Endocrine Abstracts

Background: Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with poor prognosis and very limited treatment options in advanced disease. The only curative approach is complete surgical resection. Additionally, 60% of patients show endogenous glucocorticoid (GC) excess with clinical apparent hypercortisolism and low to no immune cell infiltration. To date, no therapeutically relevant surface markers are known for ACC, which is why it has not been con...

Psychological symptoms including aggression, confusion, irritation, anxiety and depression have been observed clinically in patients with carcinoid syndrome. It has been suggested that vasoactive-hormone secretion is involved in provoking psychological symptoms. The objective of this qualitative study is to explore the presence and experience of specific psychological symptoms in carcinoid syndrome. Nine patients with carcinoid syndrome and psychological issues currently or wi...

Puberty is a major event in human development that impacts the individual, the family and society in general, but with exception of its endocrinology the fundamental biology underlying the process is poorly understood. Puberty is the result of the complete activation of the pituitary-gonadal axis that, in man, is triggered by re-augmentation of pulsatile hypothalamic GnRH release after approximately a decade of pre-pubertal development during which time this mode of neuropepti...

Puberty is a major event in human development that impacts the individual, the family and society in general, but with exception of its endocrinology the fundamental biology underlying the process is poorly understood. Puberty is the result of the complete activation of the pituitary-gonadal axis that, in man, is triggered by re-augmentation of pulsatile hypothalamic GnRH release after approximately a decade of pre-pubertal development during which time this mode of neuropepti...

Palaeopathology is the study of disease in human remains, most often, skeletal remains. The discipline serves a number of functions, from noting the first appearance of a particular disease, to studying trends in the prevalence of disease over time and space. Joint disease and dental disease are by far the most common disorders found in the skeleton, but examples of infectious disease, malignant disease, and cardio-vascular disease may also be found, and so are many examples o...

Abstract unavailable....

The first barrier to overcome in engaging your audience is in writing an abstract that motivates delegates to attend your presentation; if abstracts don’t pass the ‘so what’ test, you’ll face an uphill battle. Once you have attracted an audience, ensure that they can follow your presentation and leave with a clear take home message. There are two common considerations in writing your abstract and planning your presentation. Firstly, make sure you focus on y...

79 year old male had been admitted due to multiple falls within a space of 24 hours. On admission, he had a full set of bloods which showed hypercalcaemia and no other significant abnormality. His past medical history included Prostate Cancer, Type 2 Diabetes and Urinary retention for which he had a long-term catheter in situ. His current medications were Linagliptin, Apixaban, Bicalutamide and simple analgesia. Initially, he was fluid resuscitated, which seemed to im...

Introduction: Obese adults of South Asian origin in the UK are considered to be obese at a BMI of 27.5 kg/M2 compared with 30 kg/m2 for other groups and are at increased risk of obesity related disorders such as type 2 diabetes. From July 2021, GPs have been offered financial incentives for referral of adults to weight management services. However no provision or adjustments have been made for children and young people especially those of South Asian orig...

Very early in the Covid-19 pandemic it became clear that diabetes was a highly significant comorbidity with an increased risk of mortality in adults of up to 3.5 fold. At the same time, anecdotes started to circulate of an apparent unseasonal increase in incidence and severity of DKA in children and young people presenting with type 1 diabetes [T1DM]. In order to examine this further, the characteristics of children presenting with T1DM from January to July 2020 in North East ...