Searchable abstracts of presentations at key conferences in endocrinology

ea0074ncc16 | Highlighted Cases | SFENCC2021

AIP-mutated Acromegaly responding well to a first generation somatostatin analogue

Elamin Aisha , Debono Miguel

Introduction: Aryl hydrocarbon receptor interacting protein (AIP) mutated Acromegaly is a complex rare disease. AIP mutations are associated with an aggressive, inheritable form of acromegaly that responds poorly to SST2-specific somatostatin analogues (SSAs). Literature reports demonstrate that second generation SSA, Pasireotide LAR, is superior to first generation SSAs in treating acromegaly with AIP mutation. Treating acromegaly with AIP mutation could be quite challenging....

ea0081p740 | Thyroid | ECE2022

Sub acute thyroiditis following COVID-19 vaccination – case report and International survey

Bennet William , Elamin Aisha , Newell-Price John

Case report: A 52-year-old woman developed painful anterior neck swelling seven days after receiving the first COVID-19 vaccine AstraZeneca (AZ). Investigations showed TSH 0.14 mIU/l, CRP 34 mg/l and TRAb 0.3 IU/l. A neck Doppler ultrasound scan on day 15 showed features of thyroiditis. On day 21, she was hyperthyroid with TSH <0.02 mIU/l and free T4 70.3 pmol/l. COVID-19 test was negative, and she was advised to start Carbimazole and propranolol but took only the beta-blo...

ea0086p111 | Neuroendocrinology and Pituitary | SFEBES2022

A rare Presentation of Carcinoid Crisis Following Radioactive Iodine Treatment for Thyroid Cancer in a Patient with Metastatic Midgut Neuroendocrine Tumour

Elamin Aisha , Hussein Ziad , Wadsley Jonathan

Introduction: Carcinoid crisis represents a rare medical emergency with potentially fatal manifestations that can occur in patients with neuroendocrine tumours (NETs). The condition is caused by a substantial release of vasoactive metabolites from the NETs during diagnostic or therapeutic interventions. However, in rare instances, it can occur spontaneously. Here, we report a patient who developed a carcinoid crisis following radioactive iodine131I (RAI) treatment f...

ea0094p83 | Neuroendocrinology and Pituitary | SFEBES2023

The use of overnight fasting copeptin and glucagon stimulated copeptin to diagnose arginine vasopressin deficiency in a tertiary centre

Elamin Aisha , Munir Alia , Hussein Ziad

Introduction: Distinguishing arginine vasopressin deficiency (AVD) from primary polydipsia (PP) can be challenging in clinical practice. Copeptin is produced in equimolar amount to AV and is considered diagnostic biomarker to establish the diagnosis of AVD with and without provocative testing.Methods: Patients referred with polydipsia, hypotonic polyuria (>3L/day) and normonatraemia had overnight fasting plasma copep...

ea0094p298 | Thyroid | SFEBES2023

A case report of Lithium induced autoimmune thyroiditis in a previously hypothyroid patient

Ali Syed , Elamin Aisha , Robinson Robert

Background: There is a well-documented relationship between lithium exposure and thyroid dysfunction via multiple mechanisms. Lithium is commonly associated with goitre, hypothyroidism, and subclinical hypothyroidism. Lithium-induced autoimmune hyperthyroidism is rare and poorly understood. We report a case of autoimmune thyroiditis, Graves’ disease (GD), in a patient with longstanding primary hypothyroidism believed to be induced by Lithium.<p class=...

ea0086cc6 | Featured Clinical Case Posters | SFEBES2022

A rare presentation of avascular necrosis of the femoral head and mild cardiomyopathy in a patient with 17-hydroxylase deficiency

Elamin Aisha , Schini Marian , Eastell Richard , Debono Miguel

Introduction: Avascular necrosis of the femoral head (AVN) is most commonly a consequence of glucocorticoid excess and is believed to be due to osteocyte apoptosis. It can also be due to vascular occlusion or trauma. We describe a patient with congenital adrenal hyperplasia secondary to 17-hydroxylase deficiency who presented with osteoporotic vertebral fractures and atraumatic avascular necrosis of the femoral head. She was also found to have mild cardiomyopathy.<p class=...

ea0094p95 | Neuroendocrinology and Pituitary | SFEBES2023

Pituitary apoplexy with a twist

Elamin Aisha , Pallai Shillo , Macinerney Ruth , Khalifa Mai , Went Richard

Introduction: Multiple myeloma (MM) is a haematological disorder characterised by an aberrant rise in monoclonal paraprotein. Intrasellar plasmacytomas can be infrequent MM manifestations. They are challenging to diagnose and frequently mimic pituitary adenomas; however rarely present with pituitary apoplexy. We describe a patient with pituitary apoplexy-like symptoms, subsequently diagnosed with MM, whose intrasellar mass entirely resolved after chemotherapy....

ea0086p244 | Neuroendocrinology and Pituitary | SFEBES2022

Neuroendocrine tumour (NETs) patient experience of switching to generic somatostatin analogue during the COVID-19 pandemic

Solanke Faith , Elamin Aisha , Newell-Price John , Munir Alia , Ibbotson Victoria

Introduction: In patients with neuroendocrine tumours (NETs) somatostatin analogues are used to control symptoms in patients with functioning tumours and as antiproliferative agents in those with non-functioning tumours. During COVID-19, the ‘Sandostatin Your Choice’ service was terminated by Novartis, removing home care nurses from administering the analogue in patients’ homes. The first generic version of depot octreotide was Olatuton® produced by Teva, a...

ea0096p19 | Section | UKINETS2023

Case series of Carcinoid heart presentation with Ovarian neuroendocrine tumour in a tertiary Centre

Mohamed Nihad , Elamin Aisha , Hameed Abdul , O'Toole L , Hussein Ziad , Munir Alia

Background: Carcinoid heart disease (CHD) is a rare carcinoid syndrome (CS) manifestation, often linked to liver metastasis releasing vasoactive amines. CHD can also result from ovarian neuroendocrine tumours (NETs), an uncommon association.Cases Presentations: We reviewed three female patients at our NET centre, averaging 63years of age (59-67years). They all had primary ovarian NETs causing CS and CHD.<p class="abs...