Searchable abstracts of presentations at key conferences in endocrinology
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50th Annual Meeting of the British Society for Paediatric Endocrinology and Diabetes

Manchester, UK
08 Nov 2023 - 10 Nov 2023

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The 50th Annual BSPED Meeting will take place at the Midland Hotel, Manchester from 8-10 November 2023.

ea0095p137 | Obesity 2 | BSPED2023

Effects of daily glucocorticoid on body composition in Duchenne muscular dystrophy: Isolating fat mass increase to establish weight management interventions

Mcquillan Erin , Dunne J , Horrocks I , Mochrie R , Joseph S , Shepherd S , Wong SC

Background: Glucocorticoid (GC) therapy is the standard management for Duchenne Muscular Dystrophy (DMD), but its use is associated with significant side effects, including weight gain. Limited research exists on the impact of GC initiation on body composition in DMD, particularly regarding the timing of fat mass increase.Objective: This study aimed to assess changes in growth parameters, namely height-SDS, weight-SDS, b...

ea0095p138 | Obesity 2 | BSPED2023

Genetics of early onset obesity: Initial data from a tier 3 paediatric weight management service

Hawton Katherine , Hickingbotham Hannah , Fitzgerald Amy , Hamilton-Shield Julian , Giri Dinesh

Introduction: A proportion of severe obesity is due to monogenic inheritance, however access to genetic testing is often limited which may underestimate prevalence. We report our data obtained via the Rare Obesity Advanced Diagnosis™ genetic testing program established to diagnose rare genetic causes of obesity.Methods: 49 patients (22 male) under the care of a tier 3 paediatric weight management service with early-...

ea0095p139 | Obesity 2 | BSPED2023

The prevalence of monogenic obesity in Turkish children with non-syndromic early onset obesity. A multicenter study

Akıncı Ayşehan , Turkkahraman Doğa , Tekedereli İbrahim , Ozer Leyla , Evren, Bahri , Sahin Ibrahim , Kalkan Tarkan , Curek Yusuf , Camtosun Emine , Doger Esra , Bideci Aysun , Guven Ayla , Eren Erdal , Sangun Ozlem , Cayır Atilla , Bilir Pelin , Ergur Ayca Torel , Ercan Oya

Background: Objective: Non syndromic monogenic obesity is a rare cause of early onset severe obesity in the childhood period. This form may not be distinguishable from other forms of severe obesity without genetic analysis, particularly if patients do not exibit any physical abnormalities or developmental delay. The aim of this study was to screen 41 different obesity-related genes in children with nonsyndromic early onset severe obesity.<p class="abstext"...

ea0095p140 | Obesity 2 | BSPED2023

Evaluation of psychological and musculoskeletal outcomes in a tertiary weight management service at the Royal Manchester Children’s Hospital

Earnshaw Matthew , Skae Mars , Hughes Rhian , Tang Wing , Alim Salma

Background: Nearly a third of children aged 2–15 are overweight or obese (body mass index at or above 95th percentile) and children are becoming ‘obese’ at earlier ages and staying obese for longer. Obesity is linked to an array of medical conditions including hypertension, non-alcoholic fatty liver disease, and musculoskeletal pain and is associated with poor health-related quality of life (HRQoL) overall. Yet there is limited information on th...

ea0095p141 | Obesity 2 | BSPED2023

Continuous glucose monitoring highlights the limited effect of lifestyle intervention on early glycaemic dysregulation in CYP with severe obesity

Apperley Louise , Senniappan Senthil

Introduction: Childhood obesity is associated with complications, such as type 2 diabetes mellitus (T2DM). The use of continuous glucose monitoring (CGM) in diabetes mellitus is well established, but there is limited research evaluating the role of CGM in childhood obesity. The aim of this study was to investigate the use of CGM in identifying glycaemic dysregulation in children and young people (CYP) with obesity and the effect of lifestyle therapy.<p cla...

ea0095p142 | Obesity 2 | BSPED2023

Immune modulatory response to rituximab in ROHHAD syndrome

Hawton Katherine , Hogan Andrew , Hamilton-Shield Julian , Giri Dinesh

Background: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation (ROHHAD) is a rare syndrome associated with high morbidity. An immune-inflammatory aetiology has been postulated; however, the immune characteristics and effect of immunomodulation have not been well described.Case report: We describe the immune profile and the effect of rituximab on the immunomodulation potentially ca...

ea0095p143 | Obesity 2 | BSPED2023

Significantly higher prevalence of glycaemic dysregulation in CYP with severe obesity as identified using CGM despite normal OGTT

Apperley Louise , Parkinson Jennifer , Senniappan Senthil

Introduction: Childhood obesity is associated with complications, such as impaired glucose tolerance and type 2 diabetes mellitus. The gold standard investigation for diagnosing glycaemic alterations is an oral glucose tolerance test (OGTT). Continuous glucose monitors (CGM) are routinely used in the management of children and young people (CYP) with type 1 diabetes mellitus. The aim of our study is to investigate whether CGM is more effective in identifying g...

ea0095p144 | Obesity 2 | BSPED2023

The impact of socio-economic deprivation on the Complications from Excess weight; Insights from a Tier 3 weight management service

Clarke Ellie , Apperley Louise , Senniappan Senthil

Introduction: Socio-economic factors have a huge impact on children and young people’s (CYP) overall health status. The rates of childhood overweight and obesity continue to rise and the CYP from areas with higher social deprivation are adversely affected with higher rates of obesity. We report the link between socio-economic deprivation and complications from excess weight (CEW) in the CYP being managed in a tier 3 multi-disciplinary (MDT) weight managem...