Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Guided Posters

Bone & Calcium Homeostasis

ea0041gp31 | Bone & Calcium Homeostasis | ECE2016

Bone-specific circulating miRNA profile changes over an 8-week repeated sprint training protocol

Lombardi Giovanni , Sansoni Veronica , Perego Silvia , Vernillo Gianluca , Bonzanni Mattia , Merati Giampiero , Barbuti Andrea , La Torre Antonio , Banfi Giuseppe

Introduction: Although underlying mechanisms are largely unknown, bone metabolism is regulated by specific microRNAs and changes in their expression are associated with metabolic bone disorders. Exercise is a determinant of bone metabolism; however, different training protocols differently affect bone. Little is known about the effects of exercise on bone-specific miRNA expression.We studied the effect of a 8-week high-intensity training protocol on circ...

ea0041gp32 | Bone & Calcium Homeostasis | ECE2016

Hormone replacement therapy has favorable effects on bone microarchitecture, bone mineral density and body fat mass, without affecting lean mass: the OsteoLaus Cohort

Papadakis Georgios , Hans Didier , Vollenweider Peter , Waeber Gerard , Preisig Martin , Marques-Vidal Pedro , Lamy Olivier

Introduction: Hormonal replacement therapy (HRT) increases bone mineral density (BMD). Controversy exists regarding residual effect after withdrawal. We aimed to explore the effect of HRT and HRT withdrawal on: i) BMD and bone microarchitecture assessed by trabecular bone score (TBS); ii) fat (FMI), lean (LMI) and appendicular lean (ALMI) mass indexes.Methods: The OsteoLaus Cohort assessed 1500 women (50–80 years) for BMD, TBS, total energy expendit...

ea0041gp33 | Bone & Calcium Homeostasis | ECE2016

Relationships between lower-limb muscle strength and tibial outcomes in ageing UK men

Zengin Ayse , Pye Stephen R , Cook Michael J , Adams Judith E , Wu Frederick C W , O'Neill Terence W , Ward Kate A

Ageing is associated with sarcopenia, osteoporosis and an increased risk of falling, which together contribute to increased fracture risk. There are few data describing the associations between functional measures of muscle and bone during ageing. Therefore, the aim of this study was to examine in ageing men associations between measures of lower-limb muscle strength and age and then to investigate the relationships with tibial bone outcomes.Men (n</...

ea0041gp35 | Bone &amp; Calcium Homeostasis | ECE2016

Retrospective analysis of bone metabolism in patients waiting for simultaneous pancreas kidney transplantation

Kratochvilova Simona , Zahradnicka Martina , Brunova Jana

Objective: Osteoporosis is a typical long-term complication after solid organ transplantation. Patients after simultaneous pancreas kidney transplantation (SPK) are at a very high risk due to preceding renal osteopathy and diabetic status. To determine the best preventive strategy we analysed the bone metabolism at the point of the pretransplant examination.Design and methods: In years 2011–2014 the number of 112 patients with type 1 diabetes (69 me...

ea0041gp36 | Bone &amp; Calcium Homeostasis | ECE2016

Fontan palliation in children is associated with bone deficits

Petryk Anna , Polgreen Lynda E , Brown Roland , Marino Bradley S , Gremmels David , Shepard Charles , Kelly Aaron S , Miller Bradley S , Rudser Kyle , Kochilas Lazaros K

Background: Survivors with Fontan circulation suffer from chronic systemic hypoperfusion resulting in end-organ injury. Little is known about the effects of these hemodynamic perturbations on bone. We hypothesized that chronic Fontan circulation (>5 years after surgery) would be associated with bone deficits.Methods: Peripheral quantitative computed tomography (pQCT) was performed on 10 Fontan patients (seven males, 11.8±1.7 years) and 11 health...

ea0041gp37 | Bone &amp; Calcium Homeostasis | ECE2016

Trabecular bone score in patients with inflammatory bowel diseases

Krajcovicova Anna , Kuzma Martin , Kaniaris Aristodimos Grigorios , Killinger Zdenko , Hlavaty Tibor , Payer Juraj

Introduction: Osteoporosis is known chronic complication of inflammatory bowel diseases (IBD). It is known that areal bone mineral density (aBMD) does not sufficiently reflect bone strength and quality. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of aBMD.Aims and methods: The aim was to assess TBS in IBD patients with regard to disease behavior using in comparison with lumbar spine (LS) BMD. The...

ea0041gp38 | Bone &amp; Calcium Homeostasis | ECE2016

Influence of prematurity and low birth weight on peak bone mass

Balasuriya Chandima , Mosti Mats P , Evensen Kari Anne I , Brubakk Ann-Mari , Indredavik Marit S , Schei Berit , Stunes Astrid Kamilla , Syversen Unni

Introduction: Intrauterine weeks 36–38 with rapid transplacental mineral transfer are crucial for skeletal development. Prematurity and low birthweight may therefore lead to a subnormal peak bone mass. We evaluated the influence of gestational age and low birthweight on bone mineral density (BMD) and content (BMC) in young adults born preterm with very low birthweight (VLBW) and small for gestational age (SGA) at term.Description of methods/design: ...

ea0041gp39 | Bone &amp; Calcium Homeostasis | ECE2016

Drug holiday in osteoporosis. reducing side effects of long lasting treatments

Athanassiou Panagiotis , Pantazi Eleni , Skioti Ourania , Tzanavari Aikaterini , Kostoglou-Athanassiou Ifigenia

Introduction: Osteoporosis is a chronic and dangerous disease, as it may be silent and may express itself with a sudden catastrophic event, such as a fracture. Treatment of osteoporosis demands the use of potent pharmaceutical agents with long lasting effects. In particular, bisphosphonates, such as ibandronate, may be used. It has become evident that chronic treatment with anti-osteoporotic agents may reverse the course of the disease, patients having normal bone mineral dens...

ea0041gp40 | Bone &amp; Calcium Homeostasis | ECE2016

Severe osteomalacia caused by a phosphaturic mesenchymal tumor secreting fibroblast growth factor 23: a case report

Ravarani Lisa , Faust Michael , Quaas Alexander , Bludau Marc , Schmidt Matthias , Allendorf Inka , Topuzoglu-Muller Tengu , Hanszen Ruth , Schary Oliver , Bruning Jens C

Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome clinically presenting with recurring fractures, muscular weakness and pain. Laboratory values of affected patients are characterized by renal phosphate wasting and hypophosphatemia caused by an overexpression of fibroblast growth factor 23 (FGF- 23), a hormone belonging to the group of phosphatonins regulating phosphate and vitamin D homeostasis. Pathologically, it is secreted especially by small (and ...