Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc7.5 | Reproductive endocrinology I | ECE2007

Estrogens regulate epididymal contractility through RhoA/Rho-kinase signaling

Filippi Sandra , Morelli Annamaria , Vignozzi Linda , Mancina Rosa , Mungai Sara , Ambrosini Stefano , Vannelli Gabriella Barbara , Forti Gianni , Maggi Mario

Epididymis (epi) is a sex steroid-sensitive duct provided with spontaneous motility, allowing sperm transport. We previously demonstrated that human epi expresses a high abundance of mRNA for ER-alpha and ER-beta. We demonstrated that in epi estrogens up-regulate either oxytocin (OT) responsiveness, acting at the receptor level, and responsiveness to endothelin-1 (ET-1), another well-known stimulator of epididymal motility. However, we did not find any significant change eithe...

ea0014p624 | (1) | ECE2007

Testosterone regulates RhoA/Rho-kinase signalling in two distinct animal models of chemical diabetes

Vignozzi Linda , Morelli Annamaria , Filippi Sandra , Ambrosini Stefano , Mancina Rosa , Luconi Michaela , Mungai Sara , Barbara Vannelli Gabriella , Zhang Xin-Hua , Forti Gianni , Maggi Mario

The contractile RhoA/Rho-kinase (Rock) signalling pathway is up-regulated in penile tissue in animal models of experimental diabetes and has been proposed to contribute to diabetes-related erectile dysfunction (ED). In previous studies we demonstrated that testosterone (T) restores diabetes-induced ED by influencing the NO/cGMP/PDE5 pathway.AimTo investigate the effect of T on the RhoA/Rock signalling in course of diabetes.MethodsWe used two distinct animal models of chemical ...