Endocrine Abstracts

Cardiovascular dysfunction (CVD) is a well recognized complication in patients with hyperthyroidism and is the major cause of mortality. To date there has been no studies which had clearly evaluated the CVD and its recovery pattern between patients with Graves and Toxic multi nodular goitre(TMNG). Hence we intended to compare treatment outcomes in patients with Graves and TMNG. Patients with hyperthyroidism were grouped into, Group 1 [n=133, age<6...

Ipilimumab is a monoclonal antibody that had been shown significantly to improve survival in cases of metastatic melanoma. It blocks cytotoxic T-lymphocyte antigen 4(CTLA4) resulting in T-cell activation, proliferation and antitumor response. However recently an emerging clinical entities of different endocrinopathies have been reported in patients on ipilimumab. These are mainly related to lymphocytic hypophysistis causing anterior hypop...

Ipilimumab is a monoclonal antibody that had been shown significantly to improve survival in cases of metastatic melanoma. It blocks cytotoxic T-lymphocyte antigen 4(CTLA4) resulting in T-cell activation, proliferation and antitumor response. However recently an emerging clinical entities of different endocrinopathies have been reported in patients on ipilimumab. These are mainly related to lymphocytic hypophysistis causing anterior hypop...

We describe a case of 31 year young lady with Type 1 Diabetes, who started experiencing reduction in insulin requirement and hypoglycaemia episodes due to an endocrine disorder following Pregnancy. She presented with recurrent episodes of documented hypoglycaemia and amenorrhea following successful pregnancy. Her basal insulin requirements fell from 36 units to 24 units per day and she required little if any insulin as bolus (0.5 unit for every 10 gm). She did not breast feed....

Over recent years, the numbers of commercially available slimming aids have increased dramatically. Whilst the majority of these aids are harmless, their interaction with normal physiology is either not understood or not brought to the attention of the customer. We report the case of a 45-year-old woman who presented with clinical and biochemical thyrotoxicosis (fT4 31.5 pmol/l, fT3 14.3 pmol/l, TSH <0.02 mIU/l). She had elevated TPO antibodies (51 IU...

A 20 year old man otherwise fit and well, presented with a seizure, fall and fractured neck of femur. DEXA scan revealed osteoporosis; baseline blood tests were apparently normal in the endocrinology clinic with a Testosterone level of 24.3 nmol/l (Range 9.9–27.8) and normal bone and thyroid profile. He was then lost to follow-up. 4 years on, he was re-referred to the endocrinology clinic with a surprisingly elevated testosterone level of 34.6 nmol/l in combination with o...

: A 78-year-old male with a background of renal cell carcinoma and bilateral adrenal metastasis presented with leg cramps and lethargy. He was on Prednisolone 10 mg od for immune therapy induced pneumonitis. Prior to commencing Prednisolone, he was on Dexamethasone 2 mg for 4 months for weight loss, nausea and vomiting. He underwent a Short Synacthen Test (SST) as his serum Na was low at 119 mmol/L (134–146). His SST showed a flat response with baseline and 30 minutes cor...

A 20-year-old gentleman with an established diagnosis of Chronic fatigue syndrome was admitted to hospital with palpitations and shortness of breath on exertion. He had been taking ‘healthy supplements’ for his ME for a year. On examination, he was noted to be tachycardic with a heart rate of 120–150 beats/minute. ECG confirmed sinus tachycardia. Further investigations revealed a free thyroxine (fT4) of 29.4 pmol/l and thyroid stimulating hormone (TSH...

A 21-year-old female patient was referred from the eye clinic after she was noted to have bilateral papilloedema during a routine eye examination. She gave a 3 months history of intermittent headaches and fleeting episodes of profuse sweating and rash, unrelated to the headaches. She had been investigated by the GP with routine blood tests which were found to be normal.On examination, she was noted to be tachycardic at 100 beats/min and hypertensive at 1...

Optimal management of familial medullary thyroid cancer (MTC) involves early genetic diagnosis of affected individuals and prophylactic thyroidectomy. Patients diagnosed later may have biochemical evidence of metastases which are clinically silent. We report a family which illustrates the management difficulties which may arise with this approach. SC, a healthy 25-year-old man, presented for assessment for MTC. His mother had had a total thyroidectomy for MTC with no clinical ...