Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp28 | Adrenal (2) | ECE2016

Restoring the circadian cortisol rhythm with metyrapone in patients with adrenal incidentalomas and subclinical hypercortisolism reduces IL6 levels

Debono Miguel , Harrison Robert , Chadarevian Rita , Gueroult Carole , Abitbol Jean-Louis , Newell-Price John

Introduction: Patients with adrenal incidentalomas and sub-clinical Cushing’s (SCH) have increased cardiovascular events and mortality. We hypothesised that these patients have a disturbed cortisol rhythm amenable to being restored to normal by using timed short-acting cortisol synthesis blockade, and that this may have a positive effect on IL6 levels.Methods: In a phase 1, prospective study (Eudract No. 2012-002586-35) we recruited eight patients w...

ea0041gp153 | Pituitary - Clinical | ECE2016

Once-monthly injection of pasireotide LAR reduces urinary free cortisol (UFC) levels in patients with Cushing’s disease: Results from a randomised, multicentre, phase III trial

Newell-Price John , Petersenn Stephan , Biller Beverly M K , Roughton Michael , Ravichandran Shoba , Lacroix Andre

Background: Twice-daily formulation of pasireotide, a pituitary-directed therapy, is approved for treatment of Cushing’s disease. Here we present data from a phase III study designed to evaluate the more convenient once-monthly long-acting release (LAR) formulation of pasireotide (approved for acromegaly) in patients with Cushing’s disease.Methods: Patients with persistent, recurrent, or de novo Cushing’s disease (not candidates for surger...

ea0039oc7.4 | Oral Communications 7 | BSPED2015

The cost-effectiveness of the KIds in control of food structured education programme for adolescents with type 1 diabetes

Basirir Hasan , Brennan Alan , Jacques Richard , Pollard Daniel , Stevens Katherine , Freeman Jennifer , Wales Jeremy , Price Katherine

Objectives: Kids in control of food (KICK-OFF) is a 5-day structured education programme for 11–16 year olds with type 1 diabetes who use multiple daily insulin injections. This study evaluates whether KICk-OFF would be considered a cost effective use of NHS resources by decision makers in the UK.Methods: A cost effectiveness analysis comparing KICk-OFF to usual care was conducted. Data from the KICk-OFF trial were extrapolated to simulate lifetime ...

ea0039p5 | (1) | BSPED2015

Junior KICk-OFF (kids in control of food)-developing structured education for primary school age children

Knowles Julie , Price Kath , Hudson Terry , Herbert Jane , Elahi Farah R

Background: Currently there are no evaluated diabetes teaching packages for primary school age children which meet their learning needs, styles and are delivered by trained educators. Sheffield children’s Hospital produced and tested, as a randomized controlled trial (RCT), the KICk-OFF course for 11–16 year olds. This 5-day course based on carbohydrate counting and insulin dose adjustment showed significant improvement in HbA1c (9 mmol/mol, 0.8%) for those with poor...

ea0059oc6.3 | Neuroendocrinology and Reproduction | SFEBES2018

Gamma knife radiosurgery for the primary management of acromegaly

Sims-Williams Hugh , Rajapaksa Kaveesha , Sinha Saurabh , Radatz Matthias , Walton Lee , Yianni John , Price John Newell

Introduction: Trans-sphenoidal Surgery (TSS) remains the primary treatment for acromegaly in most patients, but no previous data exist on outcomes for patients treated with gamma knife radiosurgery (STRS) as a primary treatment.Methods: 20 patients with acromegaly underwent primary STRS at the National Centre for Radiosurgery, Sheffield, UK between 1985 and 2015. Data collection: note review, database, laboratory results, patient questionnaire, and death...

ea0059p125 | Neuroendocrinology and pituitary | SFEBES2018

Anti-POMC siRNA reduces ACTH secretion in an in vitro model of Cushing’s disease

Alzahrani Ahmed , Foulkes Elizabeth , Porter Julie , Kemp Elizabeth , Newell-Price John

Context: Cushing’s disease (CD) results from the release of high levels of adrenocorticotrophic hormone (ACTH) from a pituitary adenoma. Increased ACTH secretion stimulates excess cortisol production, causing weight gain, hypertension, diabetes and depression. The only curative treatment is transsphenoidal surgery, but the rate of recurrence is high and there is a lack of suitable medical therapies. RNA-interference is a mechanism of post-transcriptional gene silencing th...

ea0034p292 | Pituitary | SFEBES2014

Follow-up, surgery and proton beam therapy for a pituitary sella chondrosarcoma

Elhassan Yasir Mohamed , Foran Bernie , Hodgson Tim , Ince Paul , Sinha Saurabh , Newell-Price John

A 41-year-old woman was referred with 9 months history of secondary amenorrhoea and galactorrhoea. She was otherwise well and not taking any medications. Biochemical evaluation showed prolactin 2000 mU/l but otherwise unremarkable. Pituitary MRI revealed a 30 mm pituitary lesion with right cavernous sinus invasion, presumed to be a craniopharyngioma due to the presence of calcification. Surgical intervention was recommended, but the patient declined. She was commenced on caber...

ea0070aep833 | Reproductive and Developmental Endocrinology | ECE2020

First in man study of oral native testosterone in hypogonadal men shows physiological testosterone levels in fed and fasted state

Newell-Price John , Porter John , Quirke Jo , Daniel Eleni , Mumdzic Enis , Ross Richard

Introduction: Current testosterone replacement therapies have limited acceptability: gels can be messy and risk inadvertent dosing of others; injections are painful; and oral testosterone undecanoate (TU) delivers variable testosterone levels, requires concurrent ingestion of a fatty meal and may produce supraphysiological dihydrotestosterone (DHT) levels1. We present the first human trial of an oral native testosterone preparation formulated to deliver testosterone...

ea0032p218 | Clinical case reports – Pituitary/Adrenal | ECE2013

Hypopituitarism and pituitary masses in patients with non-pituitary malignancy

Kassim Saifuddin , Wright Josh , Foran Bernie , Sinha Saurabh , Newell-Price John , Ross Richard

The commonest cause of acquired hypopituitarism is a benign pituitary adenoma. However, in patients with non-pituitary malignancy different diagnoses need to be considered. We describe three oncology patients presenting with hypopituitarism and/or a pituitary mass where the cause was related either to malignant disease or its treatment.Case 1: A 56-year-old man with known metastatic melanoma presented with increasing lethargy. Investigation showed a larg...

ea0029p1542.1 | Pituitary Clinical | ICEECE2012

Evaluation of the efficacy and safety of pasireotide LAR in patients with mild-to-moderate cushing’s disease: a randomized, double-blind, multicenter, phase III study design

Ligueros-Saylan M. , Zhang Y. , Newell-Price J. , Petersenn S. , Lymperopoulos S.

Background: Cushing’s disease is associated with high morbidity and mortality, and there are currently no approved medical therapies. Twice-daily pasireotide sc showed efficacy in patients with mostly moderate-to-severe (UFC≥2×ULN) Cushing’s disease in a large, randomized, double-blind, 12-month trial. A monthly long-acting release (LAR) formulation of pasireotide has been developed to provide a smoother pharmacokinetic profile, potentially a better effica...