ea0029oc15.1 | Thyroid Basic | ICEECE2012
Chiappetta G.
, Valentino T.
, Vitiello M.
, Pasquinelli R.
, Monaco M.
, Palma G.
, Arra C.
, Fusco A.
, Fedele M.
Thyroid carcinoma arising from the thyroid follicular epithelium represents the most frequent endocrine malignancy and is mainly associated with gene rearrangements generating RET/PTC and TRK oncogenes, as well as BRAFV600E and RASV12 activating point mutations. Except for p53, which appears to be involved only in poorly differentiated and aggressive histotypes, a role of tumor-suppressor genes in the pathogenesis of thyroid cancer is still poorly known....