Searchable abstracts of presentations at key conferences in endocrinology

ea0075m13 | Metabolic Bone | EYES2021

Hypoparathyroidism after total thyroidectomy in a woman who underwent to bariatric surgery: A case report

Maggio Ettore , Veleno Miriam , Rossi Laura , Novizio Roberto , Emanuele Rizzo Gaetano , Morgante Cesare , Locantore Pietro

Background: Hypoparathyroidism (HypoPT) is characterized by low calcium and parathyroid hormone (PTH), often secondary to thyroid surgery. Treatment consists in activated vitamin D and calcium supplementation. Such treatment may be difficult in patients with malabsorption as calcium usually requires an acid environmental to dissolve, while calcitriol needs an intact intestine for a full absorption.Case report: A 36-year old woman had a history of sleeve ...

ea0102136 | Interdisciplinary Endocrinology | EYES2024

In vitro evaluation of the HEK293 cell line as a model to measure glucocorticoids activity

Rossi Lucrezia , Rosaria Ambrosio Maria , Marino Picciola Valentino , Bordignon Anna , Chiara Zatelli Maria

Introduction: Glucocorticoids (GCs) are closely related to cortisol and the dysregulation of its secretion can lead to the onset of disorders. Cushing’s syndrome (CS) is the clinical manifestation of hypercortisolism and can also develop in subjects who voluntarily or accidentally take high GCs doses. The aim of this study is to conduct preliminary investigations to characterize the HEK293 cell line, to evaluate its response to GCs and to compounds with GC-like activity.<...

ea0081p474 | Thyroid | ECE2022

Potential risk factors for post-treatment recurrence in patients with intermediate-risk differentiated thyroid carcinoma

Rossi Mattia , Mele Chiara , Rossetto Giaccherino Ruth , Brero Denise , Marsan Giulia , Aimaretti Gianluca , Ghigo Ezio , Pagano Loredana

Introduction: The recurrence rate of intermediate-risk differentiated thyroid carcinoma (DTC) ranges between 5% and 20% and the therapeutic strategy requires further evaluations.Aim: We therefore investigated the potential risk factors for post-treatment recurrence of intermediate-risk DTC at 1 and 3 years from diagnosis.Methods: This retrospective observational study included 121 patients who underwent thyroidectomy for intermedia...

ea0049gp223 | Thyroid 3 | ECE2017

Endogenous TH metabolite 3-iodothyronamine (T1AM) and synthetic thyronamine-like analogues SG-1 and SG-2 induce autophagy in human glioblastoma cells (U-87MG)

Bellusci Lorenza , Sabatini Martina , Nesi Giulia , Rapposelli Simona , Rossi Leonardo , Lenzi Paola , Fornai Francesco , Zucchi Riccardo , Chiellini Grazia

Endogenous TH metabolite 3-iodothyronamine (T1AM) and recently developed thyronamine-like synthetic analogues SG1 and SG2 have emerged as neuroprotective agents. Autophagy has proved to be an effective therapeutic approach for neurodegenerative diseases. Therefore we investigated whether these compounds can induce autophagy in human glioblastoma cells (U-87MG).Cultured U-87MG cells were initially treated with 1 μM T1AM, SG-1, SG-2 or vehicle for 30&...

ea0037ep247 | Calcium and Vitamin D metabolism | ECE2015

Clinical and biochemical response to denosumab in a young adult patient with craniofacial fibrous dysplasia

Cairoli Elisa , Eller-Vainicher Cristina , Rossi Diego Sergio , Beltramini Giada Anna , Russillo Antonio , Mantovani Giovanna , Spada Anna , Chiodini Iacopo

We report on the clinical and biochemical outcomes in a 20-year-old male suffering from active craniofacial monostotic fibrous dysplasia (MFD) treated with the RANK-L inhibitor, Denosumab, following unsatisfactory responses to prior long-term bisphosphonates therapy. The patient had been treated over 9 years with pamidronate (cumulative dose of 81 mg), but experienced only mild reductions in pain scores. Following initiation of Denosumab 60 mg subcutaneously, bone pain and bon...

ea0035p692 | Male reproduction | ECE2014

Clinical implications of measuring prolactin levels in males of infertile couples

Lotti Francesco , Corona Giovanni , Maseroli Elisa , Rossi Matteo , Silverii Antonio , Degl'Innocenti Selene , Rastrelli Giulia , Forti Gianni , Maggi Mario

Introduction: Although in females of infertile couples abnormal PRL has a definitive role in the medical flow-chart, its role in males is less clear. Animal models suggest that PRL does not play a major role in male reproduction, although its trophic action on male accessory glands was often observed. Studies in humans are scanty. We systematically evaluated possible clinical and ultrasound correlates of PRL in males of infertile couples.Methods: Out of ...

ea0035p694 | Male reproduction | ECE2014

Seminal, clinical and color-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples

Lotti Francesco , Corona Giovanni , Mondaini Nicola , Maseroli Elisa , Rossi Matteo , Filimberti Erminio , Noci Ivo , Forti Gianni , Maggi Mario

Introduction: ‘Prostatitis-like symptoms’ (PLS) are a cluster of bothersome conditions defined as ‘perineal and/or ejaculatory pain or discomfort and National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) pain subdomain score ≥4’ (Nickel’s criteria). PLS may originate from the prostate or from other portions of the male genital tract. Although PLS could be associated with ‘prostatitis’, they should not be confused. T...

ea0032p524 | Endocrine tumours and neoplasia | ECE2013

The expression of SSTR dominant negative truncated variant sst5tMD4 influences the effects of SOM-230 on prostate cells in vitro

Rossi Valentina , Visconti Daniela , De Rosa Cristina , Abbondanza Ciro , Cioffi Iolanda , De Masi Assunta , Sinisi Antonio Agostino

Introduction: The presence of truncated variant of somatostatin receptors (SSTR) has been demonstrated in pituitary tumours. These variants seems act as dominant negative of SSTR and induce the resistance to SST analogue (SSTA) treatment. A variant of SSTR5, sst5TMD4, has been found to disrupt SST signalling in breast cancer cells. In present study, we assayed the expression of sst5TMD4 in two non-transformed epithelial prostate cell lines (EPC): EPN, derived from a normal sur...

ea0029oc14.1 | Male Reproduction | ICEECE2012

X chromosome-linked copy number variations in male infertility

Krausz C. , Giachini C. , Lo Giacco D. , Daguin F. , Ars E. , Ruiz-Castane E. , Forti G. , Rossi E.

The role of CNVs in male infertility is poorly defined, and only those linked to the Y chromosome have been the object of extensive research. Although it has been predicted that the X chromosome is also enriched in spermatogenesis genes, no clinically relevant gene mutations have been identified so far. In order to advance our understanding of the role of X-linked genetic factors in male infertility, we applied high resolution X chromosome specific array-CGH in 199 men with di...

ea0029p783 | Endocrine tumours and neoplasia | ICEECE2012

Bronchial carcinoid response to mTOR inhibitors depends on mTOR expression levels

Gagliano T. , Rossi R. , Mole D. , Gentilin E. , Minoia M. , Tagliati F. , degli Uberti E. , Zatelli M.

Introduction: Bronchial carcinoids (BCs), originating from endocrine cells dispersed in the respiratory epithelium, can be divided into typical (TBC) and atypical (ABC). TBC are less aggressive, smaller, and much less likely to metastasize, while ABC are more aggressive and metastasize. mTOR has a central role in regulating cell growth, metabolism, and apoptosis. A differential mTOR activation in BCs has been previously demonstrated, suggesting that mTOR pathway might play a p...