Searchable abstracts of presentations at key conferences in endocrinology

ea0022p662 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Acromegaloidism: description of fifteen cases

Sierra Wilfredo Guanipa , Fernandez Concepcion Paramo , Catalina Pablo Fernandez , Garcia Elias Alvarez , Olivie Amalia Andrade , Pena Eduardo , Ferrer Federico Mallo

Acromegaloidism is a very rare entity (have been 54 cases reported worldwide) that presents with clinical acromegaly and normal somatotropic axis, without findings of pituitary or extrapituitary tumour. Its origin has not been clearly established, although it is associated with several pathophysiological conditions. The local ethics committee approved to perform an observational and multicenter study in three hospitals from a region with approximately 800 000 people over 18 ye...

ea0022p789 | Thyroid | ECE2010

BRAFV600E analysis on fine needle aspiration biopsy increases diagnostic accuracy for papillary thyroid cancer in clinically unsuspected nodules

Rossi Martina , Trasforini Giorgio , Leoni Stefania , Tagliati Federico , Rossi Roberta , Roti Elio , degli Uberti Ettore C , Zatelli Maria Chiara

Papillary thyroid cancer (PTC) represents the majority of differentiated thyroid cancers, presenting in 29–83% of cases the activating BRAF V600E mutation. The aim of our study was to analyse the influence of BRAF V600E mutation analysis on diagnostic accuracy of fine needle aspiration biopsies (FNAB) in clinically unsuspected thyroid nodules. We therefore enrolled 496 patients (383 females, 113 males; mean age 52 years), for a total of 671 samples. FNAB were evaluated by...

ea0020p186 | Endocrine tumours and neoplasia | ECE2009

mTOR inhibition influences cell viability of medullary thyroid carcinoma primary cultures

Filieri Carlo , Minoia Mariella , Tagliati Federico , Mole Daniela , Buratto Mattia , Margutti Angelo , degli Uberti Ettore , Chiara Zatelli Maria

Effective medical therapy for persistent/recurrent medullary thyroid carcinoma (MTC) is not available, yet. Everolimus (RAD001) is a Rapamycin derivative, a potent mTOR pathway inhibitor. RAD001 has been employed in several clinical studies demonstrating antiproliferative and apoptotic effects in human tumors, both in vitro and in vivo, also in combination with somatostatin analogs. The aim of our study was to investigate the antiproliferative effects of RAD001 i...

ea0056gp6 | Acromegaly | ECE2018

IGF-I response to pasireotide LAR treatment in acromegaly is mainly driven by somatostatin receptor subtype 2 expression

Muhammad Ammar , Coopmans Eva , Gatto Federico , Franck Sanne , Janssen Joseph , van der Lelij Aart Jan , Hofland Leo , Neggers Sebastian

Background: The response to first-generation long-acting somatostatin analogues (LA-SSA) treatment in acromegaly depends on the expression of the somatostatin receptor (SSTR) subtypes. In contrast to octreotide and lanreotide which preferentially bind to SSTR2, pasireotide targets multiple SSTRs, with the highest binding affinity for SSTR5. It has previously been suggested that SSTR5 expression could predict the response to pasireotide LAR (PAS-LAR) treatment in acromegaly.</p...

ea0056gp67 | Cardiovascular | ECE2018

Liraglutide prevented the deposition of Collagen in the animal model of Bleomycin-induced lung fibrosis

Gomez Juan Fandino , Estevez Laura Toba , Vaz Ana Alvarez , Matias Lucas Carmelo Gonzalez , Chaves Yolanda Diz , Ferrer Federico Mallo

Idiopathic pulmonary fibrosis (IPF) is an excessive accumulation of fibrous filaments in the extracellular matrix (ECM), in response to an inflammatory reaction that disrupts normal lung architecture and physiology. Collagen is the most abundant fibrous protein in the ECM. The GLP-1 receptor is highly expressed on lung tissue, where his activation plays an essential role in the synthesis and secretion of surfactant proteins. The objective of this study was to elucidate the eff...

ea0056p861 | Pituitary - Clinical | ECE2018

An open-label, multicentre, single-arm, expanded-access study of subcutaneous (s.c.) pasireotide in patients with Cushing’s disease (CD)

Fleseriu Maria , Iweha Chioma , Salgado Luiz , Mazzuco Tania Longo , Patino Heather , Campigotto Federico , Maamari Ricardo , Limumpornpetch Padiporn

Introduction: Pasireotide sc has a proven favourable efficacy and safety profile in CD patients, as shown in clinical trials. Here, we report safety and efficacy results from an expanded-access study designed to allow CD patients to receive pasireotide until regulatory approval for commercial use and reimbursement was obtained in their country.Methods: Pasireotide-naïve adults with CD (mean 24-hour urinary free cortisol [mUFC; of three samples] exce...

ea0099p563 | Reproductive and Developmental Endocrinology | ECE2024

Investigation of circulating androgens’ circadian variations: expanding the knowledge by monitoring phase II metabolites

Ponzetto Federico , Parasiliti Caprino Mirko , Campioni Lorenzo , Marinelli Lorenzo , Settanni Fabio , Nonnato Antonello , Mengozzi Giulio , Giordano Roberta , Ghigo Ezio

Background: Many endogenous steroid hormones are reported to be subjected to distinct circadian rhythms, which are driven by central regulators, hormonal bioavailability and half-life. Recently, the measurement of androgens phase II metabolites has gained interest in the diagnosis and management of different endocrinological pathologies, such as polycystic ovarian syndrome (PCOS), female adrenal hyperandrogenism and hirsutism, prostate cancer, but their circadian patterns have...

ea0099ep229 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Bridging the gap between short stature and metabolic alterations in children born small for gestational age: an exploratory study

Giulia Rodari Pankiv , citterio valeria , Collini Valentina , Risio Alessandro , Profka Eriselda , Giacchetti Federico , Mantovani Giovanna , Giavoli Claudia

Introduction: Children born small for gestational age (SGA) represent a heterogeneous population, displaying different phenotypes for both growth and metabolic status. Low birth length and/or weight increases the risks for not only growth impairment but also for metabolic derangements, the latter with an even amplified risk in children with rapid postnatal weight gain. Variability in metabolic parameters, catch-up growth as well as different GH treatment responses are still po...

ea0099ep423 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Semaglutide therapy in people with type 2 diabetes and obesity: efficacy on glycated hemoglobin and weight loss

Del Prete Michela , Eugenia Disoteo Olga , Cozzi Renato , Di Sacco Gianleone , Vignati Federico , Gavazzi Lidia , Muratori Fabrizio

Introduction: The long acting GLP-1 analogue, Semaglutide (S), is indicated for the treatment of adults with type 2 diabetes mellitus (T2DM). Since November 2021, S has also been approved by the European Medicines Agency (EMA) at a dose of 2.4 mg for the treatment of obesity. Here, we report the efficacy of S, either alone or in combination with other antidiabetic drugs, in patients with T2DM and obesity on glycated hemoglobin (HBA1C) and weight loss.Pat...

ea0099ep346 | Reproductive and Developmental Endocrinology | ECE2024

Growing up with an endocrine disease: assessing transitional features in a cohort of young patients moving from pediatric to adult clinic

Citterio Valeria , Rodari Giulia , Gaglio Alessia , Collini Valentina , Risio Alessandro , Profka Eriselda , Giacchetti Federico , Orsi Emanuela , Mantovani Giovanna , Giavoli Claudia

Introduction: Transition from childhood to adulthood represents a time-period in which adolescents/young adults (AYAs) with chronic illnesses start coping with self-managing their disease, often resulting in poor compliance to follow-up. Indeed, up to 50% of AYAs with common endocrine disorders is lost during the referral to an adult clinic. Transition in Endocrinology is poorly investigated yet, in terms of transition readiness, compliance to therapy, adherence to nutritional...