Endocrine Abstracts

We all encounter patients with osteoporosis in our daily practice - indeed the risk of osteoporotic fractures is increased in most endocrine disorders. The basic principles of diagnosing and treating osteoporosis and eliminating secondary causes remain simple and we should master them. However, providing truly excellent osteoporosis management is challenging and is much more than using the latest osteoporosis medication.There are challenges. Few clinicia...

We all encounter patients with osteoporosis in our daily practice - indeed the risk of osteoporotic fractures is increased in most endocrine disorders. The basic principles of diagnosing and treating osteoporosis and eliminating secondary causes remain simple and we should master them. However, providing truly excellent osteoporosis management is challenging and is much more than using the latest osteoporosis medication.There are challenges. Few clinicia...

Antiresorptive agents form an important part of the treatment strategy in almost every patient with osteoporosis. They are used both as the primary treatment option and as a means of maintaining gains in bone mass after bone anabolic therapy. Marketed drugs in this category comprise bisphosphonates, SERMs, calcitonin, and denosumab. By virtue of their effect on bone remodeling, potent antiresorptives have the potential to cause hypocalcaemia in susceptible patients (especially...

Background: Polycystic ovary syndrome (PCOS) could be associated with increased risk of thyroid disorders. Possible associations between TSH and cardio-metabolic risk in PCOS are debated.Methods: National Register-based study on women with PCOS in Denmark. 18,476 women had a diagnosis of PCOS in the Danish National Patient Register. PCOS Odense University Hospital (OUH, N=1,146) was an embedded cohort including premenopausal women with PCOS and ...

Diabetes mellitus (DM) is associated with an increased risk of fractures in excess of what would be expected from age and BMD. Further, DM is associated with increased risk of mortality in patients with hip fractures and possibly also other osteoporotic fractures.Study population and methods: Patients aged 50 or over who were treated for fractures of the hip, forearm, humerus and spine over 6 years (2004–2009, n=146 256) not coded as road t...

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and low grade inflammation, factors linked to cardiovascular disease (CVD).Methods: National Register-based study including women with PCOS and no previous diagnosis of CVD or hypertension. PCOS OUH (n=1165) included premenopausal women with PCOS and clinical and biochemical examination. PCOS Denmark (n=18 112) included women with PCOS in the Danish National Patient...

Objective: Describe short- and long-term changes in BMD in adults exposed to varying intensities of systemic glucocorticoid (GC) treatment.MethodsSetting: Danish Public Health Service Hospital, catchment area 500,000 individuals.Data: BMD data from 2006-2021 and data on filled prescriptions.Analysis: All adult patients with at least two DXA e...