced the incidence of this complication. Nevertheless, hypoglycemia still generates great fear and anxiety in parents of young type 1 diabetic patients, which can be accompanied by several therapeutic errors.<p c...

ea0090p186 | Reproductive and Developmental Endocrinology | ECE2023

Gene expression differences between small and large follicles

Baschieri Lara , Cimadomo Danilo , Davolio Federica , Sperduti Samantha , Mascolo Elisa , Paradiso Elia , Lazzaretti Clara , Perri Carmela , Roy Neena , Innocenti Federica , Albricci Laura , Rienzi Laura , Vaiarelli Alberto , Maria Ubaldi Filippo , Simoni Manuela , Casarini Livio

In assisted reproduction, poor ovarian response to controlled ovarian stimulation (COS) leads to poor oocyte yield and depends on the genetic background. We compared the expression of key-genes, coding proteins regulating follicular development, between small (<10 mm) and large ovarian follicles (>16 mm), assuming the size as a hallmark of follicle maturation and oocyte fate. Twenty-two patients undergoing COS were enrolled in a fertility clinics. Granulosa cells and folli...

ea0090p187 | Reproductive and Developmental Endocrinology | ECE2023

In vitro effect of visfatin on progesterone and prostaglandins’ secretion by the porcine corpus luteum. Involvement of insulin receptor and different kinases’ signalling pathways

Mlyczyńska Ewa , Zobidna Ewa , Rytelewska Edyta , Respekta Natalia , Dobrzyń Kamil , Kieżun Marta , Kopij Grzegorz , Smolińska Nina , Kamiński Tadeusz , Rak Agnieszka

Visfatin is one of adipokines that particularly regulates metabolic homeostasis. Literature data of the last decade indicate also that visfatin participates in the regulation of ovarian follicles’ steroid synthesis and oocyte maturation in women, mice, hens, and cows. However, there is still a gap in knowledge about the effect of this adipokine on the corpus luteum (CL) functions. Our previous study documented visfatin mRNA and protein expression in the porcine CL. Theref...

ea0090p188 | Reproductive and Developmental Endocrinology | ECE2023

Prognostic Value of Hormonal Examination in Adolescent Girls with Polycystic Ovarian Syndrome

Kamilova Nigar

Relevance: PCOS is a multifactorial heterogeneous disease associated with endocrine, reproductive, and metabolic manifestations. The relevance of the PCOS problem is determined by its high prevalence worldwide among women of childbearing age (5 - 20%). It is worth noting that the main reproductive signs of PCOS appear in late prepubertal and pubertal periods. The aim is to carry out a comparative analysis of hormonal indicators in PCOSMaterials and Metho...

ea0090p189 | Reproductive and Developmental Endocrinology | ECE2023

45X/46XY Mosaicism in a Male as a Rare Cause of Absence of Sexual Interest

Hale Erbatur Nuriye , Gulfem Kaya Mina , Mehlika Kuskonmaz Serife , Culha Cavit

Introduction: The incidence rate of 45X / 46XY karyotype and variants has been reported as 1 / 15,000 live births and is rare. The phenotypic spectrum of patients with 45X / 46XY varies widely from women with Turner syndrome to normal androgenized men. In adult male infertility studies, 45X / 46XY karyotype cases diagnosed as a result of genetic screening have been reported. However, there are case reports showing that, despite their normal appearance, these patients may have ...

ea0090p190 | Reproductive and Developmental Endocrinology | ECE2023

Mitochondrial uncoupling proteins (UCPs) regulate mitochondrial function in mouse Leydig Cells: a possible role on steroidogenesis?

Guerra-Carvalho Barbara , Matos Beatriz C. , Carrageta David F. , Bernardino Raquel L. , Oliveira Pedro F. , Alves Marco G.

Introduction: Mitochondrial uncoupling proteins (UCPs) are transmembrane channels present in the inner mitochondrial membrane whose function is the transport of protons and small substrates between the intermembrane space and the mitochondrial matrix. UCPs are key regulators of cellular metabolism, including mitochondrial function, oxidative phosphorylation, and reactive oxygen species (ROS) production. UCPs’ dysfunction has been associated with the onset of metabolic dis...

ea0090p191 | Reproductive and Developmental Endocrinology | ECE2023

Effects of gender affirming treatments on sex hormone levels, mental well being and body image quality of life in transgender individuals

Rasulova Nubar , Karakilic Ozturan Esin , Hacisahinogullari Hulya , Yenidunya Yalin Gulsah , Direk Tecirli Neşe , Soyluk Selcukbiricik Ozlem , Gul Nurdan , Kubat Uzum Ayse , Darendeliler Feyza

Objective: Transgender individuals endure gender dysphoria and incongruence between physical appearance and gender identity. We aimed to investigate effects of gender affirming treatments on sex hormone levels, mental well being and body image quality of life in these individuals. Material and Method: This is a descriptive cross sectional study. Transgender individuals who were transitioned from pediatric to adult care (n: 12) and who were formerly follo...

ea0090p192 | Reproductive and Developmental Endocrinology | ECE2023

Progesterone Limits the Increase in p53 caused by Dexamethasone Treatment in the Labyrinth Zone of Rat Placenta

Alqaryyan Mariam , Alawathi Maryam , Albader Maie

Introduction and objectives: Placental apoptosis plays important roles in both normal physiological and abnormal pathological placental development. Fetal growth is highly dependent on the placenta, thus any disruption in placental formation may lead to intrauterine growth restriction (IUGR). The rat placenta consists of a basal zone (BZ) and labyrinth zone (LZ). The BZ is the major site of placental hormone production and it goes under physiological apoptosis at the end of te...

ea0090p193 | Reproductive and Developmental Endocrinology | ECE2023

Occurrence of vertebral fractures, hypovitaminosis D, and osteoporosis among postmenopausal women living in rural areas

Kumar Subhash , Guha Shaibal , Ekram Md.

Background: The likelihood of developing a fragility fracture rises with age. Osteoarthritis, osteoporosis, and hypovitaminosis D are all extremely common diseases, with 50% of women and 20% of men experiencing a fragility fracture at some point in their lives.Objectives: First, compare the occurrence of osteoporosis, fragility fractures, and risk factors such as low vitamin D levels, low bone mineral density, and the presence of other illnesses that pre...

ea0090p194 | Reproductive and Developmental Endocrinology | ECE2023

Masculinizing Hormone Therapy: What Happens to Estradiol and To Total, Free and Biovailable Testosterone?

Saraiva Miguel , Ferreira Lia , Palma Isabel

Introduction: Masculinizing Gender-Affirming Hormone Therapy (GAHT) generally aims to induce testosterone levels equivalent to those of cisgender men and to reduce estradiol levels. There are no studies about bioavailable testosterone in this population.Aims: To determine the variation of the serum levels of sexual hormones in transmasculine people under GAHT and study the correlations between them and with BMI.Methods: Longitudina...

ea0090p195 | Reproductive and Developmental Endocrinology | ECE2023

School Failure in Type 1 Diabetic in Transition Period

Ouhessaine Sofia , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Adolescence represents the passage from childhood to adulthood, this transition is characterized by physical and psychological transformations as well as many social challenges. The presence of chronic disease such as diabetes makes this a major challenge.Purpose: Describe the impact of diabetes on the school career of adolescents during the transition period.Methods: Descriptive study involving 79 young people aged 1...

ea0090p196 | Reproductive and Developmental Endocrinology | ECE2023

Metabolic syndrome in Turner syndrome

Haj Kacem Akid Faten , Trimeche Oumeyma , Mnif Mouna , Mouhaymen Missaoui Abdel , Ben Salah Dhoha , Elleuch Mouna , Fatma Mnif , Charfi Nadia , Rekik Majdoub Nabila , Abid Mohamed

Introduction: Turner syndrome (TS) is a feminine chromosomic disease, defined as the partial or total loss of the X chromosome. Classic phenotype includes growth and pubertal retardation as well as a characteristic dysmorphic syndrome. Other accompanying comorbidities are frequently associated with TS such as metabolic diseases: overweight, diabetes, hypertension (HTA) and dyslipidemia. Through this report we aim to determine the frequency of metabolic diseases associated with...

ea0090p197 | Reproductive and Developmental Endocrinology | ECE2023

Polycystic ovary syndrome phenotype and therapeutic outcomes

Elleuch Mouna , Frikha Hamdi , Ben Salah Dhoha , Triki Molka , Ayadi Younes , Mnif Fatma , Mnif Mouna , Rekik Majdoub Nabila , Charfi Nadia , Haj Kacem Akid Faten , Abid Mohamed

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. PCOS has two phenotypes, obese and lean, the latter being a much less common presentation of the syndrome.Aim: Compare PCOS outcomes in patients with obese PCOS and patients with lean PCOS.Methods: A retrospective, single-center, descriptive and comparative study including patients with PCOS followed at the endocrinology d...

ea0090p198 | Reproductive and Developmental Endocrinology | ECE2023

The Effect of Menopausal Status On Anthropometric Measurements and Nutritional Status

Sevim Yonca , Kutukluler Dogan Selenay

Menopause defines the period in which women’s menstrual periods cease permanently, significant hormonal changes begin, and fertility is lost. In addition to the fact that menopause causes body weight gain, it has been found that body weight gain can negatively affect the menopausal process. In this study, the relationship between food consumption and body composition changes that may be caused by the menopause period and menopausal symptoms was investigated. In the study,...

ea0090p199 | Reproductive and Developmental Endocrinology | ECE2023

Estetrol: estrogenic activity and coregulator profiling

Gerard Celine , Chatel Guillaume , Jost Maud , Foidart Jean-Michel

Estetrol (E4) is a natural estrogen produced by the human fetal liver during pregnancy. E4 is the estrogenic component of a new combined oral contraceptive and is also in development for its use as menopausal hormone therapy. E4 displays a selective binding to human estrogen receptors (ER). In humans, after oral administration, E4 undergoes phase 2 metabolism leading to the formation of the two major metabolites E4-3-glucuronide and E4-16-glucuronide. The objectives of this st...

ea0090p200 | Reproductive and Developmental Endocrinology | ECE2023

Effect of Overweight On the Course of Early Menopause in Women

Umarkhodjaeva Ziyoda , Inoyatkhodjaeva Irodakhon , Vahabova Mukhlisa

Purpose: To study the role of varying degrees of overweight in the course of menopause.Materials and methods of the study: The study involved 278 women in the menopausal period aged 40 to 46 years, of which the main group (MG) consisted of 218 women with overweight and obesity of varying degrees. The control group (CG) included 60 women with normal body weight and a waistResults of the study: As a result of the studies, we found th...

ea0090p201 | Reproductive and Developmental Endocrinology | ECE2023

Dopamine Agonist-Resistant Prolactinoma: Case report and literature review

Nutsubidze Teona , Bakhtadze Tekle , Sharadze Tamta , Zhgenti Medea , Jamburia Rezo , Janjgava Shota

The therapy of hyperprolactinemia with dopamine agonists (DAs) is highly effective in the majority of cases (1). However, some patients fail to achieve normal prolactin levels and develop drug resistance towards prescribed medicine. This case study describes a medical history of The Georgian National Institute of Endocrinology patient, with a drug-resistant hyperprolactinemia and inability to conceive. The patient’s MRI scan result has not indicated incidence of pr...

ea0090p202 | Reproductive and Developmental Endocrinology | ECE2023

The effect of thyroid function and estrogen levels on Body Mass Index in women of reproductive age

Issabayeva Assel , Durmanova Aigul , Slyamova Gul'nur , Ibraikhanova Ulpan

Background: Obesity in women of reproductive age has a number of negative metabolic consequences, including dyslipidemia, type 2 diabetes, cardiovascular diseases, certain types of cancer. It is associated with increased ovulatory dysfunction, complications during pregnancy, endometriosis and endocrine abnormalities, including thyroid dysfunction.Aim: To study the prevalence of BMI and its correlation with thyroid disorders, female sex hormones and prese...

ea0090p203 | Reproductive and Developmental Endocrinology | ECE2023

Predictive factors of infertility among patients with polycystic ovary syndrome

Elleuch Mouna , Frikha Hamdi , Triki Molka , Ben Salah Dhoha , Souleima Trigui , Charfi Nadia , Mnif Mouna , Mnif Fatma , Rekik Majdoub Nabila , Haj Kacem Akid Faten , Abid Mohamed

Introduction: Polycystic ovary syndrome (PCOS) is occurring in approximately one in seven women. Infertility is a major issue in PCOS. Recognizing patients with higher risk of infertility is still a matter of debate.Aim: Study the predictive factors of female infertility in patients with PCOSMethods: A retrospective, single-center, comparative and analytical study including patients with PCOS followed at the endocrinology departmen...

ea0090p204 | Reproductive and Developmental Endocrinology | ECE2023

Searching For The Testicles: A Medical Mystery?

Maria Dumitrache Sabina , Stan Raluca , Grosu Iustina , Zubaci Ana , Iliescu Marina , Tarna Mihaela , Mirica Alexandra , Nicoleta Cima Luminita , Cima Luminita

Introduction: Cryptorchidism is unilateral or bilateral absence of the testes from the scrotum. One of the differential diagnosis is congenital bilateral anorchia. Vanishing testes syndrome is associated with low serum AMH concentrations and an absent or subnormal response to stimulation with hCG. We report the case of a 22-year-old boy diagnosted with bilateral cryptorchidism and hypergonadotropic hypogonadism at the age of 17 years old. At the time of diagnosis the scrotum w...

ea0090p205 | Reproductive and Developmental Endocrinology | ECE2023

HAIR-AN syndrome: about a case

Wissam Debbah , Mezoued Mouna , Khadidja Bessaid , Azzouz Malha

Introduction: HAIR-AN syndrome is a rare condition, which can affect up to 5% of women with hirsutism. It is formed by the initials of the following clinical entities: HyperAndrogenism (hyperandrogenism), Insulino-Resistance (insulin resistance) and Acanthosis Nigricans. It is therefore a clinical triad that is considered as a severe subtype of PCOS, characterized by insulin resistance that appears early, constant and major. We present the case of a patient with Hair-an syndro...

ea0090p442 | Reproductive and Developmental Endocrinology | ECE2023

Do we know how to supplement selenium in pregnancy to provide a proper micronutrient status for mother-newborn pairs?

Filipowicz Dorota , Szczepanek-Parulska Ewelina , Schomburg Lutz , Ruchała Marek

Background: Selenium (Se) sufficiency is beneficial for thyroid metabolism and pregnancy course due to its antioxidant and anti-inflammatory properties. As a part of selenoenzymes, it ameliorates autoimmune thyroid disease (AITD) progression in mothers and provides proper neurogenesis in fetuses. Despite lacking or conflicting recommendations for its supplementation in pregnancy, Se is used in a clinical setting, as a common constituent of multivitamin pregnancy diet supplemen...

ea0090p443 | Reproductive and Developmental Endocrinology | ECE2023

Protein kinase B (Akt) blockade inhibits LH/hCG-mediated 17,20-lyase, but not 17α-hydroxylase activity of CYP17a1 in mouse Leydig cell steroidogenesis

Paradiso Elia , Lazzaretti Clara , Sperduti Samantha , Melli Beatrice , Perri Carmela , D'Alessandro Sara , Baschieri Lara , Mascolo Elisa , Roy Neena , Simoni Manuela , Casarini Livio

Androgens are sex steroid hormones fundamental for human reproduction. In males, they are produced upon luteinizing hormone (LH) action through its specific receptor (LHCGR) expressed in Leydig cells, supporting spermatogenesis. The human chorionic gonadotropin (hCG), acting on the same receptor but not expressed in men, is administered to improve testosterone synthesis in specific pathological contexts, such as hypogonadotropic hypogonadism and cryptorchidism. In vitro</e...

ea0090p444 | Reproductive and Developmental Endocrinology | ECE2023

Gender Affirming Hormonal Treatment (GAHT) and Demographics of Slovenian Transgender Adults

Mlekus Kozamernik Katarina , Krokter Kogoj Tina

Introduction: The number of individuals seeking gender-affirming hormonal treatment (GAHT), as well as the ratio between transgender men and transgender women, has increased over the past two decades. The type of GAHT varies significantly among different countries due to differences in availability and reimbursement policies. We aimed to analyze the kinds of GAHT and demographic characteristics of transgender adults at our endocrine clinic, the only center caring for transgend...

ea0090p445 | Reproductive and Developmental Endocrinology | ECE2023

Auto-immune diseases in Turner syndrome

Haj Kacem Akid Faten , Trimeche Oumeyma , Mnif Mouna , Khochtali Rihab , Ben Salah Dhoha , Elleuch Mouna , Fatma Mnif , Charfi Nadia , Rekik Majdoub Nabila , Abid Mohamed

Introduction: Turner syndrome (TS) is a genetic disease, attributable to the total or partial loss of an X chromosome. The classic phenotype encompasses short stature, hypergonadotropic hypogonadism and dysmorphic features. It’s also associated with other conditions such as autoimmune (AI) diseases. Aim: Herein we aim to determine the frequency of AI diseases in TS and to identify the genetic variants of TS mostly associated with this latter conditi...

ea0090p446 | Reproductive and Developmental Endocrinology | ECE2023

Delineating molecular mechanisms involved in hypo- and hyper-prolactinemia affecting male fertility

Raut Sanketa , Khambata Kushaan , Balasinor Nafisa

The endocrine system is crucial in spermatogenesis and any hormonal alterations may affect fertility. Prolactin (Prl) plays a role in male reproduction, as evidenced by presence of prolactin receptors on various testicular cells. However, the exact mechanism and physiological role of testicular prolactin receptor during spermatogenesis remains elusive. Clinical conditions such as hyper- and hypo-prolactinemia are known to have deleterious effects on male reproduction. The aim ...

ea0090p447 | Reproductive and Developmental Endocrinology | ECE2023

Influence of ovulation, anovulation and progestin on Phoenixin-20 and Nesfatin-1 in patients with polycystic ovary syndrome (PCOS)

Schommer Julia , Weber Susanne , Sydorivska Olga , Emmer Lisa , Luppa Peter , Seifert-Klauss Vanadin

Polycystic Ovary Syndrome (PCOS) is the most common endocrinological dysfunction among women of reproductive age, often featuring hyperandrogenemia and anovulation. Reciprocal effects exist between elevated LH, androgens, anovulation and other features, increasing the hormonal disbalance, while the origins of PCOS are still not fully clear. The neuropeptides Phoenixin-20 (PNX20) and Nesfatin1 (NES1) are being co-expressed and thought to play opposing roles in the hypothalamic&...

ea0090p448 | Reproductive and Developmental Endocrinology | ECE2023

Persistent effects of anabolic, androgenic steroids on muscle mass and strengths years after cessation?

Hoeg Brandt-Jacobsen Niels , Fredberg Jeppe , Rasmussen Jon , Bulut Yeliz , Kistorp Caroline

Objective: The use of anabolic, androgenic steroids (AAS) to increase muscle mass and strength has become widespread among younger men engaged in recreational strength training. Although, repercussions exist for elite athletes with a ban of two to four years, the long-term effects on muscle mass following cessation are currently unknown. The present study aims to investigate previous users’ ability to retain lean mass and strength after long-term AAS cessation.<p clas...

ea0090p449 | Reproductive and Developmental Endocrinology | ECE2023

Maternal cortisol levels in 3rd trimester and early language development, a study of 1,093 mother-child pairs from Odense Child Cohort

Mumm Hanne , Fenger Dreyer Anja , Bleses Dorthe , Glintborg Dorte , Kold Jensen Tina , Boye Henriette , Trecca Fabio , Andersen Marianne

Background: Language development during early childhood is considered an important marker of fetal neurodevelopment. Prenatal cortisol exposure plays a critical role in maturation of the fetal brain; however, the effect on offspring language development needs further investigation. This study aimed to evaluate the association between maternal 3rd trimester cortisol and early longitudinal offspring language development and to test whether there was sex differences in...

ea0090p450 | Reproductive and Developmental Endocrinology | ECE2023

Cardiovascular Events and Gender-Affirming Hormone Therapy, 10 Years of Follow-Up

Mariaca Riveros Karla , Martinez Veronica , Claro Maria , Sola Clara , Aranda Gloria , Alexandra Hanzu Felicia , Ortega Emilio , Orois Aida , Gomez Esther , Godas Teresa , Mateu Salat Manel , Halperin Irene , Mora Mireia

Objectives: Most transgender persons (0.3-0.5% of total population) are under gender-affirming hormone therapy (GAHT). Several studies have reported an increased morbimortality due to cardiovascular events (CVE), infectious disease and suicide. However, these studies were made on small populations and short follow up. We evaluated the changes on anthropometric variables, risk factors for cardiovascular diseases (CVD) and CVE at 5 and 10 years of follow up in a transgender popu...

ea0090p451 | Reproductive and Developmental Endocrinology | ECE2023

Dysfunction of Estrogen Signaling as a Novel Molecular Signature of PolyCystic Ovary Syndrome

Marie Clementine , Pierre Alice , Mayeur Anne , Giton Frank , Grynberg Michael , Cohen-Tannoudji Joelle , Guigon Celine , Chauvin Stephanie

Estradiol (E2) plays an essential role in woman fertility. E2, locally produced by granulosa cells (GCs) of ovarian antral follicles, controls follicular development and selection, and triggers the gonadotropin surge that leads to ovulation. Dysovulation arising from the arrest of antral follicle growth and maturation occurs in up to 10 % of reproductive-aged women suffering polycystic ovary syndrome (PCOS). Although the diagnostic criteria for PCOS are clearly established, th...

ea0090p452 | Reproductive and Developmental Endocrinology | ECE2023

The relationship between steroidogenesis and healthy eating index in polycystic ovary syndrome

Omma Tulay , Cigdem Yucel , Kızılgun Murat , Osmanlıoglu Coskun Seyma , Humeyra Zengin Fatmanur , Culha Cavit

Aim: We aimed to examine the relationship between the healthy eating index (HEI) and steroidogenesis in polycystic ovary syndrome (PCOS) patients and healthy controls.Materials and Methods: In addition to demographic records and routine biochemical tests, HEI was calculated from three-day nutritional records in the Bebis program. Adrenal steroidogenesis panel was measured by LCMS.Results: The study included 50 women with PCOS and 4...

ea0090p453 | Reproductive and Developmental Endocrinology | ECE2023

In between isolated premature thelarche and central precocious puberty: when DHEAS makes the difference

Rodari Giulia , Collini Valentina , Giacchetti Federico , Profka Eriselda , Arosio Maura , Mantovani Giovanna , Giavoli Claudia

Background: Precocious puberty (PP) in girls is most frequently an idiopathic gonadotropin-releasing hormone (GnRH)-dependent PP, being thelarche the typical first sign. It is well established that increased dehydroepiandrosterone sulphate (DHEAS) levels are associated with premature adrenarche and may characterize PP too. However, its relationship with signs of hypothalamic-pituitary-gonadal (HPG) axis activation and oestrogen exposure is still to be elucidated.<p class="...

ea0090p454 | Reproductive and Developmental Endocrinology | ECE2023

Effect of selective oestrogen receptor modulators/aromatase inhibitors on semen parameters in men with secondary hypogonadism; systematic review and meta-analysis

Lakshitha de Silva Nipun , Dissanayake Harsha , Suarez Camila , Wickramarachchi R. E. , Ramasamy Ranjith , Dhillo Waljit , Minhas Suks , Corona Giovanni , Jayasena Channa

Introduction: Selective oestrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) potentially increase endogenous gonadotrophin and testosterone secretion in men. They are used off-label in men with hypogonadism and/or infertility. There is a lack of guidance on using these agents in men with secondary hypogonadism, though these agents are widely used in these people as a cheaper alternative to gonadotrophins. Methods: Systematic search was co...

ea0090p455 | Reproductive and Developmental Endocrinology | ECE2023

Decreased Quality of Life in Previous Users of Anabolic Androgenic Steroids Years After Cessation

Bulut Yeliz , Brandt-Jacobsen Niels , Kistorp Caroline , Rasmussen Jon J.

Background and Aim: Use of anabolic androgenic steroids (AAS) has moved from elite sports to the broader population. Studies suggest that AAS cessation is often associated with immediate various AAS withdrawal and hypogonadal symptoms. Quality of life using a standardized questionnaire has never been assessed in AAS users. The Short-Form 36 (SF-36) questionnaire is a highly validated and used instrument for assessment of quality of life. The questionnaire consists of a total e...

ea0090p456 | Reproductive and Developmental Endocrinology | ECE2023

Nurse-Led Care for Transgender and Gender Diverse Individuals: A Cross-Sectional Study of International Context and Practice

Greenspan Debra , White Bradley P. , Bobrowich Eli G. , Carruthers Paul , Ducar Dallas , Ernstsson Camilla , Barrett Sophia , Dwyer Andrew

Introduction: Gender minorities, including transgender and gender diverse (TGD) individuals face health disparities and significant barriers in accessing healthcare. Lack of access to providers knowledgeable in TGD health needs is the single greatest barrier to care. Existing literature on TGD care has almost exclusively focused on physicians and there is scant literature on the role of nurses. We aimed to describe exemplars of nurse-led TGD care internationally to better unde...

ea0090p457 | Reproductive and Developmental Endocrinology | ECE2023

Evaluation of Oxidative Stress Parameters and Serum Fetuin-A Levels in Patients with Polycystic Over Syndrome

Gizem Tekin Bedriye , Gulsun Arslan Cellat Esma , Tabur Suzan , Taysı Seyithan

Introduction: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and/or polycystic ovary. Hypotheses such as genetic and environmental causes, disruption of the hypothalamo-pituitary-gonadal axis, insulin resistance, hyperinsulinemia and increased oxidative stress have been proposed to explain the etiopathogenesis of PCOS. In our study, we aimed to evaluate oxidative stress parameters and serum fetuin-A levels and to investigate their role...

ea0090p458 | Reproductive and Developmental Endocrinology | ECE2023

Association between androgen levels and SPISE index in patients with polycystic ovarian syndrome

Radic Lena , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Bjekic Macut Jelica , Opalic Milica , Elezovic Kovacevic Valentina , Stanojlovic Olivera , Hrncic Dragan , Vojnovic Milutinovic Danijela , Macut Djuro P.

Introduction: Polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism, chronic oligo-/anovulation and polycystic ovarian morphology. Hyperandrogenism is a key diagnostic feature of PCOS and according to ESHRE/ASRM criteria it can be clinical and/or biochemical. SPISE index (single-point insulin sensitivity estimator index) is a new indicator of insulin sensitivity and a predictor of abnormal glucose metabolism. The aim of the research was to analyse association...

ea0090p459 | Reproductive and Developmental Endocrinology | ECE2023

Improved self-reported confidence levels to manage transitional endocrine cases following Simulation via Instant Messaging – Birmingham Advance (SIMBA) training

Ogiliev Tamzin , Sakthivel Pavithra , Elghobashy Mirna , Devi Bucktowar Anoushka , Radcliffe Abby , Elhariry Maiar , Ali Anisah , Ravi Sangamithra , Synn Cuen Pan Carina , Yat Ng Sung , Akpeki Celia , Zhou Dengyi , and CoMICs Team SIMBA , Kempegowda Punith

Introduction: Simulation via Instant Messaging – Birmingham Advance (SIMBA) is an online real-time simulation-based learning model which has proven to improve participants’ confidence in managing simulated cases in various conditions. Transitional endocrinology is a unique set of conditions which not only needs clinical skills but also requires excellent team working and communication skills. The aim of the study was to assess the effectiveness of the SIMBA model in ...

ea0090p460 | Reproductive and Developmental Endocrinology | ECE2023

Prevalence of body dysmorphism in PCOS women

Flood John , Alili Fatima

Polycystic ovary syndrome (PCOS) is the most common reproductive problem in women of childbearing age attending an endocrine clinic with a reported prevalence of between 4-8 %. The classical symptoms result from excess ovarian androgen production and chronic anovulation. Ovarian ultrasound shows more than 10 follicles, 2-10mm in diameter. A common presentation in the clinic can be menstrual dysfunction but the most characteristic feature of the syndrome is the hirsutism which ...

ea0090p461 | Reproductive and Developmental Endocrinology | ECE2023

Extremely high testosterone level in a woman without virilization signs. Is it only laboratory pitfalls?

Ostrovsky Viviana , Ulman Mira , Hemi Rina , Lurie Samuel , Hazan Inon , Ben Ari Alon , Sukmanov Oleg , Schiller Tal , Kirzhner Alena , Zornitzki Taiba

Introduction: High androgen levels and infertility in reproductive women, beyond the most common cause of polycystic ovary syndrome (PCOS), is often a challenge diagnosis. Ovarian steroid cell tumor is considered a rare subtype of hormone-secreting ovarian tumor, accounting for about 0.1% of all ovarian tumors.Aim: To report a case of extremely high testosterone levels in a woman with secondary amenorrhea but without signs of virilization, and describe d...

ea0090p462 | Reproductive and Developmental Endocrinology | ECE2023

Remission of ovarian hyperandrogenism in two post-menopausal women treated with GnRH analogue

Dionese Paola , Rotolo Laura , Bongiorno Claudio , Cecchetti Carolina , Starace Michela , Bruni Francesca , Pagotto Uberto , Gambineri Alessandra , Pelusi Carla

Background and aim: Ovarian hyperandrogenism is a known cause of post-menopausal hirsutism and virilisation, more frequently of a benign nature (e.g. ovarian hyperthecosis, Leydig cell hyperplasia). Bilateral salpingo-oophorectomy delivers both definitive diagnostic and therapeutic results. However, after excluding the presence of a suspicious ovarian mass, the use of GnRH analogues (GnRH-a) offers a valuable therapeutic alternative with cases reporting a sustained response in...

ea0090p463 | Reproductive and Developmental Endocrinology | ECE2023

Benificial Effects of Antioxidant Combination in Dimining Oxidative Stress Status and Improves Semen Parameters in Infertile Men: One Blind Placebo Controlled Trial

Zhaku Vegim , Beadini Sheqibe

Male infertility every year is becoming one of the main problems of the health system, which requires serious steps in coping this health and socioeconomic burden. Oxidative stress is emphasized as the main factor of idiopathic etiology resulting with the inability to conceive because of poor semen quality. Antioxidants have shown their beneficial effects in various studies conducted, resulting both in improving semen quality and higher chance of natural conception. Thus, the ...

ea0090p464 | Reproductive and Developmental Endocrinology | ECE2023

Visfatin expression and regulation by E2, P4, hCG and insulin in human placental cells

Dawid Monika , Kurowska Patrycja , Pawlicki Piotr , Kotula-Balak Małgorzata , Milewicz Tomasz , Rak Agnieszka

Introduction: Visfatin belongs to adipokines, i.e. hormones produced mainly by adipose tissue; its expression and role have been described in many organs, where it regulates energy metabolism, insulin resistance and inflammatory reactions. Moreover, the level of visfatin changes during pregnancy and in obese women and those with obesity related pregnancy pathologies: preeclampsia (PE), gestational diabetes (GDM) or intrauterine growth restriction (IUGR) its level increases. Th...

ea0090p465 | Reproductive and Developmental Endocrinology | ECE2023

Sexual dimorphism in the LH responses to kisspeptin and senktide administration in prepubertal mice

Maione Luigi , Naule Lydie , Yang Ling Li Chloe , Magnuson Melissa , Young Jacques , Stephanie Carroll Rona , Kaiser Ursula

Introduction: The hypothalamic-pituitary-gonadal (HPG) axis is regulated by pulsatile GnRH secretion and its action on the anterior pituitary, leading to the synthesis and secretion of LH and FSH. KNDy neurons, expressing kisspeptin, neurokinin B and dynorphin A, are the GnRH/lH pulse generator and are key regulators of puberty and fertility. The HPG axis is active during prenatal and early postnatal life in humans and rodents, but then remains quiescent until puberty in both ...

ea0090p466 | Reproductive and Developmental Endocrinology | ECE2023

Hyperprolactinemia in Turner syndrome

Haj Kacem Akid Faten , Trimeche Oumeyma , Mnif Mouna , Hamdi Frikha , Ben Salah Dhoha , Elleuch Mouna , Fatma Mnif , Charfi Nadia , Rekik Majdoub Nabila , Abid Mohamed

Introduction: Hyperprolactinemia is a relatively frequent finding. A wide range of conditions can be responsible of this biochemical abnormality. Herein we report a rather rare etiology of hyperprolactinemia which is Turner syndrome (TS).Methods: Aiming to determine the frequency of hyperprolactinemia in patients with TS, we enrolled a retrospective descriptive study in the department of Endocrinology at the Hedi Chaker Hospital. We included patients who...

ea0090p467 | Reproductive and Developmental Endocrinology | ECE2023

A rare co-occurence of Turner syndrome and acromegaly complicated by the presence of a solid pseudopapillary neoplasm of pancreas-a case report

Cylke-Falkowska Karolina , Stelmachowska-Banaś Maria , Cichocki Andrzej , Zieliński Grzegorz , Zgliczyński Wojciech

Background: Turner syndrome (TS) is the most common chromosome deficiency in women, with an incidence of 1 in 2 000 female newborns. Acromegaly is a rare disease, which occurs with a frequency of 1:140 000–250 000 of the population. To our knowledge only several cases of TS and acromegaly coexistance have been reported up to date.Case presentation: A 43-year-old woman with TS was referred to our Department with an accidentally discovered pituitary m...

ea0090p468 | Reproductive and Developmental Endocrinology | ECE2023

In vitro evaluation of the impact of two differently glycosylated recombinant FSH on signal transduction

Mascolo Elisa , Baschieri Lara , Roy Neena , Lazzaretti Clara , Paradiso Elia , Perri Carmela , Sperduti Samantha , Simoni Manuela , Casarini Livio

Follicle stimulating hormone (FSH) is produced by the anterior pituitary gland and it is a key hormone in the reproductive system. FSH is a heterodimeric glycoprotein composed with two extensively glycosylated protein sobunits (α and β) N-glycosylated in two positions (Asn52 and Asn78 in the FSHα subunit and Asn7 and Asn24 in the FSHβ subunit) giving rise to numerous isoforms of FSH. Glycosylation has been shown t...

ea0090p469 | Reproductive and Developmental Endocrinology | ECE2023

Gestational thyrotoxicosis due to molar pregnancy complicated by pre-eclampsia

Mansukhbhai Shekhda Kalyan , Zlatkin Vladislav , Kumar Sahoo Saroj , Tamjidul Islam Quazi , Naeem Ammara , Nwokolo Munachiso , Yousseif Ahmed , Karra Efthimia , Patel Dipesh , Khoo Bernard , Armeni Eleni

Introduction: Gestational trophoblastic disease (GTD) is a group of disorders arising from abnormal proliferation of placental trophoblasts. Hydatiform mole (molar pregnancy) is a premalignant condition which is further devided in to partial and complete mole. Incidence of molar pregnancy is estimated to be 1 in 1000 pregnancies. Hyperthyroidism is one of the rare complications of molar pregnancy which, if not detected and treated, can lead to adverse consequences. We describe...

ea0090p470 | Reproductive and Developmental Endocrinology | ECE2023

Unveiling follicular fluid oxidative stress biomarkers at polycystic ovary syndrome

Moreira Mafalda V. , Vale Fernandes Emidio , Bernardino Raquel , Alves Marco , P Monteiro Mariana

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorder of women at reproductive-age and accounts for 80% of the causes of anovulatory infertility. Despite the widely characterized reproductive, endocrine, and metabolic abnormalities, the mechanisms underlying PCOS remain unclear. Thus, it is essential to identify novel biomarkers that will allow to disclosure novel pathways involved PCOS pathophysiology, which could then be used to improve PCOS manage...

ea0090p471 | Reproductive and Developmental Endocrinology | ECE2023

Establishing LOQ for estradiol, LH, FSH and testosterone on Roche Cobas e801

Goreta Sanja , Zec Ivana , Bokulić Adriana , Marijančević Domagoj

Introduction: The limit of quantification (LOQ) is defined as the lowest analyte concentration that can be reproducibly measured with defined imprecision expressed as CV (coefficient of variation). Low concentrations of hormones estradiol, LH, FSH and testosterone are essential in diagnosis and monitoring of various endocrine disorders. Automated immunoassays have well known advantages, but still limited in achieving necessary analytical sensitivity. The major concern is to pr...

ea0090p472 | Reproductive and Developmental Endocrinology | ECE2023

Normosmic idiopathic hypogonadotropic hypogonadism: A case report

Akmador Nahudan , Barrera Jerome

Background: Idiopathic hypogonadotropic hypogonadism (IHH) is manifested as absent or incomplete puberty and biochemically low levels of sex hormones, with low or inappropriately normal gonadotropin hormones. In the absence of structural or functional lesions of the hypothalamic or pituitary gland, the hypogonadism is referred as idiopathic hypogonadotropic hypogonadism (IHH). IHH is a genetically heterogeneous disorder which can be caused by pathogenic variants affecting prot...

ea0090p473 | Reproductive and Developmental Endocrinology | ECE2023

Change in lipid profile and glucose levels after 12 months of testosterone therapy in transgender men

Montanez Fernandez Laura , Bayona Cebada Ane

Introduction: Approximately 0.5% of the world population experiences gender dysphoria, a discrepancy between one’s biological sex and gender identity. Transgender men (TM), individuals who were assigned female at birth but who identify as men, can benefit from therapy with testosterone (T) to address gender dysphoria. Although unfavourable changes in lipid profiles have been previously reported, most studies did not show an adverse impact of testosterone treatment on fast...

ea0090p474 | Reproductive and Developmental Endocrinology | ECE2023

Significant hyponatremia as a manifestation of severe pre eclampsia

Seshadri Shyam , Kidwai Salman , Shousha Marwa

A 32-year-old primigravida woman, low risk pregnancy, BMI 20, presented at 29 weeks of gestation with headache and mildly raised blood pressure and normal laboratory tests. The patient had no signifcant medical history and the pregnancy to date had been uneventful. Physical examination showed blood pressure (BP) of 145/93 mm Hg. (Baseline, 100/70 mm Hg). Laboratory tests showed a baseline sodium of 134 mmol/l, with the rest of the biochemistry normal. She had been commenced on...

ea0090p475 | Reproductive and Developmental Endocrinology | ECE2023

Not what it seems: an exuberant case of hirsutism in polycystic ovary syndrome

de Grine Severino Mariana , Vaz Lopes Marta , Peixe Carolina , Vicente Rocha Jose , Lacerda Nobre Ema , Joao Bugalho Maria

Introduction: Hirsutism is the presence of terminal hair growth in females with a male distribution pattern. It affects 5-15% of women, being an important sign of androgen excess. The main causes of hirsutism are polycystic ovary syndrome (PCOS) and idiopathic hyperandrogenism. Other significant but less frequent causes of hirsutism include nonclassic congenital adrenal hyperplasia (NCAH), androgen-secreting tumors, and Cushing’s syndrome.Case repor...

ea0090p476 | Reproductive and Developmental Endocrinology | ECE2023

Galanin-Like Peptide and its’ Correlation With Androgen Levels in Patients with Polycystic Ovary Syndrome

Hamiyet Yilmaz , Mustafa Demirpence Muhammed

Introduction: We aimed to investigate serum galanin-like peptide levels and its’correlation with hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS)Material and Methods: The study included 48 women (age range, 18-44 years) with a diagnosis of PCOS and control group that included 40 healthy females (age range, 18-46 years). Body mass index (BMI), waist circumference, Ferriman-Gallwey score, was evaluated and plasma glu...

ea0090p477 | Reproductive and Developmental Endocrinology | ECE2023

Hidden Cause of Decreased Fertility Rate During Grave’s Disease

Kutchukidze Tinatin , Khurodze Tea

Introduction: Thyroid autoimmune disorders interfere with the physiology of reproduction, cause premature ovarian aging, and mimic the early stage of menopause. Recently, no specific research was made to measure Grave’s disease and infertility rates in young patients.Case Report: Due to an inability to conceive for two years, a 24-year-old Caucasian female was referred to the clinic with typical symptoms and complaints of Grave’s disease. She h...

ea0090p713 | Reproductive and Developmental Endocrinology | ECE2023

A case of prolactin increase with cyproterone acetate: sublingual use of estradiol in transgender woman

Cihan Huseyin , Sarer Yurekli Banu

Introduction: Transgender women and gender diverse individuals with functioning testicles who are eligible for estrogen-based hormone therapy need to use antiandrogens in addition to estrogen to achieve adequate desired physical changes and suppress testosterone to cisgender women levels. Sublingually administered estradiol can achieve higher serum estradiol levels than traditionally administered oral estradiol, but may require multidaily dosing (1). We present a case of trans...

ea0090p714 | Reproductive and Developmental Endocrinology | ECE2023

Newly diagnosed diabetes in Turner syndrome: what is the role of incretins?

Cecchetti Carolina , Dionese Paola , Belardinelli Elisabetta , Rotolo Laura , Solmi: Beatrice , Fanelli Flaminia , Pagotto Uberto , Gambineri Alessandra

Introduction: Diabetes mellitus (DM) develops early in Turner syndrome (TS) and appears not related to common risk factors. The precise mechanism of its development is still a matter of debate: a defective insulin response seems to be involved, but the role of incretins is still undefined.Objective: To evaluate the implication of incretin release in the early stages of DM development in TS. Materials and Methods: 153 Turner patient...

ea0090p715 | Reproductive and Developmental Endocrinology | ECE2023

A systematic review of gonadotropin and GnRH therapy for the induction or completion of puberty in males with hypogonadotropic hypogonadism

Alexander Emma , Faruqi Duaa , Farquhar Robert , Unadkat Ayesha , Ng Yin Kyla , Kokotsis Vasilis , Howard Sasha

Background and aims: Hypogonadotropic hypogonadism is characterised by inadequate secretion of gonadotropins (luteinising hormone (LH) and follicle-stimulating hormone (FSH)) leading to absent, partial or arrested puberty. In males, classical treatment with testosterone promotes virilisation but does not facilitate testicular growth or spermatogenesis. Conversely, treatment with gonadotropins or gonadotropin-releasing hormone (GnRH) stimulates Sertoli and Leydig cells directly...

ea0090p716 | Reproductive and Developmental Endocrinology | ECE2023

Interleukin-22/Interleukin-22 binding protein axis and oral contraceptive use in polycystic ovary syndrome

Aksun Seren , Ersal Ece , Portakal Oytun , Yildiz Bulent

Background and Aim: Polycystic ovary syndrome (PCOS) is associated with compositional and functional alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by both innate and adaptive immune cells and closely linked to gut immunity. IL-22 is tightly controlled by its binding protein (IL-22BP), which serves as an antagonist of IL-22 signaling. Preliminary animal studies and limited human data in Asian populations suggest lower circulating levels of IL-22...

ea0090p717 | Reproductive and Developmental Endocrinology | ECE2023

Phenotypic and genotypic variation in pubertal presentation among patients with self-limited delayed puberty and hypogonadotrophic hypogonadism

Aung Yuri , Kokotsis Vasilis , Howard Sasha

Introduction: Delayed puberty (DP), affecting over 2% of adolescents, is defined as pubertal onset at 2-2.5 SDs later than the general population. Two common underlying aetiologies are self-limited DP (SLDP) and congenital hypogonadotrophic hypogonadism (HH). However, these can be difficult to discern between on first presentation of a patient to endocrinology services. This study sought to elucidate phenotypic and genotypic differences between the two diagnoses in order to op...

ea0090p718 | Reproductive and Developmental Endocrinology | ECE2023

Correlation between both serum and seminal fluid vitamin D levels and vitamin D receptor CDX polymorphism in male infertility

Vladoiu Suzana , Botezatu Anca , Muresan Andrei , Albulescu Adrian , Popa Oana-Monica , Alina Fudulu , Adriana Ples , Stancu Cristina , Iulia Virginia Iancu , Badiu Corin , Draganescu Daniela Dinu

Vitamin D (VD) now considered a steroid hormone, has been correlated with male reproductive disorders. The activity of VD is mediated through its receptor (VDR), distributed in various tissues including reproductive tissues. VDR polymorphism located in the promoter region of the gene, rs17883968 (Cdx2) G → A associated with transcriptional activity. The aim of this study was to assess both seminal and serum VD levels in a group of infertile patients (n=87, media...

ea0090p719 | Reproductive and Developmental Endocrinology | ECE2023

The fertility status of patients with Cushing’s disease under treatment

Nur Korkmaz Fatma , Gokcay Canpolat Asena , Demir Ozgur , Corapcıoğlu Demet

Introduction: The main goal of treatment in Cushing’s disease (CD) is to induce remission as well as to restore reproductive function. We aimed to evaluate the reproductive status of the female patients with CD encountered in sexually active patients after surgical with/without medical treatments.Method: The retrospective data was obtained from the medical records of the 72 female patients diagnosed with CD at hospital registration system. The patie...

ea0090p720 | Reproductive and Developmental Endocrinology | ECE2023

Endocrine and Non-Endocrine Causes of Fatigue in Adults With Turner Syndrome: Cohort Study and Review of the Literature

Rosenberg Anna , Dingemans Veerle D.A. , Roubos Anja , Luijks Sanne , Dessens Arianne B. , Dykgraaf Ramon , Roos-Hesselink Jolien W. , van Rossum Elisabeth , Jan van der Lely Aart , De Graaff Laura

Background: Turner syndrome (TS) is a rare genetic developmental disorder characterized by gonadal dysfunction, short stature and heart defects, among others. Women with TS often suffer from severe fatigue, for which they are typically referred to endocrinologists. The diagnostic work-up is generally time-consuming and invasive, but it rarely solves the problem. To prevent the personal and financial burden of unnecessary diagnostic procedures, it is crucial to understand fatig...

ea0090p721 | Reproductive and Developmental Endocrinology | ECE2023

In vitro exposure to the endocrine disruptor atrazine induces a pro-oxidant state and modulates mouse Sertoli cells metabolic support of spermatogenesis

Gomes-Andrade Daniela , Guerra-Carvalho Barbara , Carrageta David F. , Bernardino Raquel L. , Oliveira Pedro F. , de Lourdes Pereira Maria , Alves Marco G.

Introduction: Atrazine is one of the most widely used pesticides worldwide and a common contaminant in human drinking water. Atrazine is also a potent endocrine disruptor capable of causing a variety of negative health outcomes, including decreased testosterone production and infertility. Although harmful effects of atrazine on male reproductive health have been reported, little is known about its molecular mechanisms. Within the seminiferous tubules, Sertoli cells are respons...

ea0090p722 | Reproductive and Developmental Endocrinology | ECE2023

Comparison of omentin (intelectin-1) expression and regulation in ovarian follicle cells from normal weight Large White and obese Meishan pigs

Pich Karolina , Respekta Natalia , Kurowska Patrycja , Rame Christelle , Dupont Joelle , Dobrzyń Kamil , Smolińska Nina , Rak Agnieszka

Introduction: Omentin, also known as intelectin-1 (ITLN1), is a novel adipokine produced predominantly by visceral adipose tissue, which improves insulin sensitivity. Decreased levels of ITLN1 have been reported in the serum of obese and polycystic ovary syndrome patients, as well as in the serum and adipose tissue of obese Meishan (MS) compared to normal weight Large White (LW) pigs. However, the role of ITLN1 in female reproduction at different metabolic status is still unkn...

ea0090p723 | Reproductive and Developmental Endocrinology | ECE2023

Early markers of metabolic disorders, such as leucin and isoleucine level and lipid accumulation product, should be considered as the potential additional criterium in PCOS classification

Paczkowska Katarzyna , Rachoń Dominik , Berg Andrzej , Rybka Jacek , Kapczyńska Katarzyna , Bolanowski Marek , Daroszewski Jacek

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive age women and predispose to the development of metabolic disturbances. However, Rotterdam criteria, commonly used to diagnose and classify this disorder, do not include metabolic markers. Recent research has shown that several metabolic factors may play a role in PCOS pathogenesis. Branched-chain amino acids (BCAA) are the group of essential amino acids including leucine, isol...

ea0090p724 | Reproductive and Developmental Endocrinology | ECE2023

Effects of testosterone therapy on erythrocytosis and prostate adverse events in obese males with functional hypogonadism and type 2 diabetes

Groti Antonic Kristina

Aims: Testosterone therapy (TTh) has been postulated to increase the risk of prostate adverse events (PAEs) and erythrocytosis, risk further exacerbated in high-risk obese patients with type 2 diabetes (T2D) and functional hypogonadism (FH). We investigated safety aspects of TTh in obese males with FH and T2D by observing the incidence of PAEs and erythrocytosis and determining when statistically significant difference from the baseline manifests in hematocrit (Hct) and prosta...

ea0090p725 | Reproductive and Developmental Endocrinology | ECE2023

The Role of Testosterone Treatment in Patients with Type 2 Diabetes Mellitus: Results from A Meta-Analysis Study

Vena Walter , Vignozzi Linda , Maggi Mario , Sforza Alessaandra , Pizzocaro Alessandro , Corona Giovanni

Introduction: type 2 diabetes mellitus (T2DM) and hypogonadism are common conditions afflicting the aging male, often present together. The specific role of testosterone (T) replacement therapy (TRT) on glycometabolic profile and body composition, particularly in patients with T2DM, is still the object of an intense debate. The aim of the present study is to meta-analyze the role of TRT in T2DM considering all placebo and non-placebo-controlled randomized clinical trials (RCTs...

ea0090p726 | Reproductive and Developmental Endocrinology | ECE2023

The impact of pharmacological treatments on oxidative stress, inflammatory parameters and semen characteristics

Zamponi Virginia , Mazzilli Rossella , Olana Soraya , Russo Flaminia , Mancini Camilla , Faggiano Antongiulio , Salerno Gerardo

Introduction: Although the pathogenic mechanism is not completely understood, pharmacological treatments could negatively affect seminal parameters. The analysis of inflammatory (i.e. cytokines) and oxidative stress parameters represent a new tools to investigate the causes of idiopathic male infertility. The aim of this study was to evaluate the impact of medications on oxidative stress, inflammatory parameters and semen characteristics in male with idiopathic infertility.</p...

ea0090p727 | Reproductive and Developmental Endocrinology | ECE2023

Resistin as A New Regulator of Luteolysis: in Vitro Effect of Resistin on Proliferation, Apoptosis, and Autophagy in Porcine Luteal Cells

Kurowska Patrycja , Gaździk Kinga , Jasińska Agata , Mlyczyńska Ewa , Wachowska Dominika , Rak Agnieszka

To maintain proper fertility the balance between formation and luteolysis of corpus luteum (CL) are necessary and strictly controlled events in female reproduction. Degeneration of CL is correlated with apoptosis and autophagy as well as connected with decreased progesterone (P4) level. Resistin is a new key player in the regulation of luteal cells function; our previously study showed that resistin have negative effect on P4 synthesis. Thus the aim of the present study was to...

ea0090p728 | Reproductive and Developmental Endocrinology | ECE2023

Polygenic Score for Dizygotic Twinning in Mothers of Spontaneously and Artificially Conceived Twins and Singletons

Hubers Nikki , Page Christian , Mbarek Hamdi , Lambalk Nils , Ligthart Lannie , Pool Rene , Jan Hottenga Jouke , van Dongen Jenny , Haberg Siri , Ehli Erik , Harris Jennifer , Willemsen Gonneke , Boomsma Dorret

Spontaneous dizygotic (DZ) twinning results from a double ovulation and runs in families indicating a genetic component. Endocrinology studies in mothers of DZ twins observed higher levels of follicle stimulation hormone (FSH) and FSHB was, together with SMAD3, one the first loci identified as genome wide significant in genome-wide association studies (GWAS) of having DZ twins. Several additional loci were recently found that indicate genes involved with fema...

ea0090p729 | Reproductive and Developmental Endocrinology | ECE2023

Sex hormones as independent predictors of severe COVID-19 in patients with SARS-CoV-2 infection

Quinzanos Ruiz Cristina , Alexandra Zapata Maldonado Gabriela , Teresa Garcia-Unzueta Maria , Vazquez Luis , Alio Lavin Gomez Bernardo , Ruiz Ochoa David

Introduction: The SARS-CoV 2 pandemic has resulted in millions of deaths worldwide. It has been suggested that sex steroids may be involved in the prognosis of the disease.Material and methods: Male patients diagnosed with SARS-CoV-2 infection admitted to the Marqués de Valdecilla University Hospital (Spain). Testosterone, androstenedione, estradiol, DHEA and DHEAS were determined in the first 24 h of admission and severe COVID was defined as mortal...

ea0090p730 | Reproductive and Developmental Endocrinology | ECE2023

Influence of Obesity on Medically Assisted Reproduction Techniques

Araujo Catia , Baptista Carla , Paiva Isabel , Cortesao Paulo , Martins Ferreira Mafalda

Introduction: Evidence has suggested a relationship between female obesity and the outcomes of medically assisted reproduction techniques (MRT); however, the evidence regarding male obesity is still scarce and discordant. Aim: Evaluate the influence of female and male obesity on the results of MRT.Materials and methods: Retrospective analysis of 2159 couples, with and without obesity, submitted to the first treatment of medically a...

ea0090p731 | Reproductive and Developmental Endocrinology | ECE2023

Bilateral ovarian mass due to primary hypothyroidism - a case report

M V Vimal , K Nikitha , P N Ajitha

Introduction: The triad of primary hypothyroidism, precocious puberty and delayed bone age in children with cystic ovarian enlargement constitutes the syndrome of van wyk grumbach. Commonly reported as a rare complication of hypothyroidism in children, there are only a few case reports in adult population. Herewith, we are reporting the case of a 22-year-old hypothyroid lady, who presented with bilateral ovarian cysts. Considering hypothyroidism, a high risk for surgery, thyro...

ea0090p732 | Reproductive and Developmental Endocrinology | ECE2023

Impact of chromium picolinate on testicular steroidogenesis

Moreira Ruben , Moreira Silvia , Alves Marco , Oliveira Pedro , de Lourdes Pereira Maria

Low testosterone levels are one of the causes of male infertility since testosterone is a crucial hormone for the regular functioning of the male reproductive tract. Testosterone is produced by Leydig cells (LC) in a process called testicular steroidogenesis, and if these cells are injured in any way, then the steroid production may be compromised. Endocrine Disrupting Chemicals (EDCs) are a group of substances that disturbs hormonal signaling. Their chemical nature and mode o...

ea0090p733 | Reproductive and Developmental Endocrinology | ECE2023

Periodic Assessment of Biochemical-Hematological Changes in A Series of Transgender Men After 1 Year of Gender Affirming Therapy

Velasco de Cos Guillermo , Latorre Mesa Carlos , Teresa Garcia-Unzueta Maria , Vazquez Luis , Ormazabal Monterrubio Maialen , Guerra Ruiz Armando , Moyano Martinez Ana , Alexandra Zapata Maldonado Gabriela , Villar Bonet Aurelia

Introduction: During gender affirming therapy in transgender men (TXM), androgens are administered at escalating doses. As therapy progresses, changes in various analytical parameters occur that may be of potential use in establishing a personalised androgen dosage and avoiding deleterious effects of the medication. The aim of our study was to study the evolution of different parameters throughout the course of gender affirming therapy.Material and metho...

ea0090p734 | Reproductive and Developmental Endocrinology | ECE2023

A retrospective observational study of thyroid function throughout a pregnancy and its effects on the fetus and the mother

Kumar Subhash , Guha Shaibal , Kumar Choudhary Binod

Introduction: Maternal thyroid function is put under stress during pregnancy. Thyroid disorder is very common among expectant mothers. 10% of pregnancies have subclinical hypothyroidism. Anemia, low birth weight, and neonatal mental retardation are among side effects of hypothyroidism during pregnancy.Objective: The primary and main objective is to evaluate the results for pregnant women with abnormal thyroid profiles, both for the mother and the fetus. ...

ea0090p735 | Reproductive and Developmental Endocrinology | ECE2023

Biological variation data of anti-Müllerian hormone and androstenedione among women of reproductive age

Marijančević Domagoj , Bokulić Adriana , Zec Ivana , Goreta Sanja

Introduction: Biological variation (BV) data describe the variability of clinically important measurands around homeostatic set points within subjects (CVI) and between subjects (CVG). The availability of well characterized data enables the interpretation of laboratory results in clinical settings and can also be used to define analytical performance specifications. The aim of this study was to deliver BV estimates for anti-Müllerian hormone (AMH) and androstenedione amon...

ea0090p736 | Reproductive and Developmental Endocrinology | ECE2023

The Impact of Covid-19 Lockdown on Pubertal Onset in A Second Level Center

Goggi Giovanni , Moro Mirella , Chila Alessandro , Fatti Letizia , Cangiano Biagio , Federici SIlvia , Galazzi Elena , Carbone Erika , Soranna Davide , Vezzoli Valeria , Persani Luca , Bonomi Marco

Background: As of December 2019, the COVID-19 pandemic has spread rapidly, therefore Governments from all over the world promoted a strategy of social confinement through a general lockdown in order to contain it. During the months following its introduction, many studies reported a significant increase in the incidence of idiopathic central precocious puberty (CPP) throughout several countries, especially in girls.Purpose: The aim of our study was to co...

ea0090p737 | Reproductive and Developmental Endocrinology | ECE2023

Insulin-like growth factors: possible players regarding male fertility

Agualusa Nair , Carrageta David F. , Pereira Sara C. , Barros Alberto , Crisostomo Luis , Alves Marco G. , Oliveira Pedro F.

Infertility affects about 15% of couples, and, among these, 50% are related to the male factor. Male infertility can be caused by intrinsic factors, and these may either directly or indirectly affect gamete and testicular development as a consequence of endocrinopathies. In that sense, research regarding the involvement of endocrine hormones, particularly of nutritional status-linked hormones, in the male reproductive system has increased over the years. In fact, the rise on t...

ea0090p738 | Reproductive and Developmental Endocrinology | ECE2023

46, XX male (SRY positive): recalling a clinical case

de Assuncao Guilherme V. , Morais Carvalho Rui

Introduction: XX male syndrome is a disorder of sex development associated with a 46, XX karyotype and is characterized by such features as: small testes, hypergonadotropic hypogonadism, male external genitalia, gynecomastia and azoospermia. The estimated prevalence is 1/20.000 males. Gender role and gender identity are reported as male. Identification and subsequent treatment is necessary to avoid the manifestations of testosterone deficiency.Clinical C...

ea0090p739 | Reproductive and Developmental Endocrinology | ECE2023

Experiences and expectation of young women with PCOS and their mothers: A Qualitative study in India

Lathia Tejal , Selvan Chitra , Chawak Shweta , Akula Niveditha , Chittem Mahati

Women diagnosed with polycystic ovarian syndrome (PCOS) experience several physiological (weight gain, hirsutism, acne) and psychological challenges (emotional distress, anxiety, shame). This is particularly apparent in India where PCOS intersects with gender and patriarchal notions of womanhood (interfering with one’s marital prospects, compromising one’s ability to procreate). A young woman’s first source of support, therefore, is usually their mother. In Indi...

ea0090p740 | Reproductive and Developmental Endocrinology | ECE2023

Improving detection of rare overgrowth syndromes among patients referred to the endocrinology ward for treatment of acromegaly

van Essen Trui , Rosenberg Anna , W de Herder Wouter , Jan van der Lely Aart , De Graaff Laura

Background: A common request at an endocrine outpatient clinic is to rule out acromegaly in a patient with acromegaloid features. It is important to do so, since the excessive excretion of growth hormone can result in various serious comorbidities. But when growth hormone-IGF-1 axis abnormalities are excluded, the physician faces a diagnostic dilemma. Here we provide a systematic approach to these patients.Methods: We present a case series of patients vi...

ea0090p741 | Reproductive and Developmental Endocrinology | ECE2023

Functional hypogonadism and prevalence of decreased total testosterone level in type 2 diabetic male patients

Groti Antonic Kristina

Functional hypogonadism and prevalence of decreased total testosterone level in type 2 diabetic male patientsBackground: Approximately 50 % of older males with obesity and type 2 diabetes, exhibit low total testosterone levels, many also signs of hypogonadism. Functional hypogonadism negatively affects glycemic control, exacerbates early cardio-vascular complications, causes lower bone mineral density, erectile dysfunction, reduces lean body mass, and ac...

ea0090p742 | Reproductive and Developmental Endocrinology | ECE2023

Correlation of different types of headaches, their severity with BMI and hyperandrogenism in PCOS patients

Kaldani Salome , Alavidze Mariam , Oren Lana , Basheer Shamaila , Vacharadze Vazha

Background: Polycystic ovary syndrome (PCOS) is a highly prevalent disorder affecting 4%-20% of reproductive-aged women worldwide. Those affected by PCOS have a variety of clinical findings, which can affect their quality of life. Evidence suggests that polycystic ovarian syndrome and migraines are linked. However, the relationship between polycystic ovary syndrome and other types of headaches and their severity has not been studied.Objectives: The purpo...

ea0090p743 | Reproductive and Developmental Endocrinology | ECE2023

Sertoli-leydig cell tumours

Azad Fatima , Aung Nwe-Ni , Haider Najaf

Introduction: Sertoli-leydig cell tumours are neoplasms of ovarian sex cord stromal cells and account for 0.5-2% of ovarian tumours with reported incidence <0.5 % of all ovarian tumours. These tumours usually manifest in women at younger age (in 75 % patients average age of onset <30). Majority of these tumours produce hormones and up to 80% of ovarian Sertoli-Leydig cell tumours can manifest with signs of virilization.Case report: 18 year old fe...

ea0090p744 | Reproductive and Developmental Endocrinology | ECE2023

Parental Experience of the Announcement of the Diagnosis of Diabetes in Adolescents

Ouhessaine Sofia , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: The discovery of a chronic pathology in a child upsets the pre-existing family balance and generates emotional reactions in the family. With the incidence of type 1 diabetes doubling over the past 30 years, many families find themselves faced with this emblematic situation.Objectives: To describe the parental experience of being diagnosed with type 1 diabetes in adolescents.Materials and Methods: Retrospective descrip...

ea0090p745 | Reproductive and Developmental Endocrinology | ECE2023

Models of care for polycystic ovary syndrome: A systematic review

Davitadze Meri , Melson Eka , Mousa Aya , SEva working group PCOS , Teede Helena , Boivin Jacky , Thondan Mala , Thien Tay Chau , Kempegowda Punith

Introduction : Polycystic ovary syndrome (PCOS) is associated with broad reproductive, metabolic and psychological complications, as well as significant heterogeneity in presentation between and within individuals across the lifespan. Therefore, there is a need for a multidisciplinary approach. A model of care (MoC) is conceptualised as an overarching provision of care that is codesigned with end-users and aligns with evidence-based practice and defined standards. The internat...

ea0090p746 | Reproductive and Developmental Endocrinology | ECE2023

Falsely elevated estradiol levels in a young female with iatrogenic menopause

Dias Daniela , Matos Tania , Fontes-Sousa Mario , Silvestre Catarina , Serra Filipa , Sapinho Ines

False elevation of estradiol(E2) due to immunoassay interference is a rare but important phenomenon reported in the literature. It is most commonly related to cross-reactivity(CR) from drugs sharing structural similarity with E2, namely fulvestrant and exemestane. These laboratory interferences(LI) can lead to unnecessary investigation/inappropriate treatments. Therefore, in such instances, a more selective and sensitive method is required. We present the case of a young femal...

ea0090p747 | Reproductive and Developmental Endocrinology | ECE2023

Post-Menopausal Hyperandrogenism Secondary to an Ovarian Cause – When Surgery is not An Option

Antunes Carolina , Guia Lopes Leonor , Calvo Paula , Sousa Santos Francisco , Sao Pedro Veronica , Sequeira Duarte Joao

Introduction: Hyperandrogenism is a relatively common medical condition, however severe post-menopausal hyperandrogenism should raise suspicion of a malignant etiology and prompt clinical evaluation. Furthermore, androgen excess has also been associated with severely decreased quality of life. As such, identification of its cause and adequate treatment should not be delayed.Case Report: We report a case of a 66-year-old woman, who had a 5-year history of...

ea0090p748 | Reproductive and Developmental Endocrinology | ECE2023

Small for gestationnal age and short stature: What is the growth prognosis?

El Yamani Nada , Derbel Salma , Rouf Siham , Latrech Hanane

Introduction: The term « Small for gestationnel age » (SGA) defines newborn infants whose birth weight and/or crown-heel length is less than 10th percentile for gestational age, or at least 2 standard deviation below the mean for the infant’s gestational age. It is considerd as a common aetiology of short stature. The aim of our study is to describe the prevalence of SGA in short stature, and thee growth prognosis in this population.Materi...