Searchable abstracts of presentations at key conferences in endocrinology

ea0032p73 | Bone and Osteoporosis | ECE2013

Cross-correlation of circulating sclerostin over 24 h to PTH, phosphate and bone markers in healthy young men

Shankarnarayan Santosh H , Ahluwalia Rupa , Hamilton Amanda , Barraclough Dong Liu , Fraser William D , Vora Jiten P

Introduction: Osteotropic hormones demonstrate circadian rhythms which are integral to bone homeostasis. Sclerostin is a physiological inhibitor of bone formation. We have established that Sclerostin has a distinct circadian rhythm with a nocturnal peak. Analysis was performed to determine the relationship of Sclerostin levels to PTH, Calcium, Phosphate, βCTX and P1NP in healthy young men.Methods: Six healthy young men with normal BMD were admitted ...

ea0030p29 | (1) | BSPED2012

Should we check vitamin D status at time of diagnosis of type 1 diabetes mellitus?

Smith J P , Crowne E , Hamilton-Shield J P H , Burren C

Physiology shows vitamin D has a role in the immune system and glucose metabolism. Experimental and epidemiological studies demonstrate associations between type 1 diabetes mellitus (T1DM) and vitamin D levels. Vitamin D deficiency appears undesirable in T1DM, although its significance in aetiology and progression is controversial.We reviewed the outcome of implementing vitamin D screening at T1DM diagnosis. Methods were review of diabetes register, hosp...

ea0019p175 | Endocrine tumours and neoplasia | SFEBES2009

A patient with neurofibromatosis type-1 (NF1) presenting with multiple endocrine neoplasia (MEN)2B

Mon Aung , Malipatil Nagaraj , Sharma Dushyant , Aftab Rabia , Koay Yee , Whittingham Pauline , Hamilton Amanda , Vora Jiten

Background: NF1 and MEN2 are rare conditions known to associate with bilateral phaeochromochtomas. We describe, with relevant associated radiology, a NF1 patient developing a series of neuroendocrine tumours including bilateral phaeochromocytomas.Clinical case: A 39-year-old lady presented with long standing episodic abdominal pain, diarrhoea, palpitation and sweating. Past history includes first arch syndrome and NF1 at teens and total thyroidectomy for...

ea0015p14 | Bone | SFEBES2008

Effects of 6 months strontium ranelate administration on phosphocalcium metabolism in postmenopausal women with reduced bone density

Joshi AA , Ahmad AM , Whittingham P , Gupta V , Hamilton A , Durham BH , Fraser WD , Vora JP

Introduction: Strontium ranelate (SR) is a dual action bone agent that increases bone formation and reduces bone resorption. Previous long term studies with SR have demonstrated minimal reductions in parathyroid hormone (PTH) and adjusted calcium (ACa) levels with increase in phosphate (PO4) concentrations, but the exact mechanism of action of SR remains unclear. Postmenopausal women with low bone mineral density (BMD) have relatively high circulating PTH concentrat...

ea0007p46 | Diabetes, metabolism and cardiovascular | BES2004

Single nucleotide polymorphisms within oxidative stress genes affect arterial compliance: gene function relationships

Drummond R , Brosnan M , Tan C , Kirk A , Hamilton C , Connell J , Dominiczak A

Background and Hypothesis:- A common NOS3 Single nucleotide polymorphisms (SNP) (894 G/T) which encodes a Glu298Asp amino acid substitution in endothelial NO synthase has been associated with cardiovascular disorders in which NO bioactivity is impaired. The gene coding for p22phox, a critical component of the NADH/NAD(P)H oxidase enzyme system, a major source of vascular SO, is CYBA. Among the allelic polymorphisms reported in CYBA is C242T, associated wit...

ea0005oc14 | Cardiovascular Endocrinology | BES2003

A single nucleotide polymorphism in the p22phox gene affects arterial compliance

Drummond R , Brosnan M , Lee W , Kirk A , Pathi V , Hamilton C , Dominiczak A

Increased superoxide(SO) production reduces nitric oxide(NO) bioactivity and increases oxidative stress contributing to endothelial dysfunction in vascular disease. The gene coding for p22phox, a critical component of the NADH/NAD(P)H oxidase enzyme system which produces vascular SO, is CYBA. Among the allelic polymorphisms reported in CYBA is C242T which is associated with progression of coronary atherosclerosis. Radial applanation tonometry with pulse waveform analysis (PWA)...

ea0002p53 | Growth and development | SFE2001

Insulin-like growth factor acts as a Nitric-oxide-dependant vasodilator in normotensive but not hypertensive rat aortas

McCallum R , Hamilton C , Graham D , Jardine E , Connell J , Dominiczak A

Insulin-like growth factor (IGF-1) has been postulated to function as a vasodilator via a nitric oxide (NO) pathway. IGF-1/growth hormone deficiency in humans is associated with endothelial dysfunction and increased cardiovascular mortality.We compared the effects of IGF-1 on vascular function in control Wistar-Kyoto (WKY) (n=6) and stroke-prone spontaneously hypertensive rats characterised by endothelial dysfunction (SHRSP) (n=7)....

ea0095oc6.3 | Oral Communications 6 | BSPED2023

Initial experiences of using the Paediatric Sleep Questionnaire (PSQ) to screen for obstructive sleep apnoea in a tier-3 paediatric weight management clinic

Hawton Katherine , Oakley Juliette , C Langton-Hewer Simon , Sharley Tasmin , Giri Dinesh , Hamilton-Shield Julian

Background: Obstructive sleep apnoea (OSA) is characterised by recurrent upper airway obstruction during sleep resulting in abnormal ventilation and sleep patterns. Paediatric obesity is associated with a significantly increased OSA risk. Prompt recognition and management of OSA is important to reduce the risk of complications, including cardiovascular, growth, behavioural and glycaemic. We describe initial experiences of using the Paediatric Sleep Questionnai...

ea0095p103 | Diabetes 3 | BSPED2023

Dietary intervention for the management of adolescent type 2 diabetes mellitus: A systematic review

Bhanot Alisha , Hawton Katherine , Perry Rachel , Hamilton-Shield Julian , Candler Toby

Introduction: Despite an increasing incidence of adolescent type 2 diabetes mellitus (T2DM) with its associated morbidities and poor long-term prognosis, there remains uncertainty in its management. The National Institute for Health and Clinical Excellence (NICE) currently recommends initial lifestyle modifications alongside pharmacology management with metformin. Despite being shown to be effective in adults, little is known about the impact of lifestyle inte...

ea0095p138 | Obesity 2 | BSPED2023

Genetics of early onset obesity: Initial data from a tier 3 paediatric weight management service

Hawton Katherine , Hickingbotham Hannah , Fitzgerald Amy , Hamilton-Shield Julian , Giri Dinesh

Introduction: A proportion of severe obesity is due to monogenic inheritance, however access to genetic testing is often limited which may underestimate prevalence. We report our data obtained via the Rare Obesity Advanced Diagnosis™ genetic testing program established to diagnose rare genetic causes of obesity.Methods: 49 patients (22 male) under the care of a tier 3 paediatric weight management service with early-...