Searchable abstracts of presentations at key conferences in endocrinology

ea0095p19 | Diabetes 1 | BSPED2023

Improved glycaemic control with insulin hybrid closed-loop system

Lee Shien Chen , Brown Katie , Muniu Susan , Mccrea Kathryn

Introduction: Hybrid closed-loop system (HCS) in Type 1 diabetes (T1D) management uses an automated algorithm to adjust basal insulin and administer correction doses to maintain glucose homeostasis. We have more children with HbA1c <58 mmol/mol. We aim to investigate if HCS contributed to this improvement.Methods: We identified TID children who started on HCS in our hospital from the year 2019–2023. Our HCS are ...

ea0101ps1-05-02 | Clinical thyroid cancer research-1 | ETA2024

Serum anti-thyroglobulin antibody levels following total thyroidectomy are related to the recurrence of papillary thyroid carcinoma

Jung Jeong Ho , Sang Lee Yong , Chang Hang-Seok

Backgroud: Thyroid cancer, particularly papillary thyroid carcinoma (PTC), is globally on the rise, driven by increased incidental findings. PTC treatment boasts a commendable 93% 10-year survival rate, yet up to 28% of patients experience locoregional recurrences. Serum thyroglobulin (Tg) serves as a vital marker in post-operative surveillance for differentiated thyroid cancer (DTC). Anti-thyroglobulin antibodies (TgAb) play a crucial role in Tg interpretation, with their int...

ea0101ps2-15-05 | Translational thyroid cancer research-1 | ETA2024

BRAF mutation is associated with tumor volume doubling time of thyroid microcarcinoma during active surveillance

Kim Jinyoung , Kyoung Lee Min , Baek Ki-Hyun

Introduction: Active surveillance (AS) is proposed as an option for the treatment of papillary thyroid microcarcinoma (PTMC), considering the indolent nature of papillary thyroid cancer. However, ongoing discussions are needed regarding the selection of target patients and long-term safety.Methods: We enrolled patients who delayed surgery for more than one year after being diagnosed with PTMC from 2014 to 2021 at a single center, and they followed until ...

ea0101ps3-22-03 | Diagnosis of thyroid cancer-2 | ETA2024

Cost-effectiveness of diagnosis by ultrasound for asymptomatic thyroid cancer in south korea

Jung Jeong Ho , Sang Lee Yong , Chang Hang-Seok

Background: Thyroid cancer can be detected in early stage using ultrasonography, but there are also questions about the necessity of screening tests due to its relatively high survival and low recurrence rate compared to other cancers. In this study, a cost-effectiveness analysis of thyroid cancer was conducted for better patient selection with cases diagnosed by ultrasound, as well as cases diagnosed through the presence of symptoms.Methods: For the ana...

ea0101ps3-24-01 | Translational thyroid cancer research-2 | ETA2024

HIF-1α inhibitors could successfully inhibit the progression of differentiated thyroid cancer

Lee Peter , Min Jeong Seung , Jin Jun-O

Hypoxia-inducible factor (HIF)-1α plays an important role in cancer progression. In various cancers, including thyroid cancer, overexpression of HIF-1α is related to poor prognosis or treatment response. However, few studies have investigated the role of HIF-1α inhibition in thyroid cancer progression. We evaluated the utility of the HIF-1α inhibitor IDF-11774 in vitro utilizing two thyroid cancer cell lines, K1 and BCPAP. Both cell lines were test...

ea0041gp85 | Diabetes (1) | ECE2016

Impaired RBC deformability is associated with pancreatic beta cell dysfunction and diabetic retinopathy in patients with type 2 diabetes

Sung Yoon Ji , Jin Kim Ho , Sung Moon Jun , Eun Lee Ji , Chang Won Kyu , Woo Lee Hyoung

Red blood cell (RBC) deformability is an ability of RBC to change shape under stress, and it has been known to be decreased in diabetes. However, the role of RBC deformability is not determined in type 2 diabetes (T2D) yet. We attempted to clarify whether RBC deformability is related with diabetic complications. This was a cross-sectional study, and 452 T2D patients were enrolled. RBC deformability was measured by using a microfluidic ektacytometer, Rheoscan-D (Rheo-Meditech, ...

ea0041ep644 | Endocrine tumours and neoplasia | ECE2016

A case of recurred parathyroid carcinoma with multiple lymph node metastasis: concurrent with papillary thyroid cancer

Woo Lee Hyoung , Jin Kim Ho , Sung Moon Jun , Sung Yoon Ji , Chang Won Kyu , Eun Lee Ji

Parathyroid carcinoma, a rare endocrine malignancy, accounting for only 1–2% of patients with primary hyperparathyroidism (HPT). In addition, a few case have been reported coexistence of parathyroid carcinoma and papillary thyroid cancer. Here, we present a case of recurred parathyroid cancer with multiple lymph node metastasis. A 57-year-old women was presented with high serum calcium level (14.4 mg/dl) in medical check-up. Hyperparathyroidism was considered to be the re...

ea0037ep1327 | Clinical Cases–Thyroid/Other | ECE2015

A case of multiple gas-forming pyogenic liver abscesses in diabetic patient

Lee Hyoung Woo , Kim Ho Jin , Lee Jun Ho , Moon Jun Sung , Yoon Ji Sung , Won Kyu Chang

Background: Gas-forming pyogenic liver abscess is an uncommon, life-threatening infection that is usually found in poorly-controlled diabetic patients. Here, we experienced a case of gas-forming pyogenic liver abscess in diabetes caused by Klebsiella pneumoniae.Clinical case: A 77-year-old man with 25-year history of diabetes was admitted due to fever for 2 days. On the physical examination, right upper quadrant tenderness of the abdomen was present. Ini...

ea0032p252 | Clinical case reports – Pituitary/Adrenal | ECE2013

Non-Hodgkin’s lymphoma presenting as anterior hypopituitarism

Lee Shang Ming Samuel , Abel Chen Weiliang , Gabriel Cher Liu Yuan , Lee Wei Feng , Seow Cherng Jye , Kon YC

Introduction: Panhypopituitarism is a known but rare presentation of lymphoproliferative disease. We describe a patient with newly diagnosed advanced diffuse large B-cell lymphoma who presented with anterior hypopituitarism and concomitant adrenal gland involvement.Case report: A 72 year-old Chinese woman presented with a few weeks’ duration of lethargy, weight loss and functional decline. A hormonal screen done at admission suggested central hypoth...

ea0032p260 | Clinical case reports – Pituitary/Adrenal | ECE2013

Therapeutic dilemmas in a young male patient with macroprolactinoma complicated by hypogonadism

Lee Wei Feng , Cher Liu Yuan Gabriel , Lee Shang Ming Samuel , Chen Weiliang Abel , Seow Cherng Jye , Hoi Wai Han

Introduction: Hypogonadism is known to persist after treatment of hyperprolactinemia, necessitating androgen therapy in young male patients. Aromatisation of testosterone to estradiol can result in tumor expansion. We report a patient with persistent hypogonadism post treatment of macroprolactinoma and discuss challenges involved in the management.Case report: A 51-year-old gentleman was admitted for streptococcal meningitis. Brain imaging revealed a pit...