Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Guided Posters

Adrenal (2)

ea0041gp21 | Adrenal (2) | ECE2016

Clinical characteristics and tumour size evolution in patients with bilateral adrenal tumours

Galoiu Simona , Pena Raluca , Trifanescu Raluca , Niculescu Dan Alexandru , Dumitrascu Anda , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

10% of patients with adrenal tumours have bilateral lesion.Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.<p class="a...

ea0041gp22 | Adrenal (2) | ECE2016

Clinical and polysomnographical evaluation of sleep in patients with Cushing’s syndrome

Ismailogullari Sevda , Firat Sedat Tarik , Karaca Zuleyha , Tanriverdi Fatih , Unluhizarci Kursad , Kelestimur Fahrettin

Introduction: Patients with Cushing’s Syndrome (CS) frequently have sleep complaints. The aim of the study was to evaluate the prevalance sleep disturbances and sleep structure of patients with CS.Materials and methods: 33 patients with CS were evaluated both clinically and with polysomnograhy (PSG) findings in terms of sleep disorders and data were compared with 20 healthy controls.Results: Seventeen (51.1%) patients with CS ...

ea0041gp23 | Adrenal (2) | ECE2016

Deterioration of indices of insulin resistance in patients with non-functioning and cortisol secreting adrenal incidentalomas during a long term follow-up

Papanastasiou Labrini , Alexandraki Krystallenia , Fountoulakis Stelios , Kounadi Theodora , Markou Athina , Tsiavos Vaios , Androulakis Ioannis , Samara Christianna , Piaditis George , Kaltsas Gregory

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

ea0041gp24 | Adrenal (2) | ECE2016

Does measurement of serum dexamethasone increase diagnostic accuracy of the overnight dexamethasone-suppression test?

Ueland Grethe AEstrom , Methlie Paal , Thordasron Hrafnkell Baldur , Lovas Kristian , Kelp Oskar , Mellgren Gunnar , Husebye Eystein

Background: 1-mg overnight dexamethasone-suppression test (DST) is commonly used to screen for hypercortisolism. Sensitivity is high (95%), but specificity is low (80%), leading to false positive results. Identifying individuals with abnormal dexamethasone absorption or metabolism could enhance diagnostic accuracy.Aim: Use serum dexamethasone (s-DXT) to increase diagnostic accuracy of DST.Methods: Prospective study of DST for clini...

ea0041gp25 | Adrenal (2) | ECE2016

Novel genetic changes in Autosomal dominant, ACTH independent nacronodular adrenal hyperplasia associated with hypercortisolism and giant adrenals

Munter Gabriel , Altarescu Geona , Beeri Rachel , Berthon Annabel , Faucz Fabio Rueda , Weiss Ruchama , Stratakis Constantine

ACTH independent macronodular adrenal hyperplasia (AIMAH) is a rare cause of Cushing’s syndrome. Both Phosphodiesterase 11A4 (PDE11A4) mutations and inactivating mutations of armadillo repeat containing 5(ARMC5) have been associated with familial AIMAH. A family with autosomal dominant AIMAH was studied trying to elucidate the involved genetic basis.Methods and results: Adrenal hypercortisolism with giant bilateral AH was diagnosed in three adult me...

ea0041gp26 | Adrenal (2) | ECE2016

LCI699 is a potent inhibitor of cortisol production in vitro

Creemers Sara G , Feelders Richard A , de Jong Frank H , Franssen Gaston J H , de Rijke Yolanda B , van Koetsveld Peter M , Hofland Leo J

Introduction: The steroidogenesis inhibitors ketoconazole and metyrapone are frequently used for treatment of Cushing’s syndrome, but can cause side effects. LCI699 is a known 11β-hydroxylase inhibitor, but effects on other steroidogenic enzymes are unknown. We aimed to compare effects of LCI699, ketoconazole, and metyrapone in vitro.Methods: HAC-15 cells, with or without 10 nM ACTH, and three primary human adrenocortical adenoma cultu...

ea0041gp27 | Adrenal (2) | ECE2016

Evening not morning plasma cortisol level is higher in women with polycystic ovary syndrome

Kialka Marta , Milewicz Tomasz , Ociepka Agnieszka , Krzyczkowska-Sendrakowska Magdalena , Stochmal Ewa

Introduction: The aim of our study was to assess the morning and evening cortisol plasma levels in women with polycystic ovary syndrome (PCOS).Material and method: 95 patients gave their informed consent to participate in the study and were divided into two groups. Group A consisted of 40 PCOS patients and group B consisted of 55 women without features of PCOS. Between day 5 and 8 of the menstrual cycle, morning (0700 h), fasting blood samples were taken...

ea0041gp28 | Adrenal (2) | ECE2016

Restoring the circadian cortisol rhythm with metyrapone in patients with adrenal incidentalomas and subclinical hypercortisolism reduces IL6 levels

Debono Miguel , Harrison Robert , Chadarevian Rita , Gueroult Carole , Abitbol Jean-Louis , Newell-Price John

Introduction: Patients with adrenal incidentalomas and sub-clinical Cushing’s (SCH) have increased cardiovascular events and mortality. We hypothesised that these patients have a disturbed cortisol rhythm amenable to being restored to normal by using timed short-acting cortisol synthesis blockade, and that this may have a positive effect on IL6 levels.Methods: In a phase 1, prospective study (Eudract No. 2012-002586-35) we recruited eight patients w...

ea0041gp29 | Adrenal (2) | ECE2016

Plasma metabolomics profile in patients with Cushing’s syndrome

Dalmazi Guido Di , Quinkler Marcus , Deutschbein Timo , Prehn Cornelia , Rayes Nada , Kroiss Matthias , Fassnacht Martin , Berr Christina , Stalla Gunter , Adamski Jerzy , Reincke Martin , Beuschlein Felix

Background: Cushing’s syndrome (CS) is a chronic disorder characterized by endogenous cortisol excess resulting in long-term metabolic and cardiovascular consequences. The identification of metabolic alterations related to hypercortisolism could be beneficial in tailoring treatments of co-morbidities. Our aim was to characterize the metabolic alterations of patients with hypercortisolism by targeted plasma metabolomic profiling.Methods: Subjects (<e...

ea0041gp30 | Adrenal (2) | ECE2016

Hair Cortisol Measurements in the Evaluation of Cushing’s Syndrome

Zilbermint Mihail , Hodes Aaron , Sinaii Ninet , Belyavskaya Elena , Lyssikatos Charalampos , Meyer Jerrold , Lodish Maya , Stratakis Constantine

Context: Hair cortisol has been recently studied to determine evidence of hypercortisolemia in humans. This test may be valuable in estimating cortisol levels, particularly in patients with cyclical Cushing’s syndrome (CS).Objective: To determine correlations with biochemical evidence of CS, and to compare hair cortisol measurements in patients with CS to normative data.Methods: Hair samples from 49 study subjects were collect...