Searchable abstracts of presentations at key conferences in endocrinology

ea0070oc5.4 | Thyroid | ECE2020

Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer

Read Martin , Brookes Katie , Fletcher Alice , Thornton Caitlin , Alshahrani Mohammed , Khan Rashida , Nieto Hannah , Adcock Holly , Webster Jamie , Cox Liam , Alderwick Luke , Boelaert Kristien , Smith Vicki , McCabe Christopher

New combinatorial drug strategies are urgently needed to improve radioiodine (RAI) uptake and efficiently ablate thyroid cancer cells, thereby reducing the risk of recurrent disease. Drug repurposing offers the promise of identifying already approved compounds capable of inducing sodium iodide symporter (NIS) function to enhance iodide uptake. However, a lack of thyroid cell-based assays amenable to high-throughput screening has limited progress. We utilised the mutated yellow...

ea0094p66 | Metabolism, Obesity and Diabetes | SFEBES2023

Developing flare-responsive intra-articular steroid injections

Crastin Ana , S. Martin Claire , Sagmeister Michael , V. Adcock Holly , R. Adams Holly , Raza Karim , Filer Andrew , J. A. Moakes Richard , M. Grover Liam , S. Hardy Rowan

Intra-articular (IA) glucocorticoids (GCs) injections are effective in controlling joint inflammation but limited by short duration of action and off-target side effects. Gellan sheared hydrogels (SHs) area drug delivery vehicle, with unique thinning properties and enhanced release kinetics. We hypothesise that a combination of SHs and pre-receptor metabolism activated GCs provide slow-release drug delivery to target inflammation and minimise side-effects. We the release kinet...