Searchable abstracts of presentations at key conferences in endocrinology

ea0035p359 | Diabetes (epidemiology, pathophysiology) | ECE2014

The rs1746661 polymorphism in the FNDC5 (Irisin) gene is associated with increased levels of total cholesterol in white patients with type 2 diabetes mellitus

Boucas Ana Paula , Brondani Leticia , Assman Tais , Boelter Gabriela , Canani Luis Henrique , Crispim Daisy

Introduction: Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. FNDC5 gene encodes a type I membrane protein that is processed proteolytically to form a newly identified hormone secreted into the blood, termed irisin. After induction by exercise, irisin activates profound changes in the subcutaneous adipose tissue, stimulating browning and UCP1 gene expression. Th...