Endocrine Abstracts

Background: Iodine deficiency and excess are well-recognized risk factors for thyroid dysfunction. This systematic reveiw and meta-analysis was designed, for the first time, to explore whether maternal iodine status or supplementation is associated with postpartum thyroid function.Methods: Electronic databases, including the MEDLINE/PubMed, Web of Science, Embase, and Scopus were searched between January 1923 and December 2021 to identify relevant studie...

Aim: Given the aggressive biological features of metastatic prostate cancer, a more aggressive treatment with [177Lu]-PSMA might be appropriate.Materials and methods: We have treated 15 patients (mean age 69 years) with intended 3 cycles of [177Lu]-PSMA every 4 weeks. All patients have been examined with [68Ga]-PSMA PET/MRI to validate PSMA expression of all metastatic lesions. We monitored haemoglobin (Hb), platelets (Pl), leucocytes and creatinine for ...

Introduction: The effects of diabetes mellitus (DM) on bone mineralization and osteoporosis is not well established. While reduction in bone mineral density in patients with type 1 diabetes is almost confirmed, effects of type 2 diabetes on bone health is still unclear. However in some studies bone mineral density (BMD) was suggested to be normal or elevated, epidemiological reports have shown an increased risk of fracture among patients with type 2 diabetes. This paper tries ...

Background: Botulinum neurotoxin inhibits muscle function by interfering with neurotransmitter release from secretory vesicles. The mechanism underlying this effect involves cleavage of SNARE proteins which are required for vesicle docking at the plasma membrane. The ability of botulinum neurotoxin serotypes to cleave SNARE proteins and inhibit secretion is being exploited for therapeutic purposes by Syntaxin Ltd with their ‘targeted secretion inhibitor technology’ (...

Antiphospholipid antibody (APLA) syndrome is a rare autoimmune systemic disorder which can occur as primary condition or secondary to connective tissue diseases, most frequently systemic lupus erythematosis. We are presenting a rare case of a lady who developed adrenal insufficiency secondary to adrenal vein thrombosis, as a late sequel to APLA Syndrome.A 50-year-old lady admitted to the medical ICU with one day’s history of severe abdominal pain an...

This research is a descriptive and analytic study which was carried out to investigate the Fasting Blood Sugar of first trimester and 24-28 weeks , and 50-gram Glucose Challenge Test at 24-28 weeks of gestational age in non-diabetic pregnant women and their effect on the infants' weight in Shariati Hospital in Tehran .The means of the Fasting Blood Sugar for the first trimester , 24-28 weaks and Glucose Challenge Test were 81.15 , 80.8 and 111.75 miligrams per deciliter re...

Background: Patients with small bowel neuroendocrine tumors (SBNETs) frequently present with metastatic disease, and unfortunately, the range and efficacy of available therapies is limited. Immunotherapeutic checkpoint inhibitors have demonstrated benefit in other malignancies and may also play a role in SBNETs, although relatively little is known about the immune infiltrate in these tumors. Toward a goal of developing novel immunomodulatory strategies, we sought to evaluate t...