Searchable abstracts of presentations at key conferences in endocrinology
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26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

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We are pleased to announce that ECE 2024 will be held in Stockholm, Sweden from 11-14 May 2024. We will, once again, be offering the hybrid format next year so you can join us in person in Sweden or remotely with ECE@Home.

Eposter Presentations

Reproductive and Developmental Endocrinology

ea0099ep9 | Reproductive and Developmental Endocrinology | ECE2024

Use of selective adrenal and ovarian venous sampling in postmenopausal women with severe hyperandrogenism: Report of 3 cases

Arsentales Montalva Valeria , Gimenez-Palop Olga , Capel Ismael , Subias David , Romero Ana , Hernandez Alba , Muntean Andreea , Jover Judith , Costa Laura , Perendreu Juan , Garcia Carlos , Rigla Mercedes

Background: Although the majority of cases of hyperandrogenism in postmenopausal women are due to functional causes, the sudden appearance of a severe and rapidly progressive condition, especially if associated with signs of virilization and defeminization, requires always ruling out the existence of an androgen-producing tumor at both the adrenal and ovarian levels. Etiological diagnosis can be difficult because ovarian tumors are not easily demonstrable by imaging.<p cla...

ea0099ep49 | Reproductive and Developmental Endocrinology | ECE2024

Endocrine and reproductive consequences of pubertal stress in rats

Faliush Oksana , Sachynska Olga , Lymareva Anna , Perchyk Inna , Reznikov Alexander

Adolescence is one of the most dynamic periods of development, which is highly sensitive to changes induced by stressors. Disruption in hormonal balance associated with stress have a negative impact on puberty and reproductive function. The aim of the work was to study the long-term endocrine effects of chronic pubertal stress in rats. On the 22 postnatal day (PND), the Wistar rats were separated from their mothers and sorted by sex into individual cages, so that animals from ...

ea0099ep98 | Reproductive and Developmental Endocrinology | ECE2024

Orexin A is a new marker of insulin resistance in polycystic ovary syndrome

Absatarova Yulia , Evseeva Yulia , Andreeva Elena , Samsonova Margarita

Dysregulation of the neuroendocrine system is a key element in the pathogenesis of polycystic ovary syndrome (PCOS). Orexins (hypocretins) are a new class of hypothalamic neuropeptides that influence sleep-wake rhythms and the state of energy metabolism. In addition, their receptors expresses in peripheral tissues, including the endocrine system. Data have emerged on the role of orexins in the regulation of the reproductive system and, in particular, ovulation, through a direc...

ea0099ep109 | Reproductive and Developmental Endocrinology | ECE2024

Sex-specific effects of perinatal exposure to tetrabromobisphenol a, an endocrine disrupting chemical on brain development and behavior in mice

Jeung Eui-Bae , Kim YongIn , Kim Sun , Hwang Inho

Tetrabromobisphenol A (TBBPA) is a brominated flame retardant and is widely used in electronic goods, plastics, and furniture. TBBPA is frequently detected in water, soil, organisms and even in human breast milk. Though some regulatory agencies have asserted that consumer exposures to TBBPA are unlikely to have adverse implications for human health, the reported evidence of endocrine-disruption of TBBPA has raised concerns regarding its effects on neurodevelopment and behavior...

ea0099ep111 | Reproductive and Developmental Endocrinology | ECE2024

The relevance of endocrine disruptors, obesity, and cytokines for polycystic ovary syndrome

Duskova Michaela , Vitků Jana , Kolatorova Lucie , Vrbikova Jana , Vosatkova Michala , Včelak Josef , Šimkova Marketa

As genetic and environmental components contribute to the PCOS expression, we compared levels of endocrine disruptors, steroid hormones, cytokines, and metabolic parameters in twenty healthy, nine normal-weight PCOS women, and ten obese PCOS women. Steroid hormones, bisphenols (BPA, BPS, BPF, BPAF) and parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-parabens) were measured by liquid chromatography-tandem mass spectrometry. Differences between the groups were assessed using ...

ea0099ep133 | Reproductive and Developmental Endocrinology | ECE2024

Vitamin D levels in pregnant women, vitd-supplementation and its association with pregnancy outcomes

Pappa Dimitra , Barmpa Eleftheria , Tamouridis Stefanos , Evagelopoulou Aikaterini , Daponte Alexander , Bargiota Alexandra

Introduction: Data on the desirable Vitamin D (VitD) levels and VitD-supplementation during pregnancy are very controversial and thus everyday practice varies a lot. In our study the aim is to record VitD levels, as well as the VitD-supplementation and their association with pregnancy outcomes in women referred to our center in the second and third trimester of pregnancy.Methods: We studied 193 pregnant women mean age 30.34&pm;7.07 years old. In each pat...

ea0099ep149 | Reproductive and Developmental Endocrinology | ECE2024

Immunological role of progesterone and cortisol during pregnancy

Yasuda Atsushi , Seki Toshiro , Kashiwagi Hirofumi , Kitajima Natsumi , Seki Masami , Kametani Yoshie

During pregnancy, levels of pregnancy-related proteins and hormones such as progesterone (P4), estrogen, and glucocorticoids (GC) increase. Although the regulatory mechanisms of P4 production in the placenta are not completely understood, studies using mouse models have demonstrated that P4 induces immunosuppression using a GC receptor-dependent pathway, suggesting that both it has been suggested that steroid hormones have a similar effect. Understanding the orchestrated role ...

ea0099ep151 | Reproductive and Developmental Endocrinology | ECE2024

Assessment of non-invasive NAFDL indices in patients with PCOS

Elezovic Kovacevic Valentina , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Opalic Palibrk Milica , Radic Lena , Krstic Katarina , Bjekic Macut Jelica , Vojnovic Milutinovic Danijela , Stanojlović Olivera , P. Macut Djuro

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. This highly complex reproductive metabolic disorder is independently associated with high prevalence of non-alcoholic fatty liver disease (NAFLD). While the gold standard of NAFLD diagnosis is liver biopsy or MRI, it is costly and hard to perform in large population. Recently, simple and convenient markers, such as liver fat score (LFS), fatty liver inde...

ea0099ep177 | Reproductive and Developmental Endocrinology | ECE2024

Study on quality of life, self-esteem, anxiety and depression among transgender people in a healthcare area

Zayas Aguilar Irene , Lara Barea Almudena , Larran Escandon Laura , Medina Rivero Daniel , Maria Mateo Gavira Isabel

Introduction: Transgender people are a population affected by a variety of negative health indicators. Studies report, among other conditions, a high prevalence of mental health problems, however, long-term longitudinal follow-up studies are scarce.Objective: The aim of this study is to assess the quality of life (WHOWOL-BREF scale), self-esteem (RSES scale), levels of anxiety (GAD-7 scale) and depression (PHQ-9 scale) of transgender people attended at t...

ea0099ep190 | Reproductive and Developmental Endocrinology | ECE2024

Audit of the clinical utility of androstenedione

Byrne Ruth , Crowley Rachel , Twomey Patrick

Introduction: Hyperandrogenism is a diagnostic feature for polycystic ovarian syndrome (PCOS). Androstenedione is a testosterone precursor that has been shown to be useful in diagnosis of PCOS especially in the setting of normal testosterone. During 2022, our laboratory in St Vincent’s University Hospital in Dublin, Ireland, changed from using a radioimmunoassay to an electrochemiluminescence immunoassay, which requires a non-gel tube in line with manufacturers requiremen...

ea0099ep216 | Reproductive and Developmental Endocrinology | ECE2024

Low reproducibility of plasma testosterone concentrations in male patients with hypogonadism treated with transdermal testosterone gel

Lanzi Valeria , Indirli Rita , Mantovani Beatrice , Petria Iulia , Profka Eriselda , Mantovani Giovanna , Ferrante Emanuele

Introduction: Testosterone replacement therapy (TRT) in male hypogonadism aims at restoring physiological plasma testosterone (T) levels. According to current guidelines, gel formulations should resemble better the circadian T secretion and offer physiological and consistent T concentrations. However, only a few real-life studies have assessed intra-individual reproducibility of T levels in patients treated with gel formulations.Methods: Thirty patients ...

ea0099ep226 | Reproductive and Developmental Endocrinology | ECE2024

Chitosan/Alginate-loaded astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces mirna-222 expression in polycystic ovary syndrome rats

Parvini Kohnehshahri Maryam

Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women of childbearing age. This study aimed to investigate the effects of Chitosan/Alginate-loaded Astragalus hamosus extract (Chn/Al-AH) on the histology of Ovaries and uterus, miRNA-222, ESR1, and IRS1 genes expression, pro-inflammatory cytokines, lipid profiles, sex hormone levels in rats with PCOS induced by estradiol valerate (EV)....

ea0099ep230 | Reproductive and Developmental Endocrinology | ECE2024

Body composition influences on serum anti-müllerian hormone (AMH) levels in adult males imply hemodilution

Tandl Veronika , Haudum Christoph , Eberhard Katharina , Hutz Barbara , Foessl Ines , Kolesnik Ewald , Zirlik Andreas , von Lewinski Dirk , Scherr Daniel , Verheyen Nicolas , Pieber Thomas , Obermayer-Pietsch Barbara

Background: A negative relationship between body mass index (BMI) and serum Anti-Müllerian hormone (AMH) levels has been previously reported. Whether this is because of an adverse effect of adiposity on AMH production or the hormone’s dilution in a higher blood volume that accompanies larger body size (‘hemodilution’) is not yet clear. Blood volume can be estimated by body weight, body surface area (BSA) or lean mass (LM). Of note, adipose tissue is poorly ...

ea0099ep238 | Reproductive and Developmental Endocrinology | ECE2024

Unveiling the uncommon nexus: kallmann syndrome and cardiomyopathy - a singular case study

Hussien Ahmed , Nasreldin Maha

This case report delves into the intriguing connection between Kallmann syndrome and cardiomyopathy in a 62-year-old male who presented with new atrial fibrillation (AF) with rapid ventricular response and signs of fluid overload. Despite being a known case of Kallmann syndrome, the emergence of severe impaired left ventricular systolic dysfunction (LVSD) added a distinctive layer to the clinical scenario. Cardiomyopathy screenings for common causes like sarcoidosis, amyloidos...

ea0099ep253 | Reproductive and Developmental Endocrinology | ECE2024

Characterization of liver abnormalities in a population of adult turner women: results from an observational study

Cecchetti Carolina , Rotolo Laura , Dionese Paola , Belardinelli Elisabetta , Solmi Beatrice , Vestito Amanda , Dajti Elton , Colecchia Antonio , Pagotto Uberto , Gambineri Alessandra

Introduction: Liver function test abnormalities (LFA) are common in patients with Turner syndrome (TS). The etiopathogenesis of this complication remains unclear, probably being multifaceted. Metabolic syndrome, generalized vasculopathy, and autoimmunity have been proposed as possible causal mechanisms.Objectives: - To describe the prevalence and possible related factors of morpho-functional liver abnormalities in TS adult patients. - To evaluate the uti...

ea0099ep293 | Reproductive and Developmental Endocrinology | ECE2024

Impact of drospirenone-only-pill on sexual function: experience of our‘pcos and female endocrinology outpatient clinic’

Tomaselli Alessandra , Minnetti Marianna , Rosato Elena , Tarantino Chiara , De Alcubierre Dario , Ferrari Davide , Rizzo Flavio , Sciarra Francesca , Pofi Riccardo , Isidori Andrea , Pozza Carlotta

Introduction and Objectives of the Study: Combined oral contraceptives (COCs) are frequently prescribed for fertility control, however sexual dysfunction has been reported as a common side effect. In 2020, a novel progestin-only pill containing Drospirenone (DRSP) was approved as an oral contraceptive. To date, here is a notable dearth of data on the impact of DRSP on sexual function and impact on hormones, particularly regarding steroids. This study aims to investigate the po...

ea0099ep346 | Reproductive and Developmental Endocrinology | ECE2024

Growing up with an endocrine disease: assessing transitional features in a cohort of young patients moving from pediatric to adult clinic

Citterio Valeria , Rodari Giulia , Gaglio Alessia , Collini Valentina , Risio Alessandro , Profka Eriselda , Giacchetti Federico , Orsi Emanuela , Mantovani Giovanna , Giavoli Claudia

Introduction: Transition from childhood to adulthood represents a time-period in which adolescents/young adults (AYAs) with chronic illnesses start coping with self-managing their disease, often resulting in poor compliance to follow-up. Indeed, up to 50% of AYAs with common endocrine disorders is lost during the referral to an adult clinic. Transition in Endocrinology is poorly investigated yet, in terms of transition readiness, compliance to therapy, adherence to nutritional...

ea0099ep349 | Reproductive and Developmental Endocrinology | ECE2024

Early embryonic testicular regression syndrome: a rare case of primary amenorrhea

Elena Iftimie Mădălina , Dobre Ramona , Iulia-Florentina Burcea , Budulucă Larisa , Braha Emanuela , Poiana Catalina

Background: Normal sex development is warranted by a complex and coordinated interaction between mutually antagonistic activating and repressing genetic and hormonal factors that act in a strict spatio-temporal sequence. Deviations from this established pattern can result in heterogenous chromosomal, gonadal or phenotypic congenital abnormalities named disorders of sexual development (DSD). We present a rare case of early testicular regression syndrome.C...

ea0099ep359 | Reproductive and Developmental Endocrinology | ECE2024

Klinefelter syndrome (KS) prevalence at invasive prenatal diagnosis (ipd) procedures: a systematic review of the literature

Costantino Francesco , De Vincentis Sara , Chiara Decaroli Maria , Rochira Vincenzo

Introduction: KS prevalence is estimated to range from 0.1-0.2 % in men and actually the estimated frequency is of about 1:500 to 1:1000 men1. However, the real prevalence remains unknown due also to the fact that the disease is often overlooked and undermanaged1.Aim and methods: We performed a systematic literature search including studies published between 1971 and January 2024 to investigate the real prenatal prevalence of KS (in...

ea0099ep363 | Reproductive and Developmental Endocrinology | ECE2024

Beta thalassemia major, hypogonadism and cardiovascular risk

Allosso Francesca , Digitale Selvaggio Lucia , Errico Martina , Grande Graziella , Di Ludovico Claudia , Navarra Raffaele , Casale Maddalena , Perrotta Silverio , Pasquali Daniela

Beta thalassemia major (betaTM) is an inherited hematological disorder characterized by reduced or absent synthesis of beta-globin chains and anemia. Chronic transfusion treatment is necessary, exposing patients to iron overload comorbidities such as hypogonadism. It is due to iron accumulation in the pituitary gland and, more rarely, in testis and ovaries. HPG axis dysfunction can manifest as low estradiol or testosterone with low to normal serum LH and FSH, as commonly seen ...

ea0099ep370 | Reproductive and Developmental Endocrinology | ECE2024

Delayed puberty and ataxia – important clinical manifestations of polr3b-related leukodystrophy

Mifsud Simon , Debono Miguel

Background: POLR3-related leukodystrophy is an autosomal recessive hypo-myelinating leukodystrophy characterized by specific features on MRI and varying combinations of four major clinical findings1. The latter include neurological dysfunction, abnormal dentition, endocrine dysfunction, and myopia1. Endocrine dysfunction in POLR3-related leukodystrophy includes hypogonadotropic-hypogonadism (HH), short stature, growth hormone deficiency, and less commonly...

ea0099ep388 | Reproductive and Developmental Endocrinology | ECE2024

Steroid secreting ovarian tumour causing extreme hyperandrogenism, virilisation and polycythaemia in a post-menopausal female

Byrne Ruth , Moran Carla , Foley Catherine , Fadalla Kamal , Jeffers Michael , Kamran Waseem

Introduction: Hyperandrogenism causing virilisation in postmenopausal females is rare. It is caused by abnormal ovarian or adrenal androgen production, but establishing the source of androgen excess can be challenging. Testosterone levels >5 nmol/l can be associated with virilization (Hirschberg, 2022).Case: A 75-year-old post-menopausal woman, with a 3-year history of androgenic alopecia (Ludwig scale 3/3) and hirsutism (Ferrimen Gallwey Score 32/36...

ea0099ep396 | Reproductive and Developmental Endocrinology | ECE2024

Low dose estradiol gender-affirming hormone therapy (GAHT) generates rapid feminizing body changes in transgender women: a dual energy x-ray absorptiometry-based prospective study

Yaish Iris , Gindis Guy , Buch Asaf , Sofer Yael , Greenman Yona , Arbiv Mira , Moshe Yaffa , Tordjman Karen

Background and Aim: We previously demonstrated that low-dose estradiol (E2) administered sublingually alone for 6 months in treatment-naïve trans women (TW), suppressed testosterone to the same degree, but generated higher serum E2 levels as the same oral dose combined with cyproterone acetate. We now sought to assess the possible differential impact of these approaches on anthropometric and body composition measurements, sex-dependent indicators with proven metabolic pro...

ea0099ep403 | Reproductive and Developmental Endocrinology | ECE2024

Lipid profile in turnerian patients treated with growth hormone

Rhouzali Khawla , Chaymae Hamdane , Baraya Moussa , Rouf Siham , Latrech Hanane

Introduction: Turner syndrome (TS) is a rare genetic disorder characterized by an aberration of the X chromosome, most commonly associated with various comorbidities, such as metabolic disorders, particularly dyslipidemias. The aim of this study is to determine the frequency of dyslipidemias associated with TS and to evaluate the impact of growth hormone (GH) treatment on lipid metabolism.Methods: This is a descriptive and retrospective study of 22 patie...

ea0099ep431 | Reproductive and Developmental Endocrinology | ECE2024

Time-dependent progression of metabolic dysfunction in a mouse model of polycystic ovary syndrome

Basnet Jelina , Rezq Samar , M Huffman Alexandra , L Yanes Cardozo Licy , Romero Damian

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. PCOS is associated with metabolic disorders such as obesity, dyslipidemia, systemic insulin resistance (IR), and adipose IR. Hyperandrogenism is prevalent in PCOS and is linked to metabolic dysfunction in multiple tissues, including WAT. However, data on the disease onset and progression of WAT mediated metabolic derangements in PCOS women are lacking. Therefore, we ai...

ea0099ep436 | Reproductive and Developmental Endocrinology | ECE2024

Variations in the assessment and education of polycystic ovary syndrome (PCOS) during initial consultations across europe: a multinational study

Ali Anisah , Deshmukh Harshal , Wilde Alexander , Joshi Ashwin , Armeni Elena , Yesilkaya Baylan Isin , Attar Erkut , Kelestimur Fahrettin , Davitadze Meri , Kempegowda Punith , SEva Working Group PCOS

Objective: To explore the differences in various assessments recommended by the International PCOS guidelines during the initial consultation for women with PCOS across Europe.Methods: This retrospective multi-centre study was conducted from June 2023 to January 2024. All women over age 18 who attended their first consultation in a dedicated PCOS clinic from 1st January 2020 to 31st December 2023 in the UK (n=359), Turkey (n=239), Greec...

ea0099ep437 | Reproductive and Developmental Endocrinology | ECE2024

PCOS-like syndrome in the young woman with cortisone reductase deficiency type 1

Krstic Katarina , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Elezovic Kovacevic Valentina , Bjekić Macut Jelica , Opalic Palibrk Milica , Radic Lena , Stanojlović Olivera , Rasic Markovic Aleksandra , Vojnovic Milutinovic Danijela , Macut Djuro

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a dimeric enzyme that catalyzes the reduction of cortisone to cortisol within the endoplasmic reticulum. Loss of this activity results in a disorder termed cortisone reductase deficiency type 1 (CRD). Only mutations in H6PD gene, which encodes an enzyme supplying cofactor for the reaction, have been identified as the cause of disease. Biochemical features of CRD are increased cortisol clearance and A...

ea0099ep448 | Reproductive and Developmental Endocrinology | ECE2024

Clinical and biological aspects of isolated hypogonadotropic hypogonadism

Khiari Hager , Rojbi Imen , Essayeh Sawsen , Mekni Sabrine , Ibtissem Bennacef , Lakhoua Youssef , Mchirgui Nadia , Khiari Karima

Introduction: Isolated hypogonadotropic hypogonadism is a heterogeneous group of genetic abnormalities affecting the hypothalamic pituitary gonadal axis. The main mechanism consists of an impairment of the production or the action of gonadotropin releasing hormone (GnRH). While several mutations have been identified, the majority of cases remain without etiology. The objective of our study was to describe the clinical and biological profiles of these diseases.<p class="abs...

ea0099ep458 | Reproductive and Developmental Endocrinology | ECE2024

Body composition changes and satisfaction associated with gender-affirming hormone therapy in transgender men

Gomez Hoyos Emilia , Primo Martin David , Delgado Garcia Esther , Estevez Asensio Lucia , Ortola Buigues Ana , Jose Lopez Gomez Juan , Antonia Maniega Rubio Maria , Rodriguez Fernandez Carmen , Jose Bartolome Albistegui Maria , De Luis Roman Daniel

Introduction: Gender affirming hormone therapy (GAHT) in transgender men favors their virilization. Aims: To determine its impact on body composition measured by electrical impedance and the satisfaction perceived by the subject (CRES-4 questionnaire).Material and Methods: Prospective study in transgender men with GAHT (>2 years), attended at the Transgender Medicine Unit of the Hospital Clinico of Valladolid from January 2014 to January 2023. Record...

ea0099ep547 | Reproductive and Developmental Endocrinology | ECE2024

Knowledge and practices among georgian physicians regarding diagnosis and management of polycystic ovary syndrome: experiences from a middle-income country

Davitadze Meri , Kanchelashvili Giorgi , Kobaidze Ann , Tedoradze Nino , Chikhladze Nino , Chakhunashvili Giorgi

Introduction: Polycystic ovary syndrome (PCOS) affects 10-15% of women worldwide, depending on the population and the diagnostic criteria used. The diagnostic criteria include clinical and/or biochemical hyperandrogenism, oligo/anovulation, and polycystic morphologic appearance of the ovaries. PCOS is associated with high risk of obesity, diabetes, cardiovascular diseases, and a wide spectrum of mental health disorders. Despite international recommendations, there is still lac...

ea0099ep548 | Reproductive and Developmental Endocrinology | ECE2024

Beyond the surface: endocrinological implications of thoracic endometriosis syndrome

Czapla-Iskrzycka Aleksandra , Pietrzak Katarzyna , Świątkowska-Stodulska Renata , Marjański Tomasz

Introduction: Thoracic Endometriosis Syndrome (TES) is characterized by clinical symptoms associated with menstruation (eg, catamenial pneumothorax (CP), chest pain, and others) not obligatorily requiring histological confirmation. The treatment is burdened with frequent recurrences. This study aimed to characterize the treatment of women with TES and assess the concomitant diseases.Methods: A developed online survey was published in patients’ suppo...

ea0099ep549 | Reproductive and Developmental Endocrinology | ECE2024

Premature ovarian failure after cancer treatment: surveillance and management

Lopes-Pinto Mariana , Calheiros Raquel , Santos Sara , Inacio Isabel , Souteiro Pedro , Oliveira Joana , P Santos Ana , Torres Isabel

Introduction: Cancer treatment including oophorectomy, radiotherapy and chemotherapy with gonadotoxic agents may induce premature ovarian failure. Early diagnosis and treatment of ovarian failure avoids cardiovascular disorders, osteoporosis and compromised sexual health due to estrogen deficiency and also ensures growth and pubertal development in children.Aim: Raise awareness for early assessment and management of premature ovarian failure after cancer...

ea0099ep551 | Reproductive and Developmental Endocrinology | ECE2024

PCOS phenotypes and their relationship to aldosterone levels

Sabbadin Chiara , Bordin Luciana , Marin Loris , Andrisani Alessandra , Armanini Decio

Objective: Polycystic ovary syndrome (PCOS) phenotypes, generated by the possible combinations of the three Rotterdam diagnostic criteria, show a different scale of metabolic risk among PCOS women, being greatest in the classic subgroup, followed by the ovulatory and normoandrogenic phenotype. Aldosterone is an important cardiovascular risk factor. Previous studies reported increased levels of aldosterone in PCOS women, suggesting a possible role in the development of some car...

ea0099ep571 | Reproductive and Developmental Endocrinology | ECE2024

Short and long-term efficacy of minoxidil on beard growth in a group of assigned female at birth transgender people on gender affirming hormone therapy

Marinelli Lorenzo , Bichiri Andreina , Ghigo Ezio , Motta Giovanna

Introduction: Minoxidil is a vasodilator drug used as topical treatment of androgenetic alopecia; however, its efficacy for beard enhancement is reported in cisgender men and in a case-report of a transgender assigned female at birth (t-AFAB) adolescent. This study aims to evaluate the short- and long-term efficacy of topical minoxidil in a group of t-AFAB people on gender affirming hormone therapy (GAHT) with testosterone.Materials and methods:...

ea0099ep576 | Reproductive and Developmental Endocrinology | ECE2024

Combined klinefelter and down syndrome – challenges of testosterone replacement therapy

Groti Antonic Kristina , Jensterle Mojca , Janez Andrej

Introduction: Double aneuploidies are extremely rare. Klinefelter syndrome is a chromosomal disorder characterized by an extra X chromosome in male cells - approximately 80% are 47,XXY; the remaining 20% are mosaic 47,XXY/46,XY. Down syndrome is caused by trisomy of chromosome 21. The prevalence of Klinefelter syndrome is approximately 1 to 2.5 per 1000 boys and men (0.1 to 0.25 percent). The incidence of Down syndrome is approximately 1 in every 990 live births across Europe ...

ea0099ep592 | Reproductive and Developmental Endocrinology | ECE2024

Low dose sublingual estradiol decreases protein s, generating a potentially pro-thrombotic state: interim results of a controlled prospective pilot study of treatment-naïve trans women

Bar On Shelly , Yaish Iris , Barzilai Merav , Greenman Yona , Gindis Guy , Moshe Yaffa , Tordjman Karen

Background: Sublingual estradiol (E) for gender-affirming hormone therapy (GAHT) of transgender women (TW) might obviate the need for an anti-androgen, and mitigate pro-coagulant changes. We recently showed that 2 mg E, divided into 4 daily SL doses (SLE), offers no clinical advantage over the same dose given orally in combination with cyproterone acetate (CPA). Furthermore, we showed that after each sublingual administration, serum E2 (sE2) peaked to levels, the likes of whic...

ea0099ep596 | Reproductive and Developmental Endocrinology | ECE2024

Statural and weight delay revealing pituitary stalk interruption syndrome: a study of 6 cases

Boutatss Nora , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Pituitary stalk interruption syndrome (PSIS) is a rare disease. It is defined by congenital anomalies of the pituitary leading to isolated or combined anterior pituitary deficiency. Its pathophysiology is unknown. Radiologically, it is characterized by an MRI showing the association of a thin or absent pituitary stalk, ectopic and/or absent posterior pituitary, and hypoplastic anterior pituitary. Symptoms of PSIS during the neonatal and early childhood period are...

ea0099ep598 | Reproductive and Developmental Endocrinology | ECE2024

Association of celiac disease and growth hormone deficiency: a report on 4 cases

Boutatss Nora , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Celiac disease and growth hormone deficiency can sometimes coexist, presenting a unique clinical challenge. Celiac disease, an autoimmune condition triggered by gluten consumption in genetically predisposed individuals, can lead to malabsorption and various complications. Growth hormone deficiency (GHD) refers to inadequate production of growth hormone, affecting normal growth and development.Objective: To explore the association between ce...

ea0099ep609 | Reproductive and Developmental Endocrinology | ECE2024

Pregnancy planning strategy in a patient with mccune-albright syndrome

Samsonova Margarita , Absatarova Yulia , Kokorina Tatiana , Sviridenko Natalya

Background: McCune-Albright Syndrome (MAS) is a rare genetic disorder characterized by polyostotic fibrous dysplasia of the skeleton, "café-au-lait" skin hyperpigmentation, and hyperfunction of endocrine glands. A distinctive feature of the syndrome is the autonomous activation of the ovaries leading to the formation of unilateral, recurring estrogen-producing cysts. Hyperestrogenism in turn causes precocious puberty in girls and anovulation in women with MAS. Thi...

ea0099ep614 | Reproductive and Developmental Endocrinology | ECE2024

Superman-a case report of hyperandrogenemia

Grimmichova Tereza

Introduction: SARMs (Selective Androgen Receptor Modulators) are non-steroidal anabolics and should improve body strength, muscle building and aid in burning excess fat. There have been ongoing clinical trials regarding positive effects of SARMs in patients with cancer cachexia, hypogonadism, benign prostatic hyperplasia, breast cancer, Alzheimeŕs disease, osteoporosis etc. with conflicting results. Liver injury and cardiovascular disease are possible severe side-effects....

ea0099ep616 | Reproductive and Developmental Endocrinology | ECE2024

Identification of hCG- and LH-dependent ovarian luteoma resulting in marked androgen production during pregnancy states as well as after menopause: characterization in vivo and in a human ex vivo model

Jorsal Mads , Kafai Yahyavi Sam , Hjorth Andreassen Christine , Frederiksen Hanne , Juul Anders , Blomberg Jensen Martin

Context: Steroid hormone-producing tumors account for 0.1% of all primary ovarian tumors. According to the cellular origin they are classified into stromal luteomas, Leydig cell tumors and steroid tumors not otherwise specified. Symptoms and phenotype depend on the specific hormones and concentrations released from the tumor. In this report, we present a postmenopausal woman with virilization during two pregnancies and in menopause caused by an androgen producing ovarian tumor...

ea0099ep626 | Reproductive and Developmental Endocrinology | ECE2024

Is the deficiency in secondary sex characteristics a potential manifestation of SPENCD (Spondyloenchondrodysplasia)?

Yıldız İcli İrem , Onur İşler Alperen , Evşan Boyraz Nur , Cagdas Deniz , Kılıc Levent , Gurlek Alper

Background: Spondyloenchondrodysplasia (SPENCD) is a rare autosomal recessive skeletal dysplasia characterized by radiolucent spondylar and metaphyseal lesions, representing the persistence of chondroid tissue islands within the bone. Besides skeletal abnormalities and short stature, autoimmune disorders, including systemic lupus erythematosus, Sjögren’s syndrome, hemolytic anemia, thrombocytopenia, hypothyroidism, inflammatory myositis, Raynaud’s disease, and v...

ea0099ep637 | Reproductive and Developmental Endocrinology | ECE2024

Defining the normative cut-off for hirsutism in unselected populations: cluster analysis

Bizuneh Asmamaw , Joham Anju , Thien Tay Chau , Earnest Arul , Suturina Larisa , Zhao Xiaomiao , Gambineri Alessandra , Tehrani Fahimeh , Yildiz Bulent , Kim Jinju , Xu Liangzhi , Makwe Christian , Teede Helena , Azziz Riccardo

Background: Hirsutism, characterized by the male pattern distribution of terminal hair in females due to elevated androgen levels, is a diagnostic feature for polycystic ovary syndrome (PCOS), assessed by the modified Ferriman-Gallwey (mFG) score. The 2023 international PCOS guideline suggests an mFG score of 4-6 for hirsutism detection. However, the lack of universally applicable cut-offs in diverse populations necessitates further research. Therefore, this study aimed to def...

ea0099ep643 | Reproductive and Developmental Endocrinology | ECE2024

Impact of polycystic ovary syndrome on health related quality of life in correlation with marital status: a multinational cross-sectional study

Mouna Elleuch , Yesmine Elloumi , Salah Dhoha Ben , Khouloud Boujelben , Zeineb Krichen , Roua Ellouze , Fatma Mnif , Mouna Mnif , Nadia Charfi , Kacem Faten Hadj , Mohamed Abid , Nabila Mejdoub

Background and Aims: The Rotterdam criteria are the most accepted criteria for the diagnosis of polycystic ovary syndrome (PCOS). The aim of this research work is to study the quality of life of Tunisian and French women with PCOS according to their marital status.Methods: A cross-sectional study involved 172 women with PCOS. Data collection was based on telephone interviews with tunisian patients who were diagnosed with PCOS based on rotterdam criteria ...

ea0099ep644 | Reproductive and Developmental Endocrinology | ECE2024

Eating disorders in patients with polycystic ovary syndrome: in correlation with marital status

Mouna Elleuch , Elloumi Yesmine , Salah Dhoha Ben , khouloud Boujelben , Zeineb Krichen , Roua Ellouze , Mnif Fatma , Mnif Mouna , Haj Kacem Akid Faten , Charfi Nadia , Abid Mohamed , Rekik Majdoub Nabila

Background and Aims: Polycystic ovary syndrome (PCOS) may be the most common endocrine disorder in women of reproductive age. Most research findings suggest that PCOS is associated with eating disorders (ED). The aim of this research work is to study the eating disorders in women with PCOS.Methods: A cross-sectional study involved 172 women, 101 of them are Tunisian and 71 are French. Data collection was based on telephone interviews with Tunisian patien...

ea0099ep645 | Reproductive and Developmental Endocrinology | ECE2024

Ethnic disparities in PCOS consultations: findings from a multinational study highlighting variances in assessment and education

Palani Raghavendar , Ali Anisah , Wilde Alexander , Murphy Lucy , Joshi Ashwin , Yesim Yesilkaya Baylan Isin , Attar Erkut , Kelestimur Fahrettin , Davitadze Meri , Kempegowda Punith , Armeni Eleni , Seva Working group PCOS

Objective: To explore whether assessments recommended by the International PCOS guidelines during the initial consultation for PCOS varied by ethnicity.Methods: This retrospective multi-centre study was conducted from June 2023 to January 2024. All women aged >18 who attended their first consultation in a dedicated PCOS clinic from January 2020 to December 2023 in the UK (n=359), Turkey (n=239), Greece (n=92), and Georgia (...

ea0099ep646 | Reproductive and Developmental Endocrinology | ECE2024

An international multi-centre study highlights a significant gap in the assessment and education provided during PCOS consultations

Arshad Amynta , Khan Sahrish , Deshmukh Harshal , Chu Agatha , James Angharad , Lafara Kyranna , Mintziori Gesthimani , Goulis Dimitrios , Abdullayeva Elmira , Seva Working Group PCOS

Objective: To explore the trends over time in several assessments recommended by the International PCOS guidelines during the initial consultation for women with PCOS.Methods: This retrospective multi-centre study was conducted from July 2023 to January 2024. All women over the age of 18 who attended their first consultation in a dedicated PCOS clinic from 1st January 2020 to 31st December 2023 in the UK (n=359), Turkey (n=239), Greece ...

ea0099ep647 | Reproductive and Developmental Endocrinology | ECE2024

Beyond the chromosomal tale: hyperandrogenism in turner syndrome patients

Stafie Ingrid-Ioana , Bilha Stefana , Tarcau Otilia-Andreea , Matei Anca , Leustean Letitia , Preda Cristina

Introduction: Turner syndrome (TS) is a chromosomal disorder that arises due to the complete or partial loss of one sex chromosome, impacting approximately 1 in every 2500 to 3000 female births. The phenotype is attributed to haploinsufficiency of genes on the X chromosome, which are resistant to inactivation. Virilizing symptoms appearing in a patient with TS advocates for an endocrine assessment and karyotyping to ascertain the virilization’s etiology, enabling prompt i...

ea0099ep699 | Reproductive and Developmental Endocrinology | ECE2024

Micropenis diagnosed in adolescence: etiology and treatement

Zahra Najioui Fatima , Achach Ossama , Rachedi Hanae , Latifa Boutaybi , Rouf Siham , Latrech Hanane

Introduction: Micropenis represents a diagnostic and therapeutic challenge. The Diagnosis is based on the measurement of penile length. Defined by normal structure, abnormal size: -2 standard deviation (SD) below of average of age. The aim of our study is to evaluate the etiological profile and therapeutic efficacy.Patients and methods: It’s a retrospective and descriptive study including 55 childrens and adolescents with micropenis, treated with ho...

ea0099ep751 | Reproductive and Developmental Endocrinology | ECE2024

The effectiveness of cognitive behavioral therapy on insomnia severity among menopausal women: a scoping review

Ntikoudi Anastasia , Owens Dimitra , Tsartsalis Athanasios , Spyrou Alketa , Evangelou Eleni , Mastorakos George , Vlachou Eugenia

Introduction: Sleep disorders, including insomnia disorder, can affect all aspects of personal life and often occur during perimenopause, menopause, and postmenopause. Data on the number of women who suffer from sleep disorders during menopause range from 28% to 63%. Cognitive behavioral therapy for insomnia (CBT-I) is a multi-component, drug-free treatment approach that targets behavioral and cognitive factors that contribute to chronic sleep disorders. The aim of this scope ...

ea0099ep752 | Reproductive and Developmental Endocrinology | ECE2024

Mixed gonadal dysgenesis; about 5 cases

Hanane Brahimi , Malek Iabassen , Meriem Bensalah

Introduction: Mixed gonadal dysgenesis is an anomaly of sexual development, it is a rare pathology, associated with a numerical anomaly of the sex chromosomes resulting from mosaicism of the Y or X chromosome and leading to abnormal development of the gonads. The most common chromosomal formulas are 45X/46 XX, 45X/46XY, 46XX/47XXX, and 46XY/47XXY. The phenotype is variable, ranging from a completely feminine appearance of the external genitalia to masculine or ambiguous. The d...

ea0099ep766 | Reproductive and Developmental Endocrinology | ECE2024

A zebra among horses – testotoxicosis as a rare cause of peripheral precocious puberty

Popa Viviana , Florescu Alexandru , Berigoi Andra , Puscasu Irina , Florea Mihaela , Bilha Stefana , Preda Cristina

Introduction: Testotoxicosis, also known as familial male limited precocious puberty, is a rare cause of peripheral precious puberty caused by an activating mutation of the gene encoding for the LH receptor on Leydig cells (LHCGR gene, cr2p21). This causes autonomous testosterone production irrespective of prepubertal LH values. Ultimately, this can cause psychosocial complications; advanced bone age and low adult height; as well as central precocious puberty.<p class="abs...

ea0099ep771 | Reproductive and Developmental Endocrinology | ECE2024

An unusual case of arrested puberty and management of puberty induction in the adult endocrine clinic

Si Min Lee , Loo Jia Jing Fernando , Lim Su Ping Brenda

Introduction: Puberty is the process of transition from childhood to adult reproductive capability, body composition, and adult height. In males, the lack of Tanner stage progression after achieving a testicular size of at least 4 cubic cm (cc) suggests pubertal arrest. While delayed puberty could be a normal variant, arrested puberty is usually pathological, and points towards an acquired pathology rather than a congenital disorder. We describe an unusual case of arrested pub...

ea0099ep772 | Reproductive and Developmental Endocrinology | ECE2024

Influence of aromatase inhibitors on metabolic parameters in obese male patient

Janjgava Shota , Jamburia Revazi , Davitashvili Ana , Bakhtadze Tekle , Zhgenti Medea , Goletiani Natia

Overview: Numerous epidemiological studies have demonstrated that low testosterone levels are linked to poor life quality and sexual quality, and that hypoestrogenic hypogonadism in obese male patients is connected with and predicts the development of metabolic syndrome and type 2 diabetes in the future. The purpose of the study was to demonstrate how aromatase inhibitors affected anthropometric traits, HOMA-IR, blood pressure, glycosylated hemoglobin level, and dyslipidemia i...

ea0099ep873 | Reproductive and Developmental Endocrinology | ECE2024

Complications of hysteroscopic surgery in gynecology: analysis of frequency and risk factors following 2,650 operations at a single institution

Dong Chae Hee

Objective: To determine the frequency of complications after hysteroscopic surgery and to analyze the risk factors associated with these complications.Materials and Methods: We retrospectively analyzed outcomes in 2,650 patients who underwent hysteroscopic surgery at Asan Medical Center between January 1996 and September 2023.Results: Indications for hysteroscopic surgery included submucosal myoma on ultrasonography in 910 patients...

ea0099ep874 | Reproductive and Developmental Endocrinology | ECE2024

The effect of hyperprolactinemia on the hormonal profile of women with recurrent miscarriage

Mukhammedaminova Diyora , Sadrieva Sevara , Nasirova Khurshidakhon

Introduction: Hyperprolactinemia is characterized by persistently elevated levels of prolactin in the blood serum, with its most common manifestation being a disruption of the reproductive system. Hyperprolactinemia contributes to inadequate endometrial preparation for pregnancy, insufficient implantation of the fertilized egg, and may also exert pathological effects on the production of gonadotropin hormones.Objective: To investigate the hormonal status...

ea0099ep875 | Reproductive and Developmental Endocrinology | ECE2024

Prevalence of polycystic ovary syndrome and infertility in hidradenitis suppurativa

Cherif Malek , Chaabouni Rim , Hammami Fatma , Mouhaymen Missaoui Abdel , Sellami Khadija , Rekik Nabila , Turki Hamida

Introduction & Objective: Hidradenitis suppurativa (HS) is an inflammatory skin condition which predominantly affects women of childbearing age. Various metabolic and endocrine comorbidities can be associated with HS. The aim of this study was to evaluate the association of HS with male and female infertility.Materials and Methods: We conducted a retrospective study between January 2012 and December 2022 enrolling all cases of HS in our dermatology d...

ea0099ep876 | Reproductive and Developmental Endocrinology | ECE2024

Correlating adiposity with metabolic disturbances in PCOS patients: a single-centre retrospective study

Thadani Puja , Leca Bianca , Khan Uzma , Bate Danielle , Davasgaium Allan , Mattu Rajan , S. Randeva Harpal

Introduction: Polycystic Ovary Syndrome (PCOS) affects 5-10% of childbearing females and, up to 20% in specific ethnic populations (i.e. South Asians and Hispanics). It is linked with a higher prevalence of obesity and metabolic dysfunction, resulting in increased risk for dyslipidaemia, impaired glucose tolerance, type 2 diabetes mellitus (T2DM) and cardiovascular diseases.Methods: This is a retrospective study of patients diagnosed with PCOS (n</em...

ea0099ep901 | Reproductive and Developmental Endocrinology | ECE2024

Successful testicular descent induced by gonadotropin replacement therapy in young men with congenital hypogonadotropic hypogonadism

Soon Swee Du , Yew Jielin

Congenital hypogonadotropic hypogonadism is a rare reproductive disorder characterised by isolated deficiency in the secretion or action of gonadotropin-releasing hormone (GnRH). Diminished GnRH activity in the immediate postnatal months, a period known as minipuberty, has severe consequences on the ontogenesis of male reproductive tract. Affected infant boys may present with micropenis and cryptorchidism. Rarely, adolescents with CHH present with delayed puberty in associatio...

ea0099ep911 | Reproductive and Developmental Endocrinology | ECE2024

Reference ranges of total testosterone in eastern algerian men

Kendri Sara , Zouai Sarra , Amara Korba Anis , Djabi Farida

Reference ranges are the most common decision support tool used for results interpretation and so a very relevant part of the laboratory report. Their use has become increasingly prevalent in clinical practice. A low serum testosterone (T) level in combination with clinical signs and symptoms are required for hypogonadism diagnosis. The goal of this research was to establish the reference intervals of total testosterone (TT) from healthy adult males. The study sample consisted...

ea0099ep931 | Reproductive and Developmental Endocrinology | ECE2024

Two sides of the same coin: infertile couple

Moravcikova Elena , Urbankova Helena , Vanuga Peter , Kulich Michal

Introduction: Our case is a young couple, both endocrinologically monitored from childhood. Woman with diagnosis of oligomenorrhea – secondary amenorrhea. Man with delayed puberty. After complex endocrinological screening both diagnoses was changed to: woman diagnosed with prolactinoma and man with isolated idiopathic central hypogonadism (IICH). They were trying to concieve for 10 years with no succes.Case: Woman: At 17 years of age diagno...

ea0099ep943 | Reproductive and Developmental Endocrinology | ECE2024

Implications of x-linked adrenoleukodystrophy in different family members

Tonkic Luciana , Miličević Milardović Tanja , Novak Anela

Adrenoleukodystrophy (ALD) is a monogenic, X-linked hereditary disorder. Mutation in the ABCD1 gene results in the adrenoleukodystrophy protein (ALDP) deficiency which is involved in the intracellular transport and metabolism of very long-chain fatty acids (VLCFAs). Consequently, VLCFAs accumulate in the central and peripheral nervous systems and adrenal glands leading to the destruction of affected tissues and specific symptoms and signs. There are four distinct types of ALD ...

ea0099ep964 | Reproductive and Developmental Endocrinology | ECE2024

Unusual PCOS presentation and/or functional amenorrhea

Shehu Tea

Introduction: Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder traditionally classified into four phenotypes. A recently proposed hyper-/hypoandrogenic phenotype (HH-PCOS) falling under the D phenotype introduces additional complexity, emphasizing the spectrum of androgenic manifestations within this heterogeneous syndrome. This case report focuses on the complexities associated with PCOS diagnosis, particularly in the context of unconventional presentatio...

ea0099ep975 | Reproductive and Developmental Endocrinology | ECE2024

Male hypogonadism: an often overlooked consequence of substance use

Blesneac Ilona-Beatrice , Nita Diana , Tarcau Otilia-Andreea , Larisa Robu , Rosu Andreea , Matei Anca , Florescu Alexandru , Preda Cristina

Introduction: Western countries present a gradual decline in male reproductive function. The decline in testosterone levels and sperm production witnessed over the past five decades, has been ascribed to environmental factors and unhealthy behaviors. Substance and drug usage is recognized as a detrimental lifestyle choice, that can interfere with the processes of steroidogenesis and spermatogenesis. Hypogonadism due to substance and drug abuse can be reversible.<p class="a...

ea0099ep977 | Reproductive and Developmental Endocrinology | ECE2024

Genetics of the y chromosome in male infertility

Frikha Hamdi , Dhieb Nesrine , Maalej Souhir , Boujelben Khouloud , Ben Salah Dhoha , Haj Kacem Akid Faten , Mnif Fatma , Charfi Nadia , Mnif Mouna , Elleuch Mouna , Abid Mohamed , Rekik Majdoub Nabila

Introduction: Couple’s infertility is a major public health problem. Its prevalence is estimated at 15%. In half of the cases, this infertility is of male origin. Different etiologies may be involved, among which genetic abnormalities of the Y chromosome. In this context, we report the cases of two patients with a structural abnormality of the Y chromosome responsible for the abnormalities of spermatogenesisCase Description: The first 26-year-old ca...

ea0099ep996 | Reproductive and Developmental Endocrinology | ECE2024

Diagnosis of hyperandrogenism-insulin resistance-acanthosis nigricans syndrome during transition: a case report

Lassoued Najoua , Yassmine Elloumi , Baha Zantour , Wafa Alaya , Habib Sfar

Background: HAIR-AN, a syndrome of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN), is a specific subphenotype of polycystic ovary syndrome, and it is seen in almost 5% of all women with hyperandrogenism. We report the case of a HAIR-AN which posed a diagnostic challenge in a 16-year-old girl.Case Presentation: A 16-year-old girl was referred by her pediatrician to the Endocrinology Department for exploration of primary ameno...

ea0099ep999 | Reproductive and Developmental Endocrinology | ECE2024

Predictors of quality of life according to nationality in patients with polycystic ovary syndrome: a multinational cross-sectional study

Mouna Elleuch , Yesmine Elloumi , Salah Dhoha Ben , Khouloud Boujelben , Zeineb Krichen , Roua Ellouze , Fatma Mnif , Mouna Mnif , Kacem Faten Hadj , Nadia Charfi , Mohamed Abid , Majdoub Nabila Rekik

Background and Aims: Polycystic ovary syndrome (PCOS) may be the most common endocrine disorder in women of reproductive age. The Rotterdam criteria are the most accepted criteria for its diagnosis. The aim of this study is to study the predictors of quality of life in patients with PCOS according to nationality.Methods: A cross-sectional study involved 172 women, 101 of them Tunisian and 71 French. Data collection was based on telephone interviews with ...

ea0099ep1000 | Reproductive and Developmental Endocrinology | ECE2024

Impact of PCOS phenotypes on quality of life: insights from a serbian pilot study

Opalic Palibrk Milica , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Bjekic Macut Jelica , Elezovic Kovacevic Valentina , Radic Lena , Krstic Katarina , Livadas Sarantis , Mastorakos George , Macut Djuro

Introduction: Polycystic Ovary Syndrome (PCOS) stands out as the most prevalent endocrine disorder affecting women during their reproductive years. Diagnosis typically relies on the ESHRE/ASRM criteria, necessitating the presence of at least two of three criteria: anovulatory dysfunction (ANOV), hyperandrogenism (HA), and morphologically polycystic ovaries visualized through ultrasound (PCOM). Using these criteria, patients can be classified into four phenotypes: PCOS-A (HA+AN...

ea0099ep1002 | Reproductive and Developmental Endocrinology | ECE2024

Lipid profile in women with PCOS and their phenotypes

Radic Lena , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Bjekic Macut Jelica , Elezovic Kovacevic Valentina , Opalic Palibrk Milica , Krstic Katarina , Hrncic Dragan , Vojnovic Milutinovic Danijela , Macut Djuro

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance, dyslipidaemia and hyperandrogenism. The aim of the research was to analyse lipid profile in women with PCOS and their phenotypes.Subjects and methods: We evaluated 159 women with PCOS diagnosed using ESHRE/ASRM criteria (PCOS: age: 25.85&pm;5....

ea0099ep1009 | Reproductive and Developmental Endocrinology | ECE2024

Female sexual function in pregnancy: impact of gluco-metabolic profile, vitamin D status and chronotype

Scairati Roberta , Simona Auriemma Renata , Graziadio Chiara , Del Vecchio Guendalina , Verde Nunzia , Muscogiuri Giovanna , Di Spiezio Attilio , Colao Annamaria , Pivonello Rosario

Rationale: The gluco-metabolic changes during pregnancy significantly impact women’s sexual behavior. This study aimed to define the relationship between metabolic health and sexual function, along with human circadian rhythms and sleep quality during pregnancy.Methods: This study included 57 pregnant women (14 evaluated at first trimester, G1; 18 at second trimester, G2, and 25 at third trimester, G3). Among groups, no difference between age, gesta...

ea0099ep1018 | Reproductive and Developmental Endocrinology | ECE2024

Autoimmune Hashimoto’s thyroiditis in polycystic ovary syndrome

Kostoglou-Athanassiou Ifigenia , Ziambara Eleni , Samaras Charilaos

In patients with polycystic ovary syndrome (PCOS) a high prevalence of autoimmune Hashimoto’s thyroiditis has been consistently observed. Young female patients present with menstrual and reproductive disorders as well as weight gain. The aim was to present a cohort of patients with PCOS who underwent thyroid function tests and in some of whom autoimmune Hashimoto’s thyroiditis was diagnosed. A cohort of 20 female patients aged 17-34 years is described. Patients prese...

ea0099ep1109 | Reproductive and Developmental Endocrinology | ECE2024

A case of missing testicles in a transgender woman - assessment, diagnostic and treatment opportunities

Madalina Cristian Ioana , Andreea Balint Bianca , Petrescu Catalina , Mazilu Adina

Introduction: Transgender – a common widely spread term that describes people whose gender identity does not match the sex they were assigned at birth. Transgender subjects may undergo various interventions, such as hormone therapy or gender-affirming surgeries to align their physical appearance with their gender identity.Case report: A 49 year old biologicaly male who declaratively feels like a woman since childhood, who underwent all mandatory psy...

ea0099ep1124 | Reproductive and Developmental Endocrinology | ECE2024

Mental state dynamics during perimenopause in women undergone IVF procedures

Mironova Desimira , Azis Violeta

This poster delves into the nuanced realm of mental state dynamics during the perimenopausal phase in women who have undergone In Vitro Fertilization (IVF). Recognizing the perimenopausal period as a time marked by diverse emotional and physiological changes, our study places a primary focus on understanding the psychoemotional experiences in this specific cohort.Methods: A comprehensive examination of mental state dynamics was conducted, utilizing surve...

ea0099ep1125 | Reproductive and Developmental Endocrinology | ECE2024

Induced lactation in an adoptive mother: a case report

Adel Meriem , Chiboub Marwa , Hadj Sliman Chayma Bel , Kandara Hajer , Jemel Manel , Kammoun Ines

Introduction: Over the last twenty years, infertility has continued to rise. According to the WHO, the global incidence of infertility is 17.5%. Adoption is the legal process of achieving parenthood without birth. Since breastfeeding has many nutritional and psychological benefits, induced lactation, the initiation of lactation in a person who has not given birth, may be of interest to some families. We report a case of nonpuerperal induced lactation in a woman.<p class="a...

ea0099ep1126 | Reproductive and Developmental Endocrinology | ECE2024

The effects of supplementing myo-inositol plus α-lactalbumin on reproductive and metabolic abnormalities in PCOS

Velija Asimi Zelija , Zujovic Ajanovic Aida

Objective: The open-label clinical study aimed to evaluate the effects of myo-inositol plus alpha-lactalbumin in PCOS women. Alpha-lactalbumin was used being effective in increasing myo-inositol intestinal absorption. This effect is very useful in greatly reducing the therapeutic failure of myo-inositol in some patients (inositol resistant subjects).Patients and methods: The study involved 36 normal weight, overweight or obese patients aged 18 to 40 year...

ea0099ep1131 | Reproductive and Developmental Endocrinology | ECE2024

Bardet-Biedl syndrome with hypokalaemia paralysis: case report

El Haddad Hemmet , Abou Farha Manal , Sameh Ihab , Fayed Ahmed , Ezzat Asma , Salam Randa , Abdalla Alaa , Ihab Sara , Essam Haader , Khaled Rodina

Introduction: Bardet–Biedl syndrome is a rare autosomal recessive disorder with a wide range of clinical features. The primary clinical features include rod-cone dystrophy, postaxial polydactyly, central obesity, cognitive impairment, male hypogonadism and renal dysfunction.Case report: 22 Year old male, mentaly retarded with Bardet Biedle syndrome presented to our ER with vomiting and generalized weakness for 1 week. There was no history of fever, ...

ea0099ep1178 | Reproductive and Developmental Endocrinology | ECE2024

Ovarian hyperthecosis vs androgen producing tumour: A challenging and unusual case

Al-Samaraaie Elaf , Basavaraju Navya , Mari Cherrylene , Moulik Probal

Introduction: Nearly 10% of all women have experienced hirsutism with hyperandrogenism at some stage in their life. Endogenous sources of androgen excess include ovarian tumours, ovarian hyperthecosis, and adrenal tumors. We present a case highlighting the work-up of hyperandrogenism.Case report: A 47-year-old female, with background of type 2 diabetes, hypertension, polycystic ovarian syndrome (PCOS), obesity, was noted to have significant androgenisati...

ea0099ep1189 | Reproductive and Developmental Endocrinology | ECE2024

Precocious puberty: etiology and treatement

Zahra Najioui Fatima , Imane Rami , Zahra Zerrouki Fatima , Yagoubi Latifa , Rouf Siham , Latrech Hanane

Introduction: Precocious puberty results from the premature activation of the gonadal axis. It mimics physiological pubertal development, although at an inappropriate chronological age (before 8 years in girls and 9 years in boys). It is a serious challenge with repercussions on physical and psychosocial development. We aimed to evaluate the different etiology of Precocious puberty and the effectiveness of the Gonadotropin-releasing hormone (GnRH ) agonists.<p class="abste...