Endocrine Abstracts

A 27 years old primigravida, with no significant past medical history, was referred to Endocrine clinic at 37 weeks gestation with hirsutism. She developed hirsute features during pregnancy and symptoms progressed with advancing gestation. Her physical examination revealed thick coarse dark hair growth in the midline of lower abdomen, between the breasts and forearms. She noted deepening of her voice but denied headaches, visual disturbance or clitromegaly.<...

A 27 years old primigravida, with no significant past medical history, was referred to Endocrine clinic at 37 weeks gestation with hirsutism. She developed hirsute features during pregnancy and symptoms progressed with advancing gestation. Her physical examination revealed thick coarse dark hair growth in the midline of lower abdomen, between the breasts and forearms. She noted deepening of her voice but denied headaches, visual disturbance or clitromegaly.<...

A 56-year-old woman presented with progressive swelling of her face and fatigability. Investigating for Cushing’s, her 24-hour Urine Free Cortisol was negative at 43 and 70nmol/24hr (Reference interval or R.I. < 146 nmol/24hr) with overnight dexamethasone suppression test showing full suppression of cortisol to 34nmol/l. Her short synacthen test was normal at 30-minute cortisol of 753nmol/l (R.I.>420); on Zumenon. Other pituitary function tests were unremarkable b...

Case History: 37 years old female, presented to Emergency department with worsening SOB over last 24 hours. On systemic enquiry, patient complained of epigastric pain after eating and admitted to un-intentional 22 Kg weight loss in last four months. She clinically appeared dehydrated, with mild epigastric tenderness and no other abnormal signs. She denied any alcohol ingestion or illicit drug use. She had treated Vitamin B12 deficiency and idi...

We present a challenging case of a 51 years old men, diagnosed with diabetes as he presented to emergency department with osmotic symptoms and hyperglycaemia. He was started on insulin and referred to diabetes clinic.On review, glycaemic control was sub-optimal (HbA1c 94 mmol/mol) and his insulin was changed from biphasic to basal-bolus regimen. His BMI was 21 kg/m2 and no family history of diabetes was report...

Case History: 37 years old female, presented to Emergency department with worsening SOB over last 24 hours. On systemic enquiry, patient complained of epigastric pain after eating and admitted to un-intentional 22 Kg weight loss in last four months. She clinically appeared dehydrated, with mild epigastric tenderness and no other abnormal signs. She denied any alcohol ingestion or illicit drug use. She had treated Vitamin B12 deficiency and idi...

We present a challenging case of a 51 years old men, diagnosed with diabetes as he presented to emergency department with osmotic symptoms and hyperglycaemia. He was started on insulin and referred to diabetes clinic.On review, glycaemic control was sub-optimal (HbA1c 94 mmol/mol) and his insulin was changed from biphasic to basal-bolus regimen. His BMI was 21 kg/m2 and no family history of diabetes was report...

Introduction: Parathyroid carcinoma (PTHCa) is a rare malignant tumour which, although associated with higher calcium and parathyroid hormone (PTH) levels at presentation and younger age group, can only be diagnosed on histological basis. Recent studies have shown a logarithmic formula (using Calcium, PTH and age) can predict PTHCa if it scores more than 5%, with a sensitivity and specificity of 100% and 30% respectively. We describe a case where application of similar formula...

Background: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) also known as Hashimoto’s encephalopathy (HE), is a rare immune-mediated complication independent of functional status of thyroid, which leads to either stroke-like symptoms, or presents as diffuse progressive symptoms of altered mental status, seizures, and cognitive dysfunction. Here we present a case of SREAT in a female with recurrent episodes.Case histo...

Introduction: The mutation at m. 3243 adenine to guanine (A>G) in mitochondrial encoded transfer-RNA Leucine 1 (MTTL1) gene is the single most prevalent disease-causing mitochondrial DNA (MtDNA) mutation, with carrier status of 1:400 in our general population. The distinct disease phenotype is dependent on the level of heteroplasmy of wild-type vs mutation-type mtDNA in the specific target tissues, ranging from Maternally inherited diabetes and Deafness (MIDD) to mitochond...