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16th European Congress of Endocrinology

Poster Presentations

Diabetes (epidemiology, pathophysiology)

ea0035p340 | Diabetes (epidemiology, pathophysiology) | ECE2014

Metformin may reduce bladder cancer risk in patients with type 2 diabetes

Tseng Chin-Hsiao

Background: Whether metformin therapy affects bladder cancer risk in patients with type 2 diabetes mellitus (T2DM) has not been extensively investigated.Methods: The reimbursement databases of all Taiwanese patients with a new diagnosis of T2DM between 1998 and 2002 (n=940708) were retrieved from the National Health Insurance for follow-up of bladder cancer up to the end of 2009. Of these patients, 532519 were never-users and 408189 were ever-us...

ea0035p341 | Diabetes (epidemiology, pathophysiology) | ECE2014

Exenatide protects pancreatic islets against brain death-induced inflammation and viability loss

Carlessi Rodrigo , Dias Ana Luiza , Bauer Andrea , Canani Luis Henrique , Leitao Cristiane , Crispim Daisy

Introduction: Pancreatic islet transplantation is an attractive approach to re-establish glycemic homeostasis in patients with brittle type 1 diabetes. However, islet damage along the isolation procedure limits the availability of viable islets for transplantation. The donor’s brain death (BD) is among the factors contributing for islet quality loss in this scenario. Exenatide, a glucagon-like peptide-1 (GLP1) analog, exerts anti-inflammatory effects leading to an increas...

ea0035p342 | Diabetes (epidemiology, pathophysiology) | ECE2014

Higher HDL cholesterol to apolipoprotein A-I ratio is protective against the development of type 2 diabetes

Hwang You-Cheol , Jeong In-Kyung , Ahn Kyu Jeung , Chung Ho Yeon , Park Cheol-Young

Aims: HDL have many diverse functions. The goal of this study was to determine the differential effect of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) on the development of type 2 diabetes (T2D). In addition, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D.Methods: A total of 27 988 subjects with impaired fasting glucose (IFG) (18 266 men and 9722 women) aged 21 to 91 years (mean age 43.5 years)...

ea0035p343 | Diabetes (epidemiology, pathophysiology) | ECE2014

Relationship between age and Hba1c in Turkish patients

Acar Bilal , Unubol Mustafa , Senel Engin

Hemoglobin A1c (HbA1c) has been used as a clinically significant evaluation tool for analyses regarding glycemic control. Guidelines recommend patients with type 2 diabetes mellitus (T2DM) should aim for an A1C≤7.0%, but real world data is limited in the elderly regarding outcomes associated with different A1C levels.A thousand six hundred Turkish cases were enrolled in this study. The mean age of the patients was 57 (17 to 91) years. The mean HbA1...

ea0035p344 | Diabetes (epidemiology, pathophysiology) | ECE2014

Features and outcome of stroke related to type 2 diabetes mellitus (T2DM) in a community hospital

Marti Juan

Introduction: Population with DM are at substantially increased risk for stroke. Someone who’s had diabetes less than 5 years has a 70 percent increased risk of ischemic stroke, for 5–10 years has an 80 percent increased risk compared to someone without diabetes. Duration longer than 10 years was linked to more than a threefold increase in the risk.Methods and patients: We study all patients admitted at internal medicine department with diagnos...

ea0035p345 | Diabetes (epidemiology, pathophysiology) | ECE2014

CTRP3 increased the insulin sensitivity of 3T3-L1 adipocyte via decreasing the expression of inflammation factors

Li Xin , Yang Miao , Wu Yu-wen , Sun Su-xin , Sun Jia-zhong

Objective: To investigate the effects of C1q/TNF related protein 3 CTRP3 on the insulin sensitivity of adipocyte and its possible mechanisms.Methods: The insulin resistance model of 3T3-L1 adipocyte was induced by palmic acid (PA) cultivation. Such adipocytes were treated with different concentration of recombinant CTRP3 (0,10,50,250,1250 ng/ml) for 12 h, and for different time (2, 6, 12, 24 h) at the concentration of 250 ng/ml. The glucose consumption w...

ea0035p346 | Diabetes (epidemiology, pathophysiology) | ECE2014

Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus

Kim Chan Jong , Yang Eun Mi , Jung Eui Seok

Background: The purpose of this study was to investigate the occurrence of autoimmune thyroid disease in children and adolescents at onset of type 1 diabetes mellitus (T1DM) and to assess whether the presence of diabetes-specific autoantibodies may predict the autoimmune thyroid disorder.Methods: Seventy-three children with T1DM were recruited in the study. Glutamic acid decarboxylase antibodies (GADA), Islet cell antibodies (ICA), insulin autoantibodies...

ea0035p347 | Diabetes (epidemiology, pathophysiology) | ECE2014

Risk of diabetes mellitus after first-attack acute pancreatitis: a national population-based study

Shen Hsiu-Nien , Yang Chun-Chieh , Chang Ya-Hui , Lu Chin-Li , Li Chung-Yi

Objective: We longitudinally assessed the overall and age- and sex-specific incidence rates and relative risks of newly diagnosed diabetes mellitus in patients surviving the first-attack acute pancreatitis (AP) as compared to matched controls.Methods: Study cohort included 2966 AP patients and 11 864 non-AP controls individually matched on age, sex and date of index admission, with an AP/non-AP ratio of 1:4. Incidence rate was estimated under Poisson ass...

ea0035p348 | Diabetes (epidemiology, pathophysiology) | ECE2014

Low rates of attaining LDL goals despite statin use in diabetic patients in a tertiary healthcare center.

Kocabas Gokcen , Yurekli Banu

Introduction: Diabetes and dyslipidemia are two common comorbid conditions encountered in clinical practice. Diabetes is considered as a cardiovascular disease (CVD) equivalent. Most professional organizations suggest statin therapy for diabetic patients, regardless of baseline lipid levels for patients with overt cardiovascular disease or without CVD over 40 years and have one or more other CVD risk factors. For lower risk patients;the LDL goal is 100 mg/dl and for patients w...

ea0035p349 | Diabetes (epidemiology, pathophysiology) | ECE2014

Profile of type 2 diabetic patients according to HbA1c tertiles in our tertiary health care center

Yurekli Banu Sarer , Kocabas Gokcen Unal

Aim: In this study we aimed to investigate general properties and treatment modalities of our type 2 diabetic patients.Materials and methods: A total of 136 consecutive type 2 diabetic patients were investigated. Type 2 diabetic patients were divided into three different groups according to HbA1c level (<7% group 1, 7–9% group 2, >9% group 3).Results: Mean age of our type 2 diabetic patients (F n=95, M n</...

ea0035p350 | Diabetes (epidemiology, pathophysiology) | ECE2014

Clinical case of type 1 diabetes mellitus and multiple sclerosis – just bad luck?

Wessling Ana , Aragues Jose Maria , Guerra Silvia , Mascarenhas Mario

Introduction: Type 1 diabetes mellitus (T1DM) and multiple sclerosis (MS) are organ-specific autoimmune diseases. Their association, first described in a study in Sardinia, left questions about their clustering, clarified by the Familial Autoimmune and Diabetes Study, which showed for the first time an highly increased prevalence of MS in adults with T1DM, reinforced by further epidemiological studies that also revealed increased risk of T1DM in MS patients.<p class="abste...

ea0035p351 | Diabetes (epidemiology, pathophysiology) | ECE2014

A rare presentation of type 2 diabetes: diabetic ketoacidosis, acute pancreatitis, and hypertriglyceridaemia

Al-Saeed Abdulghani , Alobedallah Ahmad , Al-Hayek Ayman , Inam Sohail , Braham Rim , Al-Sabaan Fahad

Introduction: The triad of diabetic ketoacidosis (DKA), acute pancreatitis (AP), and hypertriglyceridaemia (HTG) has been described mainly in T1DM with few cases in T2DM. We report the first case of this triad revealing T2DM.Case report: A 30-year-old male with strong family history of T2DM presented to the emergency with severe epigastric pain radiating to the back associated with abdominal swelling, vomiting and diarrhea. He also reported history of po...

ea0035p352 | Diabetes (epidemiology, pathophysiology) | ECE2014

The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for developing T1DM

Assmann Tais , Brondani Leticia , Bauer Andrea , Canani Luis Henrique , Crispim Daisy

Introduction: Viral pathogens seem to play a role in triggering the autoimmune destruction that leads to type 1 diabetes mellitus (T1DM) development. Toll-like receptor 3 (TLR3) has been shown to recognize double-stranded RNA, a molecular signature of most viruses. It is expressed at high levels in pancreatic beta-cells and immune cells, suggesting a role for it in the T1DM pathogenesis. Therefore, the aim of this study was investigate if TLR3 polymorphisms are associ...

ea0035p353 | Diabetes (epidemiology, pathophysiology) | ECE2014

Association between Asp299Gly and Thr399Ile polymorphisms in TLR4 gene and type 2 diabetes mellitus: Case-control study and meta-analysis

Assmann Tais , Lemos Natalia , Brondani Leticia , Carlessi Rodrigo , Canani Luis Henrique , Crispim Daisy

Introduction: Polymorphisms in genes that encode proteins of the innate immune system, such as the toll-like receptor 4 (TLR4), could affect the immune response as well as the prevalence of type 2 diabetes mellitus (T2DM). Activated TLR4 induces expression of a spectrum of proinflammatory cytokines, which have been implicated in insulin resistance. Some studies have reported associations of the TLR4 Asp299Gly and Thr399Ile polymorphisms with T2DM. However, ot...

ea0035p354 | Diabetes (epidemiology, pathophysiology) | ECE2014

Age and gender characteristics of carbohydrate metabolism disorders in dependance on HbA1c level

Prystupiuk Lev , Naumova Liudmyla , Prystupiuk Maksym , Naumova Marianna , Prystupiuk Oleksandr

Diabetes mellitus type 2 (DM type 2) is characterized by constant increase in the number of cases. The worst consequence of this disease is the increase in mortality from injuries of the cardiovascular system. And the best prevention of this complication is active detection and then intensive treatment of DM type 2.Our study is aimed at active detection of patients with impaired glucose metabolism in different regions of Ukraine with help of determinatio...

ea0035p355 | Diabetes (epidemiology, pathophysiology) | ECE2014

Prevalence of bronchial asthma in patients with type 2 diabetes mellitus

Themeli Yllka , Ibro Mustafa , Dyrmishi Luan , Klosi Jola

Background: Bronchial Asthma is characterized by inflammation and airway hyperesponsiveness, which results in episodic airflow obstruction. A relationship between inflammation and insulin resistance has been previously noted and asthma is known to correlate with insulin resistance.Aim: The aim of this study is to evaluate the prevalence of asthma in type 2 DM patients,presented in ‘IKEDA’ Hospital, in the period of time January 2010–Decemb...

ea0035p356 | Diabetes (epidemiology, pathophysiology) | ECE2014

Prevention of cardiovascular lesions by active detection of diabetes mellitus

Naumova Liudmyla , Prystupiuk Lev , Prystupiuk Maksym , Naumova Marianna , Prystupiuk Oleksandr

Among diseases with impaired carbohydrate metabolism, DM type 2 takes first place. And one of the main complications of this non-communicable disease is cardiovascular lesions. Our joint Ukraine-Poland research to actively detect DM type 2 took place during the Euro-2012, where we examined Hb1Ac in different ages of the population in both countries. In Ukraine the study involved 1564 individuals who where tested although they considered themselves free of DM. Their ages varied...

ea0035p357 | Diabetes (epidemiology, pathophysiology) | ECE2014

Screening on type 2 diabetes mellitus incidence in Tashkent

Tashmanova Akmaral , Ismailov Said

Background and aims: Progradient course of diabetes mellitus as well as inevitable onset and progression of its late complications having polyorganic character, causing polymorbidity and high mortality of the patients underlie medical–social significance of the problem.Materials and methods: We examined 784 persons (36% men and 64% women, mean age 53 and 51 years respectively) at high risk of diabetes mellitus onset and progression being screened in...

ea0035p358 | Diabetes (epidemiology, pathophysiology) | ECE2014

Epidemiology of type 1 diabetes mellitus in children in Uzbekistan

Rakhimova Gulnara , Alimova Nasiba

The work was initiated to assess and monitoring of basic epidemiological parameters of type 1 DM among children in the course of the 2000–2007 National Register. Epidemiological data was studied on the basis of annual reports from 13 regional endocrinological dispensaries and Tashkent endocrinological dispensary as well as on the basis of register cards filled up by local endocrinologists–pediatricians. In Uzbekistan within the period from 2000 to 2007 type 1 DM prev...

ea0035p359 | Diabetes (epidemiology, pathophysiology) | ECE2014

The rs1746661 polymorphism in the FNDC5 (Irisin) gene is associated with increased levels of total cholesterol in white patients with type 2 diabetes mellitus

Boucas Ana Paula , Brondani Leticia , Assman Tais , Boelter Gabriela , Canani Luis Henrique , Crispim Daisy

Introduction: Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. FNDC5 gene encodes a type I membrane protein that is processed proteolytically to form a newly identified hormone secreted into the blood, termed irisin. After induction by exercise, irisin activates profound changes in the subcutaneous adipose tissue, stimulating browning and UCP1 gene expression. Th...

ea0035p360 | Diabetes (epidemiology, pathophysiology) | ECE2014

Atherosclerosis in patients with prediabetes and type 2 diabetes is associated with more significant microcirculation abnormalities

Shyshko Volha , Mokhort Tatjana , Konstantinova Elena , Tsapaeva Nataly

It is known that patients with prediabetes (impaired glucose tolerance and impaired fasting glucose) ant type 2 diabetes (T2D) have micro-and macrovascular complications. It may be assumed that vascular changes begin in the smallest vessels that leads to microcirculation abnormalities.Purpose: To estimate microcirculation abnormalities in patients with prediabetes and T2D and concomitant atherosclerosis.Materials and methods: One h...

ea0035p361 | Diabetes (epidemiology, pathophysiology) | ECE2014

Relationship between indices of nutriture among residents of a Coastal City in South East Nigeria

Enang Ofem , Essien Okon , Otu Akaniyene , Fasanmade Olufemi , Ohwovoriole Efedaye

Background: There is a relationship between the indices of nutriture-BMI, waist circumference (WC), waist–hip ratio (WHR) and the development of glucose intolerance.Objectives: To determine the normative values of the indices of nutriture and the inter relationship between these indices in male and female residents of a Calabar, South East Nigeria.Methods: A sample comprising 1134 subjects (645 males and 489 females) represent...

ea0035p362 | Diabetes (epidemiology, pathophysiology) | ECE2014

Pregnancy outcomes in women with gestational diabetes

Vukovic Bojan , Mitrovic Milena , Popovic Djordje , Tomic-Naglic Dragana , Novakovic-Paro Jovanka , Rankov Olivera , Pejin Radoslav , Stokic Edita , Kovacev-Zavisic Branka

Introduction: Although diagnostics and therapy are much improved over the years, women with gestational diabetes still have more adverse course and outcome of pregnancy than healthy women. Their pregnancies are more often complicated with the different forms of maternal and fetal morbidity. Our study investigates all cause early neonatal morbidity (neonatal jaundice, neonatal hypoglycemia, fetal distress syndrome and other) and newborns maturity and vitality in the groups of d...

ea0035p363 | Diabetes (epidemiology, pathophysiology) | ECE2014

Intensive and expensive new treatments or better education for patients with diabetes: Where should we begin with?

Lewandowski Krzysztof , Basinska-Lewandowska Magdalena , Kardas Przemyslaw

Design and methods: Though several new treatments for diabetes (DM) are available, their effectiveness, however, might be limited, by patients knowledge. In order to test patients’ knowledge and self-management of diabetes, we had employed a questionnaire for clinic patients with types 1 and 2 DM. This was a pilot study for a telemetric medicine EU project ( Study involved 37 subjects (19 males) with type 1 (n=18) or insulin treated type 2 DM ...

ea0035p364 | Diabetes (epidemiology, pathophysiology) | ECE2014

Does systematic error in the HbA1c measurement matter when locally analyzed HbA1c is used for benchmarking in a national diabetes register?

Carlsen Siri , Cooper John , Thue Geir , Roraas Thomas , Lovas Karianne , Goransson Lasse , Sandberg Sverre

Introduction: HbA1c is an important quality indicator when benchmarking diabetes clinics. Systematic error in the measurement of HbA1c could result in inappropriately high or low values, and if not corrected give a wrong impression of the standard of care.Methods: We included data on HbA1c from the Norwegian adult diabetes register on 3,854 type 1 diabetics attending 13 hospital clinics. Correction factors for HbA1c were derived from the results of the l...

ea0035p365 | Diabetes (epidemiology, pathophysiology) | ECE2014

UCP1, UCP2 and MnSOD expression in pancreas from brain-death subjects: A case-control study

Brondani Leticia , Boelter Gabriela , Carlessi Rodrigo , Rheinheimer Jakeline , Bauer Andrea Carla , Canani Luis Henrique , Crispim Daisy

Introduction: Long-term insulin independence after pancreatic islet transplantation depends on the engraftment of a large number of viable islets. However, the yield and quality of islets isolated from brain-death (BD) donors are negatively affected by upregulation of proinflammatory cytokines and by hypoxia and oxidative stress that occurs during the BD status. Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner mitochondrial membrane and are associ...

ea0035p366 | Diabetes (epidemiology, pathophysiology) | ECE2014

Association between UCP polymorphisms and BMI changes: A cross-sectional study and meta-analysis

Brondani Leticia , Assmann Tais , de Souza Bianca , Boucas AnaPaula , Bauer Andrea Carla , Canani Luis Henrique , Crispim Daisy

Aims: Some studies have reported associations between uncoupling protein (UCP) 1–3 polymorphisms and obesity or related-features. However, other studies have failed to confirm these associations. Thus, this study describes a cross-sectional study and a meta-analysis conducted to attempt to determine whether the -3826A/G (UCP1), -866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3) polymorphisms are associated with body mass index (BMI)...

ea0035p367 | Diabetes (epidemiology, pathophysiology) | ECE2014

Serum cytokines and proinflammatory markers in first degree relatives of patients with type 1 diabetes

Szelachowska Malgorzata , Siewko Katarzyna , Poplawska-Kita Anna , Telejko Beata , Zielinska Anna , Maciulewski Rafal , Lipinska Danuta , Gorska Maria

Background and aims: In patients with type 2 diabetes, elevated tumor necrosis factor α (TNFα), C-reactive protein (CRP), chemerin, fetuin-A, have been reported. However, it is not entirely clear whether these alterations in adipokine serum concentrations are already present in prediabetic states and in type 1 diabetes. The aim of the study was to investigate whether adipokine profiles (chemerin, fetuin-A, TNFα) and inflammatory markers (CRP) are associated with...

ea0035p368 | Diabetes (epidemiology, pathophysiology) | ECE2014

Increased prevalence of anti-thyroid and anti-gastric parietal cell antibodies in first degree relatives of patients with type 1 diabetes

Siewko Katarzyna , Poplawska-Kita Anna , Telejko Beata , Maciulewski Rafal , Zielinska Anna , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Aim: It is well known that T1D is associated with other autoimmune diseases. The aim of this study was to compare the prevalence of various auto-antibodies in first-degree relatives of patients with T1D and healthy individuals with negative family history of diabetes.Material and methods: The group studied consisted of 90 relatives and 60 healthy individuals. Serum concentrations of antibodies to anti-21-hydroxylase (21-OH-Abs), anti-gastric parietal cel...

ea0035p369 | Diabetes (epidemiology, pathophysiology) | ECE2014

Sexual function of 26–36-year-old men with type 1 diabetes

Matulevicius Valentinas , Ostrauskas Rytas , Matuleviciute Indre , Banisauskaite Ilona , Jureviciute Justina , Abramavicius Silvijus , Verkauskiene Rasa , Urbanavicius Vaidotas

Sexual dysfunction of type 1 diabetic (T1D) men is an area that has been rarely investigated until now. Investigation of reproductive health of young men was performed in Nordic and Baltic countries in 2003/2004 (‘The Reproductive function of Estonian, Latvian and Lithuanian young men’ (ELLY)) but analysis of sexual function was out of the target of the study. In this study we invited those presumably healthy men to participate as controls for investigation of T1D me...

ea0035p370 | Diabetes (epidemiology, pathophysiology) | ECE2014

Compensatory increased irisin levels in gestational diabetes mellitus

Arkan Tugba , Calan Mehmet , Cimrin Dilek , Yesil Pinar , Oktan Mehmet Asi , Aygun Kemal , Bayraktar Firat

Context: Irisin, a newly discovered hormone, is secreted by skeletal muscles into circulation. It is proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.Objective: We aimed to investigate the association of irisin and uncoupling protein 1 (UCP1) with gestational diabetes mellitus (GDM).Design and Setting: This was a cross-sectional study conducted in a university hospital.<p class="abs...

ea0035p371 | Diabetes (epidemiology, pathophysiology) | ECE2014

GCK-MODY caused by a new mutation in the GCK gene

Caldas Ana Rita , Pereira Teresa , Tavares Purificacao , Cardoso Maria Helena

Introduction: Glucokinase-MODY (Maturity onset diabetes of the young) results from heterozygous mutations in the GCK gene, impairing its enzymatic activity. GCK acts as a glucose sensor in the pancreatic beta cell and regulates insulin secretion. We describe two cases of MODY due to a GCK gene mutation not described until now.Clinical Case: A 63-year-old male is followed in our hospital for 30 years due to diabetes mellitus (DM). He was diagnose...

ea0035p372 | Diabetes (epidemiology, pathophysiology) | ECE2014

Branched-chain and aromatic amino acid plasma concentration as a markers of metabolic syndrome

Daroszewski Jacek , Rybka Jacek , Pukajlo Katarzyna , Bolanowski Marek , Stankiewicz-Olczyk Joanna , Mierzchala Magdalena , Rybka Wojciech , Gamian Andrzej

Results of metabolomic studies showed the relation of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) with metabolic disorders.Basing on this observation we assessed amino acid profile in 286 professionally active men (aged 36–60 years). 141 of them met the criteria of metabolic syndrome (MS) and remaining 142 served as controls.Quantitative analysis of BCAA (leucine-LEU, valine-VAL, isoleucine- ILE) and AAA (...

ea0035p373 | Diabetes (epidemiology, pathophysiology) | ECE2014

Acromegaly treatment and carbohydrate metabolism disturbances

Dreval Alexander V. , Trigolosova Irina V. , Vinogradova Anna V. , Ilovayskaya Irena A. , Wolffenbuttel Bruce H.R.

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. We aimed to assess the differences in insulin secretion and sensitivity depending on stage of the disease and type of treatment.Design: Sixty-four patients with acromegaly (46 women; age 53 (interquartile range, IQR 47–59) years), of whom 29 were newly-diagnosed (NA group), 20 treated with somatostatin analogues (SSA group) and 15 after transsphenoïdal s...

ea0035p374 | Diabetes (epidemiology, pathophysiology) | ECE2014

New onset T1DM after vaccination for measles: Coincidence or consequence?

polat Burcak , Aydin Cevdet , Evranos Berna , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Viruses and virus-induced lymphokines may have an important role in the pathogenesis of autoimmunity. The occurrence and significance of autoimmune manifestations after the administration of viral vaccines remain controversial. Herein we have represented a case who developed type 1 diabetes 1 month after vaccination for measles in military.Case: A 25-year-old male patient admitted to our clinics with the complaints of polyuria, poydipsia, a...

ea0035p375 | Diabetes (epidemiology, pathophysiology) | ECE2014

Adipokines, insulin resistance in early pregnancy and risk for gestational diabetes

Popova Polina , Dronova Alexandra , Sadikova Elza , Parkkinen Mary , Bolshakova Maria , Grineva Elena

Introduction: Pregnancy is characterized by a progressive insulin resistance (IR). Some, but not all, previously published studies suggest that adipokines are related to insulin resistance in pregnant women and subsequent development of gestational diabetes (GDM).The aim of this study was to investigate the relation between adiponectin, leptin, its ratio and homeostasis model assessment of IR (HOMA-IR) in the first prenatal visit and whether it could be ...

ea0035p376 | Diabetes (epidemiology, pathophysiology) | ECE2014

Prevalence of androgenic deficit in men with metabolic alterations

Roman Miriam Menacho , Fernandez Antonio Becerra , Lopez Gilberto Perez , Vicente Rosa Villar , del Rey Sanchez Jose Manuel

Introduction: The syndrome of late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age male, characterized by typical symptoms and decreased serum concentrations of testosterone, which can affect multiple organ systems and may impair quality of life. The prevalence of LOH syndrome is higher in certain patient groups, obese, diabetic and suffering from erectile dysfunction manifest LOH at higher rates than the general population.<p ...

ea0035p377 | Diabetes (epidemiology, pathophysiology) | ECE2014

Assessment of relaxin levels in pregnant women with gestational diabetes mellitus

Zaman Iftikhar , Swaminathan Ramasamyiyer , Brackenridge Anna , Sankaralingam Arun , McGowan Barbara

Introduction: Gestational diabetes mellitus (GDM) is an important co-morbidity of pregnancy, with insulin resistance a key contributor in its underlying pathology. Relaxin is a hormone considered crucial for mediating adaptations deemed vital for maintenance of pregnancy. Evidence has suggested that levels of plasma relaxin may be positively correlated with insulin sensitivity. This led us to hypothesize that relaxin may play a role in the pathogenesis of insulin resistance in...

ea0035p378 | Diabetes (epidemiology, pathophysiology) | ECE2014

Low serum 25(0H) vitamin D3 concentration is associated with increased accumulation of advanced glycation endproducts (AGEs) in the skin of patients with type 1 diabetes

Pilacinski Stanislaw , Rogowicz-Frontczak Anita , Chwialkowska Anna , Zozulinska-Ziolkiewicz Dorota , Wierusz-Wysocka Bogna

Introduction: Influence of vitamin D status on metabolic control of type 1 diabetes (T1DM) remains controversial. The marker of long-term metabolic control that was not evaluated in this context is tissue accumulation of advanced glycation endproducts (AGEs), measured using skin autofluorescence. Aim of the study was to determine the association between serum 25-hydroxyvitamin D3 (25(OH)D3) concentration and accumulation of AGEs in adults with T1DM.Mater...

ea0035p379 | Diabetes (epidemiology, pathophysiology) | ECE2014

Mean platelet volume reflects framingham risk score in intermediate hyperglycemia

Kim Sangyong , Kim Jinhwa , So Junghae

Background and aims: Intermediate hyperglycemia has been established to increase cardiovascular disease (CVD) risk. The increased platelet activity is believed to play a central role in pathogenesis of CVD. Mean platelet volume (MPV) and urinary 11-dehydro-thromboxane B2 (11-dehydro-TxB2) level have been validated as a reliable and non-invasive marker for platelet activity. The objective was to evaluate the association between these markers and CVD risk b...

ea0035p380 | Diabetes (epidemiology, pathophysiology) | ECE2014

Anthropometric and biochemical parameters in older women with a history of gestational diabetes

Topsakal Senay , Akin Fulya , Yaylali Guzin F

Introduction: Gestational diabetes mellitus (GDM) is a condition that occurs during pregnancy when the body cannot produce enough insulin to handle the effects of a growing baby and changing hormone levels. Numerous studies reported that an increased risk of GDM among women who are overweight or obese compared with lean or normal-weight women.Methods/design: The purpose of this study is to compare anthropometric and biochemical parameters in postmenopaus...

ea0035p381 | Diabetes (epidemiology, pathophysiology) | ECE2014

Changes of sphingolipid profiles in serum of patients with diabetes

Siewko Katarzyna , Car Halina , Fiedorowicz Anna , Maciulewski Rafal , Zielinska Anna , Poplawska-Kita Anna , Krzyzanowska-Grycel Edyta , Chabowski Adrian , Zendzian-Piotrowska Malgorzata , Lipinska Danuta , Milewska Anna , Gorska Maria , Szelachowska Malgorzata

Ceramide (Cer) and sphingomyelin (SM) belong to a family of sphingolipids (SLs). Both SLs are mixtures of many species, differed in length and saturation of the fatty acid chain. Cer and SM are important components of the plasma membrane. In addition, Cer is a cellular second messenger, mediating apoptosis. The altered profiles of blood plasma/serum SLs were found in many pathologies. Interestingly, circulating SLs were proposed to be the early predictors of Alzheimer disease....

ea0035p382 | Diabetes (epidemiology, pathophysiology) | ECE2014

Iranians face with the same barriers to diabetes self management as people in other parts of the world. Need for family support

Sharghi Sassan , Jamshidiat Shahram

Method: One hundred and twenty-five respondents with type 1or type 2 diabetes, of both genders, were recruited from patients attending a private diabetes clinic in Karaj, Iran. They were asked to fill out the psychosocial barriers to self-care Questionnaire designed by Glasgow et al for estimating the frequency of occurrence of both environmental (e.g. time, competing demands, social pressure) and cognitive factors that interfere with diabetes self-management. Demographics and...

ea0035p383 | Diabetes (epidemiology, pathophysiology) | ECE2014

Low apelin levels are associated with a marked increase in risk for development of the gestational diabetes mellitus

Oktan Mehmet Asi , Calan Mehmet , Calan Ozlem , Cimril Dilek , Eraslan Sevinc

Introduction: Apelin is an adipokine which plays a role in the regulation of glucose homeostasis. The relationship between apelin serum concentration and dysmetabolic conditions such as type 2 diabetes (T2D) is still controversial. The aim of our study was to investigate the association of apelin with gestational diabetes mellitus (GDM).Design and methods: This study was designed as a cross-sectional research that consecutively recruited subjects with GD...

ea0035p384 | Diabetes (epidemiology, pathophysiology) | ECE2014

Translating the A1C assay into estimated average fasting glucose values: Data from the 2011 Korea National Health and Nutrition Examination Survey V

Kang Jun Goo , Ohn Jung Hun , Park Ju Ri , Yu Sung Hoon , Ryu Ohk Hyun , Kim Chul Sik , Lee Seong Jin , Hong Eun Gyoung , Kim Doo-Man , Yoo Jae Myung , Ihm Sung Hee , Choi Moon Gi , Yoo Hyung Joon

Aim: An international expert committee, after considering data on association of HbA1c and retinopathy, recommended that diabetes be diagnosed when HbA1c is more than 48 mmol/mol (>6.5%), provided this assay is done in a standardized laboratory. However, the performance of HbA1c in detecting diabetes in the Korean population remains unknown. The purpose of this study was to evaluate the efficiency of HbA1c in diagnosing diabetes and to identify the optimal threshold in the...

ea0035p385 | Diabetes (epidemiology, pathophysiology) | ECE2014

Presence of erythrocytosis in a patient with concomitant type 1 diabetes mellitus and Gitelman syndrome

Keskin Muge , Ozcan Muge , Aydin Unsal , Culha Cavit , Koc Gonul , Aral Yalcin , Gulcelik Nese Ersoz

İntroduction: Gitelman syndrome is characterized with hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis and neurological symptoms like muscle weakness. The association of GS and type 1 diabetes is rare, only described in a few case reports. We report a patient with unusual combination of Gitelman syndrome, Type 1 Diabetes Mellitus whose presentation was erytrocytosis.Case: A 26-year old male was diagnosed as Gitelman’s syndrome 5...

ea0035p386 | Diabetes (epidemiology, pathophysiology) | ECE2014

Incidence of type 1 diabetes mellitus over 21 consecutive years among 15–39-year aged Lithuanian population

Ostrauskas Rytas , Simukauskaite Justina , Vilkelyte Egle

Objective: To document the incidence of type 1 diabetes mellitus in Lithuanian 15–39 years of age population from 1991 to 2012.Research design and methods: A specifically developed contact system with all endocrinologists and diabetologists and general practitioners involved in the diabetes care covering 100% of the Lithuanian population aged 15–39, was the initial data source. Annual reports from regional family physicians, endocrinologist&#14...

ea0035p387 | Diabetes (epidemiology, pathophysiology) | ECE2014

The HLA-A*33 haplotype enhances the risk of type 1 diabetesin ndividuals with HLA-DR3+ or DR9+ haplotype

Zhang Juanjuan , Gu Weiqiong , Wang Bokai , Gao Jie , Li Li , Cui Bin , Hong Jie , Wang Weiqing , Ning Guang

Background: To investigate the typing for HLA-I in Chinese patients with type 1 diabetes (T1D) as a complement screening for HLA-II.Methods: A total of 212 T1D patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA-I and II were examined with a high-resolution polymerase chain reaction-sequence-based typing method.Results: The novel haplotype, A*33:03-B*58:01-C*03:02(A33), was a...

ea0035p388 | Diabetes (epidemiology, pathophysiology) | ECE2014

What is the contribution of MODY gene polymorphisms in the development of gestational diabetes mellitus?

Cikman Duygu Ilke , Cikman Muzaffer Seyhan , Erbas Tomris , Alikasifoglu Mehmet , Dagdelen Selcuk

Objective: Gestational diabetes mellitus (GDM) is the consequence of increased insulin resistance during pregnancy in predisposed individuals who already have impaired insulin secretion due to beta-cell dysfunction as in maturity onset diabetes of young (MODY) cases. Here we aimed to document the association between MODY subtypes and GDM to understand the pathogenesis of GD.Design: Matched, case-control study.Method: Ninety-three p...

ea0035p389 | Diabetes (epidemiology, pathophysiology) | ECE2014

Characterization of severe hypoglycemia episodes evaluated in the emergency department of a central hospital

Esteves Cesar , Neves Manuel Celestino , Baldaia Rui , Sa Joao , Carvalho Davide

Introduction: Hypoglycemia is a major limiting factor in intensive glucose control in diabetes mellitus. Its incidence has been increasing with the demand for intensive therapy for the prevention of the diabetic chronic complications. There are few studies in our country regarding the evaluation of hypoglycemia in the emergency room (ER).Objective: To characterize severe hypoglycemia episodes and patient features in individuals admitted to the ER.<p ...

ea0035p390 | Diabetes (epidemiology, pathophysiology) | ECE2014

Characterization of the episodes of severe hypoglycemia evaluated by a pre-hospital care unit of a reference hospital

Esteves Cesar , Neves Manuel Celestino , Baldaia Rui , Sa Joao , Carvalho Davide

Introduction: Severe hypoglycemia is defined as an episode that requires the assistance of another person in order to correct it. Most of the costs associated with hypoglycemia in diabetes mellitus patients are the result of severe episodes, when treated by health care professionals. In our country there are few studies regarding the epidemiology of episodes of hypoglycemia evaluated in the pre-hospital care setting.Methods: We retrieved all episodes of ...

ea0035p391 | Diabetes (epidemiology, pathophysiology) | ECE2014

Vitamin D, insulin dependency and BMI in type 1 diabetes

Bogdanou Dimitra , Penna-Martinez Marissa , Shoghi Firouzeh , Badenhoop Klaus

Type 1 diabetes mellitus (T1D) is caused by a process of altered humoral and cellular immunity, resulting in the destruction of insulin-producing cells. VD(25(OH)D3) insufficiency is implied as risk factor for T1D, while VD substitution in infantry is associated with a reduced T1D incidence. In T1D daily insulin injection is required for a stable glucose homeostasis and insulin demand rises by a higher Body Mass Index (BMI). Today there are no studies investigating ...

ea0035p392 | Diabetes (epidemiology, pathophysiology) | ECE2014

Resistin mRNA expression in fat and placental tissue of patients with gestational diabetes

Szamatowicz Michal , Wawrusiewicz-Kurylonek Natalia , Kuzmicki Mariusz , Telejko Beata , Wilk Juliusz , Pliszka Justyna , Lipinska Danuta , Szamatowicz Jacek , Kretowski Adam , Gorska Maria

Introduction: Resistin is a cysteine–rich adipokine that was originally described as a molecular link between obesity and insulin resistance. Our previous study showed higher serum resistin levels in patients with gestational diabetes mellitus (GDM) in comparison with healthy pregnant women however conflicting results have been reported by other authors. Therefore in the present study we investigated whether there were significant differences in resistin mRNA expression i...

ea0035p393 | Diabetes (epidemiology, pathophysiology) | ECE2014

Clinic blood pressure shows low sensitivity to detect alterations in ambulatory blood pressure monitoring in patients with type 1 diabetes

Vilchez-Lopez Francisco Javier , Mateo-Gavira Isabel , Laureano Florentino Carral-San , Garcia-Palacios Maria Victoria , Ortego-Rojo Jose , Aguilar-Diosdado Manuel

Objectives: To evaluate the validity as diagnostic test of isolated blood pressure measurement compared to 24 h ambulatory blood pressure monitoring (ABPM) in a group of clinically normotensive patients with type 1 diabetes (TDM1).Methods: Cross-sectional study including 85 normotensive and normoalbuminuric patients with TDM1. Media of two blood pressure measures by conventional technique and results of the 24 h blood pressure monitoring (SPACELABS 90217...

ea0035p394 | Diabetes (epidemiology, pathophysiology) | ECE2014

Increased prevalence of hepatocellular carcinoma in patients with cirrhosis and insulin resistance candidate to liver transplantation

Grancini Valeria , Lunati Elena , Zimbalatti Dario , Beck-Peccoz Paolo , Orsi Emanuela

Introduction: Hepatocellular carcinoma (HCC) is the first cause of death in patients with cirrhosis, with an incidence of 3–5% per year and a survival of 0–10% 5 years after the diagnosis. Major risk factors for HCC are HCV, HBV infection and alcohol, while a specific cause is not identifiable in 5–30% of cases. Several studies have shown a strong association between metabolic syndrome (MS), characterized by insulin-resistance (IR) and central obesity, and HCC; ...

ea0035p395 | Diabetes (epidemiology, pathophysiology) | ECE2014

Alterations in ambulatory blood pressure monitoring are associated to proinflammatory cytokines in patients with type 1 diabetes

Mateo-Gavira Isabel , Vilchez-Lopez Francisco Javier , Laureano Florentino Carral-San , Ortego-Rojo Jose , Visiedo-Garcia Francisco Manuel , Aguilar-Diosdado Manuel

Objectives: To evaluate the prevalence of blood pressure alterations with ambulatory blood pressure monitoring (ABPM) and its association with proinflammatory cytokines (IL-6 and VEGFα) in normotensive and normoalbuminuric patients with type 1 diabetes (TDM1).Patients and methods: Cross-sectional study including normotensive and normoalbuminuric patients with TDM1. Altered ABPM was considered when: 1) Mean systolic pressure (sBP) was greater than 13...

ea0035p396 | Diabetes (epidemiology, pathophysiology) | ECE2014

Vitamin D and diabetes mellitus type 2

Kostoglou-Athanassiou Ifigenia , Athanassiou Panagiotis , Gkountouvas Anastasios , Kaldrymides Philippos

Vitamin D deficiency has been observed in diabetes mellitus type 2 patients. It has been found to be related to poor glycemic control in diabetes mellitus type 2 patients as well as in patients with gestational diabetes. The administration of vitamin D in diabetes mellitus type 2 patients with vitamin D deficiency has been found to have conflicting results on blood glucose control. The aim was to assess the effect of vitamin D administration in diabetes mellitus type 2 patient...

ea0035p397 | Diabetes (epidemiology, pathophysiology) | ECE2014

Features of patients with LADA in a Diabetes Unit

Gonzalez-Molero Inmaculada , Dominguez-Lopez Marta , de Adana Maria Soledad Ruiz , Olveira Gabriel , Tinahones Francisco

Introduction: Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is underdiagnosed and appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents).Objective: To study features of patients with LADA diagnosed and treated in our clinic.Material and methods: Retrospective study of patients attended in our clinic in ...

ea0035p398 | Diabetes (epidemiology, pathophysiology) | ECE2014

Paper of oxidative stress and placenta on the development of gestational diabetes mellitus

Lopez-Tinoco Cristina , Vilchez Francisco , Visiedo Francisco , Mateo Isabel , Segundo Carmen , Aguilar-Diosdado Manuel

The relationship between gestational diabetes mellitus (GDM) and oxidative stress is not well known and the effect of oxidative stress in GDM placenta and the impact that could have on perinatal morbidity and risk of future complications is also yet to be elucidated. The aim of the study was to evaluate the relationships between maternal and placental tissue levels of markers of oxidative stress and antioxidants in women with GDM, which potentially may have considerable clinic...

ea0035p399 | Diabetes (epidemiology, pathophysiology) | ECE2014

Evaluation of the approach to diabetic patients before the first admission to diabetologist: Is there a room for the improvement?

Maric Andreja , Poljak Bozidar , Igrec Irena , Struc Luka , Gradiser Marina

Introduction: Diabetes mellitus (DM) is a chronic disease that can be largely managed in the primary care system.Aim: We analysed medical records of diabetic patients (pts) treated in Center for diabetes in our institution, during 1 year, determining the quality of care.Material and methods: The search was focused on pts at first admission to the diabetologist. Analysis included demographic and clinical characteristics of pts, meta...

ea0035p400 | Diabetes (epidemiology, pathophysiology) | ECE2014

Impact of Impaired Fasting Glucose on Blood Pressure and Vascular Risk Profile of Normotensives and Untreated Hypertensive Subjects

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , Blanca-Martos Lourdes , Aranda-Lara Pedro

Objective: To evaluate possible differences in 24 hours blood pressure (BP) and vascular risk profile (VRP) of normotensive (NT) and untreated hypertensive (UHT) patients with normoglycemia (NG) or Impaired Fasting Glucose (IFG).Design and methods: From 9.812 nondiabetic subjects taken from the Spanish ABPM (Ambulatory Blood Pressure Monitoring) Registry, we compared 24-h BP and VRP differences between patients with NG [n-6,875 (43.3% NT and 56....

ea0035p401 | Diabetes (epidemiology, pathophysiology) | ECE2014

In human retina the A allele of the −866G/A polymorphism in the UCP2 gene is associated with increased UCP2 protein concentrations

Souza Bianca , Brondani Leticia , Kliemann Lucia , Marcon Alexandre , Canani Luis , Crispim Daisy

Introduction: Uncoupling protein 2 (UCP2) is a mitochondrial transporter present in the inner membrane of mitochondria, and it uncouples substrate oxidation from ATP synthesis, thereby dissipating the membrane potential energy and consequently decreasing ATP production by mitochondrial respiratory chain. As a consequence of the uncoupling, UCP2 decreases reactive oxygen species (ROS) formation by mitochondria. ROS overproduction is related to diabetic retinopathy (DR), a chron...

ea0035p402 | Diabetes (epidemiology, pathophysiology) | ECE2014

Association of the UCP polymorphisms with susceptibility to obesity: case–control study and meta-analysis

Souza Bianca , Brondani Leticia , Assmann Tais , Boucas Ana Paula , Bauer Andrea Carla , Canani Luis , Crispim Daisy

Introduction: Some studies have reported associations between five uncoupling protein (UCP) 1–3 polymorphisms and obesity. This paper describes a case–control study and a meta-analysis conducted to determine if the following polymorphisms are associated with obesity: −3826A/G (UCP1); −866G/A, Ala55Val and Ins/Del (UCP2) and −55C/T (UCP3).Methods: The case–control study enrolled 282 obese and 483...