Endocrine Abstracts

Background: Increased life expectancy and wider availability of neuroimaging lead to increase in diagnosis of acromegaly in elderly patients, after the age of 70. Delay in diagnosis is attributable to milder symptomatology, higher prevalence of comorbidities and symptoms overlapping with normal aging process.Objective: To investigate clinical characteristics, presenting symptoms, comorbidities and treatment modalities of acromegaly in patients diagnosed ...

Background: A subset of patients with prolactinomas does not respond satisfactorily to first-line medical therapy with dopamine agonists (DA). DA resistance is defined as failure to normalize prolactin (PRL) levels and/or to achieve ≥50% reduction in maximal tumor diameter under maximally tolerated doses (or a weekly cabergoline dose of ≥3mg). The predictive factors for DA resistance are male gender and tumor invasiveness.Aim: To characterize...

Introduction: Considering the mitogenic potential of GH and IGF1, the safety profile of growth hormone therapy since the beginning of its use has been debated. From that point of view, adolescents in transition to adulthood who were treated in childhood for endocranial tumors or malignancies require special caution.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study spanning 18 years, we analyzed 251 childhood onset...

Background: Autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive, monogenic disease, that could be presented as a group of various symptoms, but clinical diagnosis requires existence of minimum two of three leading disorders: chronic mucocutaneous candidiasis, hypoparathyroidism, and primary adrenocortical insufficiency.Case Presentation: We report the clinical cases of two siblings with APS-1, one 28-year-old male and one 25-ye...

Background: Hyperemesis gravidarum is a rare condition with multiple causes. Diagnosis is based on clinical examination and measurement of urine ketones, serum electrolytes, and renal function. Hyperparathyroidism during pregnancy can rarely be manifested with clinical presentation of hyperemesis gravidarum with substantial maternal and fetal complications. In most cases adequate hydration, with or without forced diuresis, as well as with low calcium content diet is treatment ...

Background: Hypopituitarism is a rare clinical condition which can present as partial or complete absence of pituitary hormones. The most common cause is a sellar or parasellar mass, particularly tumour, and the golden standard for differential diagnosis is magnetic resonance imaging. Intrasellar aneurysm is an unusual cause of hypopituitarism with an estimated incidence of 0,17% of cases.Case presentation: We report a case of a 72-year-old male who was ...

Introduction: The incidence of thyroid nodules is increasing. Fine-needle aspiration (FNA) of all thyroid nodules is unnecessary, but it is necessary to provide a more precise identification of those nodules that are potentially malignant in nature. In the literature there are several suggested systems for assessing malignancy of nodules in the thyroid gland.Objective: To determine the differences between EU and ACR TIRADS recommendation for fine-needle ...

Introduction: The impairment of liver function and enhancement for NAFLD development may be attributed to the ubiquitous exposure to endocrine disrupting chemicals such as phthalates. In this study the urinary levels of monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) were compared with the parameters of hepatic function and lipids in overweight, diabetic patients and normal weight population.Methods and patients: In 305 volunteers of b...

Introduction: The coexistence of primary hyperparathyroidism with autoimmune diseases is described very rarely in the literature so far. There are only few cases of immune-mediated hyperparathyroidism, associated with anti-calcium- sensing receptor autoantibodies, frequently in context with other immune diseases. Spontaneous remission of primary hyperparathyroidism in anti-TNF therapy of psoriatic arthritis has also been described in one case. Prevalence of positive antithyroi...