Endocrine Abstracts

Background and aims: The long-acting somatostatin analogs represent are nowadays the first-line medical treatment of acromegaly. To assess the efficacy and tolerability of lanreotide-SR (LSR) in the treatment of active acromegaly.Subjects and methods: Eleven patients (2 men and 9 women; aged 27–75 years, median 47.4 years) were treated in whom active acromegaly with during disease from 1 to 34 years. All patients had the macroadenoma of hypophysis i...

Glycogen storage disease type 1b is a metabolic disorder resulting in an inability to shuttle glucose-6-phosphate across the sarcoplasmic/endoplasmic reticulum (SR/ER) lumen. Mutation of the SoLute Carrier 37a4 (slc37a4) or glucose-6-phosphate transporter (G6PT) gene responsible for the distribution of G-6-P across this membrane leads to, hypoglycemia, hepatic glycogen accumulation, hyperlipidemia, resulting in life-limiting outcomes including growth retardation and neutropeni...

Adrenal-derived glucocorticoids originate from their precursor cholesterol. Scavenger receptor BI (SR-BI) is a major high-density lipoprotein (HDL) receptor that mediates the selective uptake of cholesteryl esters (CE) from this lipoprotein in the circulation. In our present studies in SR-BI knockout (KO) mice and human carriers of a functional mutation in the extracellular domain of SR-BI (P297S), we determined whether SR-BI-mediated uptake of HDL-CE is required for adrenal g...

Central precocious puberty (CPP) is a common and well-recognised condition characterised by premature activation of the hypothalamic-pituitary-gonadal axis, with consequent potential adverse health and psychosocial outcomes. Standard management of CPP is with periodic injections of gonadotropin-releasing hormone analogue therapy. Decapeptyl SR (Triptorelin pamoate) has for several years been available as a long-acting (12-weekly, 11.25 mg) preparation, but more recently is ava...

Background: TPTD treatment has been shown to reduce vertebral and non-vertebral fracture risk in postmenopausal osteoporosis efficiently. However, gains in bone mass achieved by this treatment are almost lost 2 years after cessation of treatment, unless consecutively followed by an antiresorptive treatment such as alendronate.Subjects and methods: In the present prospective randomised open-labelled study in 52 pmp women, we investigated the effect of eit...

We undertook a retrospective audit of patients with primary hyperparathyroidism. Patients were identified from the Bradford Endocrine Database.About 101 patients were identified. 13 were incorrectly labelled and excluded. Case records of 88 patients; median age 64 (range 17–87) years, 69 F:19 M, were examined. At diagnosis median corrected calcium was 2.72 (range 2.45–3.69) mmol/l, median PTH 14 (range 3–182) pmol/l and mean 24 h urine cal...

Familial hypoparathyroidism is a rare condition. A family with seven affected individuals is described. Six sets of case notes were available for comparison. The most probable type of genetic transmission is autosomal dominant. There is also a family history of renal stones and ankylosing spondylitis.At diagnosis, adjusted calcium levels ranged between 1.77 and 1.92 mmol/L. PTH levels were either undetectable or in the low-normal range. Most cases were s...

Various proinflammatory cytokines have been demonstrated to be involved in insulin resistance and other obesity related diseases. Preadipocytes and adipocytes are likely to modulate inflammatory and immune processes by intrinsic mechanisms. Toll-like receptors (TLRs) which are – together with CD14 – involved in the innate immunity and are able to recognize microbial components. Microbial components and immunosuppressive drugs modulate the cytokine expression. We addr...

A 31-year-old German lady attended A&E with a 1 week history of bilateral leg swelling. The leg swelling had been gradual in onset and was not associated with shortness of breath, chest pain or haemoptysis. She had no history of renal or cardiac disease. Her only past medical history was of mild indigestion. She did not have any regular medication use. On examination she was systemically well but had bilateral pitting lower limb oedema. Blood pressure was 120/80 mmHg (comp...

A 72 year old, non-diabetic, woman was referred with recurrent severe hypoglycaemia. Twenty-one years ago she was investigated for hypoglycaemia when inappropriate hyperinsulinaemia had been confirmed. Although a CT of her abdomen could not demonstrate an insulinoma she underwent a distal pancreatectomy and subsequent histology showed islet cell hyperplasia. She was managed with dietary intervention and diazoxide. At the time of the current referral she was suffering daily sev...