Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Eposter Presentations

Late Breaking

ea0090ep1079 | Late Breaking | ECE2023

Evaluation and treatment of cardiovascular risk factors in patients with adrenal insufficiency

Wasmuth Anja , van de Loo Iris , Domberg Julia , Bullmann Catharina , Harbeck Birgit

Introduction: Patients with adrenal insufficiency (AI) are known to have a higher cardiovascular risk (CVR) than the normal population. In particular arteriosclerosis, coronary heart disease, arterial hypertension, hyperlipoproteinemia as well as metabolic disturbances contribute to the increased morbidity and mortality. Aim of this study was to evaluate known cardiovascular risk factors as well as the quality of care by the treating physicians.Material ...

ea0090ep1080 | Late Breaking | ECE2023

Gitelman syndrome, a rare disease: case report

Dumitru Teodora , Preda Cristina , Rosu Andreea , Akad Nada , Anisia Miruna , Leustean Letitia , Christina Ungureanu Maria

Introduction: Gitelman syndrome(GS) is a salt-wasting tubulopathy characterized by renal potassium wasting, hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria and hyperreninemic hyperaldosteronism. It is caused by the mutation of genes encoding sodium chloride (NCCT) and magnesium transporters in the thiazide-sensitive segments of the distal nephron (SLC12A3 and TRMP6 gene). GS is a rare autosomal recessive disease with a prevalence of only 25 cases per one millio...

ea0090ep1081 | Late Breaking | ECE2023

Cushing Syndrome Due To Acth-Secreting Pheochromocytoma: A Case Report

Ruiz Arnal Laura , Perez Garcia Leire , Agea Diaz Leire , Vega Blanco Maria , Rosario Fuentes Gomez Clara , Gonzalez Gonzalez Sheila , Galarza Montes Aitor , Perez Alonso Octavio , Garaizabal Azkue Leire , Gonzalez Fernandez Mikel

Introduction: The most frequent causes of ACTH-dependent Cushing’s syndrome are of pituitary origin and, less frequently, due to ectopic secretion of bronchial carcinoid, small cell lung cancer, and neuroendocrine tumors; it is rarely caused by an ACTH-producing pheochromocytoma.Methodology: We present a case of a 44-year-old female with a history of poorly controlled type 2 diabetes, hypertension, and long-standing obesity with no genetic predispos...

ea0090ep1082 | Late Breaking | ECE2023

Pheochromocytoma presenting with multi-system crisis during endoscopic procedure: a case report

Ecem Yigit Sidelya , Beril Gokmen Iffet , Okuturlar Yildiz , Celik Ozlem , Havas Fadil , Bekmezci Yavuz , Aytac Erman , Tekin Ali

A 45-year-old female patient with diagnosis of hypertension was admitted to Acibadem University Hospital for colonoscopy due to perianal abscess and rectovaginal fistula. She had been diagnosed with hypertension for 7 years and had been using 3 different classes of antihypertensive drugs. Intermittent hypertensive attacks and hospitalization for myocarditis history was documented. During anesthesia induction for colonoscopy her condition acutely worsened and she became hemodyn...

ea0090ep1083 | Late Breaking | ECE2023

Abdominal extraadrenal paraganglioma: review of the literature and report of 3 cases

Jose Vallejo Herrera Maria , Vallejo Herrera Veronica , Cruz Almaraz Almaraz Maria , Serrano Puche Felix

Extraadrenal paraganglioma is a rare tumor. The clinical and pathological findings of patients with abdominal localization paragangliomas (perihepatic, paraaortic, interaortocaval and retroperitoneal) are described. Its characteristics and diagnostic imaging are analyzed, as well as its therapeutic management. Between January 2021 and January 2022, 3 patients with extra-adrenal paragangliomas were diagnosed, all of them women. The age of our patients was 26, 57 and 67 years. T...

ea0090ep1084 | Late Breaking | ECE2023

Primary adrenal lymphomas, a race against time

Zarrouk Oumayma , Abid Sana , Abdelkafi Yassmine , Bayar Ines , Hajji Ekram , Ben Amor Bilel , Sayadi Hanene , Marmouch Hela , Khochteli Ines

Introduction : Primary adrenal lymphomas (PAL) are extremely rare and constitute 0.5% of all adrenal tumors. The number of cases described is approximately 70 cases [1] and It is bilaterally manifested in approximately 70% of cases [2]. The diagnosis is made on histological features, as there is no specific symptoms. Treatement is based on chemotherapy and prognosis is usually poor. We report two cases of bilateral PAL.Cases: First case: A 63-year-old wo...

ea0090ep1085 | Late Breaking | ECE2023

A case of Primary pigmented nodular adrenocortical disease in a young woman with arterial hypertension

Morelli Valentina , Favero Vittoria , Campi Irene , Guizzardi Fabiana , Aresta Carmen , Persani Luca

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare form of ACTH-independent Cushing’s syndrome (CS). Approximately 30% of patients with PPNAD are sporadic cases and the other are familial. We describe a case of a patient affected by PPNAD presenting with isolated arterial hypertension. A 19-year-old black female patient was referred to the Endocrinology Unit in september-2021 due to severe arterial hypertension and fatigue. Previous clinical history was un...

ea0090ep1086 | Late Breaking | ECE2023

Hyponatremia and its prevalence in the outpatient setting

Messer Vanessa , Koster Denise , Harbeck Birgit

Introduction: Hyponatremia is the most common electrolyte disorder and it affects approximately 5% of adults and 35% of hospitalized patients. Diagnostic and/or therapeutic challenge is given. It is defined by a serum sodium concentration of less than 136 mmol/l. Symptoms of hyponatremia range from mild and nonspecific to severe and life-threatening. Hyponatremia is classified as mild, moderate and severe and may be acute or chronic. Mortality and morbidity are significantly i...

ea0090ep1087 | Late Breaking | ECE2023

Unusual case of iatrogenic adrenal insufficiency related to corticosteroid eye drop usage

Rathi Manjusha

Corticosteroids have been widely used within the management of wide spectrum of conditions. It is well known that long-term use of exogenous glucocorticoids leads to the suppression of the hypothalamic– pituitary–adrenal axis. Even a 5-day course of oral high-dose steroid therapy can cause adrenal suppression. Similarly, high-dose steroid therapy - administered intranasally, inhaled or applied topically to skin can cause adrenal suppression. Depending on administrati...

ea0090ep1088 | Late Breaking | ECE2023

Unconventional 21 hydroxylase block revealed by high blood pressure : about a case

Riznat Malak , Malad Mohamed , Srifi Hajar , Ahmed Anas Guerboub

Introduction: Enzyme block is a rare disorder that can be discovered at birth by a severe, life-threatening disorder or in a more attenuated form in adulthood by a clinical picture of hyperandrogenism most often. The enzyme block most commonly suspected in high blood pressure is 11 B OH blockWe report the case of a young patient who was diagnosed with 21 hydroxylase enzyme block by secondary hypertension testing.Observation: This is a 32 year old patient...

ea0090ep1089 | Late Breaking | ECE2023

Influence of muscle mass and strength on bone mineralization with consideration of sclerostin concentration

Patalong-Wojcik Martyna , Sowińska-Przepiera Elżbieta , Malczyk-Matysiak Kinga , Myszka Aleksandra , Janiec Agnieszka , Syrenicz Anhelli

Introduction: Osteoporosis is a disease characterized by a decreased bone strength, as a result of increased bone porosity and impaired mineralization. According to the mechanostat theory, loads generated by the muscle mass and muscle strength, stimulate bone reconstruction.Aim of the study: In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclero...

ea0090ep1090 | Late Breaking | ECE2023

Systematic review of cardiovascular morbidity and mortality associated with primary hyperparathyroidism; does early surgical intervention improve the outcome?

Azad Fatima , Siddique Arif Muhammad

Introduction: Primary hyperparathyroidism is associated with numerous cardiovascular complications including hypertension, left ventricular hypertrophy and calcification of cardiac valves. However, guidelines from expert panels and NICE have not included cardiovascular complications as an indication of parathyroidectomy. This literature review will be focused on benefits of parathyroidectomy on cardiovascular complications of primary hyperparathyroidism....

ea0090ep1091 | Late Breaking | ECE2023

Surgical treatment for Primary hyperparathyroidism in ederly patient

Zambrano Huerta Yolanda , Elena Jerez Arzola Maria , Moya Medina Ricardo

Introduction: Primary hyperparathyroidism (PHPT) is the third most common endocrine disease, the incidence is greater in women (ratio 3-4:1) and the prevalence increases with age (1). Surgery is the only curative treatment and usually in elderly patients there is a delay or are not considered for parathyroidectomy due to perceived high operative risk or postoperative complications (2)Clinical Case: A 84 year-old female patient was under treatment with Ci...

ea0090ep1092 | Late Breaking | ECE2023

Parathyroid Carcinoma – an uncommon endocrine malignancy

Jones Olivia , Namiq Parez , Sim Sing

Case history: A 62-year-old male presented with generalised weakness, decreased oral intake, increased lethargy and polydipsia. He had a background of type 2 diabetes, hypercholesterolemia, and was a heavy smoker. No family history of parathyroid disease, other disorders causing hypercalcaemia or other endocrine tumours.Investigations: Initial blood results showed severe hypercalcaemia adjusted calcium 3.87mmol/l (2.2 - 2.55mmol/l), significantly raised ...

ea0090ep1093 | Late Breaking | ECE2023

Spontaneous remission of primary hyperparathyroidism postpartum

Lamprinou Apostolia , Tsitlakidis Damianos , Gutekunst Rainer

Introduction: Primary hyperparathyroidism is a disorder, characterized by autonomous overproduction of parathormone resulting in hypercalcemia. The main cause is a parathyroid adenoma. Less common etiologies are parathyroid hyperplasia and carcinoma. Primary hyperparathyroidism during pregnancy is rare and the management could be challenging. Maternal and fetal/neonatal complications occur in more than 50% of the cases.Patient: We report about a 38-year-...

ea0090ep1094 | Late Breaking | ECE2023

Abstract withdrawn...

ea0090ep1095 | Late Breaking | ECE2023

Effectiveness of empirical antibiotic therapy in diabetic foot infection in a Portuguese Center

Goncalves Juliana , Guimaraes Andre , Urbano Ferreira Helena , Ribeiro Sara , Moreno Telma , Borges-Canha Marta , Silva Fabia , Clara Correia Maria , Pedro Jorge , Neves Nelia , Sao Simao Ricardo , Andrade Paulo , de Lurdes Santos Maria , Carvalho Davide , Freitas Paula

Introduction: Diabetic foot infection imposes a significant burden and is a major cause of non-traumatic limb amputation. Antibiotic therapy plays a crucial role in the management these patients. In our institution, empirical antibiotic therapy is tailored to the presence of risk factors for multidrug-resistant microorganisms. For patients without risk factors, empirical intravenous amoxicillin-clavulanate at a dose 2.2 g every 8h is used. For patients with risk factors such a...

ea0090ep1096 | Late Breaking | ECE2023

Subtypes of gestational diabetes based on indices of insulin sensitivity and insulin secretion

Fernandez Valero Andrea , Maria Linares Pineda Teresa , Lima Rubio Fuensanta , Molina Vega Maria , Gutierrez Repiso Carolina , Pena Montero Nerea , Suarez Arana Maria , Maria Fernandez Ramos Ana , J Tinahones Francisco , Jose Picon Cesar Maria , Morcilo Sonsoles

Objectives: Some authors have defined subtypes within gestational diabetes (GD) based on the calculation, from glucose and insulin levels during oral glucose overload (OGTT), of indices of insulin sensitivity (Matsuda) and insulin secretion (Stumvoll). Powe et al [1] found that 30% of women with GD had predominantly low insulin secretion, 51% low insulin sensitivity and 18% both (mixed). The aim of this work is to analyze the correlation of these indices with other kn...

ea0090ep1097 | Late Breaking | ECE2023

Action of Ro 60-0175, 5-HT2C receptor agonist in the central nervous system, in obese and diabetic Wistar rat

Bogomilov Ivaylo , Mihneva Vesela , Nikolov Rumen , Boyadjieva Nadka

Background and AIMS: Obesity can be caused because of reduction in energy expenditure and /or increased caloric intake. Total calorie intake has increased in recent decades, and research and studies on eating behaviour have reported increased intake of foods rich in fats and sugars. Excess calories alone increase body weight and reduce insulin sensitivity, even in healthy individuals who are not obese. In addition, increased consumption of sugars and fats is associated with we...

ea0090ep1098 | Late Breaking | ECE2023

Assessment of the impact of glycemic variability on the duration of the perioperative period in patients with diabetes mellitus and purulent infection of the maxillofacial region

Meleshkevich Tatiana , Luchina Evgeniya , Orazvaliev Ata , Ametov Alexander , Kurnikova Irina , Shevchenko Marina , Verzina Iuliia

Patients with diabetes mellitus (DM) are more likely to suffer from purulent infection, probably due to compromised immune response. Achieving target levels of glycemia is a prerequisite for the perioperative management of patients with DM. However, the specific parameters of glycemic variability, optimal glucose range for the effective treatment of purulent infection of the maxillofacial region have not been established yet.Purpose: to assess the impact...

ea0090ep1099 | Late Breaking | ECE2023

Associations of Pparg Gene Polymorphic Marker with Carbohydrate Metabolism in Patients with Prediabetes

Isakova Dilara , Kolomeychuk Sergey , Troshina Irina , Petrov Ivan

Purpose: To study the frequency of polymorphic alleles and genotypes of the PPARG (rs 1801282) gene and its effect on carbohydrate and lipid metabolism in patients with prediabetes.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (WHO criteria, 2009). The mean age was 44.3 ± 7.8 years. The average value of fasting glycemia - 5.7±0.42 mmol/l, the average level of gly...

ea0090ep1100 | Late Breaking | ECE2023

Diabetes mellitus secondary to BRCA2 gene mutation: the importance of insulin resistance and genetics in dysglycemia

Lopes Valentim , Brito Patricia , Machado Catarina , De Sousa Lages Adriana

Introduction: Diabetes mellitus (DM) results from a defect in insulin secretion and/or its action. The Breast-Cancer Susceptibility Gene 2 (BRCA2), like BRCA1, is a tumour suppressor gene, and its mutation is associated with an increased risk of breast cancer and, in males, testicular cancer. In patients with the BRCA1/2 mutation, the level of Insulin-like Growth Factor (IGF)-1 and, consequently, the peripheral sensitivity to insulin are reduced, suggesting that this ...

ea0090ep1101 | Late Breaking | ECE2023

Köbberling disease: Familial Partial Lipodystrophy type 1 associated with thyroid cancer

Rosu Andreea , Matei Anca , blesneac ilona-beatrice , Codruta Poleuca , Dumitru Teodora , Adina Catalina Apostol , Laura Mihalache , Preda Cristina

Introduction: Lipodystrophic syndromes are rare and heterogeneous disorders characterized by the complete or partial deficiency of adipose tissue. They can be classified according to the extent of fat loss in generalized or partial subtypes and genetic or acquired based on the pathogenic mechanisms.Case report: A 37-year-old man was referred to our department with a history of nonalcoholic steatohepatitis associated with high levels of triglycerides (720...

ea0090ep1102 | Late Breaking | ECE2023

Cystic fibrosis: diagnostic keys and new treatments

Jose Vallejo Herrera Maria , Vallejo Herrera Veronica , Carmen Bautista Recio Maria , Cruz Almaraz Almaraz Maria

A 47-year-old male with a history of severe persistent asthma and recurrent respiratory infections with admissions to the Pulmonology Department. The patient underwent a study due to weight loss, diarrhoea and Ca 19.9 elevation. Imaging tests (abdominal CT and MRI cholangio) were performed, which highlighted severe pancreatic fat infiltration. The cystic fibrosis study was completed with genetics (positive: two heterozygous switches F508del and D1152H), sweat test (45 mmol/l -...

ea0090ep1103 | Late Breaking | ECE2023

Tigecycline as a ausative agent of severe hypoglycemia

Puca Entela , Puca Edmond , Vrekaj Klei , Bitri Sonila , Xhabija Nereida

Drug-induced hypoglycemia is a major clinical concern. Antibiotics are one of the causative agents to cause hypoglycemia. Tigecycline, which is a glycylcycline antibiotic, has a broad spectrum of activity, including activity against drug-resistant gram-positive and negative organisms. It´s side effects are significant but hypoglycemia and severe hypoglycemia is a rare finding during treatments. Our aim is to present an event of severe hypoglycemia in a patient with type 2...

ea0090ep1104 | Late Breaking | ECE2023

Impact of COVID-19 pandemic on nationwide antidiabetic drug utilization

Vizdiklar Caner , Aydin Volkan , Tazegul Gokhan , Akici Ahmet

Introduction: The COVID-19 pandemic resulted in various outcomes that have altered disease prevalence and drug utilization patterns. Our study aimed to evaluate the trends in the utilization and costs of antidiabetic medications before and during the COVID-19 outbreak in Turkey.Methods: We obtained nationwide sales data for antidiabetics from IQVIA Turkey, spanning between April 2018 and March 2022. Mean monthly drug utilization and expenditure trends be...

ea0090ep1105 | Late Breaking | ECE2023

Rechallenge with a single-pill combination of sitagliptin plus extended-release metformin in patients labelled as metformin-intolerant: Mostly successful

Javier Martinez Martin Francisco , Rios-Gomez Carlos , Santana-Ojeda Borja , Jose de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Arnas-Leon Claudia , Acosta-Calero Carmen , Kuzior Agnieszka , Gonzalez-Diaz Paula , Maria Fernandez-Trujillo-Comenge Paula

Introduction: Extended-release (ER) metformin has been available in many countries for the last two decades, and it may have definite advantages vs. conventional (i.e., immediate-release) metformin: Reportedly, it may reduce gastrointestinal adverse effects by about half, thus increasing compliance; moreover, the once-a-day schedule may contribute to increased adherence and persistence, and hopefully improved outcomes. However, ER metformin was unavailable in Spain until 2022:...

ea0090ep1106 | Late Breaking | ECE2023

Diabetes treatment with dapagliflozin and its combinations: Insights from clinical practice

Mehta Ajit , Bafna Akshay , Goel Sandeep , Trivedi A.K. , Mishra Chandrakanta , Naik Preethi , Zalte Nitin , Sugumaran Amarnath

Background: Despite global guidelines recommending initiation of SGLT2i drugs like dapagliflozin in type 2 diabetes (T2DM) patients with cardiovascular (CV) or renal risk, its clinical translation is still lacking in India.Objective: To understand clinicians’ perspectives regarding the association of CV risk and T2DM in Indian patients, and the need for the use of combination therapies with dapagliflozin in T2DM patients, in Indian clinical practice...

ea0090ep1107 | Late Breaking | ECE2023

HbA1c and Lipid Profile Indices: Useful for cardiovascular risk prediction in non-diabetics?

Cicek Beyza , Okuturlar Yildiz , Cem Deniz Orhan , Okuturlar Ozgur , Celik Ozlem , Serteser Mustafa , Şahin Sevgi

Aims: Glycosylated hemoglobin (HbA1c) is a marker which demonstrates 3-month average level of blood glucose level. In individuals with high blood sugar level for a long time is associated with increased risk of cardiovascular disease (CVD). There is a need for simple and cost-effective markers to determine the risk of CVD in primary health care settings. In this study, we aimed to investigate the value of HbA1c for predicting cardiovascular risk in healthy non-diabetic individ...

ea0090ep1108 | Late Breaking | ECE2023

Utility of nutritional ultrasound for body composition in patients affected by obesity and overweight. Utility of nutritional ultrasound for body composition in patients affected by obesity and overweight

Tozzi Rossella , Garcia Delgado Yaiza , Maria Sanchez Hernandez Rosa , Gil Quintana Yaiza , Hernandez Hernandez Diego , Davila Veronica , Boronat Mauro , Mariani Stefania , Gnessi Lucio , Maria Claudia Wagner Anna

Background and aim: Dual energy X-ray absorptiometry (DXA) is considered the gold standard to evaluate BC, even if it requires the use of radiations, an expensive equipment and cannot be performed at the patient’s bedside. Nutritional ultrasound (NU) evaluates BC through the assessment of muscle mass and the abdominal subcutaneous (superficial and deep-layer) and visceral adipose tissue. We aimed at comparing the accuracy and reliability of this emerging tool with DXA in ...

ea0090ep1109 | Late Breaking | ECE2023

Design and development of mobile application for type 2 diabetes ‘Diabetes 2 Learn’

Lykoudi Elissavet , Lymperopoulos Georgios , Dokoutsidou Eleni , Vlachou Eugenia , Margari Nikoletta

Introduction: Worldwide, diabetes is a common metabolic disorder that creates many complications. Nowadays a mobile-based application could be included in the therapeutic approaches of self-management.Aim: This study presents the development of a mobile application named ‘Diabetes 2 Learn’ for people with type 2 diabetes inside the Greek population.Methods: Google Play and App Store were examined for their apps on diabete...

ea0090ep1110 | Late Breaking | ECE2023

A case of Wernicke’s encephalopathy after sleeve gastrectomy

Sani Elena , Da Prato Giuliana , Gremes Veronica , Valletta Francesco , Bariani Matilde , Grazia Zenti Maria

Introduction: Wernicke’s encephalopathy, resulting from thiamine deficiency, is a rare but serious neurological complication of bariatric procedures. The diagnosis is still difficult since the classic clinical triad (confusion, ataxia and oculomotor abnormalities) and the typical radiological features (areas of hyperintensity in mammillary bodies, thalamus, periaqueductal and periventricular gray matter) are not always present. Also, thiamine blood tests are not broadly a...

ea0090ep1111 | Late Breaking | ECE2023

Maternally inherited diabetes and deafness (MIDD): easy to detect?

Fernandez Garcia-Salazar Rosario , Manjon-Miguelez Laura , Costales Marcos Maria , Burgueno Montanes Carmen , Santirso Rodriguez Daniel , Garcia Gonzalez Noelia , Menendez Torre Edelmiro

Introduction: Maternally inherited diabetes and deafness (MIDD) that is caused by a pathogenic variant in mitochondrial DNA (mtDNA) can cause different phenotypes based on percent heteroplasmy load, with higher mutation load corresponding with disease severity. The m.A3243G mutation causes either classic MELAS or MIDD that is a partial form. The condition is characterised by diabetes, hearing impairment and maculopathy but can have several other clinical manifestations. Early ...

ea0090ep1112 | Late Breaking | ECE2023

Metabolic Control and Perinatal Outcomes According to The Planning or Lack of Planning of The Pregnancy

Fernandez Valero Andrea , Jose Simon Frapolli Victor , Generoso Pinar Marta , Molina Vega Maria , J Tinahones Francisco , Jose Picon Cesar Maria

Objectives: To analyze the data of patients seen at the Diabetes and Pregnancy Unit, assessing the frequency of pregnancy planning and whether there are differences in the degree of metabolic control before and during pregnancy, as well as in perinatal outcomes with respect to those who do not plan. All women of childbearing age with Pregestational Diabetes Mellitus(PGDM) should receive preconception counseling to optimize glycemic control, since preconception control is assoc...

ea0090ep1113 | Late Breaking | ECE2023

Does the prebiotic and probiotic supplementation influence eating behavior in patients with obesity?

Ben Othman Rym , Zemni Zeineb , El Ghali Chaima , Olfa Berriche , Douiri Wafa , Mizouri Ramla , Ben Amor Nadia , Mahjoub Faten , Henda Jamoussi

Introduction: Disordered eating attitudes and behaviors are common and persistent in patients with obesity. The objective of our work was to evaluate the effect of prebiotic and probiotic supplementation on eating behavior in addition to a weight loss program in an adult population with obesity.Methods: This is an interventional study involving 45 obese patients consulting the obesity unit of the Institute of Nutrition of Tunis in 2022. Patients were div...

ea0090ep1114 | Late Breaking | ECE2023

Wernicke Encephalopathy Due To Bariatric Surgery: Recounting A Case Report

V. de Assuncao Guilherme , Paredes Silvia , Cardoso Helena

Introduction: Wernicke Encephalopathy (WE) is an acute neurologic disorder caused by thiamine deficiency. It is characterized by the classic triad of encephalopathy, gait ataxia and oculomotor dysfunction. It occurs in the setting of poor nutrition caused by lack of dietary intake or malabsorption. Since both of them can happen in patients that underwent bariatric surgery it is of utmost importance to prevent, recognize and treat this severe complication.<p class="abstext"...

ea0090ep1115 | Late Breaking | ECE2023

Type 2 diabetes mellitus, primary biliary cholangitis and type 2 autoimmune hepatitis - a rare association

Cosma Daniel , Herascu Elena-Maria , Pietraru Mihai , Silaghi Patricia

The hepatic autoimmune diseases are rarely associated with type 2 diabetes mellitus (T2DM). Instead, it’s more often encountered in people with type 1 diabetes mellitus in the context of polyglandular autoimmune syndrome (PAS). A 64-years old female diagnosed with T2DM for 8 years, hypertension and dyslipidemia currently under treatment with Dapagliflozin/Metformin 50/1000 mg twice daily, presented for her periodic diabetes consult complaining of marked fatigability and a...

ea0090ep1116 | Late Breaking | ECE2023

Nondiabetic hypoglycemia: the role of psycho-neurological care in primary diagnosis

Yukina Marina , Nuralieva Nurana , Troshina Ekaterina

Introduction: Decreased glycemia in patients without diabetes mellitus (nondiabetic hypoglycemias; NDH) is a manifestation of severe diseases from endocrinopathies to malignant tumors. The most specific symptom of NDH is association of attack with the intake of carbohydrate-containing food. Hypoglycemia is usually manifested by neurological and mental disorders, and therefore, patients initially seek medical help not from an endocrinologist, but from psychiatrists and neurolog...

ea0090ep1117 | Late Breaking | ECE2023

Can probiotics improve weight loss in patients with obesity?

Ben Othman Rym , Zemni Zeineb , El Ghali Chaima , Douiri Wafa , Olfa Berriche , Mizouri Ramla , Ben Amor Nadia , Mahjoub Faten , Henda Jamoussi

Introduction: Probiotics are made of good live bacteria and/or yeasts that naturally live in human body which are essential for the proper functioning of the microbiota. The objective of our work was to evaluate the effect of probiotics intake on anthropometric parameters in addition to a weight loss program.Methods: This is an interventional study involving 30 obese patients consulting the obesity unit of the Institute of Nutrition of Tunis during the p...

ea0090ep1118 | Late Breaking | ECE2023

Does probiotics consumption improve glycemic parameters in adults with obesity?

Ben Othman Rym , Zemni Zeineb , El Ghali Chaima , Douiri Wafa , Olfa Berriche , Mizouri Ramla , Ben Amor Nadia , Mahjoub Faten , Henda Jamoussi

Introduction: Alteration of gut microbiota leads to increased intestinal permeability, inflammation, and metabolic disorders. The aim of our study was to determine the effect of probiotic supplementation on glycemic parameters in addition to a weight loss program.Methods: This is an interventional study including 30 obese patients consulting the obesity unit of the Institute of Nutrition in Tunis. The patients were divided into 2 groups matched for age, ...

ea0090ep1119 | Late Breaking | ECE2023

Factitious hypoglycemia: psychosocial characteristics of patients

Yukina Marina , Nuralieva Nurana , Zelenkova-Zakharchuk Tatyana , Troshina Ekaterina , Melnichenko Galina

Introduction: Hypoglycemia is a decrease of glucose in blood, which can lead to coma and death. One of the causes of hypoglycemia in patients without diabetes mellitus (DM) is deliberate intake of hypoglycemic drugs (factitious hypoglycaemia, FH, Munchausen syndrome).Objectives: To present the psychosocial characteristics of patients with FH.Methods: Anamnesis analysis of 431 patients with hypoglycemia aged 18-93 years.<p class...

ea0090ep1120 | Late Breaking | ECE2023

Comparative study on the efficacy and safety of various regimens of glucocorticoid therapy in patients with COVID-19 and Diabetes Mellitus

Meleshkevich Tatiana , Verzina Iuliia , Kurnikova Irina , Ametov Aleksandr , Luchina Evgeniya , Tavlueva Evgeniya

Purpose : To determine the effective and safe regimen of glucocorticoids administration in patients with COVID-19 and with or without DM.Materials and methods: We examined 276 patients with covid-19 and polysegmental pneumonia with CT (1-4) in inpatient treatment with an oxygen support level of up to 15 liters per minute, all patients were discharged from the hospital. Patients were divided into 2 groups according to the therapy they received. The first ...

ea0090ep1121 | Late Breaking | ECE2023

Vitamin D status in childhood obesity: prevalence and implications in a group of children from Romania

Ioana Arhire Amalia , Steluta Boroghina , Ancuta Ionita

Introduction: Obesity and vitamin D deficit are risk factors for inflammation, insulin resistance, hypertension and impeded bone mineralization and also cardiovascular disease. type 2 diabetes and osteoporosis. As globally both conditions reach pandemic levels and the level of vitamin D negatively correlates with obesity we studied this correlation and impact on a group of children suffering from obesity.Materials and method: We conducted a retrospective...

ea0090ep1122 | Late Breaking | ECE2023

Type 1 diabetes after 10 years of evolution : complications and metabolic profile

Bani Ines , Ben Othman Rym , Olfa Berriche , Mizouri Ramla , Ben Amor Nadia , Mahjoub Faten , Henda Jamoussi

Introduction : Type 1 diabetes (T1DM) is an autoimmune disease that commonly affects a young population. Its evolution can be characterized by a frequent occurrence of degenerative complications. Our aims were to study microangiopathic complications, lipid profile, and the presence of other autoimmune diseases in type 1 diabetic patients whose diabetes has been evolving for 10 years or more.Method : This is a descriptive cross-sectional study including T...

ea0090ep1123 | Late Breaking | ECE2023

Trends in Prescription of Anti-Diabetic Drugs and Metabolic Control in Type 2 Diabetes: 2015/2016 vs. 2020/2021

Soares Daniela , Palma Isabel , Helena Neto Maria , Fraga Mariana , Pereira Joel , Guimaraes Rosa , Helena Cardoso Maria , Maia Ariana , Ferreira Lia

Introduction: The development of new pharmacological classes for type 2 diabetes (T2D) treatment with extra-glycaemic benefits has led to the update of the treatment algorithm, presenting new effective alternatives to patients’ insulinization. The present study aims to evaluate the evolution of prescription and its impact in metabolic control of patients enrolled on an educational diabetes program of a tertiary hospital.Objectives: To evaluate trend...

ea0090ep1124 | Late Breaking | ECE2023

Anemia in the elderly diabetic subject

Jallouli Yesmine , Ben Othman Rym , Trabelsi Syrine , Olfa Berriche , Safi Eya , Mizouri Ramla , Mahjoub Faten , Ben Amor Nadia , Wafa Douiri , Henda Jamoussi

Introduction: Anemia is common in the elderly subject over 75 years of age. The pathophysiological mechanisms of anemia are identical to those of the younger subject and the etiological investigation is based on precise diagnostic trees.Objective: The objective of our study is to determine the prevalence of anemia in diabetic subjects over 75 years of age and to determine the associated factors. Methodology: This is a descriptive c...

ea0090ep1125 | Late Breaking | ECE2023

Uricemia and lipid profile in adult population with obesity

Zemni Zeineb , Dhieb Nesserine , Mizouri Ramla , Sdiri Chaima , Ben Othman Rym , Ben Amor Nadia , Olfa Berriche , Mahjoub Faten , Henda Jamoussi

Introduction: Hyperuricemia is associated with an increased risk of cardiovascular diseases. The aim of this study was to examine the relationship between lipid profile and blood uric acid levels in an adult population with obesity.Methods: Retrospective study including 200 patients with obesity who consulted the Obesity Unit of the National Institute of Nutrition in Tunis in 2021. Data were collected from patients’ medical records. The lipid profil...

ea0090ep1126 | Late Breaking | ECE2023

What is the Impact of Prebiotic Supplementation on Depression Symptoms in Patients with Obesity?

Ben Othman Rym , Zemni Zeineb , El Ghali Chaima , Olfa Berriche , Douiri Wafa , Mizouri Ramla , Ben Amor Nadia , Mahjoub Faten , Henda Jamoussi

Introduction: People with obesity are at risk of psychological complications such as anxiety and depression. The objective of this study was to assess the effect of prebiotic supplementation in addition to a weight loss program on depression symptoms in an adult population with obesity.Methods: Interventional study involving 30 patients with obesity consulting the obesity unit of the National Institute of Nutrition in Tunis between May and August 2022. P...

ea0090ep1127 | Late Breaking | ECE2023

All’s well that ends well

Shoaib Zaidi Muhammad

Introduction: Diabetes can involve the musculoskeletal system causing frozen shoulder, Dupuytren’s contracture, diabetic sclerodactyly, trigger finger, muscle infarction, diabetic amyotrophy, idiopathic lumbosacral radiculoplexus neuropathy, necrotizing fasciitis and many other complications. A case is described, who despite having multiple acute and chronic sequelae of diabetes, was successfully managed and discharged.Case Presentation: 54yrs old o...

ea0090ep1128 | Late Breaking | ECE2023

Neuroleptics, a source of blood sugar imbalance not to be underestimed

Antonio Nfad Colna , Malad Mohamed , Srifi Hajar , Togo Mamadou , Ahmed Anas Guerboub

Introduction: Today, atypical antipsychotics offer the advantage of less frequent extrapyramidal effects compared to conventional neuroleptics, but they are associated with weight gain and diabetes mellitus.Observation: A 31-year-old patient with positive diabetic heredity, followed for schizophrenia on Levomepromazine and Olanzapine. Having revealed his diabetes mellitus by a diabetic cardinal syndrome. Blood glucose= 3g/l. Urine dipstick shows ketonuri...

ea0090ep1129 | Late Breaking | ECE2023

Adherence to antidiabetic treatment in Tunisian type 2 diabetic patients

Trabelsi Syrine , Ben Othman Rym , Jallouli Yesmine , Olfa Berriche , Safi Eya , Mizouri Ramla , Mahjoub Faten , Ben Amor Nadia , Douiri Wafa , Henda Jamoussi

Introduction : Poor compliance in chronic diseases, including diabetes mellitus, is a major and frequent problem, with serious consequences on morbidity and mortality of diabetics.Objective: The aim was to assess adherence to antidiabetic treatment and to determine the consequences of poor compliance.Patients and methods : This was a descriptive cross-sectional study conducted in the National Institute of Nutrition. 200 type 2 diab...

ea0090ep1130 | Late Breaking | ECE2023

Flash glucose monitoring in patients with DM3c

Rebollo-Roman Angel , Carmen Serrano Laguna Mª , Manuel Alzas Teomiro Carlos , Moreno-Moreno Paloma , Angeles Galvez Moreno Maria

Objective: Flash glucose monitoring (FGM) facilitates non-invasive glucose level assessment. Since November 2020 this system is subsidized in patients with type 3c diabetes (DM3c) Our objective was to describe the characteristics of these patients and their glycemic control expressed as times in range.Methods and patients: Observational longitudinal clinical study between January 2021 and January 2023 in patients with DM3c.Results:...

ea0090ep1131 | Late Breaking | ECE2023

A 7.5 cm hyperdense heterogeneous incidental right adrenal mass: Is it cancer?

Santana-Ojeda Borja , Jose de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Rios-Gomez Carlos , Arnas-Leon Claudia , Acosta-Calero Carmen , Kuzior Agnieszka , Gonzalez-Diaz Paula , Maria Perez-Rivero Jennifer , Javier Martinez Martin Francisco

Introduction: Although usually considered as benign tumors, cavernous hemangiomas are venous malformations due to endothelial dysmorphogenesis and not true neoplasias. They are usually asymptomatic but occasionally can cause compressive symptoms or serious internal bleeding. They may arise in almost any vascularised organ, but their presentation in an adrenal gland is highly infrequent, and can masquerade as pheochromocytoma, adrenal carcinoma or metastatic malignant lesion.</...

ea0090ep1132 | Late Breaking | ECE2023

Rare phenotype association between pulmonary NET and prolonged hyperkalemia after an unilateral adrenalectomy for primary hyperaldosteronism

Tănasie Denisa-Isabella , Simona Andreea Găloiu , Lavinia Popa Maria , Iordan Ingrid , Constantin Teodor , Iorgulescu Radu , Poiana Catalina

Introduction: We describe the case of a 68-year-old patient, having two MEN1-associated tumors that are not part of the classical triad, with a penetrance of only 40%, and 2%, according to the medical literature. Furthermore, she developed a persistent hyperkalemia after the unilateral adrenalectomy, which is rare and often missed.Case report: In 2011, following a non-specific symptomatology (dry cough, fatigue), a bilobectomy was performed (medium and r...

ea0090ep1133 | Late Breaking | ECE2023

An audit of ten years experience of medullary thyroid carcinoma management from a tertiary care hospital of north India

Mohan Chakraborty Ananda , Pal Rimesh , Mukherjee Soham , Nahar Uma , Dutta Pinaki , Dahiya Divya , Kumar Panda Naresh , Kumar Bhadada Sanjay

Introduction: Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C-cells. It accounts for 5% of all thyroid carcinomas.Methods: A retrospective registry-based analysis of demography, clinical manifestation, genetics, management, and outcome of pathologically proven MTC cases presented in a tertiary care hospital in India was done.Results: Among 71 evaluated cases, the mean age of presenta...

ea0090ep1134 | Late Breaking | ECE2023

An interplay between primary hyperparathyroidism, Hashimoto thyroidis and thyroid cancer

Sparavalo Rada , Borozan Sanja

The incidence of well differentiated thyroid carcinoma (TC), mostly papillary, is higher among patients with primary hyperparathyroidism (PHPT) compared to the general population, despite the similar frequency of thyroid nodules. The link between TC and Hashimoto thyroiditis (HT) is attributed to chronic inflammation, but the molecular association is poorly undestood. Herein, we explore the possible interplay between HT, PHPT and papillary TC through a case report and a litera...

ea0090ep1135 | Late Breaking | ECE2023

Doege-Potter Syndrome, cause of paraneoplastic hypoglycaemia in a patient with a Solitary Fibrous Tumour: A Case Report

Sheikh Anum , Calvo Latorre Julia , Kehinde Razak

Background: Non-islet-cell tumour hypoglycaemia (NICTH) is a rare paraneoplastic syndrome caused by an extra pancreatic tumour(1). Solitary fibrous tumour (SFT), amongst other tumours, is one of the rare causes of NICTH. We report a case of NICTH who presented with recurrent hypoglycaemias and was identified to have a fibrous tumour as part of the work up for his symptomatic hypoglycaemias.Case Summary: A 75-year male had presented to the emergency depar...

ea0090ep1136 | Late Breaking | ECE2023

Parathyroid carcinoma - case report

Teodoriu Laura , Siriteanu Andreea , Iancu Dragos , Bugean Gema , Danila Radu , Velicescu Cristian , Andriescu Elena-Corina , Ciobanu Delia , Stefanescu Cipriana

Parathyroid carcinoma (PC) is a rare endocrine tumor accounting for 0.5–6% or less in cases of primary hyperparathyroidism. According to The American Joint Committee on Cancer (AJCC) eighth edition, the histopathological criteria for PC include the presence of vascular invasion with capsular invasion and progression and/or metastasis to adjacent tissues. However, the small number of cases of PC makes it difficult to predict prognosis in the postoperative period of PC. We ...

ea0090ep1137 | Late Breaking | ECE2023

A diagnostic challenge: Is it metastatic papillary thyroid carcinoma or papillary thyroid carcinoma arising from intramedullar teratoma?

Sakiz Davut , Yılmaz Fatih , Calapkulu Murat

Introduction: Papillary thyroid carcinoma (PTC) distant metastases without regional lymph node metastases are quite rare. Spinal cord teratomas are rare tumors mostly seen in children. To the best of our knowledge, the development of papillary carcinoma in intradural teratomas is theoretically possible, but has not been reported in literature.Case report: A 36-year-old female patient admitted with the complaint of drop foot. On MRI, 20x11x20.5 mm lesion ...

ea0090ep1138 | Late Breaking | ECE2023

Clinical spectrum of ectopic Cushing’s syndrome secondary to pheochromocytoma: A diagnostic and therapeutic challenge

Gomes Porras Mariana , Kishore Doulatram Gamgaram Viyey , Gonzalez Molero Inmaculada , Gonzalez Romero Stella , Carmen Bautista Recio Maria , Cruz Almaraz Almaraz Maria , Moreno-Torres Taboada Carolina , Olveira Fuster Gabriel

Introduction: The clinical presentation of ectopic Cushing’s syndrome secondary to pheochromocytoma differs from the classic manifestations of these endocrinopathies separately. This cosecretion causes greater morbidity, requiring a complex preoperative preparation. We describe two clinical cases, a 46-year-old male with grade II overweight and a 65-year-old female with grade I obesity, both with a personal history of hypertension poorly controlled with 7 and 3 antihypert...

ea0090ep1139 | Late Breaking | ECE2023

Metachronous Double Pituitary Adenomas: Presentation of A Case and Literature Analysis

Ruiz-Gines Miguel-Angel , Ruiz-Gines Juan-Antonio , Torres-Mateos Sandra

Introduction: Prolactinoma is the most frequent secreting pituitary tumor. They are usually treated with dopamine agonists (DA) (bromocriptine and cabergoline), which are very effective in most cases. DA resistance consists of the impossibility of reaching normal prolactin levels and/or reduction of the adenoma by at least 50%.Case presentation: We present the case of a 57-year-old man affected by visual disturbances and hypopituitarism (2019). Pituitary...

ea0090ep1140 | Late Breaking | ECE2023

Cushing’s disease: a rare case of long-term pasireotide therapy

Veleno Miriam , Chiloiro Sabrina , Giampietro Antonella , Bianchi Antonio , De Marinis Laura

Background: Cushing’s disease, the most common cause of endogenous Cushing’s syndrome, is caused by a pituitary tumor secreting adrenocorticotropic hormone (ACTH). Careful selection of treatment and management of the disease and associated comorbidities are necessary to improve prognosis.Case Presentation: A 32-year-old patient came to our observation for appearance of weight gain with abdominal obesity, hirsutism and amenorrhea. On suspicion o...

ea0090ep1141 | Late Breaking | ECE2023

Participation of pituitary activins in the control of prolactin during early post-natal development. Sex differences

Bornancini Dana , Ines Abeledo-Machado Alejandra , Pena-Zanoni Milagros , Diaz-Torga Graciela

Serum prolactin levels increase progressively from birth to adulthood in female and male rats, being higher in females from birth. Although this gradual increase was associated with concomitant maturation of prolactin-releasing and -inhibiting factors, these processes do not fully explain some sex differences observed. In in vitro studies, using lactotrophs in culture, from rats of different ages, in the absence of hypothalamic control, it was shown that the secretion...

ea0090ep1142 | Late Breaking | ECE2023

The underneaths of the pituitary stalk

Christina Ungureanu Maria , Preda Cristina , Akad Nada , Dumitru Teodora , Karolina-Agatha Drozdek

We are presenting a 23-year-old girl with a medical history of juvenile rheumatoid polyarthritis treated with methotrexate, that first addressed to the Endocrinology Department in may 2022 for primary amenorrhoea with poorly developed secondary sexual characters: height 160 cm, weight 48 kg, BMI 18.35 kg/m2, Tanner stages P1, B3. She was treated with oral contraceptives by the gynaecologist in the past without a hormonal assessment. The lab work revealed hypogonadotropic hypog...

ea0090ep1143 | Late Breaking | ECE2023

Esthesioneuroblastoma As a Cause of Panhypopituitarism: Literature Analysis and Description of An Rare Case

Ruiz-Gines Miguel-Angel , Ruiz-Gines Juan-Antonio , Torres-Mateos Sandra

Introduction: Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a malignant neuroendocrine tumor of the nasal fossa that arises from neurosensory receptor cells of the olfactory epithelium. It represents 3% of all nasal tumors. It presents a slow and progressive evolution that primarily affects the upper nasal mucosa and cribriform plate, with subsequent extension to the entire cavity and paranasal sinuses and can invade the orbit and cranial base.<p c...

ea0090ep1144 | Late Breaking | ECE2023

Ectopic ACTH Syndrome in a Patient with ACTH-secreting Pancreatic Neuroendocrine Neoplasm and Focal Pituitary Lesion-Diagnostic Challenges

Sobolewska Joanna , Dzialach Lukasz , Respondek Wioleta , Wojciechowska-Luzniak Agnieszka , Witek Przemysław

Introduction: Pancreatic neuroendocrine neoplasms (Pan-NENs) account for 1-2% of all pancreatic tumors. Adrenocorticotropic hormone (ACTH)-producing PanNEN is an extremely rare neuroendocrine tumor that accounts for approximately 4-16% of ectopic ACTH-dependent Cushing’s syndrome.Clinical case : A 58-year-old female with arterial hypertension and type 2 diabetes was referred to the Endocrinology Department due to abdominal pain, muscle weakness, and...

ea0090ep1145 | Late Breaking | ECE2023

Pasireotide LAR Treatment for Non-functioning Pituitary Adenoma: A Case Report

Menotti Sara , Giampietro Antonella , Giorgio D'Alessandris Quintino , Chiloiro Sabrina , De Marinis Laura , Bianchi Antonio

Introduction: Non functioning pituitary adenomas (NFPAs) are the most common type of pituitary tumors and are often invasive, resulting in high relapse rates. The post-surgical treatment for NFPAs remains a debated issue and include radiation therapy and additional surgery. Several clinical studies have demonstrated that dopaminergic and somatostatin receptors (SSTRs) are widely expressed in NFPAs. Furthermore, recent studies have shown the potential effectiveness of somatosta...

ea0090ep1146 | Late Breaking | ECE2023

Normal adult height in a pacient with untreated congenital hypopituitarism: a case report

Bilha Stefana , Popa Viviana , Teodoriu Laura , Christina Ungureanu Maria , Preda Cristina

With congenital hypopituitarism, the clinical manifestations of pituitary hormone deficiencies usually appear during infancy or early childhood. Typically, one or more anterior pituitary hormones are deficient, and the most severe manifestations include neonatal hypoglycemia, electrolyte imbalances and failure to thrive. We present the case of a 43 year old male, with cardiovascular and metabolic comorbidities (arterial hypertension, type 2 diabetes mellitus), with no prior ho...

ea0090ep1147 | Late Breaking | ECE2023

Presentation of A Patient with an EPI Attack and Apoplexy of A Pituitary Macroadenoma

Jambrović Martina , Maric Andreja , Mikolaj Kiric Maja

A 57-year-old female patient was presented to the neurologist in the ER because of her first grand mal-type seizure. Initial examination in the emergency department confirmed hyponatremia (Na 131 mmol/l) in laboratory findings, while CT scan of the brain and EEG were normal. During hospitalization, additional laboratory and imaging studies were performed. Neuroradiological examination was performed (CT scan of the brain, MRI of the brain and MRI of the pituitary gland), which ...

ea0090ep1148 | Late Breaking | ECE2023

Major improvement of diabetes insipidus 15 years after diagnosis of panhypopituitarism in a patient with pineal germinoma – a case report

Popa Viviana , Rosu Andreea , Crumpei Iulia , Christina Ungureanu Maria , Preda Cristina

Pineal germinomas account for the majority of intracranial germ cell tumors. Surgery and radiation are usual management options, and secondary hypopituitarism can ensue after both. Diabetes insipidus is particularly common after surgical removal of pineal tumors, but improvement in polyuria and polydipsia years after surgery is exceedingly rare. Here, we present the case of a 49-year-old male, who was diagnosed with a pineal germinoma at the age of 20, which was surgically rem...

ea0090ep1149 | Late Breaking | ECE2023

Excessive production of chromogranine A in a meningioma with somatostatin receptors expression confirmed by GA68 -DOTATATE PET

Manzanares Cordova Rossana , Rodriguez Pilar

Background: Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Meningiomas are benign brain tumors that are usually to recur. Studies have shown in vitro and in vivo that meningiomas, regardless of histology and classification, express somatostatin receptors (SSTRs). GA68-DOTATATE PET is an exciting imaging modality that has shown significant a...

ea0090ep1150 | Late Breaking | ECE2023

A case with pituitary metastasis from breast cancer presenting with hypernatremia

Puca Entela , Puca Edmond , Poci Albiona

The tumors that metastasis to the pituitary gland is a rare condition and generally are seen in patients in advance disease. The most common metastasis arises from breast and pulmonary cancer. We report a case of a 53 years old women with invasive ductal carcinoma diagnosed in 2017, previously treated with left radical mastectomy followed by --- cycles of chemotherapy and radiation. In 2022 her disease recurred with bone metastasis. She started again the chemotherapy. One mont...

ea0090ep1151 | Late Breaking | ECE2023

Non-functioning adenomas submitted to surgery: clinical characterization and outcomes

Dias Daniela , Matos Tania , Silvestre Catarina , Serra FIlipa , Palha Ana , Lucas Neto Lia , Tavares Ferreira Joana , Subtil Joao , Tortosa Francisco , Sagarribay Amets , Sapinho Ines

Introduction: Nonfunctioning pituitary adenomas (NFPAs) are a heterogeneous group of tumors with different presentations. Clinical management of these tumors is complex. Our aim was to evaluate the clinical characteristics/postsurgical outcomes of NFPAs and to identify predictive factors of good response to surgery.Methods: Retrospective analysis of NFPA, who underwent surgery and followed in our hospital, from 2015-2022.Results: W...

ea0090ep1152 | Late Breaking | ECE2023

Abstract withdrawn...

ea0090ep1153 | Late Breaking | ECE2023

A Case of Chronic Hyponatremia in Clinical Practice

Danilova Larissa I. , Korolenko Galina , Bourko Irina , Lushchyk Maxim , Ramanouski Aliaksei

Hyponatremia - a decrease in serum sodium to 135 mmol/l or less can lead to serious complications. In patients with various pathologies and serum sodium levels of 120–125 mmol/l mortality reaches 23%, in levels less than 115 mmol/l - 50%. Biochemical verification of hyponatremia is not difficult. It is difficult to establish the cause and treatment of chronic hyponatremia. Patient S., 64 years old, was hospitalized in a state of alcoholic intoxication with a diagnosis of ...

ea0090ep1154 | Late Breaking | ECE2023

Prevalence, patterns, and characteristics of hypertension diagnosis and management in patients with Turner syndrome; Descriptive analysis of real-world data from the International-Turner Syndrome registry

Apsara Dilrukshi Mathara Diddhenipothage Shani , Beck Katharina , G K Amiyangoda C , Bryce Jillian , Cima Luminita , De Groote Katya , Deyanova Yana , Globa Eugenia , Herrmann Gloria , Juul Anders , Sophie. L Kjaer Anna , Tonnes Pedersen Pedersen Anette , Poyrazoglu Sukran , Probst-Scheidegger Ursina , C.J Sas Theo , Nimali Seneviratne Sumudu , Witczak Justyna , Orchard Elizabeth , Tomlinson Jeremy , Ahmed Faisal , Turner Helen

Introduction: Hypertension is common in patients with Turner Syndrome (TS), and they appear to have an increased predisposition with various proposed disease related factors; sex hormone imbalance, aortopathy, increased activation of the renin-angiotensin-aldosterone system, insulin resistance, growth hormone deficiency/resistance, adverse imprinting during fetal life and renal malformations. Despite high susceptibility and unique challenges in managing hypertension in this gr...

ea0090ep1155 | Late Breaking | ECE2023

Family building after diagnosis of premature ovarian insufficiency - a cross-sectional survey in 324 women

Cambray Solange , Dubreuil Sophie , Tejedor Isabelle , Dulon Jerome , Touraine Philippe

Objective: The diagnosis of premature ovarian insufficiency (POI) is a traumatic event for many patients that involves poor fertility prognosis. After such diagnosis spontaneous pregnancies are rare. The alternatives for building a family are oocyte donation, embryo donation and adoption. However, we have few information on how many women with POI finally built a family after the diagnosis and which alternative they chose.Design: We performed a cross-sec...

ea0090ep1156 | Late Breaking | ECE2023

Abstract withdrawn...

ea0090ep1157 | Late Breaking | ECE2023

Prevalence of MTHFR polymorphisms and metabolic outcomes in Chilean women with Polycystic Ovary Syndrome

Carrasco Matias , Calfunao Susan , Martinez Paz , Crisosto Nicolas , Salas-Perez Francisca

Background: Polycystic ovary syndrome (PCOS) is a prevalent and multifactorial endocrine disorder, characterized by reproductive and metabolic alterations. However, the mechanisms that contribute to the development of metabolic abnormalities are not completely understood. Interestingly, women with PCOS show changes in folate and homocysteine levels suggesting an altered folate metabolism, which could be associated to changes in the methylation patterns of metabolic genes. Meth...

ea0090ep1158 | Late Breaking | ECE2023

BRCA1/2 Negative Bilateral Metastasized Breast Cancer Following Ovarian Stimulation: A Case Report

Oliveira Torres Joao , Leao Mendes Jose , Jorge Escaleira Rui , Alves Gaspar Mariana , Malheiro Rui , Martins Diana , Silva-Nunes Jose

Introduction: Breast cancer is the second most common neoplasm in women. Hormonal replacement therapy and combined hormonal contraception are established extrinsic hormonal risk factors for breast cancer. Therefore, the increase in the prevalence of infertility and the use of assisted conception techniques have raised questions regarding the potential risk of hormone-dependent neoplasms. We report the case of a woman diagnosed with bilateral metastasized breast cancer soon aft...

ea0090ep1159 | Late Breaking | ECE2023

Cytogenetic Study in 622 Infertile Men with Spermogram Abnormalities

Ben Yahia Salwa , Belil Hela , Maazoul Faouzi , Mrad Ridha , Kraoua Lilia

Background : Infertility affects 15% of couples. In 50% of cases, it can be explained by male infertility with abnormal spermatogenesis. Cytogenetic causes are identified in 15% of men with infertility.Materials and Methods: We report the results of a cytogenetic study performed in infertile men with spermogram abnormalities collected at the Department of Congenital and Hereditary Diseases of Charles Nicolle Hospital in Tunis, over 12 years from January ...

ea0090ep1160 | Late Breaking | ECE2023

Overexpression of orphan nuclear receptor REV-ERB-alpha predicts recurrence in differentiated thyroid cancer

Cheng Shih-Ping , Kuo Chi-Yu , Jhuang Jie-Yang , Chien Ming-Nan

Background: Altered circadian clock characteristics have been shown in malignant thyroid nodules. REV-ERB-alpha is a circadian clock component that functions as a transcriptional repressor which coordinates circadian rhythm and cell metabolism. However, the protein expression of REV-ERB-alpha has not been properly investigated.Methods: Immunohistochemical analysis was performed on our in-house tissue microarrays. Immunoreactivity was evaluated using H-sc...

ea0090ep1161 | Late Breaking | ECE2023

Are there any benefits of probiotic or prebiotic supplementation in hypothyroid patients? A systematic review with meta-analysis

Zawadzka Karolina , Kałuzińska Klaudia , Świerz Mateusz J. , Sawiec Zuzanna , Antonowicz Ewa , Leończyk-Sporna Monika , Kamal Abadi Ahmad , Trofimiuk-Muldner Małgorzata , Bała Małgorzata M.

Introduction: A number of studies indicate the presence of a thyroid-gut axis and the important influence of the gut microbiota on thyroid function. As prebiotics, probiotics and synbiotics show therapeutic potential in the treatment of intestinal dysbiosis, we aimed to evaluate the efficacy of their supplementation in patients with primary hypothyroidism.Material and methods: We searched electronic databases (Ovid MEDLINE, Embase, CENTRAL), registers of...

ea0090ep1162 | Late Breaking | ECE2023

Can we predict medical treatment failure in Graves’ disease? 4-year follow-up data in a single centre

Leonidas Liarakos Alexandros , Foka Anna , Mohamed Ahmed , Kavvoura Foteini

Background: Graves’ disease (GD) is the commonest cause of primary hyperthyroidism in iodine-sufficient areas. First-line treatment is a 12-18 month course of anti-thyroid drugs (ATD). However, around 50% of GD patients will relapse, requiring further assessment and definitive treatment with radioactive iodine or thyroidectomy. Identifying risk factors that predict relapse or treatment failure after stopping ATD is important in guiding management. Several risk factors hav...

ea0090ep1163 | Late Breaking | ECE2023

The Association of Immunotherapy-Related Thyroid Disorders and Mortality in Patients with RCC and Melanomas

Ehrenwald Michal , Kolitz Tamara , Karov Ruth , Brenner Ronen , Greenman Yona

Background: Immune checkpoint inhibitors (ICPIs) are indicated as treatment for metastatic renal cell carcinoma (RCC) and melanoma, among other malignancies. This group of agents is associated with immune-related adverse events (irAEs). We aimed to further investigate the association of immune-related thyroid disorders (irTDs) with clinical outcomes and mortality rates in patients with RCC or melanoma who were treated with ICPIs.Methods: We retrospective...

ea0090ep1164 | Late Breaking | ECE2023

Coexistence of Behçet Disease and Graves

Intaş Kadir

Introduction: Behcet’s disease (BD) is a systemic inflamatory disorder characterized by recurring oral and genital ulcers, uveitis, and skin lesions. Graves’ thyrotoxicosis is caused by an autoimmune reaction to thyroid autoantigens. Thyroid receptor antibody testing is used to diagnose Graves’ thyrotoxicosis. There has previously been no evidence of a link between thyroid autoimmunity and BD. We present a case of an adult male with BD coexistence, which is unco...

ea0090ep1165 | Late Breaking | ECE2023

‘Colloid leak’-A lightening effect

Mayilvaganan Sabaretnam , Bhargav Panchangam Ramakanth , Idrees Sarrah , Jagannath Spandana , Mishra Anjali , Agarwal Gaurav

Background: Thyroidectomy is the common most common endocrine surgical procedure varies from Scalpel to Robotic transoral thyroidectomy. Colloid nodules are common and easily operable without any difficulty. We report a phenomenon where in the surgery becomes difficult and lead to complications if not thought with this phenomenon – colloid leak.Material and Method: The endocrine surgeon (Associate Professor) has been involved in training of over 25 ...

ea0090ep1166 | Late Breaking | ECE2023

Challenges in operating such monstrous goitres even in this era?

Mayilvaganan Sabaretnam , Idrees Sarrah , Bhargav Panchangam Ramakanth , Jagannath Spandana , Agarwal Gaurav

A 45-year-old lady from the Iodine - deficient Himalayan belt presented to us with a gradually progressive, painless goiter for more than 20 years. Such goiters were common in her village. She neither had symptoms of hyper/hypothyroidism nor any compressive symptoms. She had four living issues and as per her, the goiter would increase in size during the second trimester of each pregnancy. On examination, she had a huge thyroid swelling involving both lobes and isthumus, measur...

ea0090ep1167 | Late Breaking | ECE2023

Baseline Serum TSH Levels Predict The Thyroid Dysfunction In Cancer Patients Treated With Tyrosine Kinase Inhibitors And Immunotherapy

Bozkoc Vasi Neslihan , Yorulmaz Goknur , Bayir Garbioglu Duygu , Yildiz Bulent , Dincer Murat

Developments of the cancer immunology have increased the frequency of use of targeted therapies and immunomodulatory therapies. Although these treatments are effective on cancer cells, they also have toxicity on the thyroid gland. We aimed to evaluate the tyrosine kinase inhibitors(TKI) and immunotherapies-induced thyroid disorders, their relationship on disease prognosis and baseline serum thyroid stimulating hormone (TSH) levels effect on the development of thyroid dysfuncti...

ea0090ep1168 | Late Breaking | ECE2023

Papillary Thyroid Carcinoma Post Radioactive Iodine therapy for Graves’ disease

Mayilvaganan Sabaretnam , Bhargav Panchangam Ramakanth , Idrees Sarrah , Jagannath Spandana , Mishra Anjali , Agarwal Gaurav

Background: Papillary Thyroid Carcinoma after Radioactive Iodine therapy for Graves’ disease is rare with few cases reported in literature. Presentation of case A 28 years gentleman, presented with multiple non tender swellings in the anterior aspect of the neck, insidious in onset, initially started as a single swelling in the left side of the size 3×2 cm. Three years prior, he received I 131 therapy for Graves thyrotoxicosis. Thereafter, developed hypothyroidism af...

ea0090ep1169 | Late Breaking | ECE2023

Distant metastasis in a female patient with thyroid and breast carcinoma with low value of Thyroglobulin. Association between thyroid and breast cancer

Teodoriu Laura , Bilha Stefana , Gafton Elena , Leustean Letitia , Ungureanu Maria-Christina , Preda Cristina , Stefanescu Cipriana

Breast cancer (BC) is the most common type of cancer and the leading cause of cancer-related death in women worldwide. A considerable number of these long-term survivors may therefore have an elevated risk of developing a second primary malignancy (SPM). Thyroid cancer (TC) is the most prevalent endocrine malignancy among women. Epidemiologic studies have indicated that patients with BC have a higher risk of developing TC as an SPM, and vice versa, than would be expected in th...