ea0070aep1083 | Hot topics (including COVID-19) | ECE2020
Juul Kildemoes Rasmus
, Højby Rasmussen Michael
, Agersø Henrik
, Viig Overgaard Rune
Somapacitan is a long-acting growth hormone (GH) derivative designed for once-weekly subcutaneous administration. Correct assessment of insulin-like growth factor-I (IGF-I) levels is essential during treatment of GH deficiency (GHD) and must account for fluctuations over a dosing interval. We evaluated whether reliable estimates of weekly mean and peak IGF-I could be obtained from a single IGF-I sample. A population pharmacokinetic/pharmacodynamic model was available from phar...