Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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16th European Congress of Endocrinology

Poster Presentations

Diabetes complications

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Diabetes (epidemiology, pathophysiology)
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Diabetes therapy

ea0035p403 | Diabetes complications | ECE2014

Does proton pump inhibitor use decrease microvascular complicaton rate in type 2 diabetic patients? A retrospective analysis

Kut Altug , Bozkus Yusuf , Anil Cuneyd , Tutuncu Neslihan Bascil

Proton pump inhibitor (PPI) drugs which are used safely to treat peptic ulcus disease since 2 decades, moderately increases gastrin hormone by decreasing gastric acid secretion. Preclinical studies show that gastrin itself, or drugs that increase gastrin levels such as PPIs, increase islet cell mass and improve glycaemic control. To the best of our knowledge one prospective and some retrospective studies claim that PPI medication in diabetic patients leads to an average decrea...
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ea0035p404 | Diabetes complications | ECE2014

The relation of left ventricular hypertrophy and markers of inflammation in type 2 diabetic patients

Nelaj Ergita , Gjata Margarita , Tase Mihal

Introduction: The association between diabetes and adverse cardiovascular outcome may be partially explained by the strong independent association of type 2 diabetes with cardiovascular target organ damage, such as left ventricular hypertrophy (LVH), a well-known predictor of cardiovascular events independent of coronary artery disease. The aim of the present study is to evaluate the relation of LVH to fibrinogen and C-reactive protein (CRP) as markers of inflammation and susc...
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ea0035p405 | Diabetes complications | ECE2014

Incidence and cost of complications among men and women with type 2 diabetes

Farshchi Amir , Esteghamati Alireza , Sari Ali Akbari , Kebriaeezadeh Abbas , Aghili Rokhsareh , Ebadi Maryam , Dorkoosh Farid Abedin , Abdollahi Mohammad

Aims/Introduction: To evaluate the impact of diabetes mellitus on the incidence of related micro- and macrovascular outcomes as well as cost analysis in people with type 2 diabetes mellitus.Materials and methods: In a cohort study, registered patients with type 2 diabetes mellitus were followed for 10 years at a tertiary care center. The type of medications and clinical data were extracted from patients’ archives. Incidence of mortality, micro- and ...
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ea0035p406 | Diabetes complications | ECE2014

Is the ankle-brachial index directly associated with current glycemic control in diabetic patients? Preliminary results of our study

Yurekli Banu Sarer , Kocabas Gokcen Unal , Mirili Cem , Yurekli Ismail , Cakir Habib

Introduction: Association between ankle-brachial index (ABI) and coronary, cerebral, and peripheral vessels involvement has been shown in different studies. The normal range of ABI is between 0.9 and 1.4. Values below 0.9 show peripheral vessel disease. An ABI more than 1.4 is characteristic for vascular rigidity. We aimed to investigate the ABI value in our type 2 diabetic patients and association of ABI with glycemic control.Materials and methods: This...
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ea0035p407 | Diabetes complications | ECE2014

Abstract unavailable....
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ea0035p408 | Diabetes complications | ECE2014

Angiogenic factors and circulating endothelial progenitor cells in patients with type 2 diabetes mellitus

Drela Ewelina , Kulwas Arleta , Jundzill Wieslaw , Ruszkowska-Ciastek Barbara , Goralczyk Barbara , Stankowska Katarzyna , Ruprecht Zofia , Kubica Jacek , Rosc Danuta

Introduction: Abnormal angiogenesis may contribute to impaired wound healing and the consequence of them is non-healing diabetic ulcers development. Therefore, the aim of the study was to evaluate the number of circulating EPCs, plasma levels of VEGF-A, sVEGF-R2 and FGF-2 in diabetic patients.Materials and methods: Totally, 75 subjects were enrolled: 45 patients with type 2 diabetes (mean age 67.1 years) and 30 healthy volunteers (mean age 63.3 years). P...
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ea0035p409 | Diabetes complications | ECE2014

Associated study of polymorphic variants in the gene for superoxide dysmutase (Mn SOD) and different types of diabetes mellitus

Pashkunova Sylvia , Ivanov Valentin , Savov Alexey

Superoxid dysmutase (SOD) is a key antioxidant enzyme engaged in detoxication of superoxide radicals. Ala/Val substitution in Mn SOD leads to a change in the effectiveness of the action of the enzyme. This polymorphism we analyzed among several groups patients with diabetes and we compared with control group of healthy volunteers. It is proved an association connection of tracked marker in some of the groups of patients with diabetes compared to the rest population sample. Suc...
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ea0035p410 | Diabetes complications | ECE2014

Depression risk factors in type 1 diabetes mellitus

Navmenova Yana , Mokhort Tatiana , Makhlina Elena

Purpose: To evaluate the possible risk factors for depression development in type 1 diabetes mellitus (DM 1).Methods: 163 patients with DM 1. Depression was determined by the hospital anxiety and depression scale (HADS). Common factors of risk depression development were assessed by questionnaire survey according to a specially designed questionnaire. The levels of HbA1c and homocysteine (HC) serum were determined.Results: Depressi...
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ea0035p411 | Diabetes complications | ECE2014

Disabilities of the arm, shoulder and hand questionnaire and diabetic complications: preliminary results

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu

Aim: Disabilities of the arm, shoulder and hand (DASH) questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale. In this study, we aimed to evaluate DASH questionnaire in 1000 type 2 diabetes mellitus (DM) patients.Material and methods: 179 patients (mean age 51.73±9.06 years, 117 women and 62 me...
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ea0035p412 | Diabetes complications | ECE2014

Relation between psychiatric symptoms and diabetic complications: preliminary results

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu

Aim: In this study, we aimed to assess psychiatric symptoms in 1000 type 2 diabetes mellitus (DM) patients.Material and methods: 179 patients (mean age 51.73±9.06 years, 117 women and 62 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytren’s contracture, tinnel sign and tendinitis was assessed. Diabetic retinopathy was assessed by direct ophthalmoscopy. Urinary albumin excretion was ...
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ea0035p413 | Diabetes complications | ECE2014

The diabetic hand: a forgotten complication?

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu

Aim: In this study, our aim was to investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabetes mellitus patients.Material and methods: 179 patients (mean age 51.73±9.06 years, 117 women and 62 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, dupuytren’s contracture, tinnel sign and tendinitis was assessed. All patients were evaluated also by the R...
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ea0035p414 | Diabetes complications | ECE2014

The results of evaluation of dynamics of levels of glycemia in diabetes mellitus type 1

Makhlina Elena , Mokhort Tatiana , Kholodova Elena , Navmenova Yana

The aim of the work was to assess the dynamics of rates of carbohydrate metabolism in DM1 in young persons.Materials and methods: The study of daily dynamics of glucose was conducted by Continuous Glucose Monitoring System. For the analysis of continuous glycaemic curve there was conducted the computation of risk index (RI) of hypoglycemia and hyperglycemia during the study period.There were examined 162 patients with DM1. First gr...
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ea0035p415 | Diabetes complications | ECE2014

Analysis of diabetic retinopathy risk factors in type 2 diabetes patients

Popovic Djordje , Mitrovic Milena , Tesic Dragan , Novakovic-Paro Jovanka , Tomic Dusan , Icin Tijana , Vukovic Bojan , Medic-Stojanoska Milica , Kovacev-Zavisic Branka

Introduction: Diabetic retinopathy screening is the most accessible method of visualization of the affected small blood vessels in diabetic patients. Diabetic retinopathy is associated with age of patients, duration of diabetes, male sex, poor blood glucose control, central obesity, arterial hypertension, increased proteinuria, chronic inflammation and lipid disorders. Our study aims to compare type 2 diabetes patients with and without developed diabetic retinopathy regarding ...
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ea0035p416 | Diabetes complications | ECE2014

Treatment of ulcer-necrotic manifestations of diabetic foot using ultrasonic cavitation

Prystupiuk Maksym , Onofriichuk Iuliia , Naumova Liudmyla , Prystupiuk Lev , Naumova Marianna , Prystupiuk Oleksandr

Around 90–95% of all patients with DM have type 2, among whom 90% could likely suffer from ulcerative-necrotic manifestations of diabetic foot (DF). The latters may develop neuropathic form of DF in 80% of cases. To examine the effectiveness of treatment of ulcers in patients with the neurotic form of DF using ultrasonic cavitation.57 patients with DM type 2 were treated who had the neurotic form of DF with 1–3 degrees of ulcers on the feet acc...
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ea0035p417 | Diabetes complications | ECE2014

Genetic dependence of urinary enzyme, neutral α-glucosidase, in diabetic nephropathy in uzbek children and adolescents with type 1 diabetes mellitus

Rakhimova Gulnara , Sadykova Akida , Alimova Nasiba

The work was initiated to assess clinical-diagnostic value of urinary α-glucosidase activity in predicting chronic renal insufficiency in type 1 diabetes mellitus in Uzbek children and adolescents. We examined 152 children and adolescents of the Uzbek population, 122 children and adolescents with type 1 diabetes mellitus (51 male and 71 female). By proteinuria the patients were divided into three groups: with normoalbuminuria (NAU) (n=52), with microalbuminuria (...
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ea0035p418 | Diabetes complications | ECE2014

Activity of neutral α-glucosidase in the urine of children and adolescents with type 1 diabetes mellitus and diabetic nephropathy

Rakhimova Gulnara , Sadykova Akida

Aim: To identify clinical significance of enzymuria in early diagnosis of DN in children and adolescents with type I diabetes mellitus.Materials and methods: We examined 112 patients (47 males/55 females) with type I diabetes mellitus. By the DN severity the patients were divided into following groups: with normoalbuminuria (NAU) (n=47), with microalbuminuria (MAU) (n=44) and with marked proteinuria (MP) (n=19). Ten healthy sub...
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ea0035p419 | Diabetes complications | ECE2014

Prevalence and risk factors of prolonged QTc interval in type 2 diabetic patients; impact of the type of treatment and quality of glycemic control

Ninkovic Vladan , Dobric Milan , Jakovljevic Djordje , Ninkovic Srdjan , Bubanja Goran , Miloradovic Vladimir , Zivojinovic Dragana , Babic Marijana , Milovanovic Bratislav , Giga Vojislav

Introduction: The aim of this study was to assess the prevalence and predictors of prolonged QTc interval in patients with type 2 diabetes (T2D).Methods: This study included 501 consecutive T2D patients (277 males, age 60.4±8.1 years) treated in National Educational Centre for Diabetes, ‘Merkur’, Vrnjacka Banja, from September 2011 to July 2012. We analysed baseline clinical and laboratory data including: age, gender, duration of diabetes,...
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ea0035p420 | Diabetes complications | ECE2014

Patients with type 1 diabetes and thyroid autoimmunity have low prevalence of microangiopathic complications

Rogowicz-Frontczak Anita , Pilacinski Stanislaw , Chwialkowska Anna , Zozulinska-Ziolkiewicz Dorota , Wierusz-Wysocka Bogna

Introduction: Type 1 diabetes (T1DM) is often associated with autoimmune thyroid disease (AITD). Common susceptibility genes increase risk for development of both AITD and T1DM. The influence of this comorbidity on the risk of diabetic microangiopathy is unknown.Methods/design: We included 100 consecutive patients with T1DM (55 men, and 45 women) aged 29 (mean, S.D.=6) with diabetes duration 13 (6) years, 35 had diagnosed at least one micr...
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ea0035p421 | Diabetes complications | ECE2014

Relationship between diabetes mellitus and hemostasis: a prothrombotic condition

Arpaci Dilek , Saglam Fatma , Ozdemir Didem , Ersoy Reyhan , Cakir Bekir

Background: Diabetes is very common disorder. Many studies have shown that patients with diabetes mellitus have incresing trombotic complications both arterial and venous trombosis. Bad control diabetes increases risk of trombosis. Recent reports have shown that shortened APTTs and increased fibrinogen indicate procoagulan situations. In this study, we aimed to evaluate whether chronic hyperglisemia or bad control diabetes causes trombosis which is reflected by shortened APTTs...
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ea0035p422 | Diabetes complications | ECE2014

Androgendeficiency in men with type 2 diabetes mellitus

Luchytskiy Eugen , Luchytskiy Vitaliy , Zubkova Galina , Rybalchenko Victoriya

Introduction: The issue of the impact of disturbances of functional status of gonads in men on the development of type 2 diabetes mellitus (T2DM) has been studied for a long time. However, the results obtained appear to be ambiguous. A number of studies conclude that blood levels of testosterone (T) in men with DM are within the normal range of fluctuations and do not play a pathogenetic role. At the same time, recent epidemiological studies demonstrate a high prevalence of lo...
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ea0035p423 | Diabetes complications | ECE2014

Characteristic features of the course of chronic venous insufficiency of the lower limbs in patients with impaired peripheral innervation of diabetes mellitus type 2

Shlyakova Anna , Korneva Kseniya , Strongin Leonid , Kudykin Maksim

Purpose: To assess the influence of diabetic polyneuropathy (DPN) on the course of chronic venous insufficiency (CVI) of the lower limbs in patients with combined pathology.Methods: 40 patients with CVI of the lower limbs in combination with diabetes mellitus (DM) type 2 were examined. DPN was diagnosed in 34 patients - group 1, 6 patients had no DPN - group 2. The diagnosis of CVI was established according to the international classification of CEAP. Th...
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ea0035p424 | Diabetes complications | ECE2014

Abstract unavailable....
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ea0035p425 | Diabetes complications | ECE2014

Benfotiamine efficiency in the stabilization of diabetic peripheral polyneuropathy

Dovgalo Veronica , Bilodid Irina , Kozlova Elena , Mokhort Tatyana

One of the most frequent complications of diabetes is diabetic sensorimotor peripheral polyneuropathy (DSPN). B vitamins successfully used for the treatment DSPN. However, prolonged use of vitamins B6 and B12 in effective doses limited by the comorbidities and possibility of the neurotoxic reactions development, as for vitamin B1, its low bioavailability of water-soluble forms. This determines whether the use of fat-soluble form of benfotiamine with maximum bioavailability.</p...
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ea0035p426 | Diabetes complications | ECE2014

Association of angiotensin-converting enzyme gene I/D polymorphism and aldosterone synthase (CYP11B2) gene −344T/C polymorphism with the risk of nephropathy in diabetic patients

Vasilkova Volha , Silin Arkadij , Martinkov Victor , Naumenko Elena , Zekenova Kulash , Mokhort Tatiana

Introduction: Diabetic nephropathy (DN) is one of the most serious chronic complications of diabetes mellitus characterized by persistent albuminuria, raised arterial blood pressure, a lowered glomerular filtration rate, and high-risk of cardiovascular morbidity and mortality. The vascular genes (Angiotensin-converting enzyme) ACE, and (aldosterone synthase) CYP11B2 are involved in alterations in vascular endothelium, and are suggested to play a role in the susceptibi...
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ea0035p427 | Diabetes complications | ECE2014

Sclerostin distribution in children and adolescents with type 1 diabetes mellitus and correlation with bone metabolism markers and bone mineral density

Tsentidis Charalampos , Gourgiotis Dimitrios , Kossiva Lydia , Marmarinos Antonios , Doulgeraki Artemis , Karavanaki Kyriaki

Introduction: Sclerostin is an inhibitor of the Wnt/β-catenin bone metabolic pathway. Increased sclerostin levels and reduced bone mineral density (BMD) have been documented in adult patients with diabetes mellitus (DM), predominantly in those with type 2 diabetes mellitus (T2DM). No relevant data exist on childhood T1DM. Our aim was to study plasma sclerostin concentration in children and adolescents with T1DM and controls and to correlate sclerostin levels with metaboli...
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ea0035p428 | Diabetes complications | ECE2014

Higher levels of osteoprotegerin and S-RANKL in children and adolescents with type 1 diabetes mellitus may indicate increased osteoclast activity and predisposition to lower bone mass

Tsentidis Charalampos , Gourgiotis Dimitrios , Kossiva Lydia , Doulgeraki Artemis , Marmarinos Antonios , Karavanaki Kyriaki

Introduction: Diabetes mellitus (DM) is a risk factor for reduced bone mass. Several bone metabolic pathways seem to be disrupted in patients with type 1 diabetes mellitus (T1DM).Materials and methods: We evaluated 40 children and adolescents with T1DM (mean±S.D., age 13.04±3.53 years, mean±S.D., T1DM duration 5.15±3.33 years) and 40 healthy age- and gender-matched controls (mean±S.D.,...
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ea0035p429 | Diabetes complications | ECE2014

The association of peripheral artery disease with renal function and albuminuria in diabetic patients

Kim Dong Sun , Park Jung Hwan , Ahn Kyu Jeung , Cha Bong Soo

Objective: The association between albuminuria and peripheral artery disease (PAD) could be confounded by renal function. Albuminuria reflects generalized disruption of endothelial cell function. This study was conducted to examine the association of PAD with low glomerular filtration rate (GFR) and albuminuria in diabetic patients.Methods: A total of 254 diabetic patients were included. We examined the age, sex, duration of diabetes, GFR, urinary albumi...
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ea0035p430 | Diabetes complications | ECE2014

Low FT4 syndrome in gestational diabetes

Mezzacapo Gianmarco , Ciminelli Carlo , Furano Simona , Oddi Caterina

About 7% of pregnancies are complicated by diabetes, out of which 97.5% gestational diabetes (GMD), 2.5% pre-gestational diabetes. We investigated 29 women at their first pregnancy who had GMD medium risk factor in the absence of pre-existing thyroid pathologies. We divided them in two groups: the first 19 women (age 33.9 years) resulted affected by GMD (OGTT effected, according to Carpenter and C criteria), between pregnancy weeks 24–28; the second ten women (age 34.3 ye...
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ea0035p431 | Diabetes complications | ECE2014

Metabolic syndrome and cardiovascular risk are less prevalent in LADA vs type 2 diabetes patients

Reghina Aura D , Constantin Madalina , Olaru Ramona , Florea Suzana , Fica Simona

Background: Latent autoimmune diabetes in adults (LADA) is a form of autoimmune diabetes with features overlapping types 1 and 2 diabetes mellitus (T2DM). Frequently patients with LADA could be confound with T2DM patients if it was not performed a glutamic acid decarboxilase antibodies (GADA) evaluation. Even thou LADA and T2DM have similar phenotype, patients with LADA seem to have less frequent macrovascular complications.The aim of the study was to co...
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ea0035p432 | Diabetes complications | ECE2014

Erectile dysfunction scores are lower in type 2 diabetes mellitus but not correlate with carotis intima media ticknes or coronary arter disease

Cander Soner , Coban Soner , Gul Ozen Oz , Altunel M Sakir , Tuncel Ercan

Aim: To evaluate prevalence of erectile dysfunction (ED) in patients with type 2 diabetes in relation to the cardiovascular risk factors.Methods: A total of 116 males including type 2 diabetic patients (n=68, mean age: 56.7 (5.8) years) and age-matched healthy controls (n=48, mean age: 57.0 (6.6) years) were included to study. Concomitant hypertension, hyperlipidemia, and coronary artery disease (CAD) were recorded in each subject along...
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ea0035p433 | Diabetes complications | ECE2014

Diabetic polyneuropathy as the only diabetes related complication associated with higher likelihood and more severe forms of erectile dysfunction in type 2 diabetes

Cander Soner , Coban Soner , Altunel M Sakir , Gul Ozen Oz , Tuncel Ercan

Aim: Erectile dysfunction (ED) has been reported to occur more commonly in diabetes than general population with the prevalence rate varies widely from 35 to 75%. Patients with diabetes was also shown to have much earlier onset of ED and more severe form of the disease associated with a poorer quality of life. We aimed to evaluate association of ED with diabetes related complications in patients with type 2 diabetes in our study.Methods: In a total of 68...
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ea0035p434 | Diabetes complications | ECE2014

The influence of maternal BMI and weight gain in gestational diabetes: results of the Portuguese population in 2011

Santos Maria Joana , Fernandes Vera , Pereira Maria Lopes , Marques Olinda

Background and aims: Maternal BMI and weight gain are associated with maternal and fetal complications in gestational diabetes (GD), but their relative contribution is not clearly defined. Our aim was to determine the influence of BMI and weight gain in the evolution of GD.Material and methods: Multicenter, retrospective study of women diagnosed with GD at the medical centers of the Portuguese Group for the Study of Diabetes and Pregnancy in 2011. We use...
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ea0035p435 | Diabetes complications | ECE2014

Hemostatic biomarkers in selected group of patients with type 1 diabetes: are they associated with different degrees of diabetic retinopathy

Polat Sefika Burcak , Ugurlu Nagihan , Yulek Fatma , Simavli Huseyin , Ersoy Reyhan , Erel Ozcan , Cakir Bekir

Background: Diabetic retinopathy (DR) is the leading cause of blindness in the world. Retinopathy and nephropathy can still progress in diabetics despite optimal metabolic control. The aim of the present study was to determine whether different degrees of DR (proliferative or non-proliferative) were associated with abnormally modulated hemostatic parameters in patients with type 1 DM.Method: 52 type 1 diabetic patients and 40 healthy controls were enroll...
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ea0035p436 | Diabetes complications | ECE2014

Markers of endothelial dysfunction in type 1 diabetics with or without microalbuminuria

Polat Sefika Burcak , Ugurlu Nagihan , Sari Cenk , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Diabetic nephropathy (DN) is an important one of the complications and is detected in almost 30-40% of the patients with type 1 diabetes mellitus (T1DM). Besides the well known risk factors, endothelial dysfunction also plays a role in the pathogenesis of DN and diabetic retinopathy. Our aim was to determine flow mediated dilation measurements and serum soluable ET-1, ICAM-1, and VCAM-1 levels in T1DM patients with or without inceased albumin excretion and compar...
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ea0035p437 | Diabetes complications | ECE2014

Skin findings among diabetic patients

Sahin Murat , Ozturk Perihan , Oguz Ayten , Korkut Ismail , Ozkaya Mesut , Gul Kamile

Aim: Diabetes mellitus affects many systems and one of them is skin. Skin findings among diabetic patients reported 30–71%. Skin findings may be due to direct metabolic effects of diabetes but complications and drugs may be cause as well. In this study our aim was to investigate the skin findings and prevalence among diabetic patients that admitted to endocrinology policlinic.Method: 81 patients involved to study, skin examination of the patients we...
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ea0035p438 | Diabetes complications | ECE2014

Vascular endothelial growth factor polymorphism +405 G/C is associated with early stage of diabetic nephropathy in patients with type 2 diabetes

Shyshko Volha , Mokhort Tatjana , Gonchar Alexander , Tsapaeva Natalia , Konstantinova Elena

Background: One of the basic genetic factors that impact on development of diabetic nephropathy is enhanced expression of vascular endothelial growth factor (VEGF).Objective: To study association between VEGF polymorphism +405 G/C and early stage of chronic kidney disease (CKD) in patients with impaired glycemic states.Materials and methods: 73 included patients were divided into three groups: group 1–26 patients with prediabe...
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ea0035p439 | Diabetes complications | ECE2014

Analysis of ultrasound structure of the thyroid gland and assessment of structural changes in patients with diabetes mellitus type 1 at different stages of chronic kidney disease

Sazonava Alena , Karlovich Natalia , Astapovich Marina , Mokhort Tatiana

Existing data on the anatomical state of the thyroid gland (ThG) in patients with chronic kidney disease (CKD) are contradictory.Objective: The aim was to analyze the anatomical features of the ThG and their correlation if it exists in patients with diabetes mellitus type 1 (T1DM) at different stages of comorbid CKD.Materials and methods: We recruited 53 patients (17 m; 36 f; age 43.7±11.3 years; BMI 25.8±5.0 kg/m2</...
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ea0035p440 | Diabetes complications | ECE2014

Comparative analysis of methods for the evaluation of renal function in patients with diabetes mellitus type 1 at different stages of chronic kidney disease

Karlovich Natalia , Sazonava Alena , Mokhort Tatiana , Trunova Natalia

The aim was to analyze the efficiency of various methods of examination to update the degree of diabetic nephropathy and to determine the optimal to predict the decline in renal function in patients with diabetes mellitus type 1 (T1DM).We examined 50 patients (17 m; 33 f; age 40.1±11.7 years; BMI 25.9±5.0 kg/m2; duration of T1DM 22.3±8.1 years; and age at T1DM onset 21.6±13.2 years) at chronic kidney disease (CKD) stages 1,...
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ea0035p441 | Diabetes complications | ECE2014

QT intervals and vitamin D levels in diabetic patients

Yetkin Demet Ozgil , Kucukkaya Belgin

Objective: Diabetes is an independent risk factor for sudden cardiac death. Prolongation of the QT interval on the ECG increases the risk of arrhytmias and sudden death, and the increased prevalance of QT prolongation is an independent risk factor for cardiovascular death in diabetic patients. Low vitamin D levels are also associated with cardiovascular mortality. The aim of this study was to investigte the relationship between QT interval and vitamin D levels in type 2 diabet...
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ea0035p442 | Diabetes complications | ECE2014

Dental care and periodontal disease in Turkish diabetic patients

Kaya Selin Kucukyurt , Sahin Demet , Askin Sezen Buyukozdemir , Ilhan Ayse , Erdal Sevgi , Dagdelen Selcuk , Nohutcu Rahime M , Erbas Tomris

Diabetes mellitus is a common and growing global health problem leading to several complications. Among these, periodontal diseases are considered as the sixth complication of diabetes. The goals of this cross-sectional study were to assess Turkish diabetic patients’ oral health behaviors and association with demographic characteristics, access to dental care and need for improved health education. The study sample consisted of 121 diabetic patients (43 M/78 F), with a me...
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ea0035p443 | Diabetes complications | ECE2014

Clinical profile and management of diabetic osteoarthropathy

Youcef Hafsa Si , Azouz Malha , Hanachi Ratiba , Mimouni Safia , Boudiba Aissa

Introduction: The diabetic foot osteoarthropathy is defined as a progressive painless arthropathy of one or more joints due to an underlying neurological injury. It is the bed of complications and severe foot infections and involves the functional prognosis. Through observations of patients we report the difficulty of management of wounds on foot osteoarthropathy.Observation: It is five diabetic patients hospitalized in our department with an array of se...
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ea0035p444 | Diabetes complications | ECE2014

Comparative assessment of parathyroid hormone and bone turnover markers in diabetic and non-diabetic patients with end-stage chronic kidney disease

Karlovich Natalia , Mokhort Tatiana

It’s well known that secondary hyperparathyroidism (SHPT) is common in patients with chronic kidney disease stage 5 (CKD5D), on dialysis. The aim of our study was to analyze peculiarities of SHPT in diabetic patients in comparison to those with other course of CKD5D.We studied 25 diabetic and 180 non-diabetic patients with CKD5D, mean age 47.5±10.8 years; age at dialysis onset 42.7±11.7 years; dialysis duration 4.7±3.9 years. Groups w...
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ea0035p445 | Diabetes complications | ECE2014

Autoimmune pancreatitis after intravenous insulin desensitization in a diabetic patient allergic to insulin without pancreatic reserve

Salas Marcel Sambo , Melero Victor Andia , Ishishi Yoko Olmedilla , Centeno Rogelio Garcia , Ramirez Maria Laura , Motilla Marta , Antiguedad Cynthia Gonzalez , Requena Maria , Lopez Javier Gonzalez , Rivadeneira Lenin , Arnoriaga Maria

Introduction: Allergy is an uncommon side-effect of insulin treatment in which desensitization represents an alternative when initial approaches are not effective. Autoimmune pancreatitis (AIP) is an even more rare disease that generally has a successful response to corticosteroids. The case of a 50-year-old diabetic man who developed both processes sequentially is presented.Case report: The patient was admitted for acute diabetes mellitus (DM) decompens...
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ea0035p446 | Diabetes complications | ECE2014

A lepromatous lepra case presented like diabetic foot

Yalcin Mehmet Muhittin , Emiroglu Tugce , Ozkan Cigdem , Altinova Alev , Yetkin Ilhan , Karakoc Ayhan , Ayvaz Goksun , Arslan Metin

A 67–year-old female patient was transferred to our hospital from a nursing home for high capillary glucose levels and foot ulcer considered as diabetic foot infection. Her past medical history could not be obtained because of mental retardation with unknown etiology and absence of relatives.A purulent foot ulcer sized 4×3 cm was found in right heel. She also had deformities in her hands, feet, and her nose. Peripheral neuropathy was also detec...
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ea0035p447 | Diabetes complications | ECE2014

Prolonged cerebellar ataxia after: severe hypoglycemic attack in a patient with T1DM: a rare but disturbing sequela

Polat Burcak , Aydin Cevdet , Evranos Berna , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Hypoglycemia is common in people with diabetes who aim to achieve strict glucose control. The neurologic manifestations of hypoglycemia are mostly reversible and includes behavioral changes, difficulty in concentration, confusion, loss of fine motor functions, and seizures. Herein we have presented a case who was pregnant and experienced severe hypoglycemia which led to permanent ataxia.Case: A 26-years-old female patient was brought to our...
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ea0035p448 | Diabetes complications | ECE2014

Mean platelet volume in type 2 diabetic patient: is there a relationship between mean platelet volume and diabetic microvasculary complications?

Cadirci Kenan , Olcaysu Okan , Yigit Derman , Carlioglu Ayse , Durmaz Dr. Senay Arikan

Aim: Most diabetic patients suffer from vascular thrombotic complications. Alterations in platelet size are associated with atherosclerotic complications in patients with diabetes. The aim of study is to determine the relationship between mean platelet volume (MPV) and microvascular complications in type 2 diabetic patients.Materials and methods: Seventy-nine type 2 diabetic patients (mean age 51.0±10.8 years and BMI 31.0±5.5 kg/m2),...
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ea0035p449 | Diabetes complications | ECE2014

Small fibre neuropathy association with increased mortality in patients with chronic kidney disease, with or without diabetes mellitus

Tesic Dragan , Tomic Dusan , Papanas Nicolaos , Mitic Igor , Mirkovic Tatjana , Sibalic Marija , Petrovic Lada

Background and aim: We carried out a prospective 1-year study to examine the association of sudomotor dysfunction with mortality in patients with chronic kidney disease.Materials and methods: 97 patients from dialysis unit (28 with diabetic nephropathy (DN); 37 with nephroangiosclerosis, (NA), 18 with glomerulonephritis (GN), 14 with other conditions (O)); 32 with type 2 DM and creatinine clearance (CrCl) 30–50 ml/min; and 24 transplanted patients w...
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ea0035p450 | Diabetes complications | ECE2014

Diabetic neuropathy in a young patient with recently diagnosed diabetes mellitus: an atypical presentation of insulin neuritis

Esteves Cesar , Neves Manuel Celestino , Lau Eva , Meneses Joana , Jorge Georgina , Carvalho Davide

Introduction: Insulin neuritis is a rare form of presentation of diabetic neuropathy, usually associated with the sudden intensification of glucose control in individuals with long standing uncontrolled diabetes mellitus.Objectives: To report a case of insulin neuritis in a young male, few weeks after diagnosis and insulin therapy initiation.Clinical case: Male, 22 years old, previous history of excess weight until he was 19 years ...
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ea0035p451 | Diabetes complications | ECE2014

Abstract withdrawn....
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ea0035p452 | Diabetes complications | ECE2014

Associations of serum lipid levels with diabetic retinopathy in type 1 diabetics

Dogan Burcu , Oner Can , Oguz Aytekin

Objective: Diabetic retinopathy was one of the important complications of diabetes both in type 1 or type 2 and cause blindness. High lipid levels was accused of endotheial dysfunction and so play a role in retinal exudate formation in retinopathy. The aim of this study was to acess the association between serum lipid levels and diabetic retinopathy.Methods: Our study was carried out retrospectively in Istanbul Medeniyet University Goztepe Training and R...
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ea0035p453 | Diabetes complications | ECE2014

Effect of diabetic nephropaty on lipid profiles of adult type 1 diabetics

Dogan Burcu , Oner Can , Oguz Aytekin

Objectives: Diabetic nephropathy is a common complication of diabetes. It can be a cause of abnormal lipoprotein metabolism and may be had an negative impact on metaboic control in diabetics. The aim of this study was to evaluate the effect of diabetic nephropathy on lipid profiles of adult type 1 diabetics.Methods: Our study was carried out retrospectively in Istanbul Medeniyet University Goztepe Training and Research Hospital between 2012 and 2013. The...
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ea0035p454 | Diabetes complications | ECE2014

Vasoinhibins are natural inhibitors of angiogenesis in the vitreous and are impaired in patients with diabetic retinopathy

Triebel Jakob , Moreno-Vega Aura Ileana , Vazquez-Membrillo Miguel , Garcia-Franco Renata , Macotela Yazmin , Lopez-Star Ellery , Escalera Gonzalo Martinez de la , Clapp Carmen

With preterm regression of the hyaloid vascular system, the human vitreous becomes devoid of blood vessels and maintains an avascular, transparent state throughout life. However, diseases of the developing and mature retina, such as retinopathy of prematurity or proliferative diabetic retinopathy (PDR), often result in the invasion of blood vessels into the vitreous, with a risk of causing vitreous hemorrhage, retinal detachment and, consequently, loss of vision or blindness. ...
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ea0035p455 | Diabetes complications | ECE2014

The correlation of foetal ultrasound and HbA1c with birth weight in women with gestational diabetes

Stepien Karolina , Rambihar Sophie , Leigh-Atkins Sue , Okinoye Gbemisola , Kyriacou Angelos , Whiteside Sigrid , Issa Basil

Background: It is estimated that gestational diabetes (GDM) accounts for 87.5% of all diabetes cases in pregnancy and is associated with worse pregnancy outcomes. Macrosomia is one of the main complications of GDM and antenatal management strategies are directed at ensuring normal foetal growth. Ultrasonography is a useful tool for estimating foetal size, but there is little data in the literature correlating foetal abdominal circumference (AC) and birth weight in GDM. Further...
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ea0035p456 | Diabetes complications | ECE2014

Undiagnosed diabetes mellitus presenting as thrombosis of the portal venous system: case report

Kermaj Marjeta , Zeqja Anisa , Muco Ermira , Keri Denisa , Hoxha Violeta , Husi Gerond , Gjicali Enkelejda , Ylli Agron

Introduction: Thrombosis of the portal venous system is rare with the prevalence about 1% in the general population reported previously, difficult to diagnose and can be fatal. We report a case of previously-undiagnosed type 2 diabetes mellitus presenting as portal venous system thrombosis and reviewed the pertinent medical literature.Case presentation: A 54-year-old white female was admitted to our hospital with 10 days history of vague...
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ea0035p457 | Diabetes complications | ECE2014

Diabetic ketoacidosis and olanzapine: case report

Garrido Susana , Pereira Teresa , Freitas Claudia , Vilaverde Joana , Amaral Claudia , Carvalho Andre , Borges Fatima

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...
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ea0035p458 | Diabetes complications | ECE2014

Intima: media thickness and endothelial dysfunction in GCK and HNF1A MODY patients

Szopa Magdalena , Osmenda Grzegorz , Wilk Grzegorz , Matejko Bartlomiej , Guzik Tomasz , Malecki Maciej

Mutations in the (glucokinase) GCK gene are, along with the HNF1A gene mutations, the most frequent cause of (maturity onset diabetes of the young) MODY. Heterozygous loss-of-function GCK mutations result in a moderate fasting hyperglycemia. The GCK-MODY patients are usually free from microvascular complications; however, little is known about atherosclerosis and intermediate related phenotypes. We aimed to examine intima-media thickness (IMT) and endothelial function in GCK-M...
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ea0035p459 | Diabetes complications | ECE2014

Prevalence of gastrointestinal diseases in the newly diagnosed pre-diabetic and diabetic patients

Cander Soner , Gul Ozen Oz , Topyildiz Figen , Ersoy Canan

Aim: Delayed gastric emptying affects a substantial proportion of patients with long-standing diabetes. On the other hand changes in gastric incretin hormones also play an important role in the pathophysiology of diabetes. In our study, we aimed to investigate the incidence of gastrointestinal disease in patients with newly diagnosed diabetes and pre-diabetes.Methods: A total of 73 patients with newly diagnosed pre-diabetes and diabetes were included in ...
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ea0035p460 | Diabetes complications | ECE2014

The influence of type 2 diabetes mellitus on periodontal disease

Silva Joao , Correia Diana , Marcelino Mafalda , Lopes Ana , Fernandes Nicholas , Ferreira Ana Lucia , Troles Tiago , Domingues Andreia , Passos Dolores , Lopes Luis , Figueiredo Joana , Luis Henrique , Silva Nuno , Mendes Jose Joao , Castro Joao Jacome de

The relationship between periodontitis and diabetes mellitus (DM) is widely accepted. Several studies identified a greater incidence of periodontitis and an increase of its severity in diabetic patients, approximately threefold.In this study, we want to investigate the influence of type 2 DM (T2DM) in the development of periodontitis.Single center, randomized trial with 90 patients T2DM. Exclusion criteria: chronic renal disease (G...
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ea0035p461 | Diabetes complications | ECE2014

Diabetes and end-stage renal disease: clinical evaluation of diabetic renal transplant candidates

Dantas Rosa , Bastos Margarida , Saraiva Joana , Moreno Carolina , Guelho Daniela , Vicente Nuno , Cardoso Luis Miguel , Simoes-Pereira Joana , Guimaraes Joana , Alves Rui , Carrilho Francisco

Introduction: Diabetes mellitus (DM) is one of the main causes of end-stage renal disease (ESRD). Renal transplantation is the most effective form or renal replacement.Methods: Retrospective, descriptive study of a sample of 108 diabetic patients admitted as candidates to renal transplant from January 1991 to December 2011, using the SPSS programme, version 20.0.Results: 11 women and 97 men were evaluated (medium age: 58±8.2 y...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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