Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

ea0090ep951 | Thyroid | ECE2023

Application of a novel multimodal-based deep learning model for prediction of recurrence in patients with papillary thyroid carcinoma

Lee Dong-Hwa , Choi Jee-Woo , Kim Geun-Hyeong , Park Seung , Jeong Jeon Hyun

Background: Thyroid cancer is the most common endocrine malignancy, and papillary thyroid carcinoma (PTC) is the most frequent type of thyroid malignancy. Although the mortality rate is low, some patients experience cancer recurrence during follow-up periods. Early detection of recurrence helps improve the outcomes of patients and reduce the socioeconomic burden. In this study, we investigated the accuracy of a novel multi-modal prediction model by simultaneously analyzing num...

ea0090ep952 | Thyroid | ECE2023

Alemtuzumab-Induced Severe Ophthalmopathy in Relapsing-Remitting Multiple Sclerosis: Experience at A Single Center

Rodriguez de Vera Gomez Pablo , Manuel Garrido Hermosilla Antonio , Mendez Muros Mariola , Javier Toyos Saenz de Miera Francisco , Lopez Ruiz Rocio , Martin Hernandez Tomas

Objectives: To identify risk factors for the development of Graves’ Orbitopathy (GO) in patients with Relapsing Remitting Multiple Sclerosis (RRMS) treated with Alemtuzumab, as well as to analyze the clinical behavior of this entity based on a case series.Methods: Retrospective observational study with real-life data. Patients with RRMS who received at least one cycle of Alemtuzumab in the period 2014-2022 in aMS reference unit in Spain were include...

ea0090ep953 | Thyroid | ECE2023

COVID-19 – a trigger of autoimmune thyropathy disorders?

Kolpakova Evgeniia , Elfimova Alina , Nikankina Larisa , Troshina Ekaterina

Introduction: Research into autoimmune disorders associated with COVID-19 in the middle of an ongoing COVID-19 pandemic is an important and urgent challenge. We focus on the potential relationship between coronavirus infection and other autoimmune diseases, and the positive therapeutic effect of the treatment of severe forms of COVID-19 with drugs traditionally used in the treatment of rheumatological diseases. The results of this study are a starting point for understanding t...

ea0090ep954 | Thyroid | ECE2023

The reduction of peripheral blood Treg differentiated fractions and the CD25 expression in Patients with Graves’ disease after Radioactive Iodine Therapy

Dudina Margarita , Savchenko Andrey , A. Dogadin Sergey , G. Borisov Alexander , Belenyuk Vasiliy , Fomina Daria

Background: Foxp3(+) regulatory T cells (Treg) play a leading role in developing immune tolerance through active suppression in Graves’ disease (GD). The influence of radioactive iodine therapy (RAI) on the differentiated fractions of Treg of GD patients is still poorly understood. Aim: To estimate the differentiated fractions of blood Tregs and the CD25 expression in patients with GD after RAI.Materials and Methods: In total,...

ea0090ep955 | Thyroid | ECE2023

Oxidative stress and the level of NAD(P)-dependent dehydrogenases of blood neutrophils in patients with compensated and relapse Graves’ hyperthyroidism ongoing thiamazole treatment

Dudina Margarita , Savchenko Andrey , A. Dogadin Sergey , Gvozdev Ivan

Background: Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and a disbalance of the cell redox state is associated with thyroid hyperfunction and the reccurence of the disease. Aim: To study the level of reactive oxygen species (ROS) and NAD(P)-dependent dehydrogenases of peripheral blood neutrophils in patients with compensated and relapse GH ongoing thiamazole. Materials and Methods: The study incl...

ea0090ep956 | Thyroid | ECE2023

Conversion from longstanding hypothyroid Hashimoto’s thyroiditis to Graves’ disease. Clinical characteristics from a large patient cohort

Feldkamp Joachim , Muenstermann Shari , Gorges Rainer , Ruderich Franz

The transition of hypothyroidism from Hashimoto’s thyroiditis into hyperthyroidism (Graves’ disease) is uncommon, and the underlying causes are still unknown. We studied clinical characteristics in patients with the conversion of preexisting Hashimoto’s thyroiditis to Graves’ disease compared to patients with Hashimoto’s thyroiditis or Graves’ disease alone.Patients and Methods: Retrospective comparative case series of 42 pa...

ea0090ep957 | Thyroid | ECE2023

Rising preoperative TPO titers decrease the risk for differentiated thyroid cancer in a linear fashion: a retrospective analysis of 1620 consecutive thyroid surgeries

Bantouna Dimitra , Zoupas Ioannis , C Jaume Juan , Imam Shanawaz , Livadas Sarantis , Angelopoulos Nicholas , Karvounis Evaggelos , Paparodis Rodis

Introduction: Chronic lymphocytic thyroiditis is an important risk factor for differentiated thyroid cancer (DTC) in surgical series, but the role of thyroid peroxidase antibodies (TPO) seems less clear in that regard. We designed the present study to evaluate that effect in our large patient population. Methods: We recruited subjects operated with total thyroidectomy in 4 sites (USA: 1, Greece: 3) during a period of 14 consecutive years. We gathered dat...

ea0090ep958 | Thyroid | ECE2023

Accuracy of the European Thyroid Imaging Reporting and Data System (EU-TIRADS)

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: There are several classifications based on thyroid ultrasound for selecting suspected malignant thyroid nodules. In 2017 the European Thyroid Association developed a new and simple European Thyroid Imaging and Reporting Data System (EU-TIRADS), which classifies the risk of malignancy of thyroid nodules in adults to the following categories: benign, low-, intermediate-, and high-risk.Objective: To evaluate the accuracy of the EU-TIRADS for d...

ea0090ep959 | Thyroid | ECE2023

Anasarca state with exceptional localization revealing a deep hypothyroidism

Alami Hassani Chaymaa , Idrissi Ayoub , Lahousssaine Abainou , Elhadri Sanae , Meftah Azzelarab , Baizri Hicham

Introduction: Hypothyroidism-related anasarca is due to the capillary permeability disorders associated with hypothyroidism. It is a rare mode of revelation especially when associated with ascites, which is an exceptional localization. We report the case of a deep hypothyroidism revealed by an ascites of great abundance. Observation: Our patient is 73 years old with a history of 2 daughters followed for Hashimoto’s thyroiditis. He consults for abdom...

ea0090ep960 | Thyroid | ECE2023

Rare case of Graves’ disease resistant to methimazole: a case report

Ismail Zahra , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: The treatment of Graves’ disease is represented principally by anti-thyroid drugs, radioiodine ablation or thyroidectomy. Methimazole is the most used drug for the initial treatment. It is rare to encounter patients with resistant hyperthyroidism despite high doses of MMI.Case presentation: A 41-year-old woman was referred to our unit for resistant thyrotoxicosis. She had a confirmed Graves’ disease with positive serum Trab. Whils...

ea0090ep961 | Thyroid | ECE2023

Alemtuzumab-Induced Autoimmune Thyroid Dysfunction. A review of two cases

Lois Chicharro Pablo , Miren Azcutia Uribe Echevarria Ane , Ferreira-Ocampo Pablo , Carolina Doejo Marciales Sandra , Fabiola Barra Malig Solange , Edward Astunague Condori Remy , Almodovar Ruiz Francisca

Introduction: Alemtuzumab is an humanized monoclonal antibody used for treatment of Relapsing remitting Multiple Sclerosis (RRMS). One of its main adverse effects is thyroid dysfunction, being a fluctuating hypothyroidism the most frequent presentation. Sometimes this thyroid disturbance is so significant that it might lead to alemtuzumab withdrawal. We present two Clinical cases of hyperthyroidism secondary to alemtuzumab with different clinical courses. <p class="abstext...

ea0090ep962 | Thyroid | ECE2023

A systematic review and meta-analysis on the associations of maternal iodine status and supplementation with thyroid function during postpartum

Nazeri Pantea , N. Pearce Elizabeth , Farrokhzad Nahid , Baghalha Fatemeh , Shariat Mamak

Background: Iodine deficiency and excess are well-recognized risk factors for thyroid dysfunction. This systematic reveiw and meta-analysis was designed, for the first time, to explore whether maternal iodine status or supplementation is associated with postpartum thyroid function.Methods: Electronic databases, including the MEDLINE/PubMed, Web of Science, Embase, and Scopus were searched between January 1923 and December 2021 to identify relevant studie...

ea0090ep963 | Thyroid | ECE2023

Frequency of Coeliac Disease in Children with Chronic Autoimmune Thyroiditis

Khyzhnyak Oksana , Oleksyk Olga , Nikolaiev Roman

Introduction: Chronic autoimmune thyroid disease (ATD) or Hashimoto thyroiditis (HT) is one of the main thyroid diseases in pediatric age. HT characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function. Coeliac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects. At presents with a pathognomonic enter...

ea0090ep964 | Thyroid | ECE2023

Factors associated with elevated liver enzymes in patients with uncontrolled hyperthyroidism

Yazidi Meriem , Oueslati Ibtissem , Khessairi Nadia , Elyes Kammoun , Chaker Fatma , Chihaoui Melika

Liver dysfunction is common in patients with hyperthyroidism. The underlying mechanisms remain unclear. Predictors of liver dysfunction and recovery are controversial. The aim of this study was to assess the prevalence of elevated liver enzymes in patients with uncontrolled hyperthyroidism and to identify its predictive factors.Methods: This is a retrospective study conducted in 131 patients with hyperthyroidism admitted in the endocrinology department o...

ea0090ep965 | Thyroid | ECE2023

The role of PTEN methylation level changes in papillary thyroid carcinoma diagnosis and prognosis

Kazlauskiene Mintaute , Zukauskaite Kristina , Klimaitė Raimonda , Kondrotienė Aistė , Daukšienė Dalia , Zilaitiene Birute , Sabaliauskaite Rasa , Dauksa Albertas

Introduction: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer (85%–90%). Today Fine needle aspiration biopsy (FNAB) is the diagnostic tool for the evaluation of thyroid nodules because of its accuracy and cost-effectiveness, but FNAB also has limitations, as it is quite challenging to take a biopsy from a small thyroid nodule moreover FNAB diagnosis is doubtful in up to 20% of cases. Therefore, non-invasive biomarkers of PTC are needed.<p clas...

ea0090ep966 | Thyroid | ECE2023

Bone metastases of differentiated thyroid cancer: characteristics and prognostic factors in a multicenter series

Pinar Gutierrez Ana , R. Romero-Lluch Ana , Duenas Disotuar Suset , De Lara-Rodriguez Irene , Angeles Galvez Moreno Maria , Martin Hernandez Tomas , Garcia Aleman Jorge , Martinez-de Pinillos Guillermo , Sanchez-Malo Carolina , Navarro Elena

Objective: To describe the characteristics, survival and prognostic factors of a cohort of patients with bone metastases (BM) of differentiated thyroid carcinoma (DTC).Methods: Multicenter retrospective observational study. Patients diagnosed with DTC and BM between 1980-2021 were included. A Cox regression was performed to study prognostic factors for 5- and 10-year survival. Kaplan-Meier and log-rank tests were performed for survival analysis and compa...

ea0090ep967 | Thyroid | ECE2023

The role of thyroid peroxidase antibodies on the risk of thyroid cancer: a systematic review and meta-analysis of surgical cohort studies

Bantouna Dimitra , Zoupas Ioannis , C Jaume Juan , Imam Shanawaz , Karvounis Evaggelos , Livadas Sarantis , Anagnostis Panagiotis , Paparodis Rodis

Introduction: Hashimoto’s thyroiditis raises the risk for thyroid cancer (TC) in surgical series, but the role of thyroid peroxidase antibodies (TPO) remains controversial in that regard. We designed the present study to evaluate the effect of preoperative TPO titers in the risk of DTC.Methods: A comprehensive search was conducted in PubMed, CENTRAand Scopus databases in November 2021 for the terms “thyroid cancer” and “TPO” or &...

ea0090ep968 | Thyroid | ECE2023

Benign and Malignant Thyroglossal Duct Cyst Remnants: Systematic Review and Case Series of 1842 Surgical Cases

Zoupas Ioannis , C Jaume Juan , Livadas Sarantis , Karvounis Evaggelos , Bantouna Dimitra , Imam Shanawaz , Paparodis Rodis

Introduction: Thyroglossal duct (TGD) carcinoma is an uncommon entity, diagnosed in patients undergoing evaluation of the neck for midline swelling, or incidentally after removal of a TGD cyst. Despite the presence of multiple publications on the topic, no systematic characterization of these tumors has been performed to date.Methods: We performed a systematic search for the term “Thyroglossal duct” in Pubmed, Embase and Cochrane databases on D...

ea0090ep969 | Thyroid | ECE2023

Hashimoto’s encephalopathy: a case report

Haj Kacem Akid Faten , Ben Salah Raida , Soomauroo Siddiqa , Mouhaymen Missaoui Abdel , Chouaib Sarra , Mnif Fatma , Frikha Faten , Bahloul Zouheir , Abid Mohamed

Introduction: Hashimoto’s encephalopathy (HE) is characterised by the combination of clinical signs of encephalitis and autoimmune thyroiditis with elevated levels of antithyroid antibodies (ATA). It is a rare condition and its etiopathogenesis is still poorly understood.Observation: we present a 33-year-old female patient who was hospitalized for gait disorders. The diagnosis of a chronic cerebellar syndrome related to Hashimoto’s encephalitis...

ea0090ep970 | Thyroid | ECE2023

Thyroid pathology in patients with familial adenomatous polyposis

de Carlos Joaquin , Zabalza Lucia , Rosario Aznarez Maria , Irigaray Ana , Anda Emma

Introduction: Familial Adenomatous Polyposis (FAP) syndrome is an autosomal dominant disorder associated with a high risk of multiple intestinal and extraintestinal cancers. They develop hundreds or thousands of adenomas in the rectum and colon during the second decade of life that. If they are not identified and treated, almost all patients develop colorectal cancer (CRC) and die by the age of 40-50 years. Thyroid carcinoma is a FAP manifestation with an unknown reported high...

ea0090ep971 | Thyroid | ECE2023

Thyroid calcifications: tragedy or stability

Aleksandrov Yuriy , Timofeeva Lubov

Thyroid calcifications are a difficult problem to interpret. The deposition of calcium salt crystals often indicates profound morphological changes, cell death, their rearrangement and dedifferentiation. The calcifications are not guaranteed markers of any process. There is also no data on the effect calcifications on the development of a process in the thyroid. The analysis of 67 thyroid nodules, in wich calcifications were detected during ultrasound. Macrocalcifications were...

ea0090ep972 | Thyroid | ECE2023

Paraneoplastic Hyperthyroidism in an Adult with Choriocarcinoma – A Case Report

Inacio Isabel , Santos Sara , Dias Silva Paulo , Goncalves Nuno , Mauricio Joaquina , Teixeira Pinto Ricardo , Vaz Ferreira Ana , Calheiros Raquel , Souteiro Pedro , Oliveira Joana , P Santos Ana , Torres Isabel

Introduction: Hyperthyroidism is an endocrine condition with multiple causes. Paraneoplastic hyperthyroidism due to marked overproduction of human chorionic gonadotropin (hCG) by choriocarcinoma is a rare diagnosis, which results from the homology of the alpha subunit of hCG to TSH.Clinical case: A 33-year-old man, with a history of cryptorchidism and orchidopexy in infancy and a euthyroid thyroid nodule, presented with nausea, constipation, and abdomina...

ea0090ep973 | Thyroid | ECE2023

Malignancy rates for Bethesda III and IV thyroid nodules in a tertiary referral hospital

Jimenez Lopez Noemi , Mauricio Chavez Villegas Alvaro , Allo Miguel Gonzalo , Blanco Urbaneja Irune , Javier Garcia Alonso Francisco , Leon Sanz Miguel

Background: Thyroid nodules are one of the most common clinical entities in Endocrinology practice. Fine needle aspiration (FNA) and the 2017 Bethesda System for Reporting Thyroid Cytopathology have been proved to be an effective tool to identify malignancy risk and guide surgical decision-making. However, thyroid nodules classified as Bethesda (BTH) III and IV remain a challenge, considering the varying risk of malignancy (ROM) found in different papers. The aim of this study...

ea0090ep974 | Thyroid | ECE2023

The Reactive Oxygen Species Level of Blood Monocytes in Patients with Graves’ Disease After Radioiodine Therapy

Fomina Daria , A. Dogadin Sergey , Savchenko Andrey , Dudina Margarita , Gvozdev Ivan

Background: Increased production of reactive oxygen species (ROS) and oxidative stress play a significant role in the initiation and persistence of the autoimmune process in Graves’ disease (GD)Aim: To study the ROS level of peripheral blood monocytes in patients with GD after radioactive iodine (RAI). Materials and Methods: The study included 48 patients with a confirmed diagnosis of GD, from 18 to 65 years (mean 46.42 &pm; 1...

ea0090ep975 | Thyroid | ECE2023

Long-term observation of thyroid immunity - Experience in a single institution of northeast Japan

Kunori Takao , Yoshida Hiroshi

Background: Abnormal thyroid autoimmunity is often experienced in thyroid clinic. Some of them are associated with hyperthyroidism (HY) or chronic thyoiditis (Hashimoto, HA). The abnormality, however, is observed not only in HY or HA, but nodular goiter (NOD), and seems to be associated with various factors; age, visiting periods, residence, ABO blood type or others. We analyzed long-term (more than 16 years) data of patients who live in northeast Japan, if there is any charac...

ea0090ep976 | Thyroid | ECE2023

Zenker diverticulum: an uncommon finding during ultrasound examination of the neck area

Chobankova Elena , Nonchev Boyan , Argatska Antoaneta

Introduction: Ultrasound examination is the preferred imaging technique for thyroid morphology assessment. Sometimes neck sonography reveals extra-thyroidal pathological formations which may be a cause for diagnostic predicaments. The Zenker diverticulum is a type of esophageal diverticulum, located in a natural area of weakness on the posterior pharyngeal wall. It appears as a structure in close proximity to the left thyroid lobe and can be in some cases misinterpreted as a t...

ea0090ep977 | Thyroid | ECE2023

Covid- associated subacute thyroiditis

Lobashova Veranika , Dydyshka Yuliya

Objectives: The number of reported cases COVID-19 associated subacute thyroiditis (ST) in literature is small thus peculiarities of its clinical features remain the subject of interest. The aim of the review is to share our experience of COVID-19 associated ST.Materials and Methods: We describe 5 cases of COVID-19 associated ST. SARS-CoV-2 diagnosis was based on the presence of its typical symptoms and real-time polymerase chain reaction on nasopharyngea...

ea0090ep978 | Thyroid | ECE2023

Phenotypic and genetic features of familial thyroid dyshormonogenesis in the Tunisian population

Haj Kacem Akid Faten , Mouhaymen Missaoui Abdel , Soomauroo Siddiqa , Ayadi Younes , Rekik Majdoub Nabila , Mnif Mouna , Abid Mohamed

Objective: To describe the phenotypic and molecular characteristics of familial thyroid dyshormonogenesis (FTDH) in the Tunisian population.Patients and Methods: A retrospective descriptive study including two related (R and K) with high consanguinity whose members are carriers of FTDH. Biological and genetic screening was proposed for all consenting members.Results: FTDH was identified in 11 patients (8 girls, 3 boys) with a mean ...

ea0090ep979 | Thyroid | ECE2023

Hypothyroidism: A challenging condition

Hawkins Anna , Enriques Nancy , Casey Edel , Grant Bonnie , Tanday Raj , Shah Usman , Nikookam Khash

Introduction: Hypothyroidism can present in a variety of ways, from unexpected abnormal blood results in seemingly asymptomatic patients to those with a multitude of debilitating symptoms. Levothyroxine dose titration is a challenge often faced by physicians. We identified 8 difficult cases which following MDT discussion underwent the Thyroxine Absorption Test (TAT) to gain further clarification (Walker et al. 2013).Aim: To identify if the issue...

ea0090ep980 | Thyroid | ECE2023

Assessment of quality of life indicators of operated and non-operated children with primary hyperparathyroidism in the observed aspect at different times

Rikhsieva Nazira

Aim: To study tne quality of life of children with primary hyperparathyroidism (PHPT).Material and methods: 90 children with suspected PHPT were examined according to anamnesis, outpatient cards and surgical logs. The children were aged from 3 to 15 years old, who were treated in stationary conditions, and then were observed by us on an outpatient basis. 50 of them were treated surgically (1st group), 40 (2nd group) refused surgery ...

ea0090ep981 | Thyroid | ECE2023

Tuberculous lymphadenitis mimicking nodal metastasis in papillary thyroid carcinoma

Jihene Houas , Arfi Taissir Ben , Monia Ghammam , Jawaher Kechiche , Omri Malika El , Mouna Bellakhder , El Abed Yosra Hasni , Abir Meherzi , Wassim Kermani , Mohamed Abdelkefi

Introduction: The tuberculous lymphadenitis is the most common form of extra-pulmonary tuberculosis. The association with thyroid cancer is rare and can mislead the physician with the lymphadenopathy being considered as metastatic. In an endemic region for tuberculosis such as Tunisia, an adequate preoperative evaluation is crucial to distinguish these two entities and provide the patient with the appropriate treatment.Material and methods: 2 cases of a ...

ea0090ep982 | Thyroid | ECE2023

Vesicular thyroid carcinoma with retropharyngeal node metastasis: case report

Jihene Houas , Sarra Lazid , Monia Ghammam , Miled Heyfa BelHadj , Omri Malika El , Mouna Bellakhdher , El Abed Yosra Hasni , abir Meherzi , Wassim Kermani , Mohamed Abdelkefi

Purpose: Retropharyngeal lymph nodes metastases from differentiated thyroid carcinoma are extremely rare. The objective of this study was to describe our experience in the management of a vesicular thyroid carcinoma with RPMs.Case report: We report a case of 60 years old female patient who presented a thyroid goiter with pressure symptoms as well as dysphagia. Initial Serum thyroid stimulating hormone (TSH) rate was normal. The ultrasound thyroid showed ...

ea0090ep983 | Thyroid | ECE2023

Role and expression of miRNAs (miRNA 149_5p, miRNA-548c-3p, miRNA 3619-3p) in Papillary thyroid cancer progression and metastasis

Bangaraiahgari Ramesh , Bangaraiahgari Rajesh , Bhargav Panchangam Ramakanth , kumar Neelagiri Udaya , Vudathala Srinivas , Reddy Banala Rajkiran , Bangaraiahgari Chakrapani

Objective: Papillary thyroid carcinoma (PTC) is themalignantcancer with altered microRNA (miR) changes. miR149-5p and miR-548c-3p participates in multiple processes of tumor development, progression, tumor suppression. Whereas miR-3619-3p plays role to promote cell migration and invasion in PTC. However, the role of miR149, miR-548c-3p, and miR-3619-3p in PTC and the underlying mechanisms remain undefined. Therefore, the present study is aimed to quantify therelative expressio...

ea0090ep984 | Thyroid | ECE2023

Fungal necrotizing otitis externa in diabetic patients

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: Pseudomonal infection is the most common cause of necrotizing otitis externa (NOE), which typically affects elderly diabetic patients. Fungi are a rare cause of this disease. Fungal NOE can be life-threatening if not recognized and treated promptly. Objective: The aim of this study is to describe the epidemiology, clinical features, management and evolution after treatment of diabetic patients with fungal NOE.Methods:...

ea0090ep985 | Thyroid | ECE2023

Surgical Management of Thyroid Differentiated Microcarcinomas

Ayedi Sirine , Kallel Souha , Haj Kacem Akid Faten , Ben Ayed Mariem , Frikha Hamdi , Abid Mohamed , Charfeddine Ilhem

Background: The management of differentiated microcarcinomas of the thyroid (DMCT) is controversial, and ranges from simple active surveillance to total thyroidectomy with bilateral lymph node dissection and post operative adjuvant therapy. Our purpose was to determine prognostic factors to guide the surgery of DMCT.Methods: This was a retrospective study conducted from January 2000 to December 2017, involving 122 patients with DMCT who were treated surg...

ea0090ep986 | Thyroid | ECE2023

Thyroid hormone replacement during Ramadan fasting is a real challenge to hypothyroid patients. A systematic review and meta-analysis

Mohammed Rabea Eslam , Mohamed Belal Mohamed , Reda Youssef Asmaa , Awaad Elalaky Nessreen , Baker Hany , Adel Muhammed Quaisy Muhammed

Background: Ramadan is the religious month in which Muslims fast from pre-dawn (suhoor) until sunset (iftar), abstaining from all kinds of food, and liquid. The major change in meal times may be challenging for hypothyroid patients on levothyroxine because levothyroxine has a narrow therapeutic index and should be taken on an empty stomach.Objective: We aim to compare pre- and post-Ramadan Thyroid function tests of hypothyroid patients taking levothyroxi...

ea0090ep987 | Thyroid | ECE2023

Risk factors for postoperative complications in total thyroidectomy

Sellami Moncef , Amine Chaabouni Mohamed , Kharrat Ines , Haj Kacem Akid Faten , Hammami Bouthaina , Abid Mohamed , Charfeddine Ilhem

Introduction: Thyroidectomy is a quite common procedure. Major postoperative complications of total thyroidectomy, including recurrent laryngeal nerve injur and hypocalcemia are not infrequent. The purpose of this study was to evaluate the incidence and risk factors of postoperative complications after total thyroidectomy.Methods: We retrospectively included patients who underwent total thyroidectomy over a period of 6 years. Hypocalcemia was defined as ...

ea0090ep988 | Thyroid | ECE2023

Evaluation of the adverse effects of antithyroid drugs in the treatment of Graves’ disease

Nouira Sawsen , Ach Taieb , Ben Abdelkarim Asma , Chadli Chaieb Molka

Introduction: Antithyroid drugs (ATD) are usually the first-line treatment for Graves’ disease (GD). It represents an effective treatment with good compliance. This therapeutic modality can be the cause of adverse effects including hematological, cutaneous and hepatic complications. The aim of our study is to evaluate the efficacy of ATD as well as its tolerance in patients with GD.Methods: It is a retrospective study that included 76 patients, with...

ea0090ep989 | Thyroid | ECE2023

Immunological and ultrasound characteristics of different forms of postpartum thyroid dysfunction

Argatska Antoaneta , Nonchev Boyan

Objective: To assess the immunological and ultrasound (US) characteristic of hypothyroidism and thyrotoxicosis developing during the postpartum period.Patients and methods: 66 women with postpartum thyroid dysfunction (PPTD) (30 with hypothyroidism and 36 with thyrotoxicosis) without history of previous thyroid disorder were included. TRAb positive women were excluded from the study. Clinical evaluation was done, TSH, FT4, FT3, TPOAb, TgAb were measured,...

ea0090ep990 | Thyroid | ECE2023

Relationship between thyroid function and metabolic parameters in healthy premenopausal women

Argatska Antoaneta , Nonchev Boyan , Chobankova Elena

Objective: To investigate the prevalence and the relation between metabolic syndrome components and TSH values below and above 2.5 mIU/l in euthyroid premenopausal women.Material and methods: 446 women of mean age 30.98&pm;9.3 (18-51 years) with no history of diabetes or lipid-lowering medications were included in the study. Standard oral glucose tolerance test with insulin measurement was performed, TSH, total cholesterol, HDL, triglycerides were measur...

ea0090ep991 | Thyroid | ECE2023

Impact of L-thyroxine intake schedule on therapeutic balance during the month of Ramadan in patients followed for hypothyroidism

Raki Nezha , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Hypothyroidism is a chronic pathology, which can have several etiologies and which requires long-term treatment. The modification of meal times during the month of Ramadan which can modify the absorption of L-thyroxine, knowing that it interferes with the taking of meals. Purpose of the study: Assess the impact of L-thyroxine intake schedule on the therapeutic balance during Ramadan in patients with hypothyroidism.Mat...

ea0090ep992 | Thyroid | ECE2023

The Prevalence of Thyrothyropin Receptor, Cytotoxic T Lymphocyte Antigen-4 and Interleukin-1 Receptor Antagonist Polymorphisms in The Group of Hashimoto Thyroiditis in Turkish Community and their Relationship with Clinical Parameters

Şeker Can Lamia , Elbasan Onur , Ilgin Can , Yaşar Şirin Duygu , Bircan Rıfat , Gozu Hulya

Aim: Hashimoto Thyroiditis (HT); is the most common form of hpothyroidism in iodine-sufficient regions. Both genes and and environmental factors are involved in the immunopathological process of HT. Our aim in this study is to determine the prevalence of Thyrothropin Receptor (TSHR), Cytotoxic T Lypmhocyte Antigen-4 (CTLA-4) and Interleukin-1 Receptor Antagonist (IL-1RN) gene polymorphisms associated with HT in Turkish population and the relationship of genotype characteristic...

ea0090ep993 | Thyroid | ECE2023

Thyroidectomy as a treatment of graves’ disease in children

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: Graves’ disease (GD) accounts for 10%-15% of thyroid disorders in children and adolescents.Material and Methods: We report the clinical, therapeutic aspects and long-term results of 9 children (<18 years) who had for Graves’ disease, from 2000 to 2021.Results: The mean age at diagnosis was 15,8 years [9 – 18 years]. Our study included 3 boys and 6 girls. One patient had coeliac disease. The surgery ...

ea0090ep994 | Thyroid | ECE2023

Resistance to thyroid hormone alpha: a case report

Griciūnaitė Greta , Šukys Marius , Danelienė Milda

Introduction: Resistance to thyroid hormones (RTH) is a rare syndrome. This condition is caused by gene mutations of thyroid hormone receptors (THR). There are two types of genes that code THR: THR alpha (THRA) and THR beta (THRB). The RTH alpha is associated with mutations in the THRA gene and is less common than RTH beta [1]. It is challenging to identify patients with RTH alpha because usually they only have mildly abnormal (or even normal) thyroid hormone levels and the se...

ea0090ep995 | Thyroid | ECE2023

Calcitonin Measurement in Needle Washout Fluid After Fine Needle Aspiration As a Complementary Diagnostic Test in Medullary Thyroid Carcinoma

Puzigaca Pavle , J Caballero Segura Manuel , Ignacio Fernandez Pena Jose , Arturo Cuellar Lloclla Eyvee , Bobillo Lobato Joaquin , Martinez de Pinillos Gordillo Guillermo

Introduction: The diagnostic accuracy of fine needle aspiration (FNA) in case of medullary thyroid cancer (MTC) has been less studied than in other thyroid cancers. The complementary measurement of calcitonin in the needle washout fluid after FNA (FNA-Ct) could improve the usefulness of this technique.Materials and Methods: Description of two cases of patients with thyroid nodules suspicious for MTC in whom FNA-Ct was measured as a complementary diagnost...

ea0090ep996 | Thyroid | ECE2023

A case report: non-germinal center type diffuse large B-cell lymphoma in thyroid

Kriksciuniene Ruta , Siusaite Gabija , Klimaite Raimonda

Introduction: The diffuse large B-cell lymphoma (DLBCL) is known as one of the most common lymphoma worldwide with the prevalence of 25 % of all of non-Hodgkin lymphoma cases [1], but it is very rearly observed in thyroid. Around 30 % of Clinical cases of the DLBCL appear from extranodal organs, the prognosis depends on the site of origin [2].Case: A 18-year-old man was admitted to endocrinologist, complaining with a palpable nodule in the front neck for...

ea0090ep997 | Thyroid | ECE2023

Levothyroxine liquid oral substitution as a treatment of refractory hypothyroidism due to gastrointestinal malabsorption

Mouelhi Yasmine , Oueslati Ibtissem , Cherchir Faten , Ben Hamida Asma , Yazidi Meriem , Chihaoui Melika

Introduction: Primary hypothyroidism is a common condition. Its treatment is simple and consists of daily levothyroxine intake. Cases with refractory hypothyroidism despite high doses of levothyroxine were reported. Herein, we report the case of a patient with refractory hypothyroidism secondary to gastrointestinal malabsorption that was improved by L-thyroxine liquid oral substitution.Observation: A 49-year-old woman was admitted for refractory hypothyr...

ea0090ep998 | Thyroid | ECE2023

Abstract withdrawn...

ea0090ep999 | Thyroid | ECE2023

Recurrence of Graves disease after 30 years

Chaimae Kadiri , Hassan Lachkar

Introduction: Graves’ disease is an autoimmune disease of the thyroid that manifests as hyperthyroidism, homogeneous goiter and sometimes ophthalmopathy. Medical treatment with synthetic antithyroid drugs restores clinical and biological euthyroidism. However, an apparently successful treatment can be followed by relapse in 40% of cases. We report the case of a patient who presented with a recurrence of Graves’ disease after 30 years of remission.<p class="abstex...

ea0090ep1000 | Thyroid | ECE2023

The relationship between TSHR methylation level and clinicopathological factors in papillary thyroid cancer

Klimaite Raimonda , Kazokaitė Mintautė , Kondrotienė Aistė , Dauksiene Dalia , Zilaitiene Birute , Dauksa Albertas

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid cancer type. It carries a good prognosis. However, approximately ten percent of cases may present with metastatic disease at initial presentation. Fine needle aspiration biopsy cytology is still the gold standard for diagnosing PTC, but there is a technical limitation. That’s why minimally invasive diagnostic test is the subject of research in nowadays.Our objective: We aimed...

ea0090ep1001 | Thyroid | ECE2023

Papillary thyroid carcinoma and Graves’ disease: a case report

Jihene Houas , Arfi Taissir Ben , Monia Ghammam , Sarra Lazid , omri Malika El , Mouna Bellakhdher , El Abed Yosra Hasni , Abir Meherzi , Wassim Kermani , Mohamed Abdelkefi

Introduction: The occurrence of a thyroid cancer on Graves’ disease is rare (0.3 to 16.6%). Most often than not, the type found is a papillary carcinoma and is discovered incidentally. Finding a thyroid nodule within the goiter must always raise suspicion of malignancy. Material and methods: We report the case of a patient followed for Grave’s disease in whom a fortuitous association with differentiated thyroid cancer was discovered on a pathol...

ea0090ep1002 | Thyroid | ECE2023

Revealing Distant Metastasis of Differentiated Thyroid Carcinoma: About 4 Cases

Jihene Houas , Heyda BelHadjMiled , Monia Ghammam , Sarra Lazid , Omri Malika El , Mouna Bellakhdher , El Abed Yosra Hasni , Abir Meherzi , wassim Kermani , Mohamed Abdelkefi

Introduction: Distant metastases of thyroid tumors are rare. They are mainly of pulmonary (10-15%), bone (9%) and brain (<1%) location. These metastases are more frequent with vesicular (20%) than papillary (3.5%) histological type carcinoma. The aim of our work is to document the clinical and radiological aspects as well as the therapeutic modalities of these entities.Materials and methods: We report 4 cases of distant metastasis that revealed a dif...

ea0090ep1003 | Thyroid | ECE2023

Safety and Efficacy of Radiofrequency Ablation of Thyroid Nodules. Our Experience With A Cohort of 43 Patients

Bernaldo Madrid Blanca , Mera Carreiro Sara , Espinosa De Los Monteros Patricia , Hernandez Olmeda Fernando , Avila Anton Laura , Sanchez-Maroto Garcia Noelia , Merino Salome , Lopez Nevado Celia , Pazos Guerra Mario , Cristina Familiar Casado Maria

Introduction: The majority of current guidelines recommend surgery for benign solid nodules with pressure symptoms or a significant growth. Currently, minimal invasive techniques have emerged such as radiofrequency ablation (RF) which achieve significant volume decrease and many cases, the improvement or disappearance of pressure symptoms.Results: We describe the efficacy and safety of one single-session of RF in our centre performed in thyroid nodules f...

ea0090ep1004 | Thyroid | ECE2023

Association Between Metabolic Syndrome Components and Urinary Iodine Concentration

Pankiv Volodymyr , Pankiv Ivan

Iodine is important in both thyroid function and human metabolism. The roles of iodine intake on the metabolic syndrome (MetS) etiology remain controversial.The aim of this study: Was to investigate the relationship between iodine status and MetS and its components. 371 subjects aged ≥20 years were included.Materials and methods: The presence of MetS was defined according to the Adult Treatment Panel (ATP) III criteria. The p...

ea0090ep1005 | Thyroid | ECE2023

Relationship between TSH and metabolic parameters in overweight and obese premenopausal euthyroid women with autoimmune thyroiditis on levothyroxine treatment and healthy women

Nonchev Boyan , Argatska Antoaneta , Chobankova Elena

Objective: To investigate the relationship between serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) and body mass index (BMI), blood glucose, serum lipids and liver in overweight and obese euthyroid healthy premenopausal women and euthyroid women with autoimmune thyroiditis on levothyroxine replacement therapy.Patients and methods: The study includes 34 premenopausal women with autoimmune hypothyroidism on stable levothyroxine dose and 12...

ea0090ep1006 | Thyroid | ECE2023

Severe symptomatic hypercalcaemia associated with thymic hyperplasia and mediastinal lymphadenopathy secondary to Graves’ Disease

Audet Samuel , Bujanova Jana , Ito, Adam Watson Erisa

Background: Hypercalcaemia of hyperthyroidism via increased bone turnover is not uncommon, however it is usually mild and asymptomatic. Corrected calcium (cCa) concentrations ≥ 3.0mmol/l are seen rarely and tend to be associated with high TSH receptor antibodies concentration. Some of the less well-known effects include thymic hyperplasia (TH) and lymphadenopathy. TH is explained by thyroid hormone acting on thyrotropin receptors in thymic tissue to increase proliferatio...

ea0090ep1007 | Thyroid | ECE2023

Graves’ orbitopathy and pretibial myxoedema developed years after thyroidectomy

Kobaidze Ann , Tserediani Ilona , Tedoradze Nino , Davitadze Meri

Background: Graves’ orbitopathy (GO), also known as thyroid eye disease, is an autoimmune condition and is one of the main extrathyroidal manifestations of Graves’ disease. GO is relatively rare and usually accompanies the onset or develops soon after the Graves’ disease. We present a case of GO that developed 18 years later from total thyroidectomy. Case report: A 64-year-old men presented at the ophthalmology clinic with one-month histor...

ea0090ep1008 | Thyroid | ECE2023

Monitoring thyroid function test in patients with growth hormone deficiency, receiving growth hormone replacement therapy

Asaad Taha , Saeed Akam

Introduction: Interaction of growth hormone system with Hypothalamic pituitary axis can be complicated, and the effect of GH treatment on thyroid function is still not completely clear. GH has inhibitory effect on conversion of T4 to reverse T3, while enhancing extrathyroidal conversion of T4 to T3.Objective: To assess thyroid function test in patients with growth hormone deficiency, receiving growth hormone replacement therapy in Slemani, Kurdistan regi...

ea0090ep1009 | Thyroid | ECE2023

50 Shades of Graves’

Newland-Jones Philip , Bujanova Jana , Pilobello Nemia , Bray Diane , Knysak Alicja

Introduction: We present a series of 10 cases of GD presenting with seemingly unrelated symptoms with limited features of thyrotoxicosis, where control of thyroid function tests (TFTs) led to complete normalisation of presenting symptoms. In all cases patients were shown to have Graves disease with thyroid antibodies.Case series review: 1. 82F with symptomatic hypercalcaemia and thymic hyperplasia on CT. Calcium normalised with standard therapy and remai...

ea0090ep1010 | Thyroid | ECE2023

Locoregional and distant recurrences of papillary thyroid carcinoma : A case series of 12 patients

Bammou Sanaa , Ait Si Ali Zineb , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Patients with PTC usually have excellent outcomes with appropriate therapy, while up to 30% of patients present with aggressive disease, including patients with locoregional recurrence and distant metastasis.The aim: Of this study is to analyze the characteristics of patients with papillary carcinoma of the thyroid with locoregional and distant recurrences.Résults: We included 12 cases of locoregional and distant...

ea0090ep1011 | Thyroid | ECE2023

Echographic characteristics of thyroid cancers in the Regional Hospital of Malaga

Soria Utrilla Virginia , Kishore Doulatram Gamgaram Viyey , Gonzalez Romero Stella

Introduction: Thyroid cancer is the most common endocrine malignancy, and its incidence is increasing worldwide.Objective: Our aim is to look at the prevalence of ultrasound features and FNA findings of nodules in patients operated on for thyroid cancer in our hospital.Material and methods: Cross-sectional observational study of patients operated on for thyroid cancer at the Regional University Hospital between 2018-2021, we collec...

ea0090ep1012 | Thyroid | ECE2023

Papillary microcarcinoma: Diagnosis, treatment and outcomes

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: Papillary microcarcinoma (PMC), is defined as papillary carcinoma of the thyroid that is less than 10 mm in diameter. Objective: The purpose of this study is to describe the diagnosis, treatment and outcomes of papillary thyroid microcarcinoma.Material and Methods: This is a retrospective study including 55 cases of papillary thyroid microcarcinoma treated at our department, from 2000 to 2021.Re...

ea0090ep1013 | Thyroid | ECE2023

Ectopic Cervical Thymic Hyperplasia In A Patient Treated For Hodgkin Lymphoma

Kallel Souha , Haj Kacem Akid Faten , Achour Imen , Hbaieb Yousef , Kallel Rim , Frikha Hamdi , Abid Mohamed , Charfeddine Ilhem

Background: True thymic hyperplasia results from stressful situations such as chemotherapy. It commonly presents as an anterior mediastinal mass; cervical location is exceptional. The aim of this work is to illustrate a case of an incidental ectopic cervical thymic hyperplasia in a patient treated for Hodgkin lymphoma.Case reprt : Here we report a case of a cervical true thymic hyperplasia in a 12-year-old girl who had a Hodgkin lymphoma treated by radio...

ea0090ep1014 | Thyroid | ECE2023

A patient with thyroid lymphoma diagnosed during follow-up with benign thyroid nodule

Birinci Cigdem , Coskun Hulya , Ucuncu Ozge , Bilginer Cuneyt , Kanburoglu Meletli Ozlem , Kocak Mustafa , Nuhoglu Irfan

Objectives: Primary thyroid lymphoma constitutes 0.5-5% of all thyroid malignancies. Its incidence is two per million persons. Patients usually present with rapidly growing masses in the thyroid their sixth-seventh decades. The disease is frequently accompanied by chronic Hashimoto’s thyroiditis. Most tumors are B-cell derived non-Hodgkin’s lymphoma.Case report: An 84-year-old male patient presented with a palpable swelling in the neck. Ultraso...

ea0090ep1015 | Thyroid | ECE2023

What are we going to do with Bethesda IV nodes in future? Do we need molecular testing for all of them?

Semenov Arseny , Buzanakov Dmitry , Chernikov Roman , Sleptsov Iliya , Makarin Viktor , Uspenskaya Anna , Timofeeva Nataliya , Gorskaya Nataliya , Vorobyev Sergey , Novokshonov Konstantin , Karelina Yuliya , Chinchuk Igor , Fedorov Elisey , Rebrova Dina , Sablin Iliya , Zolotukho Anna , Alekseeva Svetlana , Gerasimova Kseniya , Puskaruk Alexander , Levchenko Nataliia , Shihmagomedov Shamil

Background: Bethesda IV is the most common indication for thyroid surgery. As histological verification is the only 100% certain method of confirming malignancy, surgery remains the gold standard for FN treatment. Most cases of FN malignancy are variants of papillary thyroid cancer that require active surveillance alone in nodules sized less than 2 cm.Materials: A continuous cohort of 4399 patients who underwent surgery at SPbU_Hospital in the years 2020...

ea0090ep1016 | Thyroid | ECE2023

Hematological changes in patients with Graves disease

Saidova Farida , Aslanova Jale , Akhmedova Leyli , Shahsuvarov Oruc

The aim of the study is to identify the frequency of occurrence of various morphological types and various degrees of severity of anemia in patients with Graves disease(GD).Material and methods: The data of the case histories of 157 patients operated on for GD in 2012 were analyzed. When assessing hematological parameters, two groups were identified: Group 1 - patients with GD with mild anemia (n= 98), age 39.4 &pm; 1, 4, men - 41 (41.8%), women...

ea0090ep1017 | Thyroid | ECE2023

Achalasia associated with Grave’s disease: case report

Bensmaine Faiza , Beloucif Lynda , Guglielmi Jean-Marc , Botella Camille , Quittelier Regis , Pierre Jean Guillausseau

Rationale: Grave’s disease (GD) is the most common subtype of autoimmune hyperthyroidism, which can manifest with a variety of extrathyroidal clinical syndromes such as ophthalmopathy, pretibial myxedema (dermopathy), acropathy, cardiomyopathy, and encephalopathy. In very rare instances, GD can also be diagnosed following severe gastrointestinal symptoms such as dysphagia, heartburn, nausea and vomiting. We hereby describe a rare case of GD with digestive symptoms which w...

ea0090ep1018 | Thyroid | ECE2023

Possibilities and priority of ultrasound in thyroid lesions covid-19

Aleksandrov Yuriy , Semikov Vasiliy , Timofeeva Lubov , Yanovskaya Elena

Scientists have studied the direct effect of Civi19 on the pancreas and thyroid gland, in particular, on the development of subacute thyroiditis de Quervian. Our study describes 9 cases of subacute thyroiditis associated with coronavirus infection. Three patients had a mild form of covid19 (positive PCR test result). Subacute thyroiditis was one of the components of multiple organ lesions. Patients had typical manifestations of thyroiditis neck pain, cough, signs of hyperthyro...

ea0090ep1019 | Thyroid | ECE2023

Complications related to necrotizing otitis externa among patients with diabetes

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: Necrotizing otitis externa is an invasive infection of the external auditory canal and skull base, which typically occurs in older adult patients with diabetes mellitus.Objective: The purpose of this work is to describe the complications related to necrotizing otitis externa among patients with diabetes.Methods: This is a retrospective study including 10 diabetic patients with complicated necrotizing otitis externa tr...

ea0090ep1020 | Thyroid | ECE2023

Case report: Methimazole-induced eosinophilic pleural effusion in a patient recently diagnosed with Graves’ disease

Jimenez Lopez Noemi , Allo Miguel Gonzalo , Blanco Urbaneja Irune , Mauricio Chavez Villegas Alvaro , Martinez Diaz-Guerra Guillermo , Leon Sanz Miguel

Background: Thionamides are a class of drugs used to control thyrotoxicosis. A wide range of systemic adverse effects have been described, including agranulocytosis, rash, fever, arthralgia, hepatitis and even drug-induced lupus. Besides, there are some uncommon events related to their use, such as pleural effusion (only eight cases have been previously reported). We report a case of methimazole-induced eosinophilic pleural effusion.Case: Our patient is ...

ea0090ep1021 | Thyroid | ECE2023

A case of acute adrenal insufficiency revealing thyrotoxicosis

Fadia Boubaker , Souissi Mariem , Elomma Mrabet Houcem , Belkhiri Malek , Baha Zantour , Lassoued Najoua , Wafa Alaya , Mohamed Habib Sfar

Introduction: The coexistence of hyperthyroidism and adrenal insufficiency in the same individual is a rare clinical condition.A total of 20 cases has been reported in the literature [1]. These two conditions may have the same clinical manifestations such as weight loss, asthenia, and digestive disorders and each one may mask the other. We describe the case of a patient presenting to the emergency department with acute adrenal insufficiency in whom associated hyperthyroidism w...

ea0090ep1022 | Thyroid | ECE2023

Exogenous biotin interference in streptavidin-biotin immunoassays: Interpret results with caution

Innes Rachael , McGuire Jacqueline , Mukhopadhyay Babu

A 52-year-old patient with a history of secondary progressive multiple sclerosis was referred to our endocrine vetting service with deranged thyroid function tests (TFTs). Medicines reconciliation demonstrated that the patient was currently on regular fampridine and carbamazepine only. TFTs checked in the community revealed a free T4 of 65.8pmol/l (12.0-22.0pmol/l) with a TSH of 2.03mU/l (0.27-4.20mU/l) and a free T3 of 5pmol/l (3.1-6.8pmol/l). 25-OH vitamin D and vitamin B12 ...

ea0090ep1023 | Thyroid | ECE2023

Association of Basedow and primary biliary cholangitis : a case report

El Hafiani Asmae , Hinde Iraqi , Gharbi Mohamedelhassan , Kaoutar Rifai , Meryem Karimi , Fatima Toulali

Introduction: Primary biliary cholangitis (PBC) is a rare chronic cholestatic liver disease, which is most likely of autoimmune origin. It is often associated with other autoimmune diseases, although it is rarely seen with Basedow.Observation: We report the case of a 38 years old patient, chronic smoker, who presents clinical and biological hyperthyroidism related to Basedow, treated with synthetic antithyroid drugs for years with poor compliance and not...

ea0090ep1024 | Thyroid | ECE2023

Assessment of sleep quality in patients with well-controlled primary hypothyroidism

Abidi Sahar , Oueslati Ibtissem , Ben Hamida Asma , Yazidi Meriem , Chihaoui Melika

Introduction: Poorly-controlled hypothyroidism is frequently associated with sleep disorders such as impaired sleep quality and obstructive sleep apnea. The aim of this study was to evaluate the sleep quality in patients with well-controlled primary hypothyroidism.Methods: This was a single-center, cross-sectional study including 50 patients with well-controlled primary hypothyroidism (TSH level within the normal range: 0.35-4.94 mIU/l) for at least one ...

ea0090ep1025 | Thyroid | ECE2023

Clinical Significance of Basal and Stimulated Calcitonin Levels in A Case with Obesity Under Liraglutide Treatment

Bayraktaroğlu Taner , Yilmaz Doğancan , Tekin Sakin , Topaloğlu Omercan

Background: Liraglutide is a long-acting GLP-1 receptor (GLP-1R) agonist. GLP-1R is highly expressed in C-cells hyperplasia and in medullary thyroid cancer. We aimed to evaluate calcitonin levels stimulated by calcium test and possible development of C-cell hyperplasia during Liraglutide therapy in a case with obesity.Case Report: A 50-year-old woman was referred to endocrinology policlinic with complaints of increased appetite and weight gain. There wer...

ea0090ep1026 | Thyroid | ECE2023

A rare diagnosis of lateral Neck Mass

Jihene Houas , Arfi Taissir Ben , Monia Ghammam , Heyfa BelHadjMiled , Omri Malika El , Mouna Bellakhdher , El Abed Yosra Hasni , Abir Meherzi , Wassim Kermani , Mohamed Abdelkefi

Introduction: Ectopic thyroid is characterized by thyroid tissue in a location other than anterior to the upper tracheal rings. The estimated incidence of thyroid ectopia is approximately 1/100,000. The most frequent locations are along the midline from the base of the tongue (90%) to the mediastinum. Ectopic thyroid tissue in the lateral neck is rare. We present a case of an ectopic thyroid gland with an atypical presentation as a lateral neck mass.Case...

ea0090ep1027 | Thyroid | ECE2023

Complications of hypothyroidism: a series of 67 cases

Haj Kacem Akid Faten , Ben Salah Raida , Soomauroo Siddiqa , Mouhaymen Missaoui Abdel , Chouaib Sarra , Mnif Mouna , Marzouk Sameh , Bahloul Zouheir , Abid Mohamed

Introduction: Hypothyroidism is a consequence of thyroid hormone deficiency which may be of peripheral or central origin. If hypothyroidism is left untreated, the symptoms progress and lead to life-threatening complications.Patients and method: Retrospective study of 67 patients with primary hypothyroidism. We determined the different complications associated with hypothyroidism.Results: We collected 67 patients with overt hypothyr...

ea0090ep1028 | Thyroid | ECE2023

Graves’ disease and autoimmune bullous dermatosis

Haj Kacem Akid Faten , Ben Salah Raida , Soomauroo Siddiqa , Mouhaymen Missaoui Abdel , Chouaib Sarra , Marzouk Sameh , Charfi Nadia , Bahloul Zouheir , Abid Mohamed

Introduction: Autoimmune bullous dermatoses (ABD) represent a heterogeneous group of AIDs that target different epidermal or subepidermal proteins of the skin and/or mucous membranes. As with any autoimmune disease (AID), it may be associated with other AIDs. We report a case of ABD associated with Graves’ disease (GD).Observation: The ABD was a pemphigus vulgaris (PV) that was diagnosed at the age of 25 years in our patient and she was treated with...

ea0090ep1029 | Thyroid | ECE2023

PENDRED syndrome with ectopic thyroid : about a delayed diagnosis

Sara Chtioui , Si Ali Zineb Ait , Rafi Sana , Mghari Ghizlane El , Ansari Nawal El

Pendred syndrome, an autosomal recessive disorder, is the most common syndromal form of hearing loss and involves abnormalities of the cochlea, varying degrees of sensorineural hearing loss and diffuse thyroid enlargement/goiter. We describe a case of a delayed diagnosis of Pendred syndrome. The patient is a 30 years female who had a history of total thyroidectomy 13 years ago. And presented when aged 30 with a cervical abscess of ectopic thyroid under the submaxillary gland. ...

ea0090ep1030 | Thyroid | ECE2023

Primary Thyroid Lymphoma: Clinical Course vs High Suvmax in Fdg-Pet

Lopes-Pinto Mariana , Aparicio David , Paula Ricca Lacerda Nobre M Caetano Ema , Dolores Lopez-Presa Maria , Joao Bugalho Maria

Introduction: Primary thyroid lymphomas (PTL) account for 5% of all thyroid malignancies. Treatment and prognosis depend on tumor subtype. Contrasting with diffuse large B-cell lymphomas (DLBCL), that have an aggressive clinical course and higher maximum standardized uptake value (SUVmax) in Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET), thyroid extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) usually show an indolen...

ea0090ep1031 | Thyroid | ECE2023

Combination of recurrent thyroid artery embolization and sorafenib treatment in the management of inoperable papillary thyroid cancer

Koksalan Damla , Cam İsa , Cetinarslan Berrin , Canturk Zeynep , Selek Alev , Gezer Emre , Sozen Mehmet , Alkan Ozlem

Introduction: Thyroid papillary cancer is a solid organ malignancy that can be cured mostly by surgical and radioactive iodine(RAI) therapy. Metastatic disease state and radioactive iodine resistance have led to new treatment searches. In recent years, sorafenib, a tyrosine kinase inhibitor, has been used as a first-line treatment in thyroid papillary cancers that cannot be cured by surgery or radioactive iodine treatment. In addition, the use of thermal ablation and transarte...

ea0090ep1032 | Thyroid | ECE2023

Thyroid cancer yield in patients with Graves’ disease

Kallel Souha , Haj Kacem Akid Faten , Achour Imen , Charfi Slim , Frikha Hamdi , Abid Mohamed , Charfeddine Ilhem

Background: Thyroid nodules found in patients with Graves’ disease have a higher likelihood of being malignant. Management of these association is controversial.Objectives: To discuss clinical and therapeutic features of this association.Materials and methods: We report three cases of thyroid cancer occurring in Graves’ disease, treated surgically at our department.Results: There were three patients...

ea0090ep1033 | Thyroid | ECE2023

Association of papillary and medullary thyroid carcinoma in multiple endocrine neoplasia type 2a

Mohamed Ali Boutheina , Cheikh Mariem , Mohamed Moctar , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: The association of papillary carcinoma with medullary thyroid carcinoma may in rare cases be found in some members of families with multiple endocrine neoplasia type 2a (MEN 2a).Case Report: A 38-year-old patient with a family history of papillary thyroid carcinoma (PTC), operated for multinodular goiter classified Tirads 4 by total thyroidectomy, the anatomopathological examination concluded to a lobar medullary thyroid carcinoma (MTC) of ...

ea0090ep1034 | Thyroid | ECE2023

Papillary Thyroid Cancer is also more common in The Iodine Deficiency area: Evaluation of 2748 Patients

Kocak Mustafa , Erbolukbaş Gulşah , Nuhoğlu İrfan , Suat Demir Ahmet , Onder Ersoz Halil

Thyroid cancer is the most common malignancy of the endocrine system. Papillary thyroid cancer is the most common thyroid malignancy worldwide and has a good prognosis. The prevalence of follicular thyroid cancer in endemic iodine deficiency regions is higher than in regions without iodine deficiency. However, it has been observed that the incidence of follicular thyroid cancer decreases and the incidence of papillary thyroid cancer increases after iodine prophylaxis. The Our ...

ea0090ep1035 | Thyroid | ECE2023

Graves’ Disease Hiding Metastatic Papillary Thyroid Carcinoma - case report-

Musat Madalina , Septar AIlin , Boanta Roxana , Goldstein Andrei , Terzea Dana , Ioachim Dumitru , Schipor Sorina , Muresan Andrei , Niculescu Dan , Elian Viviana

The coexistence of Graves disease (GD) and thyroid carcinoma used to be considered uncommon, but association between the two is being progressively acknowledged. Case report: We present the case of a 69-year-old woman with a 10 year history of GD who was referred to our clinic for fatigue, sweating, palpable cervical mass and weight loss. She was treated only in the previous 5 months with block and replace therapy. Laboratory workup at admission showed s...

ea0090ep1036 | Thyroid | ECE2023

Formation of a database of relatives of patients of the first degree of kinship operated on for medullary thyroid cancer

Shepelkevich Alla , Dydyshka Yuliya , Kondratovich Victor , Leonova Tatiana , Sosedkova Alexandra

To analyze the data of relatives of first-degree patients operated on for medullary thyroid cancer (MTC), we analyzed the anamnestic data of the database of patients with MTC, formed on the basis of the cancer registry of the Republic of Belarus and medical records of the Republican Thyroid Tumor Center. Further examination of relatives is also performed on the basis of the Republican Center for Thyroid Tumors.The aim: of the study was to create a databa...

ea0090ep1037 | Thyroid | ECE2023

Coexistence of thyroid carcinoma and graves’ disease: report of two cases

Azriouil Manal , Qasdi Ikrame , Amira Ikram , Rifai Kaoutar , Hinde Iraqi , Gharbi Mohamedelhassan

Introduction: Graves’ disease (GD) is a common autoimmune thyroid disease. The association between GD and thyroid carcinoma (TC) remains controversial. We describe two patients presenting this association.Case report: Case 1 a 46 years old woman with clinical history of type 2 diabetes, she was diagnosed with Graves’ disease and multiple nodules were found in her enlarged thyroid gland by ultrasonography. The patient underwent total thyroidecto...

ea0090ep1038 | Thyroid | ECE2023

Intrathyroidal Parathyroid Cysts

Kallel Souha , Kharrat Ines , Haj Kacem Akid Faten , Thabet Wadii , Frikha Hamdi , Abid Mohamed , Charfeddine Ilhem

Objective: Our aim is to describe the epidemiological, clinical and paraclinical features of intrathyroidal parathyroid cysts (PCs). Materiel and Methods : We report 2 cases of intrathyroidal PC treated in our ENT department. Results : We report 2 cases of non-functioning intrathyroidal PCs: 2 women (22 and 45 years old). They were referred to our department for anterior neck mass lasting for an average of 13 months. They had no co...

ea0090ep1039 | Thyroid | ECE2023

Oculomotor paralysis and diabetes: what is the link?

Douali Widad , Zahra El Jaafari Fatima , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Oculomotor palsies in diabetes are focal mononeuropathies. It is a diabetic neurological complication, relatively rare. The oculomotor nerves affected are mainly the external oculomotor nerve (VI), the common oculomotor nerve (III), and more rarely, the pathetic nerve (IV). We report the case of a type 2 diabetic patient in whom the diagnosis of oculomotor palsy was retained.Observation: This is a 65-year-old diabetic patient, 4 years old, ...

ea0090ep1040 | Thyroid | ECE2023

Hashitoxicosis : a case report

Hanane Brahimi , Bouchenna Amira , Sara Lamara-Mohamed , Samia Ouldkablia

Introduction: Autoimmune thyroid diseases are frequent and very polymorphic pathologies. The same person can successively present with different manifestations. Graves’ disease and Hashimoto’s thyroiditis seem to be able to coexist. The name "Hashitoxicosis" has been suggested in this case, characterized by the sequential association, whatever the order, of hyper- and hypothyroidism. We report in this work, the case of a patient treated for autoimmune hypothy...

ea0090ep1041 | Thyroid | ECE2023

A 3rd degree atrioventricular block revealing hypothyroidism: a case report

Douali Widad , Zahra El Jaafari Fatima , Rafi Sana , El Ansari Nawal , El Mghari Ghizlane

Introduction: Hypothyroidism is a rare cause of atrioventricular block. We report the case of an 85 year old patient admitted with a 3rd degree AVB and in whom the biological work-up had objectified a hypothyroidism. Observation: 85-year-old patient, followed for thyreopathy for 20 years on LT4: 100 ug/d, Diabetic for 2 years on premixed regimen: 08-00-12 ui ;HTA for 5 years on amlodipine 5 mg/d presented to the emergency room for syncope. No signs of hy...

ea0090ep1042 | Thyroid | ECE2023

Navigating the differential diagnosis of thyrotropinoma and resistance to thyroid hormones

Niculaide Cristina , Mustata Theodor , Sorina Martin Carmen , Fica Simona

Introduction: Syndrome of inappropriate secretion of thyrotropin (SITSH) is a rare condition characterized by uninhibited serum TSH in the presence of high thyroid hormones, usually caused by TSH secreting adenoma or resistance to thyroid hormones (RTH). Differential diagnosis between the two is often challenging due to their overlapping features.Case report: We present the case of a 50-year-old postmenopausal woman with a history of -myocardial infarcti...

ea0090ep1043 | Thyroid | ECE2023

The current state of the problem of thyroid pathology in iodine-deficient regions of the Russia

Isaeva Maria , Troshina Ekaterina , Kolpakova Evgeniia , Makolina Natalia , Platonova Nadezhda , Galieva Maria , Pronina Ludmila , Nikankina Larisa , Zuraeva Zamira

Introduction: Interaction between genetic and environmental factors is the foundation of the pathogenesis of autoimmune thyroiditis (AIT). One of the important factors is iodine supply. Iodine deficiency is the main cause of goiter, dysfunction of the thyroid gland, disorders of mental and physical development. Main solution of that problem is the iodine salt consumption. It can decrease iodine deficiency, but the RF doesn’t have general programs of salt iodization and ha...

ea0090ep1044 | Thyroid | ECE2023

Wernicke’s encephalopathy complicating hyperemesis gravidarum associated with hashitoxicosis: Rare association

Ait Si Ali Zineb , Oussama Jaddi , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Wernicke’s encephalopathy is a rare neurological disorder initially described in alcohol-dependent and malnourished patients. It is characterised by confusion, ataxia and nystagmus. It is caused by thiamine deficiency. We report the case of a patient with hyperemesis gravidarum and hashitoxicosis complicated by Wernicke’s encephalopathy Observation: A 22 year old patient, 1G0P, without any particular pathological history, was admi...

ea0090ep1045 | Thyroid | ECE2023

Myxoedema Coma, Life Threatening with Multiple Exacerbating Factors, Presenting with Bradycardia and Hypoglycaemia, Rare Interesting Experience with Bizarre Hormonal Imbalances

Alfahal Mohammed , Omer Maria , Abdalla Omer , Mlawa Gideon , Taha Mustafa

A 91-year-old lady presented with bradycardia ‘HR ~36, she was alert and conscious initially. Soon after the initial assessment, she was found unresponsive; with blood glucose of 0.8 mmol/l; bradyapnoec; BP 151/59; GCS 5/15; temp ‘32.8°C’. She was aroused after resuscitation with intravenous Dextrose, GCS 15/15 with an element of confusion, the temperature did not exceed 34.9°C despite active warming. The patient looked in a low mood, barely audible, w...

ea0090ep1046 | Thyroid | ECE2023

A fatal case of myxedema coma

Boubagura Imane , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction and Backgrounds: Myxedema coma is a severe life threatening form of decompensated hypothyroidism which is associated with a high mortality rate. Infections and discontinuation of thyroid supplements are the major precipitating factors. It’s characterized by a decreased mental status, hypothermia, bradycardia, hypotension, and hypoventilation. Very few cases of Myxedema coma have been reported till date, actual prevalence is unclear with the estimated incidenc...

ea0090ep1047 | Thyroid | ECE2023

Thyroidectomy in Graves’ disease

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: Graves’ disease is an immune system disorder that results in the overproduction of thyroid hormones. Treatment include: anti-thyroid medications, beta blockers, radioiodine therapy and surgery.Objective: The aim of our study is to describe the role of surgery in the treatment of Graves’ disease.Patients and methods: We conducted a retrospective study including 40 patients who underwent surgery for Graves&#14...

ea0090ep1048 | Thyroid | ECE2023

Hashimoto’s thyroiditis associated with alopecia

Haj Kacem Akid Faten , Ben Salah Raida , Soomauroo Siddiqa , Mouhaymen Missaoui Abdel , Chouaib Sarra , Frikha Faten , Rekik Majdoub Nabila , Bahloul Zouheir , Abid Mohamed

Introduction: Alopecia is an autoimmune disease (AID) affecting the hair follicles. Alopecia can become generalised and affect all hairy areas (universal alopecia). As with any AID, it may be associated with other AIDs. We report 2 cases of the association of alopecia with autoimmune thyroid disease (AITD).Observation: The subjects were a man and a woman aged 48 and 54 years respectively. They presented with hypothyroidism. Hashimoto’s thyroiditis (...

ea0090ep1049 | Thyroid | ECE2023

Myopathy in hyperthyroidism : a retrospective analysis of 6 cases

Haj Kacem Akid Faten , Belabed Wafa , Mouhaymen Missaoui Abdel , Elleuch Mouna , Mnif Fatma , Mejdoub Nabila , Abid Mohamed

Background and aim: Hyperthyroidism status can be complicated by polymorphic neuromuscular manifestations sometimes revealing. In the majority of cases, these disorders regress during the transition to euthyroidism. We report in this work 6 observations illustrating the neuromuscular manifestations seen in hyperthyroidism.Observations: We report two cases of chronic myopathy: a man and a woman aged 47 and 55 years respectively, hospitalized for hyperthyr...

ea0090ep1050 | Thyroid | ECE2023

Nodular Dystrophy Revealing an Ectopic Thyroid : About A Case

Settai Yousra , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Thyroid ectopia is a rare pathology linked to a migration defect of the thyroid gland during its embryonic development. It is most often asymptomatic, but can be revealed by dysthyroidism, or a cervical or thoracic mass. We report the case of an ectopic thyroid revealed by a mediastinal mass.Observation: 61-year-old patient, with no particular history, followed for a plunging multi-hetero-nodular goiter which cervical ultrasound showed an e...

ea0090ep1051 | Thyroid | ECE2023

Neutropenia secondary to synthetic antithyroid drugs: about 5 cases including one case of agranulocytosis

Raki Nezha , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Hematological toxicity is the main risk of synthetic antithyroid drugs (ATS); the major form is acute agranulocytosis requiring adequate and urgent management. The literature concerning neutropenia and agranulocytosis under ATS is relatively poor, based on rare studies, with often small numbers of patients, and most often concerning American or Japanese populations treated.Purpose of the study: Report our experience in the endocrinology and...

ea0090ep1052 | Thyroid | ECE2023

Two rare cases of Riedel’s thyroiditis

Martins Fernandes Andreia , Rita Elvas Ana , Couto Joana , Martins Raquel G. , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Riedel’s thyroiditis (RT) is a rare chronic inflammatory disease characterized by a dense fibrosis that replaces normal thyroid parenchyma. The most common manifestation is a stony hard thyroid mass, commonly associated with compressive symptoms. Histological confirmation is essential for diagnosis and the main differential diagnosis is the anaplastic thyroid cancer. The management is challenging and there is no agreed standard treatment, since only a few ca...

ea0090ep1053 | Thyroid | ECE2023

Tuberculosis of the thyroid gland: a case study

Khadidja Bessaid , Mezoued Mouna , Azzouz Malha

Introduction: Thyroid tuberculosis is a rare entity even in countries like Algeria where tuberculosis is endemic.Observation: We report the case of a 40-year-old woman, with a history of hypertension and severe renal failure, consulting for recent cervical swelling evolving in a context of asthenia, nocturnal fever and weight loss. The clinical examination found a compressive goitre. The biological assessment objectified a primary hypothyroidism and an i...

ea0090ep1054 | Thyroid | ECE2023

Jougerot sjogreen syndrom revealing autoimmun hypothyroidism

Hassan Neima , Bammou Sanaa , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction : Jougerot –sjogreen syndrom is an auto-immune exocrinopathy secondary to the interaction between a favorable ground and environmental factors that can lead to the disease. Thyroiditis can precede sjogreen’s syndrom or follow it, just as the two diagnoses can be made at the same time.Case report : 46-year-old female patient, type 2 diabetic on oral antidiabetic 2g/d, followed for sjogreen jougerot syndrom retained in the face of oc...

ea0090ep1055 | Thyroid | ECE2023

Transient hypothyroidism post radioiodine therapy

Sabbagh Ghada , Elfekih Hamza , Aycha Ghachem , Saad Ghada , Barkallah Fatma , Taieb Ach , Hasni Yosra , Chadli Chaieb Molka

Introduction: Grave’s disease is an autoimmune disorder and is considered the most common cause of hyperthyroidism. Its treatment options include medical therapy, radioactive iodine (RAI), and surgery. RAI is commonly employed for Grave’s disease regarding its efficiency and safety. Definitive hypothyroidism is the main goal of RAI and is typically achieved within the first 3 to 6 months of therapy. Transient hypothyroidism and recurrence of hyperthyroidism after RAI...

ea0090ep1056 | Thyroid | ECE2023

Association of Crohn’s disease and Hashimoto’s thyroiditis : a case report

Gorgi Khaoula , Tadaloui Abderrahman , Chakdoufi Sanae , Errahali Yassine , Anas Guerboub Ahmed

Introduction: Crohn’s disease is a chronic inflammatory bowel disease, most commonly affecting the terminal ileum and colon. In the other hand, Hashimoto’s thyroiditis is a chronic autoimmune inflammation of the thyroid gland. The association between the 2 diseases is rare. We report the observation of a patient with this association.Observation: A 23-year-old female patient who consulted for persistent diarrhea, rectorrhagia, abdominal pain, b...

ea0090ep1057 | Thyroid | ECE2023

Diagnostic performance of fine needle aspiration biopsy in the diagnosis of medullary thyroid carcinoma

Nour El Houda Khelil

Medullary thyroid cancer (MTC)is a very polymorphic tumour, it remains difficult to diagnose, especially in cytology. The MTC is characterized by a polymotphic cell population, the amyloid stroma is found in 43 to 81% of cases. In this retro and prospective study carried out over 5 years, we included 45 lesions (8 nodules, 35 lymph nodes and 2 cervical masses) these lesions were punctured and the cytological results were compared with the definitive histology. On cytology, 13 ...

ea0090ep1058 | Thyroid | ECE2023

Lymph node metastasis in medullary carcinoma of the thyroid gland

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells. Metastatic spread commonly occurs to cervical lymph nodes.Methods: This is a retrospective study including 8 cases of medullary carcinoma of the thyroid gland between 2000 and 2020.Results: The sex-ratio (M/F) was 0.125. The mean age of our patients was 55.87 years. No personal or family history of multiple endocrine neoplasm was ...

ea0090ep1059 | Thyroid | ECE2023

An unexpected discovery of MEN 2B Syndrome in an adolescent - a case report

Manole Tiberiu , Buduluca Larisa , Schipor Sorina , Muresan Andrei , Gherlan Iuliana

Introduction: Multiple Endocrine Neoplasia Syndrome 2B (MEN 2B) is a very rare genetic disorder which affects the thyroid and the adrenal glands, the development of mucosal neuromas and the general appearance of the patient’s body. Therefore, we can encounter Medullary Thyroid Carcinomas (MTC), adrenal sympathetic paragangliomas (or Pheochromocytomas) and habitus Marfanoid. The disease represents a challenge for every clinician, especially if it occurs in a child.<p c...

ea0090ep1060 | Thyroid | ECE2023

Test for determination of stimulated calcitonin level

Leonova Tatiana , Kondratovich Victor , Sosedkova Alexandra , Shepelkevich Alla , Dydyshka Yuliya

Assessment of basal calcitonin as the main marker of medullary thyroid cancer (MTC) was introduced into routine practice in the Republic of Belarus more than 10 years ago. A number of laboratory and clinical factors can influence the result of this parameter determination. Equally important is the gender, age, weight, the deviation of the serum calcium level, certain medications.The aim: Of the study was to develop and implement of stimulated calcitonin ...

ea0090ep1061 | Thyroid | ECE2023

Prolonged Survival in Follicular Thyroid Cancer with Bone Metastasis

de Brito Marques Francisca , Simoes de Carvalho Francisco , Lima Ferreira Joana , Paula Marques Ana

Introduction: Follicular thyroid cancer (FTC) accounts for 12% of differentiated thyroid cancers (DTC). It is frequently complicated by bone metastasis (BM), which impact quality of life (QOL) and decreases the 10-year survival rate to 13-21%.Case Report: A 53-year-old woman followed at the Pain Clinic for over 10 years for lower back pain, had been operated three years before due to lumbar disc herniation. Pain relapsed one year after surgery and was re...

ea0090ep1062 | Thyroid | ECE2023

Papillary carcinoma of the thyroid in Basedow disease : case report

A Meherzi , S Jemli , E Laabidi , Omri M El , M Bellakhdher , W Kermani , M Abdelkefi

Introduction: The occurrence of Basedow disease does not eliminate the possibility of an associated thyroid cancer. Thyroid carcinoma in Basedow disease is particularly rare (1 to 2%). Most often, it is a papillary carcinoma. This is most often a chance discovery. We report a case of a papillary carcinoma in a Basedow disease taken care of in our department. Case Report : This was a 39-year-old hypertensive diabetic woman followed in endocrinology for Ba...

ea0090ep1063 | Thyroid | ECE2023

Parkinson’s disease associated to Hashimoto’s thyroiditis

Ait Si Ali Zineb , Boukhalfa Ahmed , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders characterized by bradykinesia, tremor, rigidity and postural instability as well as neurocognitive impairment and depression. Studies found a significant association between thyroid dysfunction and an increased risk of PD. We report the case of a patient treated for PD who had also Hashimoto’s thyroiditis, and we discuss the association of thyroid dysfunction with risk of PD....

ea0090ep1064 | Thyroid | ECE2023

Case of Subacute Thyroiditis after receiving the SARS-CoV-2 vaccine and the Covid-19 infection 6 months later in the same patient

Vashakmadze Natia

A 43-year-old woman received the CoronaVac COVID-19 vaccine produced by Sinovac Biotech in September 2021. 1 month after the last dose of vaccine (10/2022), she developed pain in her right neck, palpitations, and fever. Laboratory studies revealed severe thyrotoxicosis (TSH - 0.1 mIU/ml, high FT4) and increased ESR - 59 mm/h; Ultrasound showed an asymmetric thyroid due to enlargement of the hypervascular right lobe. The left lobe was intact. She was diagnosed with subacute thy...

ea0090ep1065 | Thyroid | ECE2023

Diagnosis and management of a thyrotoxicosis storm on unknown hyperthyroidism

Hanane Brahimi , Somia Fetouci , Bouchenna Amira , Samia Ouldkablia

Introduction : In the spectrum of endocrine emergencies, thyroid storm is one of the most critical complications. Recognition and appropriate management of life-threatening thyrotoxicosis is vital to prevent the high morbidity and mortality that may accompany this disorder. The incidence of thyroid storm has been noted to be less than 10% of patients hospitalized for thyrotoxicosis; however, the mortality rate secondary to thyroid storm ranges from 20 to 30%. We report in this...

ea0090ep1066 | Thyroid | ECE2023

Ectopic thymus discovered during thyroid surgery

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: The thymus is a primary lymphoid organ and the initial site for development of T cell immunological function. It originates high in the neck in early fetal life and reaches its definitive location in the mediastinum after a process of descent, generally leaving no trace behind. Occasionally, during this descent, remnants of thymic tissue can be implanted along the cervical pathway, later appearing as a cervical mass.Case Report: This is a c...

ea0090ep1067 | Thyroid | ECE2023

Hepatic Encephalopathy Complicating Graves ‘disease: A Case Report

Maryame Benlafqih , Boukhalfa Ahmed , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Hepatic encephalopathy is a neuropsychological syndrome complicating a chronic liver disease (cirrhosis), rarely acute (fulminant hepatitis). We report the case of a patient with Graves’ disease who suddenly presented with hepatic encephalopathy. Case Report: S.B., a 48-year-old woman followed for Graves’ disease treated with antithyroid drugs and also presenting vitiligo, was admitted to our facility for a relapse of Graves’...

ea0090ep1068 | Thyroid | ECE2023

A treasure hunt! An unusual presentation of benign thyroid tissue as cervical masses

Thota Geethika , Luo Hongxiu

Introduction: Cervical masses in a patient with thyroid nodules raise the possibility of thyroid cancer with nodal metastases. Our case highlights the possibility of the rare presentation of benign thyroid tissue as a lateral neck mass in a patient with a previous history of thyroid surgery.Case Description: A 66-year-old women with a past surgical history of partial left lobectomy for unclear reasons 30 years ago was referred by the surgeon for evaluati...

ea0090ep1069 | Thyroid | ECE2023

Thyroid pathology and hypofertility

Ben Salah Raida , Hadjkacem Faten , Somauroo Seddiqa , Abid Mohamed , Bahloul Zouhir

Introduction: Thyroid pathology is common in women of reproductive age. Evaluation of thyroid function is classically recommended in cases of recurrent abortion. The presence of dysthyroidism or antithyroid antibodies increases the risk of abortion. We report two observations of hypofertility related to thyroid pathology and discuss the therapeutic course.Case 1: A 33 year old woman was referred for etiological investigation of recurrent abortion. She pr...

ea0090ep1070 | Thyroid | ECE2023

A Case of Myxoedema Coma Presenting as Suspected Angioedema with Confusion

Jatinder Hayre , Etbinah Lubna , Mohamed Ayan , Mahamud Bashir , Tam Karen , Mohammed Ahmed , Nikookam Khash , Mohammed Mohammed , Mlawa Gideon

Background: Myxoedema coma although uncommon can be life-threatening in patients who are poorly compliant with levothyroxine replacement. Some of the precipitating factors include intercurrent respiratory infection, use of sedatives, and electrolyte imbalance such as hyponatremia(Wiersinga 2018). A 73-year-old man presented to the Hospital with face and tongue swelling, shortness of breath, and type 2 respiratory failure. His past medical history includes hypothyroidism, Obstr...

ea0090ep1071 | Thyroid | ECE2023

Transverse Myelitis and Covid-19 Disease in A Patient with Hashimoto’s Thyroiditis

Athanassiou Lambros , Athanassiou Panagiotis , Tsakiridis Pavlos , Nikolakopoulou Sofia , Mathiou Dimitra , Nikolidaki Maria , Athanasiou Ifigenia Kostoglou

Introduction: The SARS-CoV-2 virus has caused the recent pandemic. Most affected patients have gone through a rather mild disease. However, some of the patients have gone through a severe illness requiring admission to an acute care unit. Some survived while others succumbed to the disease. In some patients the SARS-CoV-2 infection was characterized by neurological manifestations. One of these is transverse myelitis thought to be caused either by the virus itself as the SARS-C...

ea0090ep1072 | Thyroid | ECE2023

Unusual Warthin-like variant of papillary thyroid carcinoma associated with Hashimoto’s thyroiditis

Mallea-Gil Susana , de los Angeles Sosa Maria , Bachella Marcela , Sanchez Yamila , Coca Bibiana , Marta Aparicio Maria , Sankowicz Silvina , Ballarino Carolina

Warthin-like variant of papillary thyroid carcinoma is a rare histologic variant of PTC; they resemble Warthin tumor of salivary gland, frequently associated with lymphocytic thyroiditis. There is scarce literature available regarding this tumor.Clinical case: In August 2019 a 51-year-old female patient sought consult because she complained of constant pain in the anterior surface of the neck. Medical background: arterial hypertension, she had no history...

ea0090ep1073 | Thyroid | ECE2023

Tuberculous lymphadenitis with the appearance of thyroid carcinoma metastasis

Sebile Dokmetaş Hatice , Eren Esma , Karahangil Kadriye , Akkoyun Ayşenur , Dokmetaş Meric , Şahin Onur , Zeynep Ağaoğlu Hikmet

Tuberculosis (TB) is a disease that affects all organs and progresses with a wide variety of clinical manifestations. Cases of extrapulmonary tuberculosis (EPTB) are particularly difficult to diagnose because of its atypical course.Case: A 32-year-old female patient was evaluated in our clinic with the complaint of localized swelling in both supraclavicular regions (ScR) for one and a half months. There were no fevers, cough, or weight loss symptoms pres...

ea0090ep1074 | Thyroid | ECE2023

Squamous cell carcinoma of the larynx associated with thyroid carcinoma: a case report

Guissi Loubna , Gorgi Khaoula , Echchad Lamya , Rifai Kaoutar , Iraqi Hinde , Elhassan Gharbi Mohamed

Introduction: The discovery of thyroid cancer during surgery for another malignant disease of the upper aerodigestive tract is rare. We report the case of a man presenting squamous cell carcinoma (SCC) of the larynx associated with papillary thyroid carcinoma (PTC).Case presentation: A 68-year-old patient with history of cigarette smoking underwent total laryngectomy for laryngeal cancer associated with subglottic extension. Hemithyroidectomy on the lesi...

ea0090ep1075 | Thyroid | ECE2023

A vesicular carcinoma of the thyroid on Graves’ disease: a rare association

Alami Hassani Chaymaa , Idrissi Ayoub , Lahousssaine Abainou , Elhadri Sanae , Meftah Azzelarab , Baizri Hicham

Introduction: The occurrence of vesicular carcinoma in Graves’ disease is exceptional. It is most often a papillary carcinoma rarely vesicular. We report the case of a vesicular carcinoma discovered at the anatomopathological study of a total thyroidectomy in a patient followed for Graves’ disease.Observation: This is a 61-year-old female patient with type 2 diabetes, on SGLT2 inhibitor. There isn’t any family history of thyroid cancer or ...

ea0090ep1076 | Thyroid | ECE2023

Papillay microcarcinoma in patient with graves’ disease

Masmoudi Mohamed , Zitouni Chaima , Thabet Wadii , Chebil Ezer , Hasnaoui Mehdi , Mighri Khelifa

Introduction: Patients with Graves’ disease are at a 2.5 times higher risk of developing thyroid cancer than the general population.Objective: We report here a case of a papillary microcarcinoma discovered in patient with graves’ disease.Case report: This report is about a 51-year-old woman treated with anti-thyroid drugs and β blockers for Graves’ disease. Cervical ultrasound found an enlarged, hypervascular th...

ea0090ep1077 | Thyroid | ECE2023

surprise or evil hidden behind a toxic thyroid nodule: about a case

Riznat Malak , Srifi Hajar , Kaoutar Rifai , Iraqui Hind , Mohamed Hassan Gharbi

Introduction: Thyroid TB is rare even in endemic countries, and diagnosis is often delayed by atypical presentation and clinical latency. Rarely, if ever, does a tumor and infection form in the same thyroid nodule We report the case of a subject who was followed for a hot nodule and who was found to be both thyroid tuberculosis and tumor damage.Observation: This is a 59 year old patient vaccinated against BCG, with no histrory of pulmonary or extrapulmon...

ea0090ep1078 | Thyroid | ECE2023

Clinical case: I131 resistant follicular thyroid carcinoma

Siusaite Gabija , Kairyte Beata , Klimaite Raimonda , Zilaitiene Birute

Introduction: Follicular thyroid carcinoma (FTC) is the second most common thyroid tumor and accounts for about 5-10 % of all thyroid cancers. As FTC often retains the ability to concentrate radioactive iodine (I131), tumor may be responsive to I131 therapy. However, about 60-70 % of all metastatic thyroid cancers are resistant to I131 and has a poor prognosis with 10-year survival rate of 10 % and the average life expectancy 3-5 years after di...