Endocrine Abstracts

Menopause timing is highly variable, having a direct effect on reproductive lifespan, fertility and health outcomes in later life. Endocrine and imaging tests only record changes in ovarian function that have already taken place, thus disabling early prediction and identification of women with reduced reproductive lifespan. Human genetic studies have attempted to overcome this problem by identifying genetic markers associated with menopause timing and fertility. Using data fro...

Hilary Critchley, University of Edinburgh, Edinburgh, UK AbstractHilary Critchley is Professor of Reproductive Medicine (Personal Chair awarded 1999) at the University of Edinburgh and clinical Consultant in Obstetrics and Gynaecology at the Royal Infirmary, Edinburgh.She graduated in medicine from the University of Manchester. Her research training was undertaken with Professor David Baird (Edin...

Introduction: LDL cholesterol (LDL-C) is usualy estimated using the Friedewald equation. This equation assumes a fixed factor of 5 for the ratio of triglycerides to very LPL cholesterol (TG:VLDL-C); however, the actual TG:VLDL-C ratio varies significantly across the range of triglyceride and cholesterol levels. A new method was proposed by Martin, S and co-workers using NHANES data. We aimed to evaluate the concordance Friedewald formula with the new method for LDL-C estimatio...

The Hvidoere International Study Group on Childhood Diabetes comprising of 26 paediatric diabetes centres from 23 countries (Europe, North America, Japan, and Australia) has conducted five major studies, in order to asses metabolic control and quality of life in children and young people with type 1 diabetes and determine factors influencing good metabolic control and those creating barriers.The findings of these studies have led to an internationally re...

The molecular and cellular mechanisms within the uterine endometrium regulating menstruation, involve complex interactions between the endocrine, vascular and immune systems. The endometrium is a dynamic tissue that undergoes characteristic changes (proliferation, differentiation and shedding) each menstrual cycle as a consequence of sequential exposure to the ovarian sex steroids. Oestrogen and progesterone, via their cognate receptors regulate the expression of a cascade of ...

The European Journal of Endocrinology Prize is awarded to a candidate who has contributed significantly to the advancement of the knowledge in the field of endocrinology through publication. Further information on the prize can be found at http://www.ese-hormones.org/prizes/eje.aspx. This year’s recipient is Prof. Martin Fassnacht. The prize will be presented as part of the ECE 2014 opening ceremony where ...

Introduction: Ongoing structured education for children and young people with type 1 diabetes and their families is considered essential by ISPAD (2014) and NICE (2015), because there is a lot of education and skills that need to be reinforced.In 2016 the majority of the self-management education was provided at our trust by diabetes self-management education (DSME) sessions, which are two hour sessions designed to improve self-management. This format of...

Objectives: The Diabetes Team at Birmingham Children’s Hospital modified the advanced bolus algorithm suggested by Bell (2015), to develop the KISS (Keep it Simple and Safe). KISS involves adding 25% extra insulin to meals identified as very high fat and protein, and spreading the insulin by a split bolus, 50% now and 50% over 2.5 hours. KISS also has an adjustment tool allowing extra insulin to be added and the split modified from monitoring. KISS is intended to be a sim...

We present the case of assumed ectopic GHRH from residual bronchial carcinoid on the basis of an elevated serum GH, an elevated IGF-1 impaired glucose tolerance and an acromegalic appearance. The patient was diagnosed with a left bronchial carcinoid in 1985, aged38 years. Treated with a left pneumonectomy. She remained well until she presented in 1994 with an oesophageal variceal bleed. She had no evidence of portal hypertension or liver disease. CT chest revealed a mediastina...

Objectives: Patients with diabetes have longer and more complicated hospital stays than non-diabetic patients. The 2001 UK National Service Framework (NSF) recommends that the management of these patients should be supplemented by diabetes nurse specialists (DNS). This study aimed to audit the implementation of this recommendation, how it can be targeted and the impact it has on patient care.Study design and setting: One month long cross-sectional study ...