Searchable abstracts of presentations at key conferences in endocrinology
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50th Annual Meeting of the British Society for Paediatric Endocrinology and Diabetes

Manchester, UK
08 Nov 2023 - 10 Nov 2023

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The 50th Annual BSPED Meeting will take place at the Midland Hotel, Manchester from 8-10 November 2023.

Poster Presentations

Pituitary and Growth 2

ea0095p145 | Pituitary and Growth 2 | BSPED2023

Pathways linking early growth to cardiometabolic disease risk development: Novel insights from the Manchester BabyGRO Study

Lui Chantel , Garner Terence , Stevens Adam , Higgins Lucy , Clayton Peter , Johnstone Edward , Perchard Reena

Background: Using small for gestational age (SGA) as a marker for fetal growth restriction (FGR), studies link an adverse intrauterine environment to cardiometabolic risk markers in childhood. Focusing on 3–6 year old children, where the majority were born following pregnancies at greater risk of suboptimal fetal growth (SFG) but only a minority were born SGA, cardiometabolic risk markers were measured and blood samples collected for metabolomic analysis....

ea0095p146 | Pituitary and Growth 2 | BSPED2023

Predictive value of a basal LH instead of an LHRH test in assessing pubertal suppression in children on GnRH agonist therapy

Easa Habab , Makaya Taffy

Background: Historically, a second LHRH stimulation test has been the gold standard test for the evaluation of biochemical evidence of pubertal suppression in patients with central precocious puberty (CPP) following commencement of GnRH analogue therapy. However, this test is time-consuming, costly, and uncomfortable for patients.Aims/objective: To analyse the validity of the basal LH level as a predictor to the peak LH ...

ea0095p147 | Pituitary and Growth 2 | BSPED2023

Testing a screening algorithm for the identification of growth-disorders for use in UK children

Orr Joanna , Thaventhiran Thilipan , Freer Joseph , Walton Robert , Morris Joan K , Dunkel Leo , Prendergast Andrew J. , Storr Helen L.

Background: Screening algorithms for the identification of growth-disorders are routinely used in several countries. In the UK, the use of the Coventry consensus for the referral of children with suspected growth-disorders performs poorly compared to more sophisticated screening mechanisms used elsewhere. We aimed to test an algorithm developed to screen for growth-disorders in 2- to 8-year-old UK children.Methods: The a...

ea0095p148 | Pituitary and Growth 2 | BSPED2023

An audit of the management of childhood-onset growth hormone deficiency (CO-GHD) at completion of linear growth

Gunasekara Buddhi , Adu-Gyamfi Kirpal , El-Khairi Ranna

Background: The main aim of growth hormone(GH) treatment during childhood is to attain optimal final height. As a young adult GH treatment is important to achieve optimal body composition (including peak bone mass), psychosocial development and to reduce metabolic and cardiovascular risks. At completion of linear growth (height velocity [HV] <2 cm/year), it is recommended that GH treatment should be discontinued, and GH status reassessed to determine the e...

ea0095p149 | Pituitary and Growth 2 | BSPED2023

Standard clinical diagnostic criteria for Silver–Russell Syndrome frequently overlooks monogenic causes

Palau Helena , Kurup Uttara , Ishida Miho , Maharaj Avinaash V , Davies Justin H. , Storr Helen L.

Background: A diagnosis Silver–Russell Syndrome (SRS) is important for early institution of appropriate management, access to therapy and reduces the burden of diagnostic uncertainty. SRS is molecularly heterogeneous and 11p15 LOM/upd(7)mat account for ~60% cases. Monogenic causes include variants in HMGA2, CDKN1C, IGF-2, PLAG1 and contribute to 5% cases. Clinical SRS diagnosis requires the fulfilment of ≥4/6 Netchine–Harbison Clinical Scoring ...

ea0095p150 | Pituitary and Growth 2 | BSPED2023

2 cases of congenital hypopituitarism due to pituitary stalk interruption syndrome (PSIS) diagnosed in the early infantile period

Sethuraman Chidambaram , Banerjee Kaushik , Kumarasamy Maitrayee

Introduction: PSIS is a rare congenital abnormality characterised by a triad of thin or interrupted pituitary stalk, small or absent anterior pituitary, and an absent or ectopic posterior pituitary gland. Incidence is around 0.5/100 000 births. Clinical presentation varies according to age. We herein describe two cases of PSIS diagnosed in the early infantile period.Case 1: A term female neonate born by emergency section...

ea0095p151 | Pituitary and Growth 2 | BSPED2023

Evaluation of etiology and clinical feature of precocious puberty among children presenting in a pediatric endocrinology department in a tertiary care hospital

Roshia Parveen , Versha Rani Rai , Mohsina Noor Ibrahim , Maira Riaz , Yasir Naqi Khan , Heeranand Rathore

Background: Precocious puberty is thought to occur in 1 in 5000–10 000 people. Precocious puberty is a neglected topic in Pakistan, and little research has been done so far to examine its aetiology in our population, despite its importance and relative prevalence. Objective: To find the frequency of precocious puberty in children and to compare the clinical and laboratory parameters of central and peripheral precocious puberty. M...

ea0095p152 | Pituitary and Growth 2 | BSPED2023

An unusual presentation of a giant prolactinoma

McKenna Martha , Heffernan Emmeline

Introduction: We report a patient with a giant prolactinoma due to Multiple Endocrine Neoplasia type 1 (MEN1) with consequential growth hormone deficiency and central hypothyroidism.Case report: A 12-year-old girl attended the genetic clinic, as her father had MEN-1 mutation. On questioning, she reported severe headaches, increasing in frequency over several months, with fatigue and hair loss. She had breast development ...