Endocrine Abstracts

Background: MEN2A-causing RET variants are considered highly penetrant, and early prophylactic thyroidectomy is recommended to prevent the development of Medullary thyroid cancer (MTC). However, existing risk estimates may be exaggerated due to their reliance on clinically selected patients, leading to unnecessary surgeries. To address this, we conducted a comprehensive study of 450,000 clinically unselected individuals to evaluate the risk of MTC wit...

5α-Reductase (5αR) inhibitors decrease prostatic dihydrotestosterone in benign prostatic hyperplasia (BPH) treatment; finasteride inhibits 5αR type 2, while dutasteride inhibits 5αR1 and 2. 5αRs, especially 5αR1, are also expressed in metabolic tissues regulating actions of androgens and other substrates, including glucocorticoids.Hypothesis: 5αR1 inhibition with dutasteride induces metabolic dyshomeostasis.<p class...

Holistic care for NEN patients:: Holistic care is a ‘gold-standard’ model, defined as that which treats the whole person. A key factor to ensure that all the cogs in the NEN pathway work collaboratively, towards this goal, is to ensure that we are all listening to the perspective of the person living with NEN and that we focus conversations on Quality of Life: what it means to each individual and how we can, together, best help them manage and live well with their il...

Steroid-dependence is a life-long condition with a risk of premature mortality from undertreated adrenal crisis or omission of steroids. Previous studies identified rates of adrenal crisis around 8.3/100 patient years (Hahner 2015). We invited members of Addison’s Disease Self-Help Group to complete an online questionnaire about any experiences of adrenal crisis. Respondents(N=628) were asked to provide demographic information and details of their most recent adr...

Despite advances in therapies and healthcare, the prevalence of diabetes has reached epidemic proportions with increasing numbers of children and their families affected.The psychological and psychosocial challenges facing families in living with the burden of diabetes are immense and have a direct and detrimental impact on their ability to achieve optimal glycaemic control. A paradigm shift away from a purely medical model to a greater emphasis on psych...

I would like to present the case of a 66-year-old gentleman with McCune–Albright syndrome. This unusual condition consists of three main features; namely, polyostotic fibrous dysplasia, café au lait patches on the skin and hormonal abnormalities, including acromegaly.The presentation will look briefly at these three elements and the investigations leading up to diagnosis. However, the main focus will be on the psychological impact illness has h...

Introduction: Hyperandrogenism causing virilisation in postmenopausal females is rare. It is caused by abnormal ovarian or adrenal androgen production, but establishing the source of androgen excess can be challenging. Testosterone levels >5 nmol/l can be associated with virilization (Hirschberg, 2022).Case: A 75-year-old post-menopausal woman, with a 3-year history of androgenic alopecia (Ludwig scale 3/3) and hirsutism (Ferrimen Gallwey Score 32/36...

Project Aim: To review the data from the Out of hours service across the 8 years it has been running to identify common themes in calls, review service useage, identify gaps in patient/parental knowledge and review if admissions have reduced during this time.Objectives: • To understand the frequency of calls to the out of hours service• To highlight patterns and trends in the numbers and frequency of calls<p class...

People with intellectual disabilities are known to face many inequalities in healthcare that lead to poor health as well as premature and preventable death. They often experience multiple comorbidities, often at a younger age than the wider population, and often these include endocrine disorders. However, many of the barriers they face to accessing timely and appropriate health care are preventable and/or their impact can be reduced. This presentation aims to highlight both th...

Introduction: In 2011, the East of England Children and Young Peoples Diabetes Network (EECYPN) sought to find a solution to the provision of out of hours advice regionally, and coordinated the development of the Out of Hours (OoH) Consortium.Objectives: • To review the timing, nature and outcome of the calls received to the Out of Hours service over a 12-month period (1 April 2021 and 31 March 2022). • To high...