Searchable abstracts of presentations at key conferences in endocrinology

ea0028p299 | Reproduction | SFEBES2012

Motility of bovine mixed and sex-sorted spermatozoa incubated in physiologically normal or high-glucose media

Long Sophie , Fisher Pat , Gardner David

Background: A moderately high fructose diet fed to rat dams shifts the secondary sex ratio in the litters towards males. These dams, as well as diabetic pregnant mice, have elevated plasma glucose. Hence, high uterine fluid glucose or a hormone that may mark high glucose, may result in preferential selection of Y-bearing sperm at the point of fertilisation through effects of glucose on sperm motility. In this study, we assessed sperm motility after incubation in media with/wit...

ea0005p50 | Clinical Case Reports | BES2003

Hirsutism and subclinical Cushing syndrome

Franke B , Foote J , Fisher R

Hirsutism of gradual onset is most commonly caused by polycystic ovarian syndrome (PCOS). Measurement of testosterone, sex-hormone binding globulin (SHBG), LH and FSH form part of the investigations. It is still a matter of debate at which level of testosterone further investigations are necessary to exclude an androgen-producing tumor.A 31-year-old woman presented with an eight-year history of hirsutism without her fertility and menstrual cycles being affected. Examinatio...

ea0021p91 | Clinical practice/governance and case reports | SFEBES2009

Failure of renin determined by immunoassay to suppress in a case of adrenocortical carcinoma secreting excess mineralocorticoid

Fox Thomas , Mihai R , Fisher Roy , Foote John

A 48-year-old woman presented to her GP with polyuria and proximal muscle weakness. She was found to have newly developed hypertension at 180/96 and her serum potassium was 2.7 mmol/l. Lisinopril 40 mg od and Slow-K 1 tablet bd were started and she was referred for further investigation.On clinic review blood pressure was 188/110 supine and 190/110 standing. Serum sodium was 147 mmol/l, potassium 3.7 mmol/l and total bicarbonate 29 mmol/l. Her Lisinopril...

ea0017p18 | (1) | BSPED2008

A case of primary Leydig cell hyperplasia presenting as unilateral testicular enlargement and peripheral precocious puberty in a 7-year-old male child

Mukherjee AL , Greening J , Fisher R , Meyers N

Testicular tumours are uncommon causes of precocious puberty (10%). The majority are Leydig cell tumours and require surgical removal plus chemotherapy. We present an 8 years (8.04 years) old male child who presented with rapid onset of pubic hair growth and right testicular swelling. Examination: his height was (143.3 cm, just above 99.6 th centile), weight (32.3 kg, 91st centile). Pubertal staging at A1, P2, G 4. Left testis 2 ml/right 8 ml. Bloods taken showed prepubertal L...

ea0011p138 | Clinical case reports | ECE2006

Resolution of diagnostic uncertainties with DAX-1 gene mutation analysis

Arundel P , Fisher R , Chu C , Alvi S

Mutations in the DAX-1 gene are well described in patients with adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism but can be a useful tool in the elucidation of unusual or difficult cases of adrenal insufficiency. As the clinical presentation of congenital adrenal hyperplasia and AHC can be clinically identical, diagnosis in the neonate often depends on the levels of 17-hydroxyprogesterone (17-OHP). If these are unavailable or non-diagnostic, gene analysis c...

ea0094p310 | Adrenal and Cardiovascular | SFEBES2023

Unilateral nonhemorrhagic adrenal infarction presenting as acute abdomen in a pregnant woman

Muhammad Zubair Ullah Hafiz , Fisher Stephen , Littlewood Gail , Watson Wendy

Introduction: Diagnosing acute abdominal presentations in pregnant women poses challenges due to the physiological and anatomical changes during pregnancy. The differential diagnosis is broad, encompassing both obstetric and non-obstetric causes. Among the rare occurrences, nonhemorrhagic adrenal infarction presents a particularly unusual scenario, lacking established guidelines for management and follow-up. We discuss a case of nonhemorrhagic adrenal infarcti...

ea0063oc14.2 | Sex Hormones | ECE2019

The effect of testosterone therapy on serum oestradiol levels in transgender men

Defreyne Justine , Aers Xavier-Philippe , Daphne Fisher Alessandra , Schreiner Thomas , Den Heijer Martin , T'Sjoen Guy

Background: Testosterone therapy in transgender men (TM) is aimed at achieving serum testosterone levels in the male reference range. It remains unknown if serum oestradiol levels in TM should be evaluated and/or adjusted. Although reported serum oestradiol levels in TM are variable in the current literature, these values may be affected through two possible mechanisms: serum oestradiol levels may increase through aromatization of exogenous testosterone, while the effects of e...

ea0049ep1032 | Pituitary - Clinical | ECE2017

Does cyproterone acetate therapy contribute to the observed elevation in serum prolactin levels in trans women?

Defreyne Justine , Nota Nienke , Perreira Cecilia , Thomas Schreiner , Daphne Fisher Alessandra , Guy T'Sjoen

Objective: Hormonal treatment in trans women (MtF transgender persons) in Europe usually consists of estrogens and anti-androgens, e.g. cyproterone acetate (CPA). After initiation of cross-sex hormone therapy, an elevation in serum prolactin levels is frequently observed in trans women, which was previously attributed to estrogen agents. This analysis evaluates whether CPA contributes to the elevation of prolactin in trans women receiving cross-sex hormones.<p class="abste...

ea0041ep397 | Developmental endocrinology | ECE2016

Cross-sex hormone therapy affects body fat distribution in transgender persons

Klaver Maartje , Dekker Marieke , Schreiner Thomas , Fisher Alessandra , T'sjoen Guy , den Heijer Martin

Introduction: Fat distribution is an important secondary sex characteristic, which is generally peripherally or pear-shaped (gynoid) in females and centrally or apple-shaped (android) in males. Total body fat increases in male-to-females (MtFs) and decreases in female-to-males (FtMs) during cross-sex hormone therapy (CSHT), approaching body fat amounts of the desired sex. However, changes in android or gynoid fat distribution might be a better measure for masculinization and f...

ea0041ep846 | Paediatric endocrinology | ECE2016

Pharmacokinetic and pharmacodynamic modeling of long acting human growth hormone (MOD-4023) in growth hormone deficient children

Fisher Dennis M. , Jaron-Mendelson Michal , Amitzi Leanne , Koren Ronit , Hart Gili

Introduction: OPKO Biologics has produced a long-acting human growth hormone (hGH), MOD-4023, containing three copies of a naturally-occurring peptide (C-terminal peptide, CTP) that markedly increases growth hormone’s in vivo residence. We describe the development and validation of a pharmacokinetic (PK) and pharmacodynamic (PD) model to characterize the relationship between MOD-4023 dose, serum concentrations (Cserum), and IGF-1 responses in healthy adults, GHD adults, a...