Endocrine Abstracts

Objective: Vitamin D deficiency has been shown to alter insulin synthesis and secretion in both humans and animal models. However, less is known on the association between vitamin D and type 2 diabetes mellitus. In the current study we aimed to analyze the relationship between vitamin D levels with glycemic control in type 2 diabetic patients.Material and methods: Three hundred and twenty diabetic patients who are follow up at least 6 months for diabetes...

Objective: The prevalence and incidence of diabetes mellitus (DM) are increasing at all ages, including older populations. Several studies have shown that elderly diabetics have impaired cognitive function compared to age-matched non-diabetics, as well as a higher risk of dementia. In the current study we aimed to analyze relationship between microalbuminuria and cognitive dysfunction in elderly patients with type 2 diabetes.Material and Methods: One hun...

Introduction: Anterior pituitary cells are characterised by functional lineages based on the expression pattern of transcription factors. Functional differentiation in the form of pituitary adenomas co-secreting ACTH and growth hormone is very rare. We report a case of multiple cell line pituitary adenoma resulting in acromegaly and ACTH dependent Cushing’s.Case: A 52-year-old woman of Ghanian origin (BMI of 57.5 kg/m2) presented with pro...

The VHL gene is a tumor suppressor gene located on chromosome 3p25.3. Mutations in this gene prevent production of the VHL protein and as a result, cells grow and divide uncontrollably to form the tumors and cysts. Germline VHL gene mutations predispose to a variety of tumors, most commonly retinal and cerebellar haemangioblastomas, renal cell carcinoma and phaeochromocytoma. Papillary cystadenomas of the epidididymis are seen in 10–26% of men are rarely...

A 60 year old Caucasian woman presented with a three month history of rapidly enlarging neck swelling and hoarseness of voice. Her past medical history included Hypothyroidism. Her neck ultrasound scans showed 3.5 cm left thyroid nodule with bilateral lymphadenopathy (U5). The Fine needle aspiration (FNA) revealed densely grouped variable sized irregular epithelial cells with nuclear atypia and spindle shaped fragments with focal areas of lymphocytic thyroiditis. The different...

Section 1: Case history: A 39-year-old Asian lady at 18 weeks of gestation, after in vitro fertilisation pregnancy, was found to have an adjusted calcium level of 3.08 (range 2.20-2.60 mmol/l) on routine blood tests. She was asymptomatic. Her Parathyroid hormone (PTH) was 14.1 (1.1-6.9pmol/l) and 25 hydroxy vitamin D 16 (15-174 nmol/l). She had insulin treated diabetes following an episode of pancreatitis for which no cause was identified. She was treated as an inpati...

Case History: 41-year-old female presented with a 3-day history of fever, cough, and breathlessness. She had palpitations, diarrhoea and weight loss of 4-5 kg over 1 month. Graves” disease had been diagnosed 5 years prior to this episode and she had been treated with carbimazole but was not in remission. On this occasion, she was febrile and had atrial fibrillation. She also had right pleural effusion and bilateral pedal oedema.Investigations: Blood...

Graves’ disease is one of the reversible causes of pulmonary hypertension (PAH). The association was first reported in 1980. Studies have suggested an elevated pulmonary artery systolic pressure in about 36% of patients with Graves’ disease by Doppler echocardiography. We report a case of Graves disease associated with pulmonary hypertension in a young female.Case report: A 41 year old female presented with history of worsening breathless and p...

Aim: Ghrelin plays an important role in the stimulation of food intake and long-term regulation of body weight. In present study we investigate the long term effect of exenatide treatment on serum fasting ghrelin levels in patients with type 2 diabetes mellitus.Methods: Type 2 diabetic patients who were using metformin with and without the other oral antihiperglycemic drugs on a stable dose for at least 3 months were enrolled in the study. Body mass inde...

Introduction: The involvement of certain organs such as the adrenal gland is rare in non-Hodgkin’s lymphoma (NHL). Although lymphomas can involve virtually all extranodal organs, different organs show different frequency of involvement. Adrenal gland involvement is usually bilateral. We report that a rare case of unilateral adrenal involvement of diffuse large B-cell lymphoma presenting with abdominal pain.Case: A 64-year-old-man presented with abdo...