Endocrine Abstracts

Type 2 diabetes is a progressive chronic disease that is on a global upward trend and involves high healthcare costs. Obstacles to adaptation to this disease include knowledge of the disease, fear of treatment, inability to adapt to changes in lifestyle, lack of physical activity and exhaustion. Type 2 diabetes significantly affects brain function, including cognitive function, and increases the risk of depression. The studies reveal that there has been no comparison of neurol...

The aim of this study is to analyze the risk factors that lead to cognitive impairment, depression, and psychosocial problems in type 2 diabetes and discern what aspects they have in common. Type 2 diabetes is associated with a higher risk of cognitive impairment, including dementia, which in turn increases the risk of hospitalization, falls, and premature mortality. In this study, we conducted a systematic review to achieve this goal, including searches on electronic database...

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a popular tool for the treatment of type 2 diabetes. Unlike many other antidiabetic drug classes, distinct GLP-1 RAs have different therapeutic profiles, mostly due to their different pharmacokinetic properties. Animal experiments and human data indicate that tolerance develops toward at least some of their effects, e.g., gastric motility. Whether tolerance develops toward the glucose-lowering effect...